Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
December-2017 Volume 16 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
December-2017 Volume 16 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Bioinformatics analysis of fibroblasts exposed to TGF‑β at the early proliferation phase of wound repair

  • Authors:
    • Bobin Mi
    • Guohui Liu
    • Wu Zhou
    • Huijuan Lv
    • Kun Zha
    • Yi Liu
    • Qipeng Wu
    • Jing Liu
  • View Affiliations / Copyright

    Affiliations: Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, P.R. China, Department of Rheumatology, Tangdu Hospital, The Fourth Military Medical University, Xi'an, Shaanxi 710000, P.R. China
    Copyright: © Mi et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 8146-8154
    |
    Published online on: September 26, 2017
       https://doi.org/10.3892/mmr.2017.7619
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The aim of the current study was to identify gene signatures during the early proliferation stage of wound repair and the effect of TGF‑β on fibroblasts and reveal their potential mechanisms. The gene expression profiles of GSE79621 and GSE27165 were obtained from GEO database. Differentially expressed genes (DEGs) were identified using Morpheus and co‑expressed DEGs were selected using Venn Diagram. Gene ontology (GO) function and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis of DEGs were performed using the Database for Annotation, Visualization and Integrated Discovery (DAVID) online tool. Protein‑protein interaction (PPI) networks of the DEGs were constructed using Cytoscape software. PPI interaction network was divided into subnetworks using the MCODE algorithm and the function of the top one module was analyzed using DAVID. The results revealed that upregulated DEGs were significantly enriched in biological process, including the Arp2/3 complex‑mediated actin nucleation, positive regulation of hyaluronan cable assembly, purine nucleobase biosynthetic process, de novo inosine monophosphate biosynthetic process, positive regulation of epithelial cell proliferation, whereas the downregulated DEGs were enriched in the regulation of blood pressure, negative regulation of cell proliferation, ossification, negative regulation of gene expression and type I interferon signaling pathway. KEGG pathway analysis showed that the upregulated DEGs were enriched in shigellosis, pathogenic Escherichia coli infection, the mitogen‑activated protein kinase signaling pathway, Ras signaling pathway and bacterial invasion of epithelial cells. The downregulated DEGs were enriched in systemic lupus erythematosus, lysosome, arachidonic acid metabolism, thyroid cancer and allograft rejection. The top 10 hub genes were identified from the PPI network. The top module analysis revealed that the included genes were involved in ion channel, neuroactive ligand‑receptor interaction pathway, purine metabolism and intestinal immune network for IgA production pathway. The functional analysis revealed that TGF‑β may promote fibroblast migration and proliferation and defend against microorganisms at the early proliferation stage of wound repair. Furthermore, these results may provide references for chronic wound repair.
View Figures

Figure 1

Figure 2

Figure 3

View References

1 

Ueha S, Shand FH and Matsushima K: Cellular and molecular mechanisms of chronic inflammation-associated organ fibrosis. Front Immunol. 3:712012. View Article : Google Scholar : PubMed/NCBI

2 

Jacinto A, Martinez-Arias A and Martin P: Mechanisms of epithelial fusion and repair. Nat Cell Biol. 3:E117–E123. 2001. View Article : Google Scholar : PubMed/NCBI

3 

Baer ML and Colello RJ: Endogenous bioelectric fields: A putative regulator of wound repair and regeneration in the central nervous system. Neural Regen Res. 11:861–864. 2016.PubMed/NCBI

4 

Xie SY, Peng LH, Shan YH, Niu J, Xiong J and Gao JQ: Adult stem cells seeded on electrospinning silk fibroin nanofiberous scaffold enhance wound repair and regeneration. J Nanosci Nanotechnol. 16:5498–5505. 2016. View Article : Google Scholar : PubMed/NCBI

5 

Smith-Bolton R: Drosophila imaginal discs as a model of epithelial wound repair and regeneration. Adv Wound Care (New Rochelle). 5:251–261. 2016. View Article : Google Scholar : PubMed/NCBI

