Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
December-2017 Volume 16 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
December-2017 Volume 16 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

SH003‑induced G1 phase cell cycle arrest induces apoptosis in HeLa cervical cancer cells

  • Authors:
    • Kang Min Lee
    • Kangwook Lee
    • Youn Kyung Choi
    • Yu‑Jeong Choi
    • Hye‑Sook Seo
    • Seong‑Gyu Ko
  • View Affiliations / Copyright

    Affiliations: Department of Science in Korean Medicine, Graduate School, Kyung Hee University, Seoul 02247, Republic of Korea, Jeju International Marine Science Center for Research & Education, Korea Institute of Ocean Science and Technology, Jeju 63349, Republic of Korea, Department of Cancer Preventive Material Development, Graduate School, Kyung Hee University, Seoul 02247, Republic of Korea, Department of Preventive Medicine, College of Korean Medicine, Kyung Hee University, Seoul 02247, Republic of Korea
  • Pages: 8237-8244
    |
    Published online on: September 25, 2017
       https://doi.org/10.3892/mmr.2017.7597
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Cervical cancer is a prevalent disease that may lead to mortality in women. In spite of the development of common therapeutic agents to treat cancer, there are several limitations of their use owing to side effects and drug resistance, which may induce cancer recurrence. The anticancer effects of the new herbal mixture SH003 (comprising Astragalus membranaceus, Angelica gigas and Trichosanthes kirilowii Maximowicz) have been examined in various types of cancer. Thus, the present study hypothesized that SH003 may be an effective treatment for cervical cancer. SH003 treatment inhibited the growth of HeLa cells, whereas it did not affect the growth of rat intestinal epithelial cells. In addition, SH003 treatment increased the expression of apoptosis‑related proteins and promoted apoptotic cell death in HeLa cells. SH003 treatment also led to G1 phase arrest in HeLa cells. Furthermore, SH003 treatment induced the production of reactive oxygen species (ROS); however, ROS production did not appear to be related to SH003‑mediated apoptosis. Results from the present study indicated that the SH003‑induced inhibition of HeLa cell growth may be mediated through G1 phase arrest and extrinsic apoptosis, suggested that SH003 may be a potential treatment for cervical cancer.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

Popat K, McQueen K and Feeley TW: The global burden of cancer. Best Pract Res Clin Anaesthesiol. 27:399–408. 2013. View Article : Google Scholar : PubMed/NCBI

2 

Siegel RL, Miller KD and Jemal A: Cancer statistics, 2015. CA Cancer J Clin. 65:5–29. 2015. View Article : Google Scholar : PubMed/NCBI

3 

Vaccarella S, Bruni L and Seoud M: Burden of human papillomavirus infections and related diseases in the extended Middle East and North Africa region. Vaccine. 31 Suppl 6:G32–G44. 2013. View Article : Google Scholar : PubMed/NCBI

4 

Pecorelli S, Zigliani L and Odicino F: Revised FIGO staging for carcinoma of the cervix. Int J Gynaecol Obstet. 105:107–108. 2009. View Article : Google Scholar : PubMed/NCBI

5 

Dueñas-González A, Cetina L, Coronel J and González-Fierro A: The safety of drug treatments for cervical cancer. Expert Opin Drug Saf. 15:169–180. 2016. View Article : Google Scholar : PubMed/NCBI

6 

Choi EJ and Kim GH: Antioxidant and anticancer activity of Artemisia princeps var. Orientalis extract in HepG2 and Hep3B hepatocellular carcinoma cells. Chin J Cancer Res. 25:536–543. 2013.PubMed/NCBI

7 

Fang L, Wang Z, Kong WY, Feng JG, Ma SL and Lin NM: Anti-tumor and apoptotic effects in vitro and in vivo of a traditional Chinese medicine prescription. Chin Med J (Engl). 124:3583–3587. 2011.PubMed/NCBI

