Expression of microRNA‑222 in serum of patients with Alzheimer's disease

  • Authors:
    • Qinghong Zeng
    • Linqing Zou
    • Li Qian
    • Fang Zhou
    • Hongxia Nie
    • Shanhua Yu
    • Jiandong Jiang
    • Aixia Zhuang
    • Chuanqi Wang
    • Haojiang Zhang
  • View Affiliations

  • Published online on: August 21, 2017     https://doi.org/10.3892/mmr.2017.7301
  • Pages: 5575-5579
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Abstract

The aim of the present study was to determine the association between Alzheimer's disease (AD) and microRNA‑222 in the serum of patients with AD. The expression of microRNAs was detected and the results were verified using microarray analysis and reverse transcription‑quantitative polymerase chain reaction. The results indicated that there were 35 strips of microRNA in the mild AD group, in which the difference of expression signal was >500 IU/ml. There were 26 strips of microRNA with a difference in expression signal of >500 IU/ml in the mild and moderate AD groups. The downregulation of microRNA‑222 in the mild and moderate groups was statistically significant (P<0.01), and the expression of microRNA‑222 in the moderate group was significantly lower, compared with that in the mild AD group (P<0.05). It was concluded that microRNA‑222 may affect the occurrence and development of AD through a variety of mechanisms, and may serve as a biomarker for the early diagnosis of AD.

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October-2017
Volume 16 Issue 4

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Zeng Q, Zou L, Qian L, Zhou F, Nie H, Yu S, Jiang J, Zhuang A, Wang C, Zhang H, Zhang H, et al: Expression of microRNA‑222 in serum of patients with Alzheimer's disease. Mol Med Rep 16: 5575-5579, 2017
APA
Zeng, Q., Zou, L., Qian, L., Zhou, F., Nie, H., Yu, S. ... Zhang, H. (2017). Expression of microRNA‑222 in serum of patients with Alzheimer's disease. Molecular Medicine Reports, 16, 5575-5579. https://doi.org/10.3892/mmr.2017.7301
MLA
Zeng, Q., Zou, L., Qian, L., Zhou, F., Nie, H., Yu, S., Jiang, J., Zhuang, A., Wang, C., Zhang, H."Expression of microRNA‑222 in serum of patients with Alzheimer's disease". Molecular Medicine Reports 16.4 (2017): 5575-5579.
Chicago
Zeng, Q., Zou, L., Qian, L., Zhou, F., Nie, H., Yu, S., Jiang, J., Zhuang, A., Wang, C., Zhang, H."Expression of microRNA‑222 in serum of patients with Alzheimer's disease". Molecular Medicine Reports 16, no. 4 (2017): 5575-5579. https://doi.org/10.3892/mmr.2017.7301