6 

Yang S, Ma K, Geng Z, Sun X and Fu X: Oriented cell division: New roles in guiding skin wound repair and regeneration. Biosci Rep. 35:pii: e002802015. View Article : Google Scholar

7 

Peng LH, Wei W, Shan YH, Zhang TY, Zhang CZ, Wu JH, Yu L, Lin J, Liang WQ, Khang G and Gao JQ: β-Cyclodextrin-linked polyethylenimine nanoparticles facilitate gene transfer and enhance the angiogenic capacity of mesenchymal stem cells for wound repair and regeneration. J Biomed Nanotechnol. 11:680–690. 2015. View Article : Google Scholar : PubMed/NCBI

8 

Kotwal GJ, Sarojini H and Chien S: Pivotal role of ATP in macrophages fast tracking wound repair and regeneration. Wound Repair Regen. 23:724–727. 2015. View Article : Google Scholar : PubMed/NCBI

9 

Shingyochi Y, Orbay H and Mizuno H: Adipose-derived stem cells for wound repair and regeneration. Expert Opin Biol Ther. 15:1285–1292. 2015. View Article : Google Scholar : PubMed/NCBI

10 

Eming SA, Martin P and Tomic-Canic M: Wound repair and regeneration: Mechanisms, signaling, and translation. Sci Transl Med. 6:265sr62014. View Article : Google Scholar : PubMed/NCBI

11 

Xu S, Sang L, Zhang Y, Wang X and Li X: Biological evaluation of human hair keratin scaffolds for skin wound repair and regeneration. Mater Sci Eng C Mater Biol Appl. 33:648–655. 2013. View Article : Google Scholar : PubMed/NCBI

12 

Sen CK and Roy S: OxymiRs in cutaneous development, wound repair and regeneration. Semin Cell Dev Biol. 23:971–980. 2012. View Article : Google Scholar : PubMed/NCBI

13 

Reinke JM and Sorg H: Wound repair and regeneration. Eur Surg Res. 49:35–43. 2012. View Article : Google Scholar : PubMed/NCBI

14 

Li H and Fu X: Mechanisms of action of mesenchymal stem cells in cutaneous wound repair and regeneration. Cell Tissue Res. 348:371–377. 2012. View Article : Google Scholar : PubMed/NCBI

15 

Eldardiri M, Martin Y, Roxburgh J, Lawrence-Watt DJ and Sharpe JR: Wound contraction is significantly reduced by the use of microcarriers to deliver keratinocytes and fibroblasts in an in vivo pig model of wound repair and regeneration. Tissue Eng Part A. 18:587–597. 2012. View Article : Google Scholar : PubMed/NCBI

16 

Peng LH, Tsang SY, Tabata Y and Gao JQ: Genetically-manipulated adult stem cells as therapeutic agents and gene delivery vehicle for wound repair and regeneration. J Control Release. 157:321–330. 2012. View Article : Google Scholar : PubMed/NCBI

17 

Fu X and Li H: Mesenchymal stem cells and skin wound repair and regeneration: Possibilities and questions. Cell Tissue Res. 335:317–321. 2009. View Article : Google Scholar : PubMed/NCBI

18 

Gurtner GC, Werner S, Barrandon Y and Longaker MT: Wound repair and regeneration. Nature. 453:314–321. 2008. View Article : Google Scholar : PubMed/NCBI

19 

Yao F and Eriksson E: Gene therapy in wound repair and regeneration. Wound Repair Regen. 8:443–451. 2000. View Article : Google Scholar : PubMed/NCBI

20 

Puchelle E: Airway epithelium wound repair and regeneration after injury. Acta Otorhinolaryngol Belg. 54:263–270. 2000.PubMed/NCBI

21 

Clark LD, Clark RK and Heber-Katz E: A new murine model for mammalian wound repair and regeneration. Clin Immunol Immunopathol. 88:35–45. 1998. View Article : Google Scholar : PubMed/NCBI

