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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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October-2017 Volume 16 Issue 4

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

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Long noncoding RNA colon cancer associated transcript‑1 promotes the proliferation, migration and invasion of cervical cancer

  • Authors:
    • Ligang Jia
    • Yuan Zhang
    • Fei Tian
    • Zhaoping Chu
    • Hong Xin

  • View Affiliations / Copyright

    Affiliations: Department of Gynecology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei 050000, P.R. China, Department of Gynecology, Hebei General Hospital, Shijiazhuang, Hebei 050000, P.R. China, Department of Obstetrics, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei 050000, P.R. China
  • Pages: 5587-5591
    |
    Published online on: August 21, 2017
       https://doi.org/10.3892/mmr.2017.7302
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Abstract

Previous studies have revealed significant roles for long noncoding RNA (lncRNA) in the tumorigenesis, metastasis and invasion of various tumors, including cervical cancer. The present study aimed to investigate the potential roles of lncRNA colon cancer associated transcript 1 (CCAT1) in the metastasis and invasion of cervical cancer, and to reveal the potential underlying mechanism. The mRNA expression of lncRNA CCAT1 in cervical cancer tissue was measured using the reverse transcription‑quantitative polymerase chain reaction, and the association between lncRNA CCAT1 and the metastasis of cervical cancer was analyzed. The effects of lncRNA CCAT1 expression on HeLa cell viability, and migration and invasion were also analyzed by MTT and Transwell assays. The results demonstrated that lncRNA CCAT1 was highly expressed in the cervical cancer tissue compared with the adjacent normal tissue. High expression of lncRNA CCAT1 was positively associated with tumor size, and there was correlation between high lncRNA CCAT1 expression and a poor survival rate of cervical cancer. The cell viability, and migratory and invasive abilities were suppressed by silencing CCAT1. The results of the present study indicate that lncRNA CCAT1 was highly expressed in cervical cancer, and may serve important roles in promoting the progression and metastasis of cervical cancer.

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Copy and paste a formatted citation
Spandidos Publications style
Jia L, Zhang Y, Tian F, Chu Z and Xin H: Long noncoding RNA colon cancer associated transcript‑1 promotes the proliferation, migration and invasion of cervical cancer. Mol Med Rep 16: 5587-5591, 2017.
APA
Jia, L., Zhang, Y., Tian, F., Chu, Z., & Xin, H. (2017). Long noncoding RNA colon cancer associated transcript‑1 promotes the proliferation, migration and invasion of cervical cancer. Molecular Medicine Reports, 16, 5587-5591. https://doi.org/10.3892/mmr.2017.7302
MLA
Jia, L., Zhang, Y., Tian, F., Chu, Z., Xin, H."Long noncoding RNA colon cancer associated transcript‑1 promotes the proliferation, migration and invasion of cervical cancer". Molecular Medicine Reports 16.4 (2017): 5587-5591.
Chicago
Jia, L., Zhang, Y., Tian, F., Chu, Z., Xin, H."Long noncoding RNA colon cancer associated transcript‑1 promotes the proliferation, migration and invasion of cervical cancer". Molecular Medicine Reports 16, no. 4 (2017): 5587-5591. https://doi.org/10.3892/mmr.2017.7302
Copy and paste a formatted citation
x
Spandidos Publications style
Jia L, Zhang Y, Tian F, Chu Z and Xin H: Long noncoding RNA colon cancer associated transcript‑1 promotes the proliferation, migration and invasion of cervical cancer. Mol Med Rep 16: 5587-5591, 2017.
APA
Jia, L., Zhang, Y., Tian, F., Chu, Z., & Xin, H. (2017). Long noncoding RNA colon cancer associated transcript‑1 promotes the proliferation, migration and invasion of cervical cancer. Molecular Medicine Reports, 16, 5587-5591. https://doi.org/10.3892/mmr.2017.7302
MLA
Jia, L., Zhang, Y., Tian, F., Chu, Z., Xin, H."Long noncoding RNA colon cancer associated transcript‑1 promotes the proliferation, migration and invasion of cervical cancer". Molecular Medicine Reports 16.4 (2017): 5587-5591.
Chicago
Jia, L., Zhang, Y., Tian, F., Chu, Z., Xin, H."Long noncoding RNA colon cancer associated transcript‑1 promotes the proliferation, migration and invasion of cervical cancer". Molecular Medicine Reports 16, no. 4 (2017): 5587-5591. https://doi.org/10.3892/mmr.2017.7302
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