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Frequency and distribution of CD4+CXCR5+ follicular B helper T cells within involved tissues in IgG4‑related ophthalmic disease

  • Authors:
    • Huimin Yang
    • Ruili Wei
    • Qiang Liu
    • Yongheng Shi
    • Jin Li
  • View Affiliations / Copyright

    Affiliations: Department of Ophthalmology, School of Medicine, Renji Hospital, Shanghai Jiao Tong University, Shanghai 200127, P.R. China, Department of Ophthalmology, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai 200003, P.R. China, Department of Pathology, School of Medicine, Renji Hospital, Shanghai Jiao Tong University, Shanghai 200127, P.R. China
    Copyright: © Yang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 9512-9520
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    Published online on: October 12, 2017
       https://doi.org/10.3892/mmr.2017.7780
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Abstract

Immonoglobulin G4‑related ophthalmic disease (IgG4‑ROD) is a IgG4‑RD and exhibits two main characteristics: Fibrosis that is not necessarily marked histopathologically; and frequent formation of germinal centers (GCs). Follicular B helper T (Tfh) cells are now recognized as the true helper cells for B cells in antibody responses. In the present study, the profile and distribution of Tfh cells in involved tissues from patients with IgG4‑ROD was compared to those of type 1 autoimmune pancreatitis (AIP) and patients with IgG4‑related lymphadenopathy (IgG4‑RL). A total of 7 patients with IgG4‑ROD, 7 patients with type 1 AIP or IgG4‑RL and 7 IgG4‑negative controls were evaluated. The expression of Tfh‑cell immunological proteins, the inducible T‑cell costimulator, B‑cell lymphoma 6 protein, C‑X‑C chemokine receptor type 5 (CXCR5) and interleukin‑21 (IL‑21) in affected tissues was analyzed using immunohistochemical staining and dual immunofluorescence. It was demonstrated that patients with IgG4‑RD exhibited a significantly increased number of CD4+CXCR5+ Tfh cells compared with the IgG4‑negative controls. Furthermore, CD4+CXCR5+ Tfh cells were detected in and outside of GCs in patients with IgG4‑ROD and IgG4‑RLF, whereas CD4+CXCR5+ Tfh cells were randomly distributed in areas demonstrating type 1 AIP. Fewer CD4+CXCR5+ Tfh cells were observed in patients with type 1 AIP compared with patients with IgG4‑ROD and IgG4‑RL. In addition, increased expression of IL‑21 was observed in patients with IgG4‑ROD and IgG4‑RL compared with type 1 AIP. IL‑21 expression was positively correlated with the IgG4/IgG ratio in immunohistochemically‑positive cells. The results of the present study indicate that Tfh cells are involved in the histopathological pathogenesis of IgG4‑RD and may serve a different role in IgG4‑ROD and type 1 AIP. Tfh cells may serve a direct role in the IL‑21‑mediated pathogenesis of IgG4‑ROD.
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View References

1 

Hamano H, Kawa S, Horiuchi A, Unno H, Furuya N, Akamatsu T, Fukushima M, Nikaido T, Nakayama K, Usuda N and Kiyosawa K: High serum IgG4 concentrations in patients with sclerosing pancreatitis. N Engl J Med. 344:732–738. 2001. View Article : Google Scholar : PubMed/NCBI

2 

Hamanou H, Kawa S, Ochi Y, Unno H, Shiba N, Wajiki M, Nakazawa K, Shimojo H and Kiyosawa K: Hydronephrosis associated with retroperitoneal fibrosis and sclerosing pancreatitis. Lancet. 359:1403–1404. 2002. View Article : Google Scholar : PubMed/NCBI

3 

Stone JH, Khosroshahi A, Deshpande V, Chan JK, Heathcote JG, Aalberse R, Azumi A, Bloch DB, Brugge WR, Carruthers MN, et al: Recommendations for the nomenclature of IgG4-related disease and its individual organ system manifestations. Arthritis Rheum. 64:3061–3067. 2012. View Article : Google Scholar : PubMed/NCBI

4 

Umehara H, Okazaki K, Masaki Y, Kawano M, Yamamoto M, Saeki T, Matsui S, Sumida T, Mimori T, Tanaka Y, et al: A novel clinical entity, IgG4-related disease (IgG4RD): General concept and details. Mod Rheumatol. 22:1–14. 2012. View Article : Google Scholar : PubMed/NCBI

