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Article

Protective effect of catalpol on nicotine‑induced injury of alveolar bone and associated underlying mechanisms

  • Authors:
    • Yanwu Li
    • Xingai Jin
    • Limin Mao
  • View Affiliations / Copyright

    Affiliations: Department of Periodontology, College of Stomatology, Harbin Medical University, Harbin, Heilongjiang 150001, P.R. China, Department of Pediatrics, College of Stomatology, Harbin Medical University, Harbin, Heilongjiang 150001, P.R. China, Department of Oral and Maxillofacial Surgery, College of Stomatology, Harbin Medical University, Harbin, Heilongjiang 150001, P.R. China
  • Pages: 8345-8350
    |
    Published online on: September 25, 2017
       https://doi.org/10.3892/mmr.2017.7604
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Abstract

Smoking is an important factor that causes periodontitis, which manifests as alveolar bone injury and absorption, and has a high incidence and unfavorable treatment efficacy. Nicotine causes ischemia and inflammation of the periodontium and inhibits the mineralization of alveolar bones. Previous studies have revealed the anti‑tumor biological activities of catalpol, in addition to neuroprotection and anti‑inflammation. The present study therefore investigated the underlying protective mechanism of catalpol in alveolar bone injury. A total of 24 Wistar rats were infused with nicotine (0.7 mg/kg for 30 days), followed by subcutaneous injection of catalpol (2 µg/kg for 14 days). The loss of alveolar bone was examined, and bone alkaline phosphatase (AP) and osteocalcin levels were examined by ELISA. The expression of tumor necrosis factor (TNF)‑α and cyclooxygenase‑2 (COX‑2) was quantified by reverse transcription‑quantitative polymerase chain reaction analysis and western blotting. Treatment with nicotine decreased AP and osteocalcin levels, increased TNF‑α and COX‑2 expression levels, and led to alveolar bone loss compared with the control group. Catalpol decreased bone loss, increased AP and osteocalcin, and decreased TNF‑α and COX‑2 expression compared with the nicotine treatment group. Catalpol may alleviate nicotine‑induced injury and alveolar bone loss via inhibition of inflammatory factors, and facilitate the mineralization of alveolar bones.
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1 

Trubiani O, Giacoppo S, Ballerini P, Diomede F, Piattelli A, Bramanti P and Mazzon E: Alternative source of stem cells derived from human periodontal ligament: A new treatment for experimental autoimmune encephalomyelitis. Stem Cell Res Ther. 7:12016. View Article : Google Scholar : PubMed/NCBI

2 

Toregeani JF, Nassar CA, Nassar PO, Toregeani KM, Gonzatto GK, Vendrame R, Castilhos JS, Rotta LS, Reinheimer AC, Longoni A and Barcella MW: Evaluation of periodontitis treatment effects on carotid intima-media thickness and expression of laboratory markers related to atherosclerosis. Gen Dent. 64:55–62. 2016.PubMed/NCBI

3 

Yang J, Zhang Q, Chen M, Wu WZ, Wang R, Liu CJ, Li B, Shi XL, Du HS and Tan HB: Association between Helicobacter pylori infection and risk of periodontal diseases in Han Chinese: A case-control study. Med Sci Monit. 22:121–126. 2016. View Article : Google Scholar : PubMed/NCBI

4 

Pullishery F, Panchmal GS and Siddique S: Salivary thiocyanate, uric acid and pH as biomarkers of periodontal disease in tobacco users and non-users- an in-vitro study. J Clin Diagn Res. 9:ZC47–ZC50. 2015.PubMed/NCBI

5 

Wyganowska-Swiatkowska M and Nohawica MM: Effect of tobacco smoking on human gingival and periodontal fibroblasts. A systematic review of literature. Przegl Lek. 72:158–160. 2015.PubMed/NCBI

6 

Warad S, Kalburgi NB, Manak M, Kalburgi VC, Koregol AC, Patanashetti J, Rao S and Kokatnur MV: Determining the effect of Gutkha on serum levels of vitamin B12 and folic acid as compared to smoking among chronic periodontitis subjects: A cross-sectional study. J Clin Diagn Res. 8:ZC85–ZC89. 2014.PubMed/NCBI