8 

Cheng YL, Chang WL, Lee SC, Liu YG, Chen CJ, Lin SZ, Tsai NM, Yu DS, Yen CY and Harn HJ: Acetone extract of Angelica sinensis inhibits proliferation of human cancer cells via inducing cell cycle arrest and apoptosis. Life Sci. 75:1579–1594. 2004. View Article : Google Scholar : PubMed/NCBI

9 

Sato T, Kita K, Sato C and Kaneda A: Hochu-ekki-to (Bu-zhong-yi-qi-tang), a herbal medicine, enhances cisplatin-induced apoptosis in HeLa cells. Mol Med Rep. 12:6215–6220. 2015. View Article : Google Scholar : PubMed/NCBI

10 

Duan D, Zhang J, Yao J, Liu Y and Fang J: Targeting thioredoxin reductase by parthenolide contributes to inducing apoptosis of HeLa cells. J Biol Chem. 291:10021–10031. 2016. View Article : Google Scholar : PubMed/NCBI

11 

Qian S and Li M: Chamaejasmine induces apoptosis in HeLa cells through the PI3K/Akt signaling pathway. Anticancer Drugs. 28:40–50. 2017. View Article : Google Scholar : PubMed/NCBI

12 

Choi YK, Cho SG, Woo SM, Yun YJ, Park S, Shin YC and Ko SG: Herbal extract SH003 suppresses tumor growth and metastasis of MDA-MB-231 breast cancer cells by inhibiting STAT3-IL-6 signaling. Mediators Inflamm. 2014:4921732014. View Article : Google Scholar : PubMed/NCBI

13 

Choi HS, Kim MK, Lee K, Lee KM, Choi YK, Shin YC, Cho SG and Ko SG: SH003 represses tumor angiogenesis by blocking VEGF binding to VEGFR2. Oncotarget. 7:32969–32979. 2016. View Article : Google Scholar : PubMed/NCBI

14 

Zhang J, Li L, Jiang C, Xing C, Kim SH and Lü J: Anti-cancer and other bioactivities of Korean Angelica gigas Nakai (AGN) and its major pyranocoumarin compounds. Anticancer Agents Med Chem. 12:1239–1254. 2012. View Article : Google Scholar : PubMed/NCBI

15 

Yang B, Xiao B and Sun T: Antitumor and immunomodulatory activity of Astragalus membranaceus polysaccharides in H22 tumor-bearing mice. Int J Biol Macromol. 62:287–290. 2013. View Article : Google Scholar : PubMed/NCBI

16 

Zhang WL, Zheng KY, Zhu KY, Zhan JY, Bi CW, Chen JP, Du CY, Zhao KJ, Lau DT, Dong TT and Tsim KW: Chemical and biological assessment of Angelica herbal decoction: Comparison of different preparations during historical applications. Phytomedicine. 19:1042–1048. 2012. View Article : Google Scholar : PubMed/NCBI

17 

Kim BS, Seo H, Kim HJ, Bae SM, Son HN, Lee YJ, Ryu S, Park RW and Nam JO: Decursin from Angelica gigas Nakai inhibits B16F10 melanoma growth through induction of apoptosis. J Med Food. 18:1121–1127. 2015. View Article : Google Scholar : PubMed/NCBI

18 

Cui R, He J, Wang B, Zhang F, Chen G, Yin S and Shen H: Suppressive effect of Astragalus membranaceus Bunge on chemical hepatocarcinogenesis in rats. Cancer Chemother Pharmacol. 51:75–80. 2003. View Article : Google Scholar : PubMed/NCBI

19 

Lv J, Zhao Z, Chen Y, Wang Q, Tao Y, Yang L, Fan TP and Liu C: The chinese herbal decoction danggui buxue tang inhibits angiogenesis in a rat model of liver fibrosis. Evid Based Complement Alternat Med. 2012:2849632012. View Article : Google Scholar : PubMed/NCBI