22 

Sicard RE and Nguyen LM: An in vivo model for evaluating wound repair and regeneration microenvironments. In Vivo. 10:477–481. 1996.PubMed/NCBI

23 

Suga H, Sugaya M, Fujita H, Asano Y, Tada Y, Kadono T and Sato S: TLR4, rather than TLR2, regulates wound healing through TGF-β and CCL5 expression. J Dermatol Sci. 73:117–124. 2014. View Article : Google Scholar : PubMed/NCBI

24 

Lee MJ, Shin JO and Jung HS: Thy-1 knockdown retards wound repair in mouse skin. J Dermatol Sci. 69:95–104. 2013. View Article : Google Scholar : PubMed/NCBI

25 

Liu J, Wang Y, Pan Q, Su Y, Zhang Z, Han J, Zhu X, Tang C and Hu D: Wnt/β-catenin pathway forms a negative feedback loop during TGF-β1 induced human normal skin fibroblast-to-myofibroblast transition. J Dermatol Sci. 65:38–49. 2012. View Article : Google Scholar : PubMed/NCBI

26 

Chen J, Zeng B, Yao H and Xu J: The effect of TLR4/7 on the TGF-β-induced Smad signal transduction pathway in human keloid. Burns. 39:465–472. 2013. View Article : Google Scholar : PubMed/NCBI

27 

Diegelmann RF and Evans MC: Wound healing: An overview of acute, fibrotic and delayed healing. Front Biosci. 9:283–289. 2004. View Article : Google Scholar : PubMed/NCBI

28 

Elgaaen BV, Olstad OK, Sandvik L, Odegaard E, Sauer T, Staff AC and Gautvik KM: ZNF385B and VEGFA are strongly differentially expressed in serous ovarian carcinomas and correlate with survival. PLoS One. 7:e463172012. View Article : Google Scholar : PubMed/NCBI

29 

Li C, Zhen G, Chai Y, Xie L, Crane JL, Farber E, Farber CR, Luo X, Gao P, Cao X and Wan M: RhoA determines lineage fate of mesenchymal stem cells by modulating CTGF-VEGF complex in extracellular matrix. Nat Commun. 7:114552016. View Article : Google Scholar : PubMed/NCBI

30 

Al-Rekabi Z, Wheeler MM, Leonard A, Fura AM, Juhlin I, Frazar C, Smith JD, Park SS, Gustafson JA, Clarke CM, et al: Activation of the IGF1 pathway mediates changes in cellular contractility and motility in single-suture craniosynostosis. J Cell Sci. 129:483–491. 2016. View Article : Google Scholar : PubMed/NCBI

31 

Chigurupati S, Mughal MR, Okun E, Das S, Kumar A, McCaffery M, Seal S and Mattson MP: Effects of cerium oxide nanoparticles on the growth of keratinocytes, fibroblasts and vascular endothelias cells in cutaneous wound healing. Biomaterials. 34:2194–2201. 2013. View Article : Google Scholar : PubMed/NCBI

32 

Zhao H, Han T, Hong X and Sun D: Adipose differentiation-related protein knockdown inhibits vascular smooth muscle cell proliferation and migration and attenuates neointima formation. Mol Med Rep. 16:3079–3086. 2017.PubMed/NCBI

33 

Ridley AJ, Schwartz MA, Burridge K, Firtel RA, Ginsberg MH, Borisy G, Parsons JT and Horwitz AR: Cell migration: Integrating signals from front to back. Science. 302:1704–1709. 2003. View Article : Google Scholar : PubMed/NCBI

34 

Le Clainche C and Carlier MF: Regulation of actin assembly associated with protrusion and adhesion in cell migration. Physiol Rev. 88:489–513. 2008. View Article : Google Scholar : PubMed/NCBI

35 

Fotedar R and Margolis RL: WISp39 and Hsp90: Actin' together in cell migration. Oncotarget. 6:17871–17872. 2015. View Article : Google Scholar : PubMed/NCBI

