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Article

Integrated analysis reveals candidate genes and transcription factors in lung adenocarcinoma

  • Authors:
    • Baiwang Chen
    • Shuhong Gao
    • Changwei Ji
    • Ge Song
  • View Affiliations / Copyright

    Affiliations: Intensive Care Unit, Jining No. 1 People's Hospital, Jining, Shandong 272011, P.R. China
  • Pages: 8371-8379
    |
    Published online on: September 28, 2017
       https://doi.org/10.3892/mmr.2017.7656
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Abstract

Lung adenocarcinoma is the most common type of non‑small cell lung cancer in Asia. Therefore, it is important to improve understanding of the underlying transcriptional regulatory mechanisms involved. The present study aimed to identify potential candidate genes and transcription factors (TFs) associated with the disease. Four gene expression profiles were downloaded from the Gene Expression Omnibus database, which included 141 lung adenocarcinoma patients and 191 healthy controls. The differentially expressed genes (DEGs) were screened out and functional annotation was performed. In addition, TFs were identified and a global transcriptional regulatory network was constructed. Integrated analysis gave rise to a total of 1,238 DEGs in lung adenocarcinoma when compared with healthy tissues, including 970 upregulated and 268 downregulated DEGs. The six overexpressed outlier genes of ceruloplasmin, heparan sulfate 6‑O‑sulfotransferase 2, transmembrane protease serine 4, anillin actin binding protein, cellular retinoic acid binding protein 2 and cystatin SN may serve important roles in the development of lung adenocarcinoma. In addition, the downregulation of carbonic anhydrase 4 and S100 calcium binding protein A12 may render these effective diagnostic biomarkers. The results of the transcriptional regulatory network demonstrated that the hub nodes were sex determining region Y‑box 10, Spi‑B transcription factor and nuclear receptor subfamily 4 group A member 2. The four TFs, forkhead box D1, E74‑like ETS transcription factor 5, homeobox A5 and kruppel‑like factor 5, may warrant future investigations into their function in disease development. In conclusion, the present study provided for further studies a list of candidate genes and TFs for the detection and treatment of lung adenocarcinoma.
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1 

Minna JD, Roth JA and Gazdar AF: Focus on lung cancer. Cancer cell. 1:49–52. 2002. View Article : Google Scholar : PubMed/NCBI

2 

Zhao N, Liu Y, Chang Z, Li K, Zhang R, Zhou Y, Qiu F, Han X and Xu Y: Identification of biomarker and co-regulatory motifs in lung adenocarcinoma based on differential interactions. PLoS One. 10:e01391652015. View Article : Google Scholar : PubMed/NCBI

3 

Bandyopadhyay S, Mehta M, Kuo D, Sung MK, Chuang R, Jaehnig EJ, Bodenmiller B, Licon K, Copeland W, Shales M, et al: Rewiring of genetic networks in response to DNA damage. Science. 330:1385–1389. 2010. View Article : Google Scholar : PubMed/NCBI

4 

Liu X, Liu ZP, Zhao XM and Chen L: Identifying disease genes and module biomarkers by differential interactions. J Am Med Inform Assoc. 19:241–248. 2012. View Article : Google Scholar : PubMed/NCBI

5 

Latchman DS: Transcription factors: An overview. Int J Biochem Cell Biol. 29:1305–1312. 1997. View Article : Google Scholar : PubMed/NCBI

6 

Mitchell PJ and Tjian R: Transcriptional regulation in mammalian cells by sequence-specific DNA binding proteins. Science. 245:371–378. 1989. View Article : Google Scholar : PubMed/NCBI

7 

Meng X, Lu P, Bai H, Xiao P and Fan Q: Transcriptional regulatory networks in human lung adenocarcinoma. Mol Med Rep. 6:961–966. 2012. View Article : Google Scholar : PubMed/NCBI

8 

Chen CY, Chen ST, Fuh CS, Juan HF and Huang HC: Coregulation of transcription factors and microRNAs in human transcriptional regulatory network. BMC Bioinformatics. 12 Suppl 1:S412011. View Article : Google Scholar : PubMed/NCBI

