Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
December-2017 Volume 16 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
December-2017 Volume 16 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Brain iron deposition analysis using susceptibility weighted imaging and its association with body iron level in patients with mild cognitive impairment

  • Authors:
    • Lili Gao
    • Zhihong Jiang
    • Zhaocheng Cai
    • Ming Cai
    • Qing Zhang
    • Yingying Ma
    • Guoliang Li
    • Fengzhu Zhao
    • Qiang Ma
  • View Affiliations / Copyright

    Affiliations: Department of Neurology, Affiliated Zhongshan Hospital of Dalian University, Dalian, Liaoning 116000, P.R. China, Department of Radiology, Affiliated Zhongshan Hospital of Dalian University, Dalian, Liaoning 116000, P.R. China
    Copyright: © Gao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 8209-8215
    |
    Published online on: September 29, 2017
       https://doi.org/10.3892/mmr.2017.7668
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The aim of the present study was to analyze brain and body iron levels among patients with mild cognitive impairment (MCI), Alzheimer's disease (AD), and normal controls (NCs). A total of 90 participants (30 MCI, 30 AD, 30 NC) were enrolled. Brain iron content was quantified using susceptibility weighted imaging (SWI). Phase values were used to calculate bilateral iron content in the hippocampus (HP), substantia nigra, red nucleus (RN), dentate nucleus (DN), caudate nucleus (CN), globus pallidus (GP), putamen (PUT), frontal white matter, temporal cortex (TC), and parietal cortex. Body iron indices, including serum iron, serum transferrin, ferritin and total iron binding capacity, were measured. Phase values of the left (L)‑DN, L‑CN, and bilateral PUT in the MCI group were significantly lower compared with NC group. Phase values of the right (R)‑RN, bilateral DN, and bilateral PUT in the AD group were significantly lower compared with the MCI group. Phase values of the bilateral HP, DN, RN, CN, GP, PUT, and L‑TC in the AD group were significantly lower compared with the NC group. Serum ferritin levels in the MCI and AD groups were significantly lower compared with the NC group. Only serum iron in the AD group was positively associated with iron content in the R‑HP. Brain iron deposition and body iron levels both increased in MCI and AD patients, however, excessive brain iron accumulation may have no association with body iron level. SWI was particularly effective at recognizing the presence of brain iron in the MCI and AD groups.
View Figures

Figure 1

Figure 2

Figure 3

View References

1 

Sperling RA, Aisen PS, Beckett LA, Bennett DA, Craft S, Fagan AM, Iwatsubo T, Jack CR Jr, Kaye J, Montine TJ, et al: Toward defining the reclinical stages of Alzheimer's disease: Recommendations from the National Institute on Aging-Alzhermer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimers Dement. 7:280–292. 2011. View Article : Google Scholar : PubMed/NCBI

2 

Albert MS, DeKosky ST, Dickson D, Dubois B, Feldman HH, Fox NC, Gamst A, Holtzman DM, Jagust WJ, Petersen RC, et al: The diagnosis of mild cognitive impairment due to Alzheimer's disease: Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimers Dement. 7:270–279. 2011. View Article : Google Scholar : PubMed/NCBI

3 

McKhann GM, Knopman DS, Chertkow H, Hyman BT, Jack CR Jr, Kawas CH, Klunk WE, Koroshetz WJ, Manly JJ, Mayeux R, et al: The diagnosis of dementia due to Alzheimer's disease: Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimers Dement. 7:263–269. 2011. View Article : Google Scholar : PubMed/NCBI

4 

Petersen RC: Mild cognitive impairment. Continuum (Minneap Minn). 22:404–418. 2016.PubMed/NCBI

5 

Ota K, Oishi N, Ito K and Fukuyama H; SEAD-J Study Group, : Alzheimer's Disease Neuroimaging Initiative: Effects of imaging modalities, brain atlases and feature selection on prediction of Alzheimer's disease. J Neurosci Methods. 256:168–183. 2015. View Article : Google Scholar : PubMed/NCBI

6 

Goodman L: Alzheimer's disease; a clinico-pathologic analysis of twenty-three cases with a theory on pathogenesis. J Nerv Ment Dis. 118:97–130. 1953. View Article : Google Scholar : PubMed/NCBI

7 

Honda K, Casadesus G, Petersen RB, Perry G and Smith MA: Oxidative stress and redox-active iron in Alzheimer's disease. Ann N Y Acad Sci. 1012:179–182. 2004. View Article : Google Scholar : PubMed/NCBI

