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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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October-2017 Volume 16 Issue 4

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International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Article

Expression of pro-inflammatory cytokines in the auditory cortex of rats with salicylate-induced tinnitus

  • Authors:
    • Xiang‑Hong Chen
    • Li‑Li Zheng
  • View Affiliations / Copyright

    Affiliations: Department of Endocrinology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, P.R. China
  • Pages: 5643-5648
    |
    Published online on: August 11, 2017
       https://doi.org/10.3892/mmr.2017.7235
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Abstract

Tinnitus often results in severe psychological distress. The present study hypothesized that tinnitus acts as a chronic stressor and induces dysregulation of the production of cytokines. The gap pre‑pulse inhibition of acoustic startle paradigm was applied to test tinnitus‑like behavior in rats. Following this, the mRNA and protein expression levels of interferon (IFN)‑γ, tumor necrosis factor (TNF)‑α, interleukin (IL)‑6 and N‑methyl D‑aspartate receptor subunit 2A (NR2A) were measured in rats subjected to acute and chronic salicylate treatment, using reverse transcription‑quantitative polymerase chain reaction and western blot analysis, respectively. The gap prepulse inhibition of acoustic startle paradigm detected the tinnitus‑like behavior of rats. The expression of TNF‑α and NR2A genes were increased in the auditory cortex (AC) following long‑term administration of salicylate, whereas the expression of IFN‑γ genes decreased; however, the mRNA levels reversed back to normal baseline 14 days following the cease of salicylate administration. IL‑6 gene expression, however, was not fundamentally altered by salicylate treatment. The data demonstrated that chronic salicylate administration induces tinnitus, in part, via dysregulation of cytokines and specific membrane receptors in the AC.

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Copy and paste a formatted citation
Spandidos Publications style
Chen XH and Zheng LL: Expression of pro-inflammatory cytokines in the auditory cortex of rats with salicylate-induced tinnitus. Mol Med Rep 16: 5643-5648, 2017.
APA
Chen, X., & Zheng, L. (2017). Expression of pro-inflammatory cytokines in the auditory cortex of rats with salicylate-induced tinnitus. Molecular Medicine Reports, 16, 5643-5648. https://doi.org/10.3892/mmr.2017.7235
MLA
Chen, X., Zheng, L."Expression of pro-inflammatory cytokines in the auditory cortex of rats with salicylate-induced tinnitus". Molecular Medicine Reports 16.4 (2017): 5643-5648.
Chicago
Chen, X., Zheng, L."Expression of pro-inflammatory cytokines in the auditory cortex of rats with salicylate-induced tinnitus". Molecular Medicine Reports 16, no. 4 (2017): 5643-5648. https://doi.org/10.3892/mmr.2017.7235
Copy and paste a formatted citation
x
Spandidos Publications style
Chen XH and Zheng LL: Expression of pro-inflammatory cytokines in the auditory cortex of rats with salicylate-induced tinnitus. Mol Med Rep 16: 5643-5648, 2017.
APA
Chen, X., & Zheng, L. (2017). Expression of pro-inflammatory cytokines in the auditory cortex of rats with salicylate-induced tinnitus. Molecular Medicine Reports, 16, 5643-5648. https://doi.org/10.3892/mmr.2017.7235
MLA
Chen, X., Zheng, L."Expression of pro-inflammatory cytokines in the auditory cortex of rats with salicylate-induced tinnitus". Molecular Medicine Reports 16.4 (2017): 5643-5648.
Chicago
Chen, X., Zheng, L."Expression of pro-inflammatory cytokines in the auditory cortex of rats with salicylate-induced tinnitus". Molecular Medicine Reports 16, no. 4 (2017): 5643-5648. https://doi.org/10.3892/mmr.2017.7235
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