9 

Garber ME, Troyanskaya OG, Schluens K, Petersen S, Thaesler Z, Pacyna-Gengelbach M, van de Rijn M, Rosen GD, Perou CM, Whyte RI, et al: Diversity of gene expression in adenocarcinoma of the lung. Proc Natl Acad Sci USA. 98:pp. 13784–13789. 2001; View Article : Google Scholar : PubMed/NCBI

10 

Director's Challenge Consortium for the Molecular Classification of Lung Adenocarcinoma, ; Shedden K, Taylor JM, Enkemann SA, Tsao MS, Yeatman TJ, Gerald WL, Eschrich S, Jurisica I, Giordano TJ, et al: Gene expression-based survival prediction in lung adenocarcinoma: A multi-site, blinded validation study. Nat Med. 14:822–827. 2008. View Article : Google Scholar : PubMed/NCBI

11 

Stearman RS, Dwyer-Nield L, Zerbe L, Blaine SA, Chan Z, Bunn PA Jr, Johnson GL, Hirsch FR, Merrick DT, Franklin WA, et al: Analysis of orthologous gene expression between human pulmonary adenocarcinoma and a carcinogen-induced murine model. Am J Pathol. 167:1763–1775. 2005. View Article : Google Scholar : PubMed/NCBI

12 

Zhang W, Gong W, Ai H, Tang J and Shen C: Gene expression analysis of lung adenocarcinoma and matched adjacent non-tumor lung tissue. Tumori. 100:338–345. 2014.PubMed/NCBI

13 

Jiang H, Deng Y, Chen HS, Tao L, Sha Q, Chen J, Tsai CJ and Zhang S: Joint analysis of two microarray gene-expression data sets to select lung adenocarcinoma marker genes. BMC Bioinformatics. 5:812004. View Article : Google Scholar : PubMed/NCBI

14 

Fu S, Pan X and Fang W: Differential co-expression analysis of a microarray gene expression profiles of pulmonary adenocarcinoma. Mol Med Rep. 10:713–718. 2014.PubMed/NCBI

15 

Lin CC, Chen YJ, Chen CY, Oyang YJ, Juan HF and Huang HC: Crosstalk between transcription factors and microRNAs in human protein interaction network. BMC Syst Biol. 6:182012. View Article : Google Scholar : PubMed/NCBI

16 

Li BQ, You J, Chen L, Zhang J, Zhang N, Li HP, Huang T, Kong XY and Cai YD: Identification of lung-cancer-related genes with the shortest path approach in a protein-protein interaction network. Biomed Res Int. 2013:2673752013.PubMed/NCBI

17 

Barrett T, Wilhite SE, Ledoux P, Evangelista C, Kim IF, Tomashevsky M, Marshall KA, Phillippy KH, Sherman PM, Holko M, et al: NCBI GEO: Archive for functional genomics data sets-update. Nucleic Acids Res. 41(Database Issue): D991–D995. 2013.PubMed/NCBI

18 

Ritchie ME, Phipson B, Wu D, Hu Y, Law CW, Shi W and Smyth GK: limma powers differential expression analyses for RNA-sequencing and microarray studies. Nucleic Acids Res. 43:e472015. View Article : Google Scholar : PubMed/NCBI

19 

Hardcastle TJ: Generalized empirical Bayesian methods for discovery of differential data in high-throughput biology. Bioinformatics. 32:195–202. 2016.PubMed/NCBI

20 

Eden E, Navon R, Steinfeld I, Lipson D and Yakhini Z: GOrilla: A tool for discovery and visualization of enriched GO terms in ranked gene lists. BMC Bioinformatics. 10:482009. View Article : Google Scholar : PubMed/NCBI

21 

Eden E, Lipson D, Yogev S and Yakhini Z: Discovering motifs in ranked lists of DNA sequences. PLoS Comput Biol. 3:e392007. View Article : Google Scholar : PubMed/NCBI

22 

Ashburner M, Ball CA, Blake JA, Botstein D, Butler H, Cherry JM, Davis AP, Dolinski K, Dwight SS, Eppig JT, et al: Gene ontology: Tool for the unification of biology. The gene ontology consortium. Nat Genet. 25:25–29. 2000. View Article : Google Scholar : PubMed/NCBI