8 

Chamberlain R, Reyes D, Curran GL, Marjanska M, Wengenack TM, Poduslo JF, Garwood M and Jack CR Jr: Comparison of amyloid plaque contrast generated by T2-weighted, T2*-weighted, and susceptibility-weighted imaging methods in transgenic mouse models of Alzheimer's disease. Magn Reson Med. 61:1158–1164. 2009. View Article : Google Scholar : PubMed/NCBI

9 

Zhou XX, Qin HL, Li XH, Huang HW, Liang YY, Liang XL and Pu XY: Characterizing brain mineral deposition in patients with Wilson disease using susceptibility-weighted imaging. Neurol India. 62:362–366. 2014. View Article : Google Scholar : PubMed/NCBI

10 

Crespo ÂC, Silva B, Marques L, Marcelino E, Maruta C, Costa S, Timóteo A, Vilares A, Couto FS, Faustino P, et al: Genetic and biochemical markers in patients with Alzheimer's disease support a concerted systemic iron homeostasis dysregulation. Neurobiol Aging. 35:777–785. 2014. View Article : Google Scholar : PubMed/NCBI

11 

Petersen RC, Smith GE, Waring SC, Ivnik RJ, Tangalos EG and Kokmen E: Mild cognitive impairment: Clinical characterization and outcome. Arch Neurol. 56:303–308. 1999. View Article : Google Scholar : PubMed/NCBI

12 

Dubois B, Feldman HH, Jacova C, Dekosky ST, Barberger-Gateau P, Cummings J, Delacourte A, Galasko D, Gauthier S, Jicha G, et al: Research criteria for the diagnosis of Alzheimer's disease: Revising the NINCDS-ADRDA criteria. Lancet Neurol. 6:734–746. 2007. View Article : Google Scholar : PubMed/NCBI

13 

Hallgren B and Sourander P: The effect of age on the non-haemin iron in the human brain. J Neurochem. 3:41–51. 1958. View Article : Google Scholar : PubMed/NCBI

14 

Lan AP, Chen J, Chai ZF and Hu Y: The neurotoxicity of iron, copper and cobalt in Parkinson's disease through ROS-mediated mechanisms. Biometals. 29:665–678. 2016. View Article : Google Scholar : PubMed/NCBI

15 

Wu Y, Passananti M, Brigante M, Dong W and Mailhot G: Fe(III)-EDDS complex in Fenton and photo-Fenton processes: From the radical formation to the degradation of a target compound. Environ Sci Pollut Res Int. 21:12154–12162. 2014. View Article : Google Scholar : PubMed/NCBI

16 

Connor JR, Menzies SL, St Martin SM and Mufson EJ: A histochemical study of iron, transferrin, and ferritin in Alzheimer's diseased brains. J Neurosci Res. 31:75–83. 1992. View Article : Google Scholar : PubMed/NCBI

17 

Grundke-Iqbal I, Fleming J, Tung YC, Lassmann H, Iqbal K and Joshi JG: Ferritin is a component of the neuritic (senile) plaque in Alzheimer dementia. Acta Neuropathol. 81:105–110. 1990. View Article : Google Scholar : PubMed/NCBI

18 

Liu B, Moloney A, Meehan S, Morris K, Thomas SE, Serpell LC, Hider R, Marciniak SJ, Lomas DA and Crowther DC: Iron promotes the toxicity of amyloid beta peptide by impeding its ordered aggregation. J Biol Chem. 286:4248–4256. 2011. View Article : Google Scholar : PubMed/NCBI

19 

Egaña JT, Zambrano C, Nuñez MT, Gonzalez-Billault C and Maccioni RB: Iron-induced oxidative stress modify tau phosphorylation patterns in hippocampal cell cultures. Biometals. 16:215–223. 2003. View Article : Google Scholar : PubMed/NCBI

20 

Ayton S, Faux NG and Bush AI: Association of cerebrospinal fluid ferritin level with preclinical cognitive decline in APOE-ε4 carriers. JAMA Neurol. 74:122–125. 2017. View Article : Google Scholar : PubMed/NCBI

21 

Haacke EM, Makki M, Ge Y, Maheshwari M, Sehgal V, Hu J, Selvan M, Wu Z, Latif Z, Xuan Y, et al: Characterizing iron deposition in multiple sclerosis lesions using susceptibility weighted imaging. J Magn Reson Imaging. 29:537–544. 2009. View Article : Google Scholar : PubMed/NCBI

