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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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October-2017 Volume 16 Issue 4

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Article Open Access

MicroRNA‑518b functions as a tumor suppressor in glioblastoma by targeting PDGFRB

  • Authors:
    • Xiaolong Xu
    • Fenglin Zhang
    • Xianzhen Chen
    • Qi Ying

  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery, The Tenth People's Hospital Affiliated to Tongji University School of Medicine, Shanghai 200072, P.R. China, Department of Neurosurgery, The 411th Hospital of PLA, Shanghai 200081, P.R. China
    Copyright: © Xu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 5326-5332
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    Published online on: August 21, 2017
       https://doi.org/10.3892/mmr.2017.7298
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Abstract

Glioblastoma (GBM) is the most common and aggressive type of primary human brain tumor in China. Dysregulated microRNA (miRNA/miR) expression has been hypothesized to serve a role in the tumorigenesis and progression of human GBM. To explore the potential mechanisms affecting GBM tumorigenesis, the function of miR‑518b in regulating GBM cell proliferation and angiogenesis was examined in vitro by CCK‑8 and tube formation assay and in vivo by xenograft assay. The present study demonstrated that the expression of miR‑518b was downregulated in GBM tissues and in GBM cell lines (U87 and U251). In addition, the expression levels of miR‑518b were highly associated with tumor size, World Health Organization grade and prognosis. Furthermore, overexpression of miR‑518b suppressed GBM cell proliferation and angiogenesis, and induced GBM cell apoptosis in vitro and in vivo. Overexpression of miR‑518b also inhibited the expression of platelet‑derived growth factor receptor β (PDGFRB), and the present study confirmed that the 3' untranslated region (3'UTR) of PDGFRB was a direct target of miR‑518b. In conclusion, to the best of our knowledge, the present study is the first to present evidence suggesting that miR‑518b may serve as a potential marker and target in GBM treatment.

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Copy and paste a formatted citation
Spandidos Publications style
Xu X, Zhang F, Chen X and Ying Q: MicroRNA‑518b functions as a tumor suppressor in glioblastoma by targeting PDGFRB. Mol Med Rep 16: 5326-5332, 2017.
APA
Xu, X., Zhang, F., Chen, X., & Ying, Q. (2017). MicroRNA‑518b functions as a tumor suppressor in glioblastoma by targeting PDGFRB. Molecular Medicine Reports, 16, 5326-5332. https://doi.org/10.3892/mmr.2017.7298
MLA
Xu, X., Zhang, F., Chen, X., Ying, Q."MicroRNA‑518b functions as a tumor suppressor in glioblastoma by targeting PDGFRB". Molecular Medicine Reports 16.4 (2017): 5326-5332.
Chicago
Xu, X., Zhang, F., Chen, X., Ying, Q."MicroRNA‑518b functions as a tumor suppressor in glioblastoma by targeting PDGFRB". Molecular Medicine Reports 16, no. 4 (2017): 5326-5332. https://doi.org/10.3892/mmr.2017.7298
Copy and paste a formatted citation
x
Spandidos Publications style
Xu X, Zhang F, Chen X and Ying Q: MicroRNA‑518b functions as a tumor suppressor in glioblastoma by targeting PDGFRB. Mol Med Rep 16: 5326-5332, 2017.
APA
Xu, X., Zhang, F., Chen, X., & Ying, Q. (2017). MicroRNA‑518b functions as a tumor suppressor in glioblastoma by targeting PDGFRB. Molecular Medicine Reports, 16, 5326-5332. https://doi.org/10.3892/mmr.2017.7298
MLA
Xu, X., Zhang, F., Chen, X., Ying, Q."MicroRNA‑518b functions as a tumor suppressor in glioblastoma by targeting PDGFRB". Molecular Medicine Reports 16.4 (2017): 5326-5332.
Chicago
Xu, X., Zhang, F., Chen, X., Ying, Q."MicroRNA‑518b functions as a tumor suppressor in glioblastoma by targeting PDGFRB". Molecular Medicine Reports 16, no. 4 (2017): 5326-5332. https://doi.org/10.3892/mmr.2017.7298
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