36 

Mast BA, Diegelmann RF, Krummel TM and Cohen IK: Hyaluronic acid modulates proliferation, collagen and protein synthesis of cultured fetal fibroblasts. Matrix. 13:441–446. 1993. View Article : Google Scholar : PubMed/NCBI

37 

Balaji S, King A, Marsh E, LeSaint M, Bhattacharya SS, Han N, Dhamija Y, Ranjan R, Le LD, Bollyky PL, et al: The role of interleukin-10 and hyaluronan in murine fetal fibroblast function in vitro: Implications for recapitulating fetal regenerative wound healing. PLoS One. 10:e1243022015. View Article : Google Scholar

38 

Wu YS and Chen SN: Apoptotic cell: Linkage of inflammation and wound healing. Front Pharmacol. 5:12014. View Article : Google Scholar : PubMed/NCBI

39 

Matsuki K, Hathaway CK, Lawrence MG, Smithies O and Kakoki M: The role of transforming growth factor β1 in the regulation of blood pressure. Curr Hypertens Rev. 10:223–238. 2014. View Article : Google Scholar : PubMed/NCBI

40 

Agarwal SK, Wu M, Livingston CK, Parks DH, Mayes MD, Arnett FC and Tan FK: Toll-like receptor 3 upregulation by type I interferon in healthy and scleroderma dermal fibroblasts. Arthritis Res Ther. 13:R32011. View Article : Google Scholar : PubMed/NCBI

41 

Zhang Y, Alexander PB and Wang XF: TGF-β family signaling in the control of cell proliferation and survival. Cold Spring Harb Perspect Biol. 9:pii: a0221452017. View Article : Google Scholar

42 

DiRenzo DM, Chaudhary MA, Shi X, Franco SR, Zent J, Wang K, Guo LW and Kent KC: A crosstalk between TGF-β/Smad3 and Wnt/beta-catenin pathways promotes vascular smooth muscle cell proliferation. Cell Signal. 28:498–505. 2016. View Article : Google Scholar : PubMed/NCBI

43 

Ghosh AK, Mori Y, Dowling E and Varga J: Trichostatin A blocks TGF-beta-induced collagen gene expression in skin fibroblasts: Involvement of Sp1. Biochem Biophys Res Commun. 354:420–426. 2007. View Article : Google Scholar : PubMed/NCBI

44 

Lu J, Shi J, Li M, Gui B, Fu R, Yao G, Duan Z, Lv Z, Yang Y, Chen Z, et al: Activation of AMPK by metformin inhibits TGF-β-induced collagen production in mouse renal fibroblasts. Life Sci. 127:59–65. 2015. View Article : Google Scholar : PubMed/NCBI

45 

Zhang W and Liu HT: MAPK signal pathways in the regulation of cell proliferation in mammalian cells. Cell Res. 12:9–18. 2002. View Article : Google Scholar : PubMed/NCBI

46 

Takino K, Ohsawa S and Igaki T: Loss of Rab5 drives non-autonomous cell proliferation through TNF and Ras signaling in Drosophila. Dev Biol. 395:19–28. 2014. View Article : Google Scholar : PubMed/NCBI

47 

Gause WC, Wynn TA and Allen JE: Type 2 immunity and wound healing: Evolutionary refinement of adaptive immunity by helminths. Nat Rev Immunol. 13:607–614. 2013. View Article : Google Scholar : PubMed/NCBI

48 

Samuelsson B: Arachidonic acid metabolism: Role in inflammation. Z Rheumatol. 50 Suppl 1:S3–S6. 1991.

