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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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October-2017 Volume 16 Issue 4

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Article Open Access

PML(NLS¯) protein: A novel marker for the early diagnosis of acute promyelocytic leukemia

  • Authors:
    • Zhi‑Ling Shan
    • Xin‑Yu Zhu
    • Peng‑Peng Ma
    • Hui Wang
    • Jianbin Chen
    • Jun Li
    • Liang Zhong
    • Bei‑Zhong Liu

  • View Affiliations / Copyright

    Affiliations: Department of Laboratory Medicine and Central Laboratory of Yong‑chuan Hospital, Chongqing Medical University, Chongqing 402160, P.R. China, Department of Hematology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 630014, P.R. China, Department of Clinical Laboratory, The Third People's Hospital of Chongqing, Chongqing 400014, P.R. China, Key Laboratory of Laboratory Medical Diagnostics, Department of Laboratory Medicine, Ministry of Education, Chongqing Medical University, Chongqing 400016, P.R. China
    Copyright: © Shan et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 5418-5424
    |
    Published online on: August 17, 2017
       https://doi.org/10.3892/mmr.2017.7272
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Abstract

Promyelocyte leukemia‑retinoic acid receptor α (PML‑RARα) is known as a fusion gene of acute promyelocytic leukemia (APL). Previous studies have reported that neutrophil elastase (NE) cleaves PML‑RARα in early myeloid cells, which leads to the removal of the nuclear localization signal (NLS) in PML and increases the incidence of APL. The resultant PML without the NLS is termed PML(NLS‑). The aim of the present study was to verify the existence and location of the PML(NLS‑) protein in NB4 cells. NB4 cells underwent electroporation with the pCMV‑HA‑NE plasmid to form NB4‑HA‑NE cells, which were then transplanted to produce tumors in nude mice and samples were collected from patients with APL. Western blot analysis, an immunofluorescence assay, confocal laser microscopy and immunohistochemistry were performed to detect the expression and localization of the PML(NLS‑) protein. The findings demonstrated that PML(NLS‑) was detectable in the cytoplasm of NB4‑HA‑NE cells, the tumors in nude mice and in neutrophils from patients with APL. This indicated that PML(NLS‑) may be an effective and novel target for the diagnosis of APL.

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Copy and paste a formatted citation
Spandidos Publications style
Shan ZL, Zhu XY, Ma PP, Wang H, Chen J, Li J, Zhong L and Liu BZ: PML(NLS¯) protein: A novel marker for the early diagnosis of acute promyelocytic leukemia. Mol Med Rep 16: 5418-5424, 2017.
APA
Shan, Z., Zhu, X., Ma, P., Wang, H., Chen, J., Li, J. ... Liu, B. (2017). PML(NLS¯) protein: A novel marker for the early diagnosis of acute promyelocytic leukemia. Molecular Medicine Reports, 16, 5418-5424. https://doi.org/10.3892/mmr.2017.7272
MLA
Shan, Z., Zhu, X., Ma, P., Wang, H., Chen, J., Li, J., Zhong, L., Liu, B."PML(NLS¯) protein: A novel marker for the early diagnosis of acute promyelocytic leukemia". Molecular Medicine Reports 16.4 (2017): 5418-5424.
Chicago
Shan, Z., Zhu, X., Ma, P., Wang, H., Chen, J., Li, J., Zhong, L., Liu, B."PML(NLS¯) protein: A novel marker for the early diagnosis of acute promyelocytic leukemia". Molecular Medicine Reports 16, no. 4 (2017): 5418-5424. https://doi.org/10.3892/mmr.2017.7272
Copy and paste a formatted citation
x
Spandidos Publications style
Shan ZL, Zhu XY, Ma PP, Wang H, Chen J, Li J, Zhong L and Liu BZ: PML(NLS¯) protein: A novel marker for the early diagnosis of acute promyelocytic leukemia. Mol Med Rep 16: 5418-5424, 2017.
APA
Shan, Z., Zhu, X., Ma, P., Wang, H., Chen, J., Li, J. ... Liu, B. (2017). PML(NLS¯) protein: A novel marker for the early diagnosis of acute promyelocytic leukemia. Molecular Medicine Reports, 16, 5418-5424. https://doi.org/10.3892/mmr.2017.7272
MLA
Shan, Z., Zhu, X., Ma, P., Wang, H., Chen, J., Li, J., Zhong, L., Liu, B."PML(NLS¯) protein: A novel marker for the early diagnosis of acute promyelocytic leukemia". Molecular Medicine Reports 16.4 (2017): 5418-5424.
Chicago
Shan, Z., Zhu, X., Ma, P., Wang, H., Chen, J., Li, J., Zhong, L., Liu, B."PML(NLS¯) protein: A novel marker for the early diagnosis of acute promyelocytic leukemia". Molecular Medicine Reports 16, no. 4 (2017): 5418-5424. https://doi.org/10.3892/mmr.2017.7272
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