7 

Ng TK, Huang L, Cao D, Yip YW, Tsang WM, Yam GH, Pang CP and Cheung HS: Cigarette smoking hinders human periodontal ligament-derived stem cell proliferation, migration and differentiation potentials. Sci Rep. 5:78282015. View Article : Google Scholar : PubMed/NCBI

8 

Archana MS, Bagewadi A and Keluskar V: Assessment and comparison of phagocytic function and viability of polymorphonuclear leukocytes in saliva of smokers and non-smokers. Arch Oral Biol. 60:229–233. 2015. View Article : Google Scholar : PubMed/NCBI

9 

Huang R, Li M, Ye M, Yang K, Xu X and Gregory RL: Effects of Nicotine on Streptococcus gordonii growth, biofilm formation, and cell aggregation. Appl Environ Microbiol. 80:7212–7218. 2014. View Article : Google Scholar : PubMed/NCBI

10 

Lallier TE, Maturin E, Brady M, Stoute D and Ward T: Resistance to cigarette smoke is increased in periodontal ligament cells by attachment to collagen and fibronectin. J Periodontol. 86:91–100. 2015. View Article : Google Scholar : PubMed/NCBI

11 

Imamura K, Kokubu E, Kita D, Ota K, Ishihara K and Saito A: Cigarette smoke condensate modulates migration of human gingival epithelial cells and their interactions with Porphyromonas gingivalis. J Periodontal Res. 50:411–421. 2015. View Article : Google Scholar : PubMed/NCBI

12 

Hedna VS, Ansari S, Shahjouei S, Cai PY, Ahmad AS, Mocco J and Qureshi AI: Validity of laser doppler flowmetry in predicting outcome in murine intraluminal middle cerebral artery occlusion stroke. J Vasc Interv Neurol. 8:74–82. 2015.PubMed/NCBI

13 

Xue B, Ma B, Zhang Q, Li X, Zhu J, Liu M, Wu X, Wang C and Wu Z: Pharmacokinetics and tissue distribution of Aucubin, Ajugol and Catalpol in rats using a validated simultaneous LC-ESI-MS/MS assay. J Chromatogr B Analyt Technol Biomed Life Sci. 1002:245–253. 2015. View Article : Google Scholar : PubMed/NCBI

14 

Wang JM, Yang LH, Zhang YY, Niu CL, Cui Y, Feng WS and Wang GF: BDNF and COX-2 participate in anti-depressive mechanisms of catalpol in rats undergoing chronic unpredictable mild stress. Physiol Behav. 151:360–368. 2015. View Article : Google Scholar : PubMed/NCBI

15 

Xu Z, Zhang L, Li X, Jiang Z, Sun L, Zhao G, Zhou G, Zhang H, Shang J and Wang T: Mitochondrial fusion/fission process involved in the improvement of catalpol on high glucose-induced hepatic mitochondrial dysfunction. Acta Biochim Biophys Sin (Shanghai). 47:730–740. 2015. View Article : Google Scholar : PubMed/NCBI

16 

Tewari D, Khan MP, Sagar N, China SP, Singh AK, Kheruka SC, Barai S, Tewari MC, Nagar GK, Vishwakarma AL, et al: Ovariectomized rats with established Osteopenia have Diminished Mesenchymal stem cells in the bone marrow and Impaired Homing, Osteoinduction and Bone Regeneration at the fracture site. Stem Cell Rev. 11:309–321. 2015. View Article : Google Scholar : PubMed/NCBI

17 

Souza DM, Ricardo LH, Kantoski KZ and Rocha RF: Influence of alcohol consumption on alveolar bone level associated with ligature-induced periodontitis in rats. Braz Oral Res. 23:326–332. 2009. View Article : Google Scholar : PubMed/NCBI

18 

Javed F, Ahmed H Bashir and Romanos GE: Association between environmental tobacco smoke and periodontal disease: a systematic review. Environ Res. 133:117–122. 2014. View Article : Google Scholar : PubMed/NCBI

19 

Tao JH, Zhao M, Wang DG, Yang C, Du LY, Qiu WQ and Jiang S: Biotransformation and metabolic profile of catalpol with human intestinal microflora by ultra-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci: 1009-1010. 1–169. 2016.

