Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
December-2017 Volume 16 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
December-2017 Volume 16 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Arctiin regulates collagen type 1α chain 1 mRNA expression in human dermal fibroblasts via the miR‑378b‑SIRT6 axis

  • Authors:
    • Karam Kim
    • Sungkwan An
    • Byung Gon Choi
    • Dahye Joo
    • Young Min Choi
    • Kyu Joong Ahn
    • In‑Sook An
    • Hwa Jun Cha
  • View Affiliations / Copyright

    Affiliations: KISCS Incorporated, 2nd Enterprise Research Building, Cheongju, Chungcheongbuk 361‑951, Republic of South Korea, Korea Institute for Skin and Clinical Sciences, Konkuk University, Seoul 143‑701, Republic of South Korea, Department of Dermatology, Konkuk University School of Medicine, Seoul 143‑701, Republic of South Korea
  • Pages: 9120-9124
    |
    Published online on: October 2, 2017
       https://doi.org/10.3892/mmr.2017.7679
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Arctiin, a lignin isolated from Arctium lappa, exhibits a variety of biological effects, including anti‑viral, anti‑inflammatory, and anti‑proliferative actions, in mammalian cells. In a previous study, arctiin was demonstrated to induce procollagen type I synthesis and exhibited protective effects against ultraviolet B (UVB) radiation in normal human dermal fibroblasts (nHDFs). However, the underlying molecular mechanism of arctiin‑mediated collagen synthesis remains unknown. In the present study, the mechanism for increased expression of collagen type 1α 1 chain (COL1A1) mRNA in arctiin‑induced nHDFs was identified. The expression of microRNA‑378b (miR‑378b), downregulated by arctiin, was correlated with the expression of sirtuin‑6 (SIRT6) mRNA, a regulator of COL1A1 mRNA. Furthermore, it was revealed that arctiin protected the UVB radiation‑mediated decrease in COL1A1 mRNA expression, through the miR‑378b/SIRT6 signaling pathway. In conclusion, these results suggest that arctiin regulates COL1A1 through the miR‑378b‑SIRT6 axis.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

Quan T and Fisher GJ: Role of age-associated alterations of the dermal extracellular matrix microenvironment in human skin aging: A mini-review. Gerontology. 61:427–434. 2015. View Article : Google Scholar : PubMed/NCBI

2 

Darlenski R, Kazandjieva J and Tsankov N: Skin barrier function: Morphological basis and regulatory mechanisms. J Clin Med. 4:36–45. 2011.

3 

Eckert RL and Rorke EA: Molecular biology of keratinocyte differentiation. Environ Health Perspect. 80:109–116. 1989. View Article : Google Scholar : PubMed/NCBI

4 

Varani J, Dame MK, Rittie L, Fligiel SE, Kang S, Fisher GJ and Voorhees JJ: Decreased collagen production in chronologically aged skin: Roles of age-dependent alteration in fibroblast function and defective mechanical stimulation. Am J Pathol. 168:1861–1868. 2006. View Article : Google Scholar : PubMed/NCBI

5 

Wulf HC, Sandby-Møller J, Kobayasi T and Gniadecki R: Skin aging and natural photoprotection. Micron. 35:185–191. 2004. View Article : Google Scholar : PubMed/NCBI

6 

Egbert M, Ruetze M, Sattler M, Wenck H, Gallinat S, Lucius R and Weise JM: The matricellular protein periostin contributes to proper collagen function and is downregulated during skin aging. J Dermatol Sci. 73:40–48. 2014. View Article : Google Scholar : PubMed/NCBI

7 

Farage MA, Miller KW, Elsner P and Maibach HI: Characteristics of the aging skin. Adv Wound Care (New Rochelle). 2:5–10. 2013. View Article : Google Scholar : PubMed/NCBI

8 

Debacq-Chainiaux F, Leduc C, Verbeke A and Toussaint O: UV stress and aging. Dermatoendocrinol. 4:236–240. 2012. View Article : Google Scholar : PubMed/NCBI

9 

Katiyar SK and Mukhtar H: Green tea polyphenol (−)-epigallocatechin-3-gallate treatment to mouse skin prevents UVB-induced infiltration of leukocytes, depletion of antigenpresenting cells, and oxidative stress. J Leukoc Biol. 69:719–726. 2001.PubMed/NCBI

10 

Wlaschek M, Tantcheva-Poór I, Naderi L, Ma W, Schneider LA, Razi-Wolf Z, Schüller J and Scharffetter-Kochanek K: Solar UV irradiation and dermal photoaging. J Photochem Photobiol B. 63:41–51. 2001. View Article : Google Scholar : PubMed/NCBI

11 

Fisher GJ, Kang S, Varani J, Bata-Csorgo Z, Wan Y, Datta S and Voorhees JJ: Mechanisms of photoaging and chronological skin aging. Arch Dermatol. 138:1462–1470. 2002. View Article : Google Scholar : PubMed/NCBI