5 

Deshpande V, Zen Y, Chan JK, Yi EE, Sato Y, Yoshino T, Klöppel G, Heathcote JG, Khosroshahi A, Ferry JA, et al: Consensus statement on the pathology of IgG4-related disease. Mod Pathol. 25:1181–1192. 2012. View Article : Google Scholar : PubMed/NCBI

6 

Stone JH, Zen Y and Deshpande V: IgG4-Related Disease. N Engl J Med. 366:539–551. 2012. View Article : Google Scholar : PubMed/NCBI

7 

Goto H, Takahira M and Azumi A; Japanese Study Group for IgG4-Related Ophthalmic Disease, : Diagnostic criteria for IgG4-related ophthalmic disease. Jpn J Ophthalmol. 59:1–7. 2015. View Article : Google Scholar : PubMed/NCBI

8 

MacLennan IC: Germinal centers. Annu Rev Immunol. 12:117–139. 1994. View Article : Google Scholar : PubMed/NCBI

9 

Klein U and Dalla-Favera R: Germinal centres: Role in B-cell physiology and malignancy. Nat Rev Immunol. 8:22–33. 2008. View Article : Google Scholar : PubMed/NCBI

10 

Crotty S: Follicular helper CD4 T cells (TFH). Annu Rev Immunol. 29:621–663. 2011. View Article : Google Scholar : PubMed/NCBI

11 

Vinuesa CG, Linterman MA, Yu D and MacLennan IC: Follicular Helper T Cells. Annu Rev Immunol. 34:335–368. 2016. View Article : Google Scholar : PubMed/NCBI

12 

Schaerli P, Willimann K, Lang AB, Lipp M, Loetscher P and Moser B: Cxc chemokine receptor 5 expression defines follicular homing T cells with B cell helper function. J Exp Med. 192:1553–1562. 2000. View Article : Google Scholar : PubMed/NCBI

13 

Breitfeld D, Ohl L, Kremmer EK, Ellwart J, Sallusto F, Lipp M and Förster R: Follicular B helper T Cells express Cxc chemokine receptor 5, Localize to B cell follicles and support immunoglobulin production. J Exp Med. 192:1545–1552. 2000. View Article : Google Scholar : PubMed/NCBI

14 

Ansel KM, McHeyzer-Williams LJ, Ngo VN, McHeyzer-Williams MG and Cyster JG: In vivo activated CD4 T cells upregulate CXC chemokine receptor 5 and reprogram their response to lymphoid chemokines. J Exp Med. 190:1123–1134. 1999. View Article : Google Scholar : PubMed/NCBI

15 

Zlotnik A and Yoshie O: Chemokines: A new classification system and their role in immunity. Immunity. 12:121–127. 2000. View Article : Google Scholar : PubMed/NCBI

16 

Chtanova T, Tangye SG, Newton R, Frank N, Hodge MR, Rolph MS and Mackay CR: T Follicular helper cells express a distinctive transcriptional profile, reflecting their role as Non-Th1/Th2 effector cells that provide help for B Cells. J Immunol. 173:68–78. 2004. View Article : Google Scholar : PubMed/NCBI

17 

Johnston RJ, Poholek AC, DiToro D, Yusuf I, Eto D, Barnett B, Dent AL, Craft J and Crotty S: Bcl6 and Blimp-1 are reciprocal and antagonistic regulators of T follicular helper cell differentiation. Science. 325:1006–1010. 2009. View Article : Google Scholar : PubMed/NCBI

18 

Nurieva RI, Chung Y, Martinez GJ, Yang XO, Tanaka S, Matskevitch TD, Wang YH and Dong C: Bcl6 mediates the development of T follicular helper cells. Science. 325:1001–1005. 2009. View Article : Google Scholar : PubMed/NCBI

19 

Yu D, Rao S, Tsai LM, Lee SK, He Y, Sutcliffe EL, Srivastava M, Linterman M, Zheng L, Simpson N, et al: The transcriptional repressor Bcl-6 directs T follicular helper cell lineage commitment. Immunity. 31:457–468. 2009. View Article : Google Scholar : PubMed/NCBI

20 

King C: New insights into the differentiation and function of T follicular helper cells. Nat Rev Immunol. 9:757–766. 2009. View Article : Google Scholar : PubMed/NCBI

21 

Choi YS, Kageyama R, Eto D, Escobar TC, Johnston RJ, Monticelli L, Lao C and Crotty S: ICOS receptor instructs T follicular helper cell versus effector cell differentiation via induction of the transcriptional repressor Bcl6. Immunity. 34:932–946. 2011. View Article : Google Scholar : PubMed/NCBI

