|
1
|
Mokdad AA, Lopez AD, Shahraz S, Lozano R,
Mokdad AH, Stanaway J, Murray CJ and Naghavi M: Liver cirrhosis
mortality in 187 countries between 1980 and 2010: A systematic
analysis. BMC Med. 12:1452014. View Article : Google Scholar : PubMed/NCBI
|
|
2
|
Muir AJ: Understanding the complexities of
cirrhosis. Clin Ther. 37:1822–1836. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
3
|
Ramos-Lopez O, Martinez-Lopez E, Roman S,
Fierro NA and Panduro A: Genetic, metabolic and environmental
factors involved in the development of liver cirrhosis in Mexico.
World J Gastroenterol. 21:11552–11566. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
4
|
Ibañez P, Solis N, Pizarro M, Aguayo G,
Duarte I, Miquel JF, Accatino L and Arrese M: Effect of losartan on
early liver fibrosis development in a rat model of nonalcoholic
steatohepatitis. J Gastroenterol Hepatol. 22:846–851. 2007.
View Article : Google Scholar : PubMed/NCBI
|
|
5
|
Friedman SL: Mechanisms of hepatic
fibrogenesis. Gastroenterology. 134:1655–1669. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
6
|
Garbuzenko DV, Arefyev NO and Belov DV:
Mechanisms of adaptation of the hepatic vasculature to the
deteriorating conditions of blood circulation in liver cirrhosis.
World J Hepatol. 8:665–672. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
7
|
Wang F, Liu S, Du T, Chen H, Li Z and Yan
J: NF-κB inhibition alleviates carbon tetrachloride-induced liver
fibrosis via suppression of activated hepatic stellate cells. Exp
Ther Med. 8:95–99. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
8
|
Shen M, Chen K, Lu J, Cheng P, Xu L, Dai
W, Wang F, He L, Zhang Y, Chengfen W, et al: Protective effect of
astaxanthin on liver fibrosis through modulation of TGF-β1
expression and autophagy. Mediators Inflamm. 2014:9545022014.
View Article : Google Scholar : PubMed/NCBI
|
|
9
|
Gu L, Deng WS, Sun XF, Zhou H and Xu Q:
Rapamycin ameliorates CCl4-induced liver fibrosis in mice through
reciprocal regulation of the Th17/Treg cell balance. Mol Med Rep.
14:1153–1161. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
10
|
Garcíade León Mdel C, Montfort I, Montes E
Tello, López Vancell R, García A Olivos, González Canto A,
Nequiz-Avendaño M and Pérez-Tamayo R: Hepatocyte production of
modulators of extracellular liver matrix in normal and cirrhotic
rat liver. Exp Mol Pathol. 80:97–108. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
11
|
Kang M, Zhao L, Ren M, Deng M and Li C:
Zinc mediated hepatic stellate cell collagen synthesis reduction
through TGF-β signaling pathway inhibition. Int J Clin Exp Med.
8:20463–20471. 2015.PubMed/NCBI
|
|
12
|
Hellerbrand C: Molecular targets for
antifibrotic therapy in liver disease: Using magic bullets for
crossfire rather than a one-sided shotgun attack. Gut.
63:1039–1041. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
13
|
Muñoz-Ortega MH, Llamas-Ramírez RW,
Romero-Delgadillo NI, Elías-Flores TG, Tavares-Rodríguez Ede J,
Campos-Esparza Mdel R, Cervantes-García D, Muñoz-Fernández L,
Gerardo-Rodríguez M and Ventura-Juárez J: Doxazosin treatment
attenuates carbon tetrachloride-induced liver fibrosis in hamsters
through a decrease in transforming growth factor β secretion. Gut
Liver. 10:101–108. 2016. View
Article : Google Scholar : PubMed/NCBI
|
|
14
|
Ceral J and Solar M: Doxazosin: Safety and
efficacy in the treatment of resistant arteria hypertension. Blood
Press. 18:74–77. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
15
|
Tahmatzopoulos A, Rowland RG and Kyprianou
N: The role of alpha-blockers in the management of prostate cancer.
Expert Opin Pharmacother. 5:1279–1285. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
16
|
Mazzolini G, Alfaro C, Sangro B, Feijoó E,
Ruiz J, Benito A, Tirapu I, Arina A, Sola J, Herraiz M, et al:
Intratumoral injection of dendritic cells engineered to secrete
interleukin-12 by recombinant adenovirus in patients with
metastatic gastrointestinal carcinomas. J Clin Oncol. 23:999–1010.
