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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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October-2017 Volume 16 Issue 4

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Article

Polysaccharide purified from Lycium barbarum protects differentiated PC12 cells against L‑Glu‑induced toxicity via the mitochondria‑associated pathway

  • Authors:
    • Ling Kou
    • Mingzhao Du
    • Chaopu Zhang
    • Zhiyin Dai
    • Xuan Li
    • Baohai Zhang
    • Xinyu Hu

  • View Affiliations / Copyright

    Affiliations: Department of Vasculocardiology, Affiliated Hospital of Jiangsu University, Jiangsu University, Zhenjiang, Jiangsu 212001, P.R. China, Faculty of Medicine, Changchun Medical College, Changchun, Jilin 130013, P.R. China
  • Pages: 5533-5540
    |
    Published online on: August 18, 2017
       https://doi.org/10.3892/mmr.2017.7289
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Abstract

The present study successfully demonstrated the neuroprotective effects of purified Lycium barbarum polysaccharide (LBPS02) against glutamate (L‑Glu)‑induced differentiated PC12 (DPC12) cell apoptosis. Purified polysaccharide was obtained by using a diethylaminoethyl‑52 cellulose anion exchange column and a Sepharose G‑100 column. During identification and characterization, LBPS02 was validated to be a fraction with 68 kDa molecular weight, and with a structure containing 1→3, 1→4 and 1→6 linkages. Data further revealed that LBPS02 pretreatment effectively improved cell viability, reduced apoptosis rate, and restored the mitochondrial dysfunction in L‑Glu‑exposed cells. LBPS02 suppressed L‑Glu‑induced reactive oxygen species (ROS accumulation in DPC12 cells. N‑acetylcysteine, a ROS inhibitor, strongly enhanced the efficacy of LBPS02. Furthermore, LBPS02 normalized the levels of anti‑apoptotic proteins, and regulated the phosphorylation of extracellular signal‑regulated kinases (ERKs) and protein kinase B (Akt) in L‑Glu‑explored DPC12 cells. In conclusion, LBPS02‑mediated neuroprotective effects are at least partially associated with the modulation of Akt and ERKs, and the subsequent inhibition of the mitochondrial apoptotic pathway. LBPS02 may be a candidate for neurodegenerative disease treatment.

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Copy and paste a formatted citation
Spandidos Publications style
Kou L, Du M, Zhang C, Dai Z, Li X, Zhang B and Hu X: Polysaccharide purified from Lycium barbarum protects differentiated PC12 cells against L‑Glu‑induced toxicity via the mitochondria‑associated pathway. Mol Med Rep 16: 5533-5540, 2017.
APA
Kou, L., Du, M., Zhang, C., Dai, Z., Li, X., Zhang, B., & Hu, X. (2017). Polysaccharide purified from Lycium barbarum protects differentiated PC12 cells against L‑Glu‑induced toxicity via the mitochondria‑associated pathway. Molecular Medicine Reports, 16, 5533-5540. https://doi.org/10.3892/mmr.2017.7289
MLA
Kou, L., Du, M., Zhang, C., Dai, Z., Li, X., Zhang, B., Hu, X."Polysaccharide purified from Lycium barbarum protects differentiated PC12 cells against L‑Glu‑induced toxicity via the mitochondria‑associated pathway". Molecular Medicine Reports 16.4 (2017): 5533-5540.
Chicago
Kou, L., Du, M., Zhang, C., Dai, Z., Li, X., Zhang, B., Hu, X."Polysaccharide purified from Lycium barbarum protects differentiated PC12 cells against L‑Glu‑induced toxicity via the mitochondria‑associated pathway". Molecular Medicine Reports 16, no. 4 (2017): 5533-5540. https://doi.org/10.3892/mmr.2017.7289
Copy and paste a formatted citation
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Spandidos Publications style
Kou L, Du M, Zhang C, Dai Z, Li X, Zhang B and Hu X: Polysaccharide purified from Lycium barbarum protects differentiated PC12 cells against L‑Glu‑induced toxicity via the mitochondria‑associated pathway. Mol Med Rep 16: 5533-5540, 2017.
APA
Kou, L., Du, M., Zhang, C., Dai, Z., Li, X., Zhang, B., & Hu, X. (2017). Polysaccharide purified from Lycium barbarum protects differentiated PC12 cells against L‑Glu‑induced toxicity via the mitochondria‑associated pathway. Molecular Medicine Reports, 16, 5533-5540. https://doi.org/10.3892/mmr.2017.7289
MLA
Kou, L., Du, M., Zhang, C., Dai, Z., Li, X., Zhang, B., Hu, X."Polysaccharide purified from Lycium barbarum protects differentiated PC12 cells against L‑Glu‑induced toxicity via the mitochondria‑associated pathway". Molecular Medicine Reports 16.4 (2017): 5533-5540.
Chicago
Kou, L., Du, M., Zhang, C., Dai, Z., Li, X., Zhang, B., Hu, X."Polysaccharide purified from Lycium barbarum protects differentiated PC12 cells against L‑Glu‑induced toxicity via the mitochondria‑associated pathway". Molecular Medicine Reports 16, no. 4 (2017): 5533-5540. https://doi.org/10.3892/mmr.2017.7289
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