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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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October-2017 Volume 16 Issue 4

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

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Article

Expression of microRNA‑222 in serum of patients with Alzheimer's disease

  • Authors:
    • Qinghong Zeng
    • Linqing Zou
    • Li Qian
    • Fang Zhou
    • Hongxia Nie
    • Shanhua Yu
    • Jiandong Jiang
    • Aixia Zhuang
    • Chuanqi Wang
    • Haojiang Zhang

  • View Affiliations / Copyright

    Affiliations: Department of Neurology, The Second People's Hospital of Lianyungang, Lianyungang, Jiangsu 222006, P.R. China, Department of Human Anatomy, Jiangsu Key Laboratory of Neuroregeneration, Nantong University, Nantong, Jiangsu 226019, P.R. China, Department of Clinical Laboratory, The Second People's Hospital of Lianyungang, Lianyungang, Jiangsu 222006, P.R. China
  • Pages: 5575-5579
    |
    Published online on: August 21, 2017
       https://doi.org/10.3892/mmr.2017.7301
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Abstract

The aim of the present study was to determine the association between Alzheimer's disease (AD) and microRNA‑222 in the serum of patients with AD. The expression of microRNAs was detected and the results were verified using microarray analysis and reverse transcription‑quantitative polymerase chain reaction. The results indicated that there were 35 strips of microRNA in the mild AD group, in which the difference of expression signal was >500 IU/ml. There were 26 strips of microRNA with a difference in expression signal of >500 IU/ml in the mild and moderate AD groups. The downregulation of microRNA‑222 in the mild and moderate groups was statistically significant (P<0.01), and the expression of microRNA‑222 in the moderate group was significantly lower, compared with that in the mild AD group (P<0.05). It was concluded that microRNA‑222 may affect the occurrence and development of AD through a variety of mechanisms, and may serve as a biomarker for the early diagnosis of AD.

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Copy and paste a formatted citation
Spandidos Publications style
Zeng Q, Zou L, Qian L, Zhou F, Nie H, Yu S, Jiang J, Zhuang A, Wang C, Zhang H, Zhang H, et al: Expression of microRNA‑222 in serum of patients with Alzheimer's disease. Mol Med Rep 16: 5575-5579, 2017.
APA
Zeng, Q., Zou, L., Qian, L., Zhou, F., Nie, H., Yu, S. ... Zhang, H. (2017). Expression of microRNA‑222 in serum of patients with Alzheimer's disease. Molecular Medicine Reports, 16, 5575-5579. https://doi.org/10.3892/mmr.2017.7301
MLA
Zeng, Q., Zou, L., Qian, L., Zhou, F., Nie, H., Yu, S., Jiang, J., Zhuang, A., Wang, C., Zhang, H."Expression of microRNA‑222 in serum of patients with Alzheimer's disease". Molecular Medicine Reports 16.4 (2017): 5575-5579.
Chicago
Zeng, Q., Zou, L., Qian, L., Zhou, F., Nie, H., Yu, S., Jiang, J., Zhuang, A., Wang, C., Zhang, H."Expression of microRNA‑222 in serum of patients with Alzheimer's disease". Molecular Medicine Reports 16, no. 4 (2017): 5575-5579. https://doi.org/10.3892/mmr.2017.7301
Copy and paste a formatted citation
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Spandidos Publications style
Zeng Q, Zou L, Qian L, Zhou F, Nie H, Yu S, Jiang J, Zhuang A, Wang C, Zhang H, Zhang H, et al: Expression of microRNA‑222 in serum of patients with Alzheimer's disease. Mol Med Rep 16: 5575-5579, 2017.
APA
Zeng, Q., Zou, L., Qian, L., Zhou, F., Nie, H., Yu, S. ... Zhang, H. (2017). Expression of microRNA‑222 in serum of patients with Alzheimer's disease. Molecular Medicine Reports, 16, 5575-5579. https://doi.org/10.3892/mmr.2017.7301
MLA
Zeng, Q., Zou, L., Qian, L., Zhou, F., Nie, H., Yu, S., Jiang, J., Zhuang, A., Wang, C., Zhang, H."Expression of microRNA‑222 in serum of patients with Alzheimer's disease". Molecular Medicine Reports 16.4 (2017): 5575-5579.
Chicago
Zeng, Q., Zou, L., Qian, L., Zhou, F., Nie, H., Yu, S., Jiang, J., Zhuang, A., Wang, C., Zhang, H."Expression of microRNA‑222 in serum of patients with Alzheimer's disease". Molecular Medicine Reports 16, no. 4 (2017): 5575-5579. https://doi.org/10.3892/mmr.2017.7301
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