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Identification and bioinformatics analysis of miRNAs associated with human muscle invasive bladder cancer

  • Authors:
    • Liang Chen
    • Lushun Yuan
    • Gang Wang
    • Rui Cao
    • Jianping Peng
    • Bo Shu
    • Guofeng Qian
    • Xinghuan Wang
    • Yu Xiao
  • View Affiliations / Copyright

    Affiliations: Department of Urology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei 430071, P.R. China, Department of Endocrinology, The First Affiliated Hospital of Zhejiang University, Hangzhou, Zhejiang 310000, P.R. China
    Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 8709-8720
    |
    Published online on: October 4, 2017
       https://doi.org/10.3892/mmr.2017.7726
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Abstract

Accumulated evidence has indicated that micro (mi)RNAs play vital roles in the occurrence and development of human muscle invasive bladder cancer (MIBC), however, little is known about the miRNAs' regulatory networks. In the present study, the authors aimed to use bioinformatics analysis to identify the key miRNAs and potential target genes, as well as studying the underlying mechanisms for MIBC. They collected several human MIBC tissues to generate a miRNA expression analysis by microarray analysis comparing with normal bladder tissues, identifying 104 differentially expressed miRNAs (102 were downregulated and 2 were upregulated) and predicted 11,884 putative target genes of the dysregulated miRNAs. To understand the function of dysregulated miRNAs in the development of MIBC, networks among miRNAs and genes, gene ontologies and pathways were built. The subsequent bioinformatics analysis indicated that the mitogen‑associated protein kinase (MAPK) signaling pathway, apoptosis and pathways in cancer and the cell cycle, were significantly enriched Overall, these results provided comprehensive information on the biological function of dysregulated miRNAs in the development of MIBC. The identification of miRNAs and their putative targets may offer new diagnostic and therapeutic strategies for human muscle invasive bladder cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Chen L, Yuan L, Wang G, Cao R, Peng J, Shu B, Qian G, Wang X and Xiao Y: Identification and bioinformatics analysis of miRNAs associated with human muscle invasive bladder cancer. Mol Med Rep 16: 8709-8720, 2017.
APA
Chen, L., Yuan, L., Wang, G., Cao, R., Peng, J., Shu, B. ... Xiao, Y. (2017). Identification and bioinformatics analysis of miRNAs associated with human muscle invasive bladder cancer. Molecular Medicine Reports, 16, 8709-8720. https://doi.org/10.3892/mmr.2017.7726
MLA
Chen, L., Yuan, L., Wang, G., Cao, R., Peng, J., Shu, B., Qian, G., Wang, X., Xiao, Y."Identification and bioinformatics analysis of miRNAs associated with human muscle invasive bladder cancer". Molecular Medicine Reports 16.6 (2017): 8709-8720.
Chicago
Chen, L., Yuan, L., Wang, G., Cao, R., Peng, J., Shu, B., Qian, G., Wang, X., Xiao, Y."Identification and bioinformatics analysis of miRNAs associated with human muscle invasive bladder cancer". Molecular Medicine Reports 16, no. 6 (2017): 8709-8720. https://doi.org/10.3892/mmr.2017.7726
Copy and paste a formatted citation
x
Spandidos Publications style
Chen L, Yuan L, Wang G, Cao R, Peng J, Shu B, Qian G, Wang X and Xiao Y: Identification and bioinformatics analysis of miRNAs associated with human muscle invasive bladder cancer. Mol Med Rep 16: 8709-8720, 2017.
APA
Chen, L., Yuan, L., Wang, G., Cao, R., Peng, J., Shu, B. ... Xiao, Y. (2017). Identification and bioinformatics analysis of miRNAs associated with human muscle invasive bladder cancer. Molecular Medicine Reports, 16, 8709-8720. https://doi.org/10.3892/mmr.2017.7726
MLA
Chen, L., Yuan, L., Wang, G., Cao, R., Peng, J., Shu, B., Qian, G., Wang, X., Xiao, Y."Identification and bioinformatics analysis of miRNAs associated with human muscle invasive bladder cancer". Molecular Medicine Reports 16.6 (2017): 8709-8720.
Chicago
Chen, L., Yuan, L., Wang, G., Cao, R., Peng, J., Shu, B., Qian, G., Wang, X., Xiao, Y."Identification and bioinformatics analysis of miRNAs associated with human muscle invasive bladder cancer". Molecular Medicine Reports 16, no. 6 (2017): 8709-8720. https://doi.org/10.3892/mmr.2017.7726
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