2005. View Article : Google Scholar : PubMed/NCBI
|
|
17
|
Hahn GV, Cohen RB, Wozney JM, Levitz CL,
Shore EM, Zasloff MA and Kaplan FS: A bone morphogenetic protein
subfamily: Chromosomal localization of human genes for BMP5, BMP6,
and BMP7. Genomics. 14:759–762. 1992. View Article : Google Scholar : PubMed/NCBI
|
|
18
|
Andrews PW, Damjanov I, Berends J, Kumpf
S, Zappavigna V, Mavilio F and Sampath K: Inhibition of
proliferation and induction of differentiation of pluripotent human
embryonal carcinoma cells by osteogenic protein-1 (or bone
morphogenetic protein-7). Lab Invest. 71:243–251. 1994.PubMed/NCBI
|
|
19
|
Midorikawa Y, Ishikawa S, Iwanari H,
Imamura T, Sakamoto H, Miyazono K, Kodama T, Makuuchi M and
Aburatani H: Glypican-3, overexpressed in hepatocellular carcinoma,
modulates FGF2 and BMP-7 signaling. Int J Cancer. 103:455–465.
2003. View Article : Google Scholar : PubMed/NCBI
|
|
20
|
Knight PG and Glister C: TGF-beta
superfamily members and ovarian follicle development. Reproduction.
132:191–206. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
21
|
Genander M, Cook PJ, Ramsköld D, Keyes BE,
Mertz AF, Sandberg R and Fuchs E: BMP signaling and its pSMAD1/5
target genes differentially regulate hair follicle stem cell
lineages. Cell Stem Cell. 15:619–633. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
22
|
Su YH, Cai HB, Ye ZY and Tan WS: BMP-7
improved proliferation and hematopoietic reconstitution potential
of ex vivo expanded cord blood-derived CD34(+) cells. Hum Cell.
28:14–21. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
23
|
Beck SE, Jung BH, Fiorino A, Gomez J,
Rosario ED, Cabrera BL, Huang SC, Chow JY and Carethers JM: Bone
morphogenetic protein signaling and growth suppression in colon
cancer. Am J Physiol Gastrointest Liver Physiol. 291:G135–G145.
2016. View Article : Google Scholar
|
|
24
|
Pegorier S, Campbell GA, Kay AB and Lloyd
CM: Bone morphogenetic protein (BMP)-4 and BMP-7 regulate
differentially transforming growth factor (TGF)-beta1 in normal
human lung fibroblasts (NHLF). Respir Res. 11:852010. View Article : Google Scholar : PubMed/NCBI
|
|
25
|
Zhang P and Dressler GR: The Groucho
protein Grg4 suppresses Smad7 to activate BMP signaling. Biochem
Biophys Res Commun. 440:454–459. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
26
|
Lim RR, Tan A, Liu YC, Barathi VA, Mohan
RR, Mehta JS and Chaurasia SS: ITF2357 transactivates Id3 and
regulate TGFβ/BMP7 signaling pathways to attenuate corneal
fibrosis. Sci Rep. 6:208412016. View Article : Google Scholar : PubMed/NCBI
|
|
27
|
Kaimori A, Potter J, Kaimori JY, Wang C,
Mezey E and Koteish A: Transforming growth factor-beta1 induces an
epithelial-to-mesenchymal transition state in mouse hepatocytes in
vitro. J Biol Chem. 282:22089–22101. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
28
|
Wang S and Hirschberg R: Bone
morphogenetic protein-7 signals opposing transforming growth factor
beta in mesangial cells. J Biol Chem. 279:23200–23206. 2004.
View Article : Google Scholar : PubMed/NCBI
|
|
29
|
Yanagita M: Inhibitors/antagonists of
TGF-β system in kidney fibrosis. Nephrol Dial Transplant.
27:3686–3691. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
30
|
Yang G, Zhu Z, Wang Y, Gao A, Niu P and
Tian L: Bone morphogenetic protein-7 inhibits silica-induced
pulmonary fibrosis in rats. Toxicol Lett. 220:103–108. 2013.
View Article : Google Scholar : PubMed/NCBI
|
|
31
|
Wang SL, Yang CQ, Qi XL, Yuan M, Chang YZ,
Yang L and Gao HJ: Inhibitory effect of bone morphogenetic
protein-7 on hepatic fibrosis in rats. Int J Clin Exp Pathol.