22 

Schiepers OJ, van Boxtel MP, de Groot RH, Jolles J, de Kort WL, Swinkels DW, Kok FJ, Verhoef P and Durga J: Serum iron parameters, HFE C282Y genotype, and cognitive performance in older adults: Results from the FACIT study. J Gerontol A Biol Med Sci. 65:1312–1321. 2010. View Article : Google Scholar

23 

Milward EA, Bruce DG, Knuiman MW, Divitini ML, Cole M, Inderjeeth CA, Clarnette RM, Maier G, Jablensky A and Olynyk JK: A cross-sectional community study of serum iron measures and cognitive status in older adults. J Alzheimers Dis. 20:617–623. 2010. View Article : Google Scholar : PubMed/NCBI

24 

Wang ZX, Tan L, Wang HF, Ma J, Liu J, Tan MS, Sun JH, Zhu XC, Jiang T and Yu JT: Serum iron, zinc, and copper levels in patients with Alzheimer's disease: A replication study and meta-analyses. J Alzheimers Dis. 47:565–581. 2015. View Article : Google Scholar : PubMed/NCBI

25 

House MJ, St Pierre TG, Milward EA, Bruce DG and Olynyk JK: Relationship between brain R(2) and liver and serum iron concentrations in elder men. Magn Reson Med. 63:275–281. 2010. View Article : Google Scholar : PubMed/NCBI

26 

Lin D, Ding J, Liu JY, He YF, Dai Z, Chen CZ, Cheng WZ, Zhou J and Wang X: Decreased serum hepcidin concentration correlates with brain iron deposition in patients with HBV-related cirrhosis. PLoS One. 8:e655512013. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Gao L, Jiang Z, Cai Z, Cai M, Zhang Q, Ma Y, Li G, Zhao F and Ma Q: Brain iron deposition analysis using susceptibility weighted imaging and its association with body iron level in patients with mild cognitive impairment. Mol Med Rep 16: 8209-8215, 2017.
APA
Gao, L., Jiang, Z., Cai, Z., Cai, M., Zhang, Q., Ma, Y. ... Ma, Q. (2017). Brain iron deposition analysis using susceptibility weighted imaging and its association with body iron level in patients with mild cognitive impairment. Molecular Medicine Reports, 16, 8209-8215. https://doi.org/10.3892/mmr.2017.7668
MLA
Gao, L., Jiang, Z., Cai, Z., Cai, M., Zhang, Q., Ma, Y., Li, G., Zhao, F., Ma, Q."Brain iron deposition analysis using susceptibility weighted imaging and its association with body iron level in patients with mild cognitive impairment". Molecular Medicine Reports 16.6 (2017): 8209-8215.
Chicago
Gao, L., Jiang, Z., Cai, Z., Cai, M., Zhang, Q., Ma, Y., Li, G., Zhao, F., Ma, Q."Brain iron deposition analysis using susceptibility weighted imaging and its association with body iron level in patients with mild cognitive impairment". Molecular Medicine Reports 16, no. 6 (2017): 8209-8215. https://doi.org/10.3892/mmr.2017.7668
Copy and paste a formatted citation
x
Spandidos Publications style
Gao L, Jiang Z, Cai Z, Cai M, Zhang Q, Ma Y, Li G, Zhao F and Ma Q: Brain iron deposition analysis using susceptibility weighted imaging and its association with body iron level in patients with mild cognitive impairment. Mol Med Rep 16: 8209-8215, 2017.
APA
Gao, L., Jiang, Z., Cai, Z., Cai, M., Zhang, Q., Ma, Y. ... Ma, Q. (2017). Brain iron deposition analysis using susceptibility weighted imaging and its association with body iron level in patients with mild cognitive impairment. Molecular Medicine Reports, 16, 8209-8215. https://doi.org/10.3892/mmr.2017.7668
MLA
Gao, L., Jiang, Z., Cai, Z., Cai, M., Zhang, Q., Ma, Y., Li, G., Zhao, F., Ma, Q."Brain iron deposition analysis using susceptibility weighted imaging and its association with body iron level in patients with mild cognitive impairment". Molecular Medicine Reports 16.6 (2017): 8209-8215.
Chicago
Gao, L., Jiang, Z., Cai, Z., Cai, M., Zhang, Q., Ma, Y., Li, G., Zhao, F., Ma, Q."Brain iron deposition analysis using susceptibility weighted imaging and its association with body iron level in patients with mild cognitive impairment". Molecular Medicine Reports 16, no. 6 (2017): 8209-8215. https://doi.org/10.3892/mmr.2017.7668
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team