12 

Shindo Y, Witt E and Packer L: Antioxidant defense mechanisms in murine epidermis and dermis and their responses to ultraviolet light. J Invest Dermatol. 100:260–265. 1993. View Article : Google Scholar : PubMed/NCBI

13 

Lee S, Shin S, Kim H, Han S and Kim K, Kwon J, Kwak JH, Lee CK, Ha NJ, Yim D and Kim K: Anti-inflammatory function of arctiin by inhibiting COX-2 expression via NF-κB pathways. J Inflamm (Lond). 8:162011. View Article : Google Scholar : PubMed/NCBI

14 

Wu JG, Wu JZ, Sun LN, Han T, Du J, Ye Q, Zhang H and Zhang YG: Ameliorative effects of arctiin from Arctium lappa on experimental glomerulonephritis in rats. Phytomedicine. 16:1033–1041. 2009. View Article : Google Scholar : PubMed/NCBI

15 

Knott A, Reuschlein K, Mielke H, Wensorra U, Mummert C, Koop U, Kausch M, Kolbe L, Peters N, Stäb F, et al: Natural Arctium lappa fruit extract improves the clinical signs of aging skin. J Cosmet Dermatol. 7:281–289. 2008. View Article : Google Scholar : PubMed/NCBI

16 

Cha HJ, Lee GT, Lee KS, Lee KK, Hong JT, Lee NK, Kim SY, Lee BM, An IS, Hahn HJ, et al: Photoprotective effect of arctiin against ultraviolet B-induced damage in HaCaT keratinocytes is mediated by microRNA expression changes. Mol Med Rep. 10:1363–1370. 2014. View Article : Google Scholar : PubMed/NCBI

17 

Syed DN, Khan MI, Shabbir M and Mukhtar H: MicroRNAs in skin response to UV radiation. Curr Drug Targets. 14:1128–1134. 2013. View Article : Google Scholar : PubMed/NCBI

18 

Honda N, Jinnin M, Kajihara I, Makino T, Makino K, Masuguchi S, Fukushima S, Okamoto Y, Hasegawa M, Fujimoto M and Ihn H: TGF-β-mediated down-regulation of microRNA-196a contributes to the constitutive upregulated type I collagen expression in scleroderma dermal fibroblasts. J Immunol. 188:3323–3331. 2012. View Article : Google Scholar : PubMed/NCBI

19 

Yamauchi M, Prisayanh P, Haque Z and Woodley DT: Collagen cross-linking in sun-exposed and unexposed sites of aged human skin. J Invest Dermatol. 97:938–941. 1991. View Article : Google Scholar : PubMed/NCBI

20 

Sohal RS and Weindruch R: Oxidative stress, caloric restriction, and aging. Science. 273:59–63. 1996. View Article : Google Scholar : PubMed/NCBI

21 

Benedetto AV: The environment and skin aging. Clinics Derm. 16:129–139. 1998. View Article : Google Scholar

22 

Kwon DN, Chang BS and Kim JH: MicroRNA dysregulation in liver and pancreas of CMP-Neu5Ac hydroxylase null mice disrupts insulin/PI3K-AKT signaling. Biomed Res Int. 2014:2363852014. View Article : Google Scholar : PubMed/NCBI

23 

Al-Gubory KH, Fowler PA and Garrel C: The roles of cellular reactive oxygen species, oxidative stress and antioxidants in pregnancy outcomes. Int J Biochem Cell Biol. 42:1634–1650. 2010. View Article : Google Scholar : PubMed/NCBI

24 

Lucas K and Raikhel AS: Insect microRNAs: Biogenesis, expression profiling and biological functions. Insect Biochem Mol Biol. 43:24–38. 2013. View Article : Google Scholar : PubMed/NCBI

25 

Jung HJ and Suh Y: MicroRNA in aging: From discovery to biology. Curr Genomics. 13:548–557. 2012. View Article : Google Scholar : PubMed/NCBI

26 

Banerjee J, Chan YC and Sen CK: MicroRNAs in skin and wound healing. Physiol Genomics. 43:543–556. 2011. View Article : Google Scholar : PubMed/NCBI

27 

Krol J, Loedige I and Filipowicz W: The widespread regulation of microRNA biogenesis, function and decay. Nat Rev Genet. 9:597–610. 2010.