20 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

21 

Fernandes BS, Hodge JM, Pasco JA, Berk M and Williams LJ: Effects of depression and serotonergic antidepressants on bone: Mechanisms and implications for the treatment of depression. Drugs Aging. 33:21–25. 2016. View Article : Google Scholar : PubMed/NCBI

22 

Fernandes G, Wang C, Yuan X, Liu Z, Dziak R and Yang S: Combination of controlled release platelet-rich plasma alginate beads and bone morphogenetic Protein-2 genetically modified mesenchymal stem cells for bone regeneration. J Periodontol. 87:470–480. 2016. View Article : Google Scholar : PubMed/NCBI

23 

Gołąbek K, Ostrowska Z, Ziora K, Oświęcimska J, Świętochowska E, Marek B, Kajdaniuk D, Strzelczyk J and Kos-Kudła B: Association between omentin-1, bone metabolism markers, and cytokines of the RANKL/RANK/OPG system in girls with anorexia nervosa. Endokrynol Pol. 66:514–520. 2015. View Article : Google Scholar : PubMed/NCBI

24 

Wadhwa D, Bey A, Hasija M, Moin S, Kumar A, Aman S and Sharma VK: Determination of levels of nitric oxide in smoker and nonsmoker patients with chronic periodontitis. J Periodontal Implant Sci. 43:215–220. 2013. View Article : Google Scholar : PubMed/NCBI

25 

Lazăr L, Loghin A, Bud ES, Cerghizan D, Horváth E and Nagy EE: Cyclooxygenase-2 and matrix metalloproteinase-9 expressions correlate with tissue inflammation degree in periodontal disease. Rom J Morphol Embryol. 56:1441–1446. 2015.PubMed/NCBI

26 

Liu JY, Zheng CZ, Hao XP, Zhang DJ, Mao AW and Yuan P: Catalpol ameliorates diabetic atherosclerosis in diabetic rabbits. Am J Transl Res. 8:4278–4288. 2016.PubMed/NCBI

27 

Tian YY, An LJ, Jiang L, Duan YL, Chen J and Jiang B: Catalpol protects dopaminergic neurons from LPS-induced neurotoxicity in mesencephalic neuron-glia cultures. Life Sci. 80:193–199. 2006. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Li Y, Jin X and Mao L: Protective effect of catalpol on nicotine‑induced injury of alveolar bone and associated underlying mechanisms. Mol Med Rep 16: 8345-8350, 2017.
APA
Li, Y., Jin, X., & Mao, L. (2017). Protective effect of catalpol on nicotine‑induced injury of alveolar bone and associated underlying mechanisms. Molecular Medicine Reports, 16, 8345-8350. https://doi.org/10.3892/mmr.2017.7604
MLA
Li, Y., Jin, X., Mao, L."Protective effect of catalpol on nicotine‑induced injury of alveolar bone and associated underlying mechanisms". Molecular Medicine Reports 16.6 (2017): 8345-8350.
Chicago
Li, Y., Jin, X., Mao, L."Protective effect of catalpol on nicotine‑induced injury of alveolar bone and associated underlying mechanisms". Molecular Medicine Reports 16, no. 6 (2017): 8345-8350. https://doi.org/10.3892/mmr.2017.7604
Copy and paste a formatted citation
x
Spandidos Publications style
Li Y, Jin X and Mao L: Protective effect of catalpol on nicotine‑induced injury of alveolar bone and associated underlying mechanisms. Mol Med Rep 16: 8345-8350, 2017.
APA
Li, Y., Jin, X., & Mao, L. (2017). Protective effect of catalpol on nicotine‑induced injury of alveolar bone and associated underlying mechanisms. Molecular Medicine Reports, 16, 8345-8350. https://doi.org/10.3892/mmr.2017.7604
MLA
Li, Y., Jin, X., Mao, L."Protective effect of catalpol on nicotine‑induced injury of alveolar bone and associated underlying mechanisms". Molecular Medicine Reports 16.6 (2017): 8345-8350.
Chicago
Li, Y., Jin, X., Mao, L."Protective effect of catalpol on nicotine‑induced injury of alveolar bone and associated underlying mechanisms". Molecular Medicine Reports 16, no. 6 (2017): 8345-8350. https://doi.org/10.3892/mmr.2017.7604
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