20 

Shin JW, Son JY, Kang JK, Han SH, Cho CK and Son CG: Trichosanthes kirilowii tuber extract induces G2/M phase arrest via inhibition of tubulin polymerization in HepG2 cells. J Ethnopharmacol. 115:209–216. 2008. View Article : Google Scholar : PubMed/NCBI

21 

Kongtun S, Jiratchariyakul W, Kummalue T, Tan-ariya P, Kunnachak S and Frahm AW: Cytotoxic properties of root extract and fruit juice of Trichosanthes cucumerina. Planta Med. 75:839–842. 2009. View Article : Google Scholar : PubMed/NCBI

22 

Heo BG, Chon SU, Park YJ, Bae JH, Park SM, Park YS, Jang HG and Gorinstein S: Antiproliferative activity of Korean wild vegetables on different human tumor cell lines. Plant Foods Hum Nutr. 64:257–263. 2009. View Article : Google Scholar : PubMed/NCBI

23 

Li LK, Kuang WJ, Huang YF, Xie HH, Chen G, Zhou QC, Wang BR and Wan LH: Anti-tumor effects of Astragalus on hepatocellular carcinoma in vivo. Indian J Pharmacol. 44:78–81. 2012. View Article : Google Scholar : PubMed/NCBI

24 

Cho WC and Leung KN: In vitro and in vivo anti-tumor effects of Astragalus membranaceus. Cancer Lett. 252:43–54. 2007. View Article : Google Scholar : PubMed/NCBI

25 

Cheng XD, Hou CH, Zhang XJ, Xie HY, Zhou WY, Yang L, Zhang SB and Qian RL: Effects of Huangqi (Hex) on inducing cell differentiation and cell death in K562 and HEL cells. Acta Biochim Biophys Sin (Shanghai). 36:211–217. 2004. View Article : Google Scholar : PubMed/NCBI

26 

Yin G, Tang D, Dai J, Liu M, Wu M, Sun YU, Yang Z, Hoffman RM, Li L, Zhang S and Guo X: Combination efficacy of astragalus membranaceus and curcuma wenyujin at different stages of tumor progression in an imageable orthotopic nude mouse model of metastatic human ovarian cancer expressing red fluorescent protein. Anticancer Res. 35:3193–3207. 2015.PubMed/NCBI

27 

Lee HJ, Lee HJ, Lee EO, Lee JH, Lee KS, Kim KH, Kim SH and Lü J: In vivo anti-cancer activity of Korean Angelica gigas and its major pyranocoumarin decursin. Am J Chin Med. 37:127–142. 2009. View Article : Google Scholar : PubMed/NCBI

28 

Fang EF, Zhang CZ, Zhang L, Wong JH, Chan YS, Pan WL, Dan XL, Yin CM, Cho CH and Ng TB: Trichosanthin inhibits breast cancer cell proliferation in both cell lines and nude mice by promotion of apoptosis. PLoS One. 7:e415922012. View Article : Google Scholar : PubMed/NCBI

29 

Li M, Li X and Li JC: Possible mechanisms of trichosanthin-induced apoptosis of tumor cells. Anat Rec (Hoboken). 293:986–992. 2010. View Article : Google Scholar : PubMed/NCBI

30 

Woo SM, Choi YK, Cho SG, Park S and Ko SG: A New Herbal Formula, KSG-002, suppresses breast cancer growth and metastasis by Targeting NF-κB-dependent TNF α production in macrophages. Evid Based Complement Alternat Med. 2013:7282582013. View Article : Google Scholar : PubMed/NCBI

31 

Degterev A and Yuan J: Expansion and evolution of cell death programmes. Nat Rev Mol Cell Biol. 9:378–390. 2008. View Article : Google Scholar : PubMed/NCBI

32 

Kerr JF, Wyllie AH and Currie AR: Apoptosis: A basic biological phenomenon with wide-ranging implications in tissue kinetics. Br J Cancer. 26:239–257. 1972. View Article : Google Scholar : PubMed/NCBI