28 

Greussing R, Hackl M, Charoentong P, Pauck A, Monteforte R, Cavinato M, Hofer E, Scheideler M, Neuhaus M, Micutkova L, et al: Identification of microRNA-mRNA functional interactions in UVB-induced senescence of human diploid fibroblasts. BMC Genomics. 14:2242013. View Article : Google Scholar : PubMed/NCBI

29 

Yi R and Fuchs E: MicroRNA-mediated control in the skin. Cell Death Differ. 17:229–235. 2010. View Article : Google Scholar : PubMed/NCBI

30 

Hildebrand J, Rütze M, Walz N, Gallinat S, Wenck H, Deppert W, Grundhoff A and Knott A: A comprehensive analysis of microRNA expression during human keratinocyte differentiation in vitro and in vivo. J Invest Dermatol. 13:20–29. 2011. View Article : Google Scholar

31 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

32 

Matsuzaki Y, Koyama M, Hitomi T, Yokota T, Kawanaka M, Nishikawa A, Germain D and Sakai T: Arctiin induces cell growth inhibition through the down-regulation of cyclin D1 expression. Oncol Rep. 19:721–727. 2008.PubMed/NCBI

33 

Hayashi K, Narutaki K, Nagaoka Y, Hayashi T and Uesato S: Therapeutic effect of arctiin and arctigenin in immunocompetent and immunocompromised mice infected with influenza A virus. Biol Pharm Bull. 33:1199–1205. 2010. View Article : Google Scholar : PubMed/NCBI

34 

Binic I, Lazarevic V, Ljubenovic M, Mojsa J and Sokolovic D: Skin ageing: Natural weapons and strategies. Evid Based Complement Alternat Med. 2013:8272482013. View Article : Google Scholar : PubMed/NCBI

35 

Baohua Y and Li L: Effects of SIRT6 silencing on collagen metabolism in human dermal fibroblasts. Cell Biol Int. 36:105–108. 2012. View Article : Google Scholar : PubMed/NCBI

36 

Tilstra JS, Clauson CL, Niedernhofer LJ and Robbins PD: NF-κB in aging and disease. Aging Dis. 2:449–465. 2011.PubMed/NCBI

37 

Osorio FG, López-Otín C and Freije JM: NF-kB in premature aging. Aging (Albany NY). 4:726–727. 2012. View Article : Google Scholar : PubMed/NCBI

38 

Tanaka K, Asamitsu K, Uranishi H, Iddamalgoda A, Ito K, Kojima H and Okamoto T: Protecting skin photoaging by NF-kappaB inhibitor. Curr Drug Metab. 11:431–435. 2010. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Kim K, An S, Choi BG, Joo D, Choi YM, Ahn KJ, An IS and Cha HJ: Arctiin regulates collagen type 1α chain 1 mRNA expression in human dermal fibroblasts via the miR‑378b‑SIRT6 axis. Mol Med Rep 16: 9120-9124, 2017.
APA
Kim, K., An, S., Choi, B.G., Joo, D., Choi, Y.M., Ahn, K.J. ... Cha, H.J. (2017). Arctiin regulates collagen type 1α chain 1 mRNA expression in human dermal fibroblasts via the miR‑378b‑SIRT6 axis. Molecular Medicine Reports, 16, 9120-9124. https://doi.org/10.3892/mmr.2017.7679
MLA
Kim, K., An, S., Choi, B. G., Joo, D., Choi, Y. M., Ahn, K. J., An, I., Cha, H. J."Arctiin regulates collagen type 1α chain 1 mRNA expression in human dermal fibroblasts via the miR‑378b‑SIRT6 axis". Molecular Medicine Reports 16.6 (2017): 9120-9124.
Chicago
Kim, K., An, S., Choi, B. G., Joo, D., Choi, Y. M., Ahn, K. J., An, I., Cha, H. J."Arctiin regulates collagen type 1α chain 1 mRNA expression in human dermal fibroblasts via the miR‑378b‑SIRT6 axis". Molecular Medicine Reports 16, no. 6 (2017): 9120-9124. https://doi.org/10.3892/mmr.2017.7679
Copy and paste a formatted citation
x
Spandidos Publications style
Kim K, An S, Choi BG, Joo D, Choi YM, Ahn KJ, An IS and Cha HJ: Arctiin regulates collagen type 1α chain 1 mRNA expression in human dermal fibroblasts via the miR‑378b‑SIRT6 axis. Mol Med Rep 16: 9120-9124, 2017.
APA
Kim, K., An, S., Choi, B.G., Joo, D., Choi, Y.M., Ahn, K.J. ... Cha, H.J. (2017). Arctiin regulates collagen type 1α chain 1 mRNA expression in human dermal fibroblasts via the miR‑378b‑SIRT6 axis. Molecular Medicine Reports, 16, 9120-9124. https://doi.org/10.3892/mmr.2017.7679
MLA
Kim, K., An, S., Choi, B. G., Joo, D., Choi, Y. M., Ahn, K. J., An, I., Cha, H. J."Arctiin regulates collagen type 1α chain 1 mRNA expression in human dermal fibroblasts via the miR‑378b‑SIRT6 axis". Molecular Medicine Reports 16.6 (2017): 9120-9124.
Chicago
Kim, K., An, S., Choi, B. G., Joo, D., Choi, Y. M., Ahn, K. J., An, I., Cha, H. J."Arctiin regulates collagen type 1α chain 1 mRNA expression in human dermal fibroblasts via the miR‑378b‑SIRT6 axis". Molecular Medicine Reports 16, no. 6 (2017): 9120-9124. https://doi.org/10.3892/mmr.2017.7679
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team