22 

Weber JP, Fuhrmann F, Feist RK, Lahmann A, Al Baz MS, Gentz LJ, Vu Van D, Mages HW, Haftmann C, Riedel R, et al: ICOS maintains the T follicular helper cell phenotype by down-regulating Kruppel-like factor 2. J Exp Med. 212:217–233. 2015. View Article : Google Scholar : PubMed/NCBI

23 

Zen Y, Fujii M, Harada K, Kawano M, Yamada K, Takahira M and Nakanuma Y: Th2 and regulatory immune reactions are increased in immunoglobin G4-related sclerosing pancreatitis and cholangitis. Hepatology. 45:1538–1546. 2007. View Article : Google Scholar : PubMed/NCBI

24 

Tanaka A, Moriyama M, Nakashima H, Miyake K, Hayashida JN, Maehara T, Shinozaki S, Kubo Y and Nakamura S: Th2 and regulatory immune reactions contribute to IgG4 production and the initiation of Mikulicz disease. Arthritis Rheum. 64:254–263. 2012. View Article : Google Scholar : PubMed/NCBI

25 

Komori T, Kondo S, Wakisaka N, Nakanishi Y, Nakanishi-Yagi S, Tsuji A, Endo K, Murono S and Yoshizaki T: IL-18 is highly expressed in inflammatory infiltrates of submandibular glands in patients with immunoglobulin G4-related disease. Hum Pathol. 46:1850–1858. 2015. View Article : Google Scholar : PubMed/NCBI

26 

Maehara T, Mattoo H, Ohta M, Mahajan VS, Moriyama M, Yamauchi M, Drijvers J, Nakamura S, Stone JH and Pillai SS: Lesional CD4+ IFN-γ+ cytotoxic T lymphocytes in IgG4-related dacryoadenitis and sialoadenitis. Ann Rheum Dis. 76:377–385. 2017. View Article : Google Scholar : PubMed/NCBI

27 

Simpson N, Gatenby PA, Wilson A, Malik S, Fulcher DA, Tangye SG, Manku H, Vyse TJ, Roncador G, Huttley GA, et al: Expansion of circulating T cells resembling follicular helper T cells is a fixed phenotype that identifies a subset of severe systemic lupus erythematosus. Arthritis Rheum. 62:234–244. 2010. View Article : Google Scholar : PubMed/NCBI

28 

Choi JY, Ho JH, Pasoto SG, Bunin V, Kim ST, Carrasco S, Borba EF, Goncalves CR, Costa PR, Kallas EG, et al: Circulating follicular helper-like T cells in systemic lupus erythematosus: Association with disease activity. Arthritis Rheumatol. 67:988–999. 2015. View Article : Google Scholar : PubMed/NCBI

29 

Zhu C, Ma J, Liu Y, Tong J, Tian J, Chen J, Tang X, Xu H, Lu L and Wang S: Increased frequency of follicular helper T cells in patients with autoimmune thyroid disease. J Clin Endocrinol Metab. 97:943–950. 2012. View Article : Google Scholar : PubMed/NCBI

30 

Zhang M, Zhou Y, Guo J, Li H, Tian F, Gong L, Wang X, Lan M, Li Z and Zhang W: Thymic TFH cells involved in the pathogenesis of myasthenia gravis with thymoma. Exp Neurol. 254:200–205. 2014. View Article : Google Scholar : PubMed/NCBI

31 

Zhang CJ, Gong Y, Zhu W, Qi Y, Yang CS, Fu Y, Chang G, Li Y, Shi S, Wood K, et al: Augmentation of Circulating Follicular Helper T Cells and Their Impact on Autoreactive B Cells in Myasthenia Gravis. J Immunol. 197:2610–2617. 2016. View Article : Google Scholar : PubMed/NCBI

32 

Akiyama M, Suzuki K, Yamaoka K, Yasuoka H, Takeshita M, Kaneko Y, Kondo H, Kassai Y, Miyazaki T, Morita R, et al: Number of circulating follicular helper 2 T cells correlates with IgG4 and interleukin-4 levels and plasmablast numbers in IgG4-related disease. Arthritis Rheumatol. 67:2476–2481. 2015. View Article : Google Scholar : PubMed/NCBI