33 

Youle RJ and Strasser A: The BCL-2 protein family: Opposing activities that mediate cell death. Nat Rev Mol Cell Biol. 9:47–59. 2008. View Article : Google Scholar : PubMed/NCBI

34 

Ola MS, Nawaz M and Ahsan H: Role of Bcl-2 family proteins and caspases in the regulation of apoptosis. Mol Cell Biochem. 351:41–58. 2011. View Article : Google Scholar : PubMed/NCBI

35 

McIlwain DR, Berger T and Mak TW: Caspase functions in cell death and disease. Cold Spring Harb Perspect Biol. 5:a0086562013. View Article : Google Scholar : PubMed/NCBI

36 

Lavrik IN and Krammer PH: Regulation of CD95/Fas signaling at the DISC. Cell Death Differ. 19:36–41. 2012. View Article : Google Scholar : PubMed/NCBI

37 

Vermeulen K, Van Bockstaele DR and Berneman ZN: The cell cycle: A review of regulation, deregulation and therapeutic targets in cancer. Cell Prolif. 36:131–149. 2003. View Article : Google Scholar : PubMed/NCBI

38 

Song J, Li J, Qiao J, Jain S, Evers B Mark and Chung DH: PKD prevents H2O2-induced apoptosis via NF-kappaB and p38 MAPK in RIE-1 cells. Biochem Biophys Res Commun. 378:610–614. 2009. View Article : Google Scholar : PubMed/NCBI

39 

Song Y, Li X, Li Y, Li N, Shi X, Ding H, Zhang Y, Li X, Liu G and Wang Z: Non-esterified fatty acids activate the ROS-p38-p53/Nrf2 signaling pathway to induce bovine hepatocyte apoptosis in vitro. Apoptosis. 19:984–997. 2014. View Article : Google Scholar : PubMed/NCBI

40 

Circu ML and Aw TY: Reactive oxygen species, cellular redox systems, and apoptosis. Free Radic Biol Med. 48:749–762. 2010. View Article : Google Scholar : PubMed/NCBI

41 

Trachootham D, Alexandre J and Huang P: Targeting cancer cells by ROS-mediated mechanisms: A radical therapeutic approach? Nat Rev Drug Discov. 8:579–591. 2009. View Article : Google Scholar : PubMed/NCBI

42 

Chaithongyot S, Asgar A, Senawong G, Yowapuy A, Lattmann E, Sattayasai N and Senawong T: Anticancer effects of curcuma C20-dialdehyde against colon and cervical cancer cell lines. Asian Pac J Cancer Prev. 16:6513–6519. 2015. View Article : Google Scholar : PubMed/NCBI

43 

Luo H, Wang F, Bai Y, Chen T and Zheng W: Selenium nanoparticles inhibit the growth of HeLa and MDA-MB-231 cells through induction of S phase arrest. Colloids Surf B Biointerfaces. 94:304–308. 2012. View Article : Google Scholar : PubMed/NCBI

44 

Song JM, Anandharaj A, Upadhyaya P, Kirtane AR, Kim JH, Hong KH, Panyam J and Kassie F: Honokiol suppresses lung tumorigenesis by targeting EGFR and its downstream effectors. Oncotarget. 7:57752–57769. 2016. View Article : Google Scholar : PubMed/NCBI

45 

Wang S, Wu X, Tan M, Gong J, Tan W, Bian B, Chen M and Wang Y: Fighting fire with fire: Poisonous Chinese herbal medicine for cancer therapy. J Ethnopharmacol. 140:33–45. 2012. View Article : Google Scholar : PubMed/NCBI

46 

Cheng HM, Li CC, Chen CY, Lo HY, Cheng WY, Lee CH, Yang SZ, Wu SL, Hsiang CY and Ho TY: Application of bioactivity database of Chinese herbal medicine on the therapeutic prediction, drug development, and safety evaluation. J Ethnopharmacol. 132:429–437. 2010. View Article : Google Scholar : PubMed/NCBI