49 

Chen X, Stauffer S, Chen Y and Dong J: Ajuba Phosphorylation by CDK1 Promotes Cell Proliferation and Tumorigenesis. J Biol Chem. 291:14761–14772. 2016. View Article : Google Scholar : PubMed/NCBI

50 

Lin L, Zhang JH, Panicker LM and Simonds WF: The parafibromin tumor suppressor protein inhibits cell proliferation by repression of the c-myc proto-oncogene. Proc Natl Acad Sci USA. 105:pp. 17420–17425. 2008; View Article : Google Scholar : PubMed/NCBI

51 

Bunnell TM, Burbach BJ, Shimizu Y and Ervasti JM: β-Actin specifically controls cell growth, migration, and the G-actin pool. Mol Biol Cell. 22:4047–4058. 2011. View Article : Google Scholar : PubMed/NCBI

52 

Liu D, Huang Y, Bu D, Liu AD, Holmberg L, Jia Y, Tang C, Du J and Jin H: Sulfur dioxide inhibits vascular smooth muscle cell proliferation via suppressing the Erk/MAP kinase pathway mediated by cAMP/PKA signaling. Cell Death Dis. 5:e12512014. View Article : Google Scholar : PubMed/NCBI

53 

Jiang Y, Chen C, Li Z, Guo W, Gegner JA, Lin S and Han J: Characterization of the structure and function of a new mitogen-activated protein kinase (p38beta). J Biol Chem. 271:17920–17926. 1996. View Article : Google Scholar : PubMed/NCBI

54 

Hsu YL, Wang MY, Ho LJ, Huang CY and Lai JH: Up-regulation of galectin-9 induces cell migration in human dendritic cells infected with dengue virus. J Cell Mol Med. 19:1065–1076. 2015. View Article : Google Scholar : PubMed/NCBI

55 

Adachi T, Sakurai T, Kashida H, Mine H, Hagiwara S, Matsui S, Yoshida K, Nishida N, Watanabe T, Itoh K, et al: Involvement of heat shock protein a4/apg-2 in refractory inflammatory bowel disease. Inflamm Bowel Dis. 21:31–39. 2015. View Article : Google Scholar : PubMed/NCBI

56 

Sakurai T, Kashida H, Hagiwara S, Nishida N, Watanabe T, Fujita J and Kudo M: Heat shock protein A4 controls cell migration and gastric ulcer healing. Dig Dis Sci. 60:850–857. 2015. View Article : Google Scholar : PubMed/NCBI

57 

Wang Z, Fan M, Candas D, Zhang TQ, Qin L, Eldridge A, Wachsmann-Hogiu S, Ahmed KM, Chromy BA, Nantajit D, et al: Cyclin B1/Cdk1 coordinates mitochondrial respiration for cell-cycle G2/M progression. Dev Cell. 29:217–232. 2014. View Article : Google Scholar : PubMed/NCBI

58 

Han IS, Seo TB, Kim KH, Yoon JH, Yoon SJ and Namgung U: Cdc2-mediated Schwann cell migration during peripheral nerve regeneration. J Cell Sci. 120:246–255. 2007. View Article : Google Scholar : PubMed/NCBI

59 

Dawkins E and Small DH: Insights into the physiological function of the β-amyloid precursor protein: Beyond Alzheimer's disease. J Neurochem. 129:756–769. 2014. View Article : Google Scholar : PubMed/NCBI

60 

Saitoh T, Sundsmo M, Roch JM, Kimura N, Cole G, Schubert D, Oltersdorf T and Schenk DB: Secreted form of amyloid beta protein precursor is involved in the growth regulation of fibroblasts. Cell. 58:615–622. 1989. View Article : Google Scholar : PubMed/NCBI

61 

Ponugoti B, Xu F, Zhang C, Tian C, Pacios S and Graves DT: FOXO1 promotes wound healing through the up-regulation of TGF-β1 and prevention of oxidative stress. J Cell Biol. 203:327–343. 2013. View Article : Google Scholar : PubMed/NCBI

62 

Wang YL, Sun GY, Zhang Y, He JJ, Zheng S and Lin JN: Tormentic acid inhibits H2O2-induced oxidative stress and inflammation in rat vascular smooth muscle cells via inhibition of NF-kB signaling pathway. Mol Med Rep. 14:3559–3564. 2016. View Article : Google Scholar : PubMed/NCBI