33 

Akiyama M, Yasuoka H, Yamaoka K, Suzuki K, Kaneko Y, Kondo H, Kassai Y, Koga K, Miyazaki T, Morita R, et al: Enhanced IgG4 production by follicular helper 2 T cells and the involvement of follicular helper 1 T cells in the pathogenesis of IgG4-related disease. Arthritis Res Ther. 18:1672016. View Article : Google Scholar : PubMed/NCBI

34 

Umehara H, Okazaki K, Masaki Y, Kawano M, Yamamoto M, Saeki T, Matsui S, Yoshino T, Nakamura S, Kawa S, et al: Comprehensive diagnostic criteria for IgG4-related disease (IgG4-RD), 2011. Mod Rheumatol. 22:21–30. 2012. View Article : Google Scholar : PubMed/NCBI

35 

Friedrichs K, Gluba S, Eidtrnann H and Jonat W: Overexpression of p53 and Prognosis in Breast Cancer. Cancer. 72:3641–3647. 1993. View Article : Google Scholar : PubMed/NCBI

36 

Zhu J, Yamane H and Paul WE: Differentiation of effector CD4 T cell populations (*). Annu Rev Immunol. 28:445–489. 2010. View Article : Google Scholar : PubMed/NCBI

37 

Sato Y, Ohshima K, Ichimura K, Sato M, Yamadori I, Tanaka T, Takata K, Morito T, Kondo E and Yoshino T: Ocular adnexal IgG4-related disease has uniform clinicopathology. Pathol Int. 58:465–470. 2008. View Article : Google Scholar : PubMed/NCBI

38 

Poholek AC, Hansen K, Hernandez SG, Eto D, Chandele A, Weinstein JS, Dong X, Odegard JM, Kaech SM, Dent AL, et al: In vivo regulation of Bcl6 and T follicular helper cell development. J Immunol. 185:313–326. 2010. View Article : Google Scholar : PubMed/NCBI

39 

Hatzi K, Nance JP, Kroenke MA, Bothwell M, Haddad EK, Melnick A and Crotty S: BCL6 orchestrates Tfh cell differentiation via multiple distinct mechanisms. J Exp Med. 212:539–553. 2015. View Article : Google Scholar : PubMed/NCBI

40 

Fazilleau N, Mark L, McHeyzer-Williams LJ and McHeyzer-Williams MG: Follicular helper T cells: Lineage and location. Immunity. 30:324–335. 2009. View Article : Google Scholar : PubMed/NCBI

41 

King C, Tangye SG and Mackay CR: T follicular helper (TFH) cells in normal and dysregulated immune responses. Annu Rev Immunol. 26:741–766. 2008. View Article : Google Scholar : PubMed/NCBI

42 

Zen Y: The Pathology of IgG4-Related Disease in the Bile Duct and Pancreas. Semin Liver Dis. 36:242–256. 2016. View Article : Google Scholar : PubMed/NCBI

43 

Spolski R and Leonard WJ: IL-21 and T follicular helper cells. Int Immunol. 22:7–12. 2010. View Article : Google Scholar : PubMed/NCBI

44 

Good KL, Bryant VL and Tangye SG: Kinetics of Human B cell behavior and amplification of proliferative responses following stimulation with IL-21. J Immunol. 177:5236–5247. 2006. View Article : Google Scholar : PubMed/NCBI

45 

Bryant VL, Ma CS, Avery DT, Li Y, Good KL, Corcoran LM, de Waal Malefyt R and Tangye SG: Cytokine-mediated regulation of human B cell differentiation into ig-secreting cells: Predominant Role of IL-21 produced by CXCR5+ T follicular helper cells. J Immunol. 179:8180–8190. 2007. View Article : Google Scholar : PubMed/NCBI

46 

Zotos D, Coquet JM, Zhang Y, Light A, D'Costa K, Kallies A, Corcoran LM, Godfrey DI, Toellner KM, Smyth MJ, et al: IL-21 regulates germinal center B cell differentiation and proliferation through a B cell-intrinsic mechanism. J Exp Med. 207:365–378. 2010. View Article : Google Scholar : PubMed/NCBI

47 

Linterman MA, Beaton L, Yu D, Ramiscal RR, Srivastava M, Hogan JJ, Verma NK, Smyth MJ, Rigby RJ and Vinuesa CG: IL-21 acts directly on B cells to regulate Bcl-6 expression and germinal center responses. J Exp Med. 207:353–363. 2010. View Article : Google Scholar : PubMed/NCBI