47 

Choi YJ, Choi YK, Lee KM, Cho SG, Kang SY and Ko SG: SH003 induces apoptosis of DU145 prostate cancer cells by inhibiting ERK-involved pathway. BMC Complement Altern Med. 16:5072016. View Article : Google Scholar : PubMed/NCBI

48 

Choi EK, Kim SM, Hong SW, Moon JH, Shin JS, Kim JH, Hwang IY, Jung SA, Lee DH, Lee EY, et al: SH003 selectively induces p73-dependent apoptosis in triple-negative breast cancer cells. Mol Med Rep. 14:3955–3960. 2016. View Article : Google Scholar : PubMed/NCBI

49 

Woo SM, Kim AJ, Choi YK, Shin YC, Cho SG and Ko SG: Synergistic effect of SH003 and doxorubicin in triple-negative breast cancer. Phytother Res. 30:1817–1823. 2016. View Article : Google Scholar : PubMed/NCBI

50 

Hartwell LH and Weinert TA: Checkpoints: Controls that ensure the order of cell cycle events. Science. 246:629–634. 1989. View Article : Google Scholar : PubMed/NCBI

51 

Liou GY and Storz P: Reactive oxygen species in cancer. Free Radic Res. 44:479–496. 2010. View Article : Google Scholar : PubMed/NCBI

52 

Storz P: Reactive oxygen species in tumor progression. Front Biosci. 10:1881–1896. 2005. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Lee KM, Lee K, Choi YK, Choi YJ, Seo HS and Ko SG: SH003‑induced G1 phase cell cycle arrest induces apoptosis in HeLa cervical cancer cells. Mol Med Rep 16: 8237-8244, 2017.
APA
Lee, K.M., Lee, K., Choi, Y.K., Choi, Y., Seo, H., & Ko, S. (2017). SH003‑induced G1 phase cell cycle arrest induces apoptosis in HeLa cervical cancer cells. Molecular Medicine Reports, 16, 8237-8244. https://doi.org/10.3892/mmr.2017.7597
MLA
Lee, K. M., Lee, K., Choi, Y. K., Choi, Y., Seo, H., Ko, S."SH003‑induced G1 phase cell cycle arrest induces apoptosis in HeLa cervical cancer cells". Molecular Medicine Reports 16.6 (2017): 8237-8244.
Chicago
Lee, K. M., Lee, K., Choi, Y. K., Choi, Y., Seo, H., Ko, S."SH003‑induced G1 phase cell cycle arrest induces apoptosis in HeLa cervical cancer cells". Molecular Medicine Reports 16, no. 6 (2017): 8237-8244. https://doi.org/10.3892/mmr.2017.7597
Copy and paste a formatted citation
x
Spandidos Publications style
Lee KM, Lee K, Choi YK, Choi YJ, Seo HS and Ko SG: SH003‑induced G1 phase cell cycle arrest induces apoptosis in HeLa cervical cancer cells. Mol Med Rep 16: 8237-8244, 2017.
APA
Lee, K.M., Lee, K., Choi, Y.K., Choi, Y., Seo, H., & Ko, S. (2017). SH003‑induced G1 phase cell cycle arrest induces apoptosis in HeLa cervical cancer cells. Molecular Medicine Reports, 16, 8237-8244. https://doi.org/10.3892/mmr.2017.7597
MLA
Lee, K. M., Lee, K., Choi, Y. K., Choi, Y., Seo, H., Ko, S."SH003‑induced G1 phase cell cycle arrest induces apoptosis in HeLa cervical cancer cells". Molecular Medicine Reports 16.6 (2017): 8237-8244.
Chicago
Lee, K. M., Lee, K., Choi, Y. K., Choi, Y., Seo, H., Ko, S."SH003‑induced G1 phase cell cycle arrest induces apoptosis in HeLa cervical cancer cells". Molecular Medicine Reports 16, no. 6 (2017): 8237-8244. https://doi.org/10.3892/mmr.2017.7597
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team