23 

Nogales-Cadenas R, Carmona-Saez P, Vazquez M, Vicente C, Yang X, Tirado F, Carazo JM and Pascual-Montano A: GeneCodis: Interpreting gene lists through enrichment analysis and integration of diverse biological information. Nucleic Acids Res. 37(Web Server Issue): W317–W322. 2009. View Article : Google Scholar : PubMed/NCBI

24 

Tabas-Madrid D, Nogales-Cadenas R and Pascual-Montano A: GeneCodis3:A non-redundant and modular enrichment analysis tool for functional genomics. Nucleic Acids Res. 40(Web Server Issue): W478–W483. 2012. View Article : Google Scholar : PubMed/NCBI

25 

Carmona-Saez P, Chagoyen M, Tirado F, Carazo JM and Pascual-Montano A: GENECODIS: A web-based tool for finding significant concurrent annotations in gene lists. Genome Biol. 8:R32007. View Article : Google Scholar : PubMed/NCBI

26 

Matys V, Fricke E, Geffers R, Gössling E, Haubrock M, Hehl R, Hornischer K, Karas D, Kel AE, Kel-Margoulis OV, et al: TRANSFAC: Transcriptional regulation, from patterns to profiles. Nucleic Acids Res. 31:374–378. 2003. View Article : Google Scholar : PubMed/NCBI

27 

Smoot ME, Ono K, Ruscheinski J, Wang PL and Ideker T: Cytoscape 2.8: New features for data integration and network visualization. Bioinformatics. 27:431–432. 2011. View Article : Google Scholar : PubMed/NCBI

28 

Shannon P, Markiel A, Ozier O, Baliga NS, Wang JT, Ramage D, Amin N, Schwikowski B and Ideker T: Cytoscape: A software environment for integrated models of biomolecular interaction networks. Genome Res. 13:2498–2504. 2003. View Article : Google Scholar : PubMed/NCBI

29 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

30 

Wang KK, Liu N, Radulovich N, Wigle DA, Johnston MR, Shepherd FA, Minden MD and Tsao MS: Novel candidate tumor marker genes for lung adenocarcinoma. Oncogene. 21:7598–7604. 2002. View Article : Google Scholar : PubMed/NCBI

31 

Backen AC, Cole CL, Lau SC, Clamp AR, McVey R, Gallagher JT and Jayson GC: Heparan sulphate synthetic and editing enzymes in ovarian cancer. Br J Cancer. 96:1544–1548. 2007. View Article : Google Scholar : PubMed/NCBI

32 

Chikaishi Y, Uramoto H, Koyanagi Y, Yamada S, Yano S and Tanaka F: TMPRSS4 expression as a marker of recurrence in patients with lung cancer. Anticancer Res. 36:121–127. 2016.PubMed/NCBI

33 

Oegema K, Savoian MS, Mitchison TJ and Field CM: Functional analysis of a human homologue of the Drosophila actin binding protein anillin suggests a role in cytokinesis. J Cell Biol. 150:539–552. 2000. View Article : Google Scholar : PubMed/NCBI

34 

Suzuki C, Daigo Y, Ishikawa N, Kato T, Hayama S, Ito T, Tsuchiya E and Nakamura Y: ANLN plays a critical role in human lung carcinogenesis through the activation of RHOA and by involvement in the phosphoinositide 3-kinase/AKT pathway. Cancer Res. 65:11314–11325. 2005. View Article : Google Scholar : PubMed/NCBI

35 

Han SS, Kim WJ, Hong Y, Hong SH, Lee SJ, Ryu DR, Lee W, Cho YH, Lee S, Ryu YJ, et al: RNA sequencing identifies novel markers of non-small cell lung cancer. Lung Cancer. 84:229–235. 2014. View Article : Google Scholar : PubMed/NCBI

36 

Cai X, Luo J, Yang X, Deng H, Zhang J, Li S, Wei H, Yang C, Xu L, Jin R, et al: In vivo selection for spine-derived highly metastatic lung cancer cells is associated with increased migration, inflammation and decreased adhesion. Oncotarget. 6:22905–22917. 2015. View Article : Google Scholar : PubMed/NCBI

