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Article

Aberrant production of soluble inducible T cell co‑stimulator and soluble programmed cell death protein 1 in patients with chronic hepatitis B

  • Authors:
    • Dongsheng Wang
    • Qin Du
    • Guangcheng Luo
    • Qiang Wang
    • Guangrong Wang
    • Guoyuan Zhang
    • Zhengwei Leng
    • Xiaolan Guo
  • View Affiliations / Copyright

    Affiliations: Department of Laboratory Medicine, The Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan 637000, P.R. China, Department of Immunology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430074, P.R. China
  • Pages: 8556-8562
    |
    Published online on: September 26, 2017
       https://doi.org/10.3892/mmr.2017.7630
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Abstract

Previous studies demonstrated that immune dysregulation is an important cause of hepatitis B virus (HBV)‑mediated liver damage. Co‑stimulators including programmed cell death protein 1 (PD‑1) and inducible T cell co‑stimulator (ICOS) are involved in the pathogenesis of HBV. In the present study, the serum levels of soluble (s)PD‑1 and sICOS in patients with chronic HBV infections, were investigated, and the association between sPD‑1 and sICOS levels and liver injury degree was investigated. Serum sPD‑1 and sICOS levels were increased in the HBV‑patient group particularly in the HBV external core antigen positive group. In the immune clearance group, sPD‑1 and sICOS were increased compared with the tolerance group. Furthermore, the relative mRNA expression levels were also increased in patients with HBV. However there was no correlation between sPD‑1 and sICOS levels and HBV antibodies or PD‑1/ICOS mRNA copies. The altered sPD‑1 and sICOS serum levels in the different HBV groups may reflect the dysregulation of T cell activation, and may be associated with the HBV pathological process.
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Copy and paste a formatted citation
Spandidos Publications style
Wang D, Du Q, Luo G, Wang Q, Wang G, Zhang G, Leng Z and Guo X: Aberrant production of soluble inducible T cell co‑stimulator and soluble programmed cell death protein 1 in patients with chronic hepatitis B. Mol Med Rep 16: 8556-8562, 2017.
APA
Wang, D., Du, Q., Luo, G., Wang, Q., Wang, G., Zhang, G. ... Guo, X. (2017). Aberrant production of soluble inducible T cell co‑stimulator and soluble programmed cell death protein 1 in patients with chronic hepatitis B. Molecular Medicine Reports, 16, 8556-8562. https://doi.org/10.3892/mmr.2017.7630
MLA
Wang, D., Du, Q., Luo, G., Wang, Q., Wang, G., Zhang, G., Leng, Z., Guo, X."Aberrant production of soluble inducible T cell co‑stimulator and soluble programmed cell death protein 1 in patients with chronic hepatitis B". Molecular Medicine Reports 16.6 (2017): 8556-8562.
Chicago
Wang, D., Du, Q., Luo, G., Wang, Q., Wang, G., Zhang, G., Leng, Z., Guo, X."Aberrant production of soluble inducible T cell co‑stimulator and soluble programmed cell death protein 1 in patients with chronic hepatitis B". Molecular Medicine Reports 16, no. 6 (2017): 8556-8562. https://doi.org/10.3892/mmr.2017.7630
Copy and paste a formatted citation
x
Spandidos Publications style
Wang D, Du Q, Luo G, Wang Q, Wang G, Zhang G, Leng Z and Guo X: Aberrant production of soluble inducible T cell co‑stimulator and soluble programmed cell death protein 1 in patients with chronic hepatitis B. Mol Med Rep 16: 8556-8562, 2017.
APA
Wang, D., Du, Q., Luo, G., Wang, Q., Wang, G., Zhang, G. ... Guo, X. (2017). Aberrant production of soluble inducible T cell co‑stimulator and soluble programmed cell death protein 1 in patients with chronic hepatitis B. Molecular Medicine Reports, 16, 8556-8562. https://doi.org/10.3892/mmr.2017.7630
MLA
Wang, D., Du, Q., Luo, G., Wang, Q., Wang, G., Zhang, G., Leng, Z., Guo, X."Aberrant production of soluble inducible T cell co‑stimulator and soluble programmed cell death protein 1 in patients with chronic hepatitis B". Molecular Medicine Reports 16.6 (2017): 8556-8562.
Chicago
Wang, D., Du, Q., Luo, G., Wang, Q., Wang, G., Zhang, G., Leng, Z., Guo, X."Aberrant production of soluble inducible T cell co‑stimulator and soluble programmed cell death protein 1 in patients with chronic hepatitis B". Molecular Medicine Reports 16, no. 6 (2017): 8556-8562. https://doi.org/10.3892/mmr.2017.7630
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