48 

Maehara T, Moriyama M, Nakashima H, Miyake K, Hayashida JN, Tanaka A, Shinozaki S, Kubo Y and Nakamura S: Interleukin-21 contributes to germinal centre formation and immunoglobulin G4 production in IgG4-related dacryoadenitis and sialoadenitis, so-called Mikulicz's disease. Ann Rheum Dis. 71:2011–2019. 2012. View Article : Google Scholar : PubMed/NCBI

49 

Martinez-Valle F, Fernandez-Codina A, Pinal-Fernandez I, Orozco-Galvez O and Vilardell-Tarres M: IgG4-related disease: Evidence from six recent cohorts. Autoimmun Rev. 16:168–172. 2017. View Article : Google Scholar : PubMed/NCBI

50 

Yamamoto M, Awakawa T and Takahashi H: Is rituximab effective for IgG4-related disease in the long term? Experience of cases treated with rituximab for 4 years. Ann Rheum Dis. 74:e462015. View Article : Google Scholar : PubMed/NCBI

51 

Yamamoto M, Takahashi H, Takano K, Shimizu Y, Sakurai N, Suzuki C, Naishiro Y, Yajima H, Awakawa T, Himi T and Nakase H: Efficacy of abatacept for IgG4-related disease over 8 months. Ann Rheum Dis. 75:1576–1578. 2016. View Article : Google Scholar : PubMed/NCBI

52 

Bai F, Tian H, Niu Z, Liu M, Ren G, Yu Y, Sun T, Li S and Li D: Chimeric anti-IL-17 full-length monoclonal antibody is a novel potential candidate for the treatment of rheumatoid arthritis. Int J Mol Med. 33:711–721. 2014. View Article : Google Scholar : PubMed/NCBI

53 

Yoshiga Y, Goto D, Segawa S, Ohnishi Y, Matsumoto I, Ito S, Tsutsumi A, Taniguchi M and Sumida T: Invariant NKT cells produce IL-17 through IL-23-dependent and -independent pathways with potential modulation of Th17 response in collagen-induced arthritis. Int J Mol Med. 22:369–374. 2008.PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Yang H, Wei R, Liu Q, Shi Y and Li J: Frequency and distribution of CD4+CXCR5+ follicular B helper T cells within involved tissues in IgG4‑related ophthalmic disease. Mol Med Rep 16: 9512-9520, 2017.
APA
Yang, H., Wei, R., Liu, Q., Shi, Y., & Li, J. (2017). Frequency and distribution of CD4+CXCR5+ follicular B helper T cells within involved tissues in IgG4‑related ophthalmic disease. Molecular Medicine Reports, 16, 9512-9520. https://doi.org/10.3892/mmr.2017.7780
MLA
Yang, H., Wei, R., Liu, Q., Shi, Y., Li, J."Frequency and distribution of CD4+CXCR5+ follicular B helper T cells within involved tissues in IgG4‑related ophthalmic disease". Molecular Medicine Reports 16.6 (2017): 9512-9520.
Chicago
Yang, H., Wei, R., Liu, Q., Shi, Y., Li, J."Frequency and distribution of CD4+CXCR5+ follicular B helper T cells within involved tissues in IgG4‑related ophthalmic disease". Molecular Medicine Reports 16, no. 6 (2017): 9512-9520. https://doi.org/10.3892/mmr.2017.7780
Copy and paste a formatted citation
x
Spandidos Publications style
Yang H, Wei R, Liu Q, Shi Y and Li J: Frequency and distribution of CD4+CXCR5+ follicular B helper T cells within involved tissues in IgG4‑related ophthalmic disease. Mol Med Rep 16: 9512-9520, 2017.
APA
Yang, H., Wei, R., Liu, Q., Shi, Y., & Li, J. (2017). Frequency and distribution of CD4+CXCR5+ follicular B helper T cells within involved tissues in IgG4‑related ophthalmic disease. Molecular Medicine Reports, 16, 9512-9520. https://doi.org/10.3892/mmr.2017.7780
MLA
Yang, H., Wei, R., Liu, Q., Shi, Y., Li, J."Frequency and distribution of CD4+CXCR5+ follicular B helper T cells within involved tissues in IgG4‑related ophthalmic disease". Molecular Medicine Reports 16.6 (2017): 9512-9520.
Chicago
Yang, H., Wei, R., Liu, Q., Shi, Y., Li, J."Frequency and distribution of CD4+CXCR5+ follicular B helper T cells within involved tissues in IgG4‑related ophthalmic disease". Molecular Medicine Reports 16, no. 6 (2017): 9512-9520. https://doi.org/10.3892/mmr.2017.7780
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