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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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October-2017 Volume 16 Issue 4

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Article

Dopamine and serotonin contribute to Paecilomyces hepiali against chronic unpredictable mild stress induced depressive behavior in Sprague Dawley rats

  • Authors:
    • Juan Wang
    • Yange Liu
    • Lanzhou Li
    • Yidi Qi
    • Yuanzhu Zhang
    • Longtu Li
    • Lirong Teng
    • Di Wang

  • View Affiliations / Copyright

    Affiliations: School of Life Sciences, Jilin University, Changchun, Jilin 130012, P.R. China
  • Pages: 5675-5682
    |
    Published online on: August 16, 2017
       https://doi.org/10.3892/mmr.2017.7261
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Abstract

Paecilomyces hepiali contains identical chemical constituents to Cordyceps sinensis, and it presents antidepressant‑like activity via regulating noradrenergic and dopaminergic systems. Behavioral despair depression models serve important roles in scientific screening and evaluation of antidepressants. The present study aims to investigate the antidepressant‑like activity of P. hepiali extract (PHC) in chronic unpredictable mild stress (CUMS)‑induced rat model of depression. Following four weeks of treatment, similar to fluoxetine at 3 mg/kg (positive drug), PHC at doses from 0.08 to 2.0 g/kg strongly increased sucrose preference and reduced the immobility time of depression‑like rats in forced swimming test. The hypo‑level of adrenocorticotropic hormone, noradrenaline and glucocorticoid receptor in serum and hypothalamus of depression‑like rats was enhanced by PHC. PHC normalized CUMS‑induced disorders of dihydroxyphenylacetic acid, dopamine, 5‑hydroxytryptamine (5‑HT) and 5‑hydroxyindoleacetic acid in serum and/or hypothalamus of depression‑like rats. Moreover, PHC enhanced the expression of tyrosine hydroxylase and reduced the levels of dopamine D2 receptor and 5‑HT2A receptor in hypothalamus. These results suggested that the antidepressant‑like effects of PHC in CUMS‑induced depression are associated with not only the modulation of dopamine, but also the regulation of 5-HT.

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Copy and paste a formatted citation
Spandidos Publications style
Wang J, Liu Y, Li L, Qi Y, Zhang Y, Li L, Teng L and Wang D: Dopamine and serotonin contribute to Paecilomyces hepiali against chronic unpredictable mild stress induced depressive behavior in Sprague Dawley rats. Mol Med Rep 16: 5675-5682, 2017.
APA
Wang, J., Liu, Y., Li, L., Qi, Y., Zhang, Y., Li, L. ... Wang, D. (2017). Dopamine and serotonin contribute to Paecilomyces hepiali against chronic unpredictable mild stress induced depressive behavior in Sprague Dawley rats. Molecular Medicine Reports, 16, 5675-5682. https://doi.org/10.3892/mmr.2017.7261
MLA
Wang, J., Liu, Y., Li, L., Qi, Y., Zhang, Y., Li, L., Teng, L., Wang, D."Dopamine and serotonin contribute to Paecilomyces hepiali against chronic unpredictable mild stress induced depressive behavior in Sprague Dawley rats". Molecular Medicine Reports 16.4 (2017): 5675-5682.
Chicago
Wang, J., Liu, Y., Li, L., Qi, Y., Zhang, Y., Li, L., Teng, L., Wang, D."Dopamine and serotonin contribute to Paecilomyces hepiali against chronic unpredictable mild stress induced depressive behavior in Sprague Dawley rats". Molecular Medicine Reports 16, no. 4 (2017): 5675-5682. https://doi.org/10.3892/mmr.2017.7261
Copy and paste a formatted citation
x
Spandidos Publications style
Wang J, Liu Y, Li L, Qi Y, Zhang Y, Li L, Teng L and Wang D: Dopamine and serotonin contribute to Paecilomyces hepiali against chronic unpredictable mild stress induced depressive behavior in Sprague Dawley rats. Mol Med Rep 16: 5675-5682, 2017.
APA
Wang, J., Liu, Y., Li, L., Qi, Y., Zhang, Y., Li, L. ... Wang, D. (2017). Dopamine and serotonin contribute to Paecilomyces hepiali against chronic unpredictable mild stress induced depressive behavior in Sprague Dawley rats. Molecular Medicine Reports, 16, 5675-5682. https://doi.org/10.3892/mmr.2017.7261
MLA
Wang, J., Liu, Y., Li, L., Qi, Y., Zhang, Y., Li, L., Teng, L., Wang, D."Dopamine and serotonin contribute to Paecilomyces hepiali against chronic unpredictable mild stress induced depressive behavior in Sprague Dawley rats". Molecular Medicine Reports 16.4 (2017): 5675-5682.
Chicago
Wang, J., Liu, Y., Li, L., Qi, Y., Zhang, Y., Li, L., Teng, L., Wang, D."Dopamine and serotonin contribute to Paecilomyces hepiali against chronic unpredictable mild stress induced depressive behavior in Sprague Dawley rats". Molecular Medicine Reports 16, no. 4 (2017): 5675-5682. https://doi.org/10.3892/mmr.2017.7261
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