63 

Ohsawa R, Miyazaki H, Niisato N, Shiozaki A, Iwasaki Y, Otsuji E and Marunaka Y: Intracellular chloride regulates cell proliferation through the activation of stress-activated protein kinases in MKN28 human gastric cancer cells. J Cell Physiol. 223:764–770. 2010.PubMed/NCBI

64 

Bear CE: Phosphorylation-activated chloride channels in human skin fibroblasts. Febs Lett. 237:145–149. 1988. View Article : Google Scholar : PubMed/NCBI

65 

Sorrell JM and Caplan AI: Fibroblasts-a diverse population at the center of it all. Int Rev Cell Mol Biol. 276:161–214. 2009. View Article : Google Scholar : PubMed/NCBI

66 

Zhang Z, Yu B, Gu Y, Zhou S, Qian T, Wang Y, Ding G, Ding F and Gu X: Fibroblast-derived tenascin-C promotes Schwann cell migration through β1-integrin dependent pathway during peripheral nerve regeneration. Glia. 64:374–385. 2016. View Article : Google Scholar : PubMed/NCBI

67 

Pedley AM and Benkovic SJ: A new view into the regulation of purine metabolism: The purinosome. Trends Biochem Sci. 42:141–154. 2017. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Mi B, Liu G, Zhou W, Lv H, Zha K, Liu Y, Wu Q and Liu J: Bioinformatics analysis of fibroblasts exposed to TGF‑β at the early proliferation phase of wound repair. Mol Med Rep 16: 8146-8154, 2017.
APA
Mi, B., Liu, G., Zhou, W., Lv, H., Zha, K., Liu, Y. ... Liu, J. (2017). Bioinformatics analysis of fibroblasts exposed to TGF‑β at the early proliferation phase of wound repair. Molecular Medicine Reports, 16, 8146-8154. https://doi.org/10.3892/mmr.2017.7619
MLA
Mi, B., Liu, G., Zhou, W., Lv, H., Zha, K., Liu, Y., Wu, Q., Liu, J."Bioinformatics analysis of fibroblasts exposed to TGF‑β at the early proliferation phase of wound repair". Molecular Medicine Reports 16.6 (2017): 8146-8154.
Chicago
Mi, B., Liu, G., Zhou, W., Lv, H., Zha, K., Liu, Y., Wu, Q., Liu, J."Bioinformatics analysis of fibroblasts exposed to TGF‑β at the early proliferation phase of wound repair". Molecular Medicine Reports 16, no. 6 (2017): 8146-8154. https://doi.org/10.3892/mmr.2017.7619
Copy and paste a formatted citation
x
Spandidos Publications style
Mi B, Liu G, Zhou W, Lv H, Zha K, Liu Y, Wu Q and Liu J: Bioinformatics analysis of fibroblasts exposed to TGF‑β at the early proliferation phase of wound repair. Mol Med Rep 16: 8146-8154, 2017.
APA
Mi, B., Liu, G., Zhou, W., Lv, H., Zha, K., Liu, Y. ... Liu, J. (2017). Bioinformatics analysis of fibroblasts exposed to TGF‑β at the early proliferation phase of wound repair. Molecular Medicine Reports, 16, 8146-8154. https://doi.org/10.3892/mmr.2017.7619
MLA
Mi, B., Liu, G., Zhou, W., Lv, H., Zha, K., Liu, Y., Wu, Q., Liu, J."Bioinformatics analysis of fibroblasts exposed to TGF‑β at the early proliferation phase of wound repair". Molecular Medicine Reports 16.6 (2017): 8146-8154.
Chicago
Mi, B., Liu, G., Zhou, W., Lv, H., Zha, K., Liu, Y., Wu, Q., Liu, J."Bioinformatics analysis of fibroblasts exposed to TGF‑β at the early proliferation phase of wound repair". Molecular Medicine Reports 16, no. 6 (2017): 8146-8154. https://doi.org/10.3892/mmr.2017.7619
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team