37 

Chen L, Zhuo D, Chen J and Yuan H: Screening feature genes of lung carcinoma with DNA microarray analysis. Int J Clin Exp Med. 8:12161–12171. 2015.PubMed/NCBI

38 

Lim MY and Thomas PS: Biomarkers in exhaled breath condensate and serum of chronic obstructive pulmonary disease and non-small-cell lung cancer. Int J Chronic Dis. 2013:5786132013.PubMed/NCBI

39 

Brooks GD, McLeod L, Alhayyani S, Miller A, Russell PA, Ferlin W, Rose-John S, Ruwanpura S and Jenkins BJ: IL6 Trans-signaling Promotes KRAS-Driven lung carcinogenesis. Cancer Res. 76:866–876. 2016. View Article : Google Scholar : PubMed/NCBI

40 

Katoh M and Katoh M: Human FOX gene family (Review). Int J Oncol. 25:1495–1500. 2004.PubMed/NCBI

41 

Nakayama S, Soejima K, Yasuda H, Yoda S, Satomi R, Ikemura S, Terai H, Sato T, Yamaguchi N, Hamamoto J, et al: FOXD1 expression is associated with poor prognosis in non-small cell lung cancer. Anticancer Res. 35:261–268. 2015.PubMed/NCBI

42 

Ciribilli Y, Singh P, Spanel R, Inga A and Borlak J: Decoding c-Myc networks of cell cycle and apoptosis regulated genes in a transgenic mouse model of papillary lung adenocarcinomas. Oncotarget. 6:31569–31592. 2015. View Article : Google Scholar : PubMed/NCBI

43 

Wang CC, Su KY, Chen HY, Chang SY, Shen CF, Hsieh CH, Hong QS, Chiang CC, Chang GC, Yu SL and Chen JJ: HOXA5 inhibits metastasis via regulating cytoskeletal remodelling and associates with prolonged survival in non-small-cell lung carcinoma. PLoS One. 10:e01241912015. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Chen B, Gao S, Ji C and Song G: Integrated analysis reveals candidate genes and transcription factors in lung adenocarcinoma. Mol Med Rep 16: 8371-8379, 2017.
APA
Chen, B., Gao, S., Ji, C., & Song, G. (2017). Integrated analysis reveals candidate genes and transcription factors in lung adenocarcinoma. Molecular Medicine Reports, 16, 8371-8379. https://doi.org/10.3892/mmr.2017.7656
MLA
Chen, B., Gao, S., Ji, C., Song, G."Integrated analysis reveals candidate genes and transcription factors in lung adenocarcinoma". Molecular Medicine Reports 16.6 (2017): 8371-8379.
Chicago
Chen, B., Gao, S., Ji, C., Song, G."Integrated analysis reveals candidate genes and transcription factors in lung adenocarcinoma". Molecular Medicine Reports 16, no. 6 (2017): 8371-8379. https://doi.org/10.3892/mmr.2017.7656
Copy and paste a formatted citation
x
Spandidos Publications style
Chen B, Gao S, Ji C and Song G: Integrated analysis reveals candidate genes and transcription factors in lung adenocarcinoma. Mol Med Rep 16: 8371-8379, 2017.
APA
Chen, B., Gao, S., Ji, C., & Song, G. (2017). Integrated analysis reveals candidate genes and transcription factors in lung adenocarcinoma. Molecular Medicine Reports, 16, 8371-8379. https://doi.org/10.3892/mmr.2017.7656
MLA
Chen, B., Gao, S., Ji, C., Song, G."Integrated analysis reveals candidate genes and transcription factors in lung adenocarcinoma". Molecular Medicine Reports 16.6 (2017): 8371-8379.
Chicago
Chen, B., Gao, S., Ji, C., Song, G."Integrated analysis reveals candidate genes and transcription factors in lung adenocarcinoma". Molecular Medicine Reports 16, no. 6 (2017): 8371-8379. https://doi.org/10.3892/mmr.2017.7656
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