6:897–903. 2013.PubMed/NCBI
|
|
32
|
Wang LP, Dong JZ, Xiong LJ, Shi KQ, Zou
ZL, Zhang SN, Cao ST, Lin Z and Chen YP: BMP-7 attenuates liver
fibrosis via regulation of epidermal growth factor receptor. Int J
Clin Exp Pathol. 7:3537–3547. 2014.PubMed/NCBI
|
|
33
|
Hernandez-Hurtado AA, Borrego-Soto G,
Marino-Martinez IA, Lara-Arias J, Romero-Diaz VJ, Abrego-Guerra A,
Vilchez-Cavazos JF, Elizondo-Riojas G, Martinez-Rodriguez HG,
Espinoza-Juarez MA, et al: Implant composed of demineralized bone
and mesenchymal stem cells genetically modified with AdBMP2/AdBMP7
for the regeneration of bone fractures in ovis aries. Stem Cells
Int. 2016:74038902016. View Article : Google Scholar : PubMed/NCBI
|
|
34
|
Bradford MM: A rapid and sensitive method
for the quantitation of microgram quantities of protein utilizing
the principle of protein-dye binding. Anal Biochem. 72:248–254.
1976. View Article : Google Scholar : PubMed/NCBI
|
|
35
|
Schmittgen TD and Livak KJ: Analyzing
real-time PCR data by the comparative C(T) method. Nat Protoc.
3:1101–1108. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
36
|
Kondou H, Mushiake S, Etani Y, Miyoshi Y,
Michigami T and Ozono K: A blocking peptide for transforming growth
factor-beta1 activation prevents hepatic fibrosis in vivo. J
Hepatol. 39:742–748. 2003. View Article : Google Scholar : PubMed/NCBI
|
|
37
|
Osawa Y, Oboki K, Imamura J, Kojika E,
Hayashi Y, Hishima T, Saibara T, Shibasaki F, Kohara M and Kimura
K: Inhibition of cyclic adenosine monophosphate (cAMP)-response
element-binding protein (CREB)-binding protein (CBP)/β-catenin
reduces liver fibrosis in mice. EBioMedicine. 2:1751–1758. 2015.
View Article : Google Scholar : PubMed/NCBI
|
|
38
|
Bravo E, D'Amore E, Ciaffoni F and Mammola
CL: Evaluation of the spontaneous reversibility of carbon
tetrachloride-induced liver cirrhosis in rabbits. Lab Anim.
46:122–128. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
39
|
Maros T, Seres-Sturm L, Lakatos O,
Seres-Sturm MT and Blazsek V: Spontaneous reversibility of advanced
toxic liver cirrhosis. Acta Morphol Acad Sci Hung. 23:293–302.
1975.PubMed/NCBI
|
|
40
|
Muriel P, Moreno MG, Hernández Mdel C,
Chávez E and Alcantar LK: Resolution of liver fibrosis in chronic
CCl4 administration in the rat after discontinuation of treatment:
Effect of silymarin, silibinin, colchicine and trimethylcolchicinic
acid. Basic Clin Pharmacol Toxicol. 96:375–380. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
41
|
Chávez E, Segovia J, Shibayama M, Tsutsumi
V, Vergara P, Castro-Sánchez L, Salazar EP, Moreno MG and Muriel P:
Antifibrotic and fibrolytic properties of celecoxib in liver damage
induced by carbon tetrachloride in the rat. Liver Int. 30:969–978.
2010. View Article : Google Scholar : PubMed/NCBI
|
|
42
|
Lv P, Meng Q, Liu J and Wang C:
Thalidomide accelerates the degradation of extracellular matrix in
rat hepatic cirrhosis via down-regulation of transforming growth
factor-β1. Yonsei Med J. 56:1572–1581. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
43
|
Xu F, Liu C, Zhou D and Zhang L:
TGF-β/SMAD pathway and its regulation in hepatic fibrosis. J
Histochem Cytochem. 64:157–167. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
44
|
Hao ZM, Cai M, Lv YF, Huang YH and Li HH:
Oral administration of recombinant adeno-associated virus-mediated
bone morphogenetic protein-7 suppresses CCl(4)-induced hepatic
fibrosis in mice. Mol Ther. 20:2043–2051. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
45
|
Tandon A, Sharma A, Rodier JT, Klibanov
AM, Rieger FG and Mohan RR: BMP7 gene transfer via gold
nanoparticles into stroma inhibits corneal fibrosis in vivo. PLoS
One. 8:e664342013. View Article : Google Scholar : PubMed/NCBI
|
|
46
|
Sugimoto H, Grahovac G, Zeisberg M and
Kalluri R: Renal fibrosis and glomerulosclerosis in a new mouse
model of diabetic nephropathy and its regression by bone
morphogenic protein-7 and advanced glycation end product
inhibitors. Diabetes. 56:1825–1833. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
47
|
Hou F, Liu R, Liu X, Cui L, Wen Y, Yan S
and Yin C: Attenuation of liver fibrosis by herbal compound 861 via
upregulation of BMP-7/Smad signaling in the bile duct ligation
model rat. Mol Med Rep. 13:4335–4342. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
48
|
Gallego-Delgado J, Lazaro A, Gomez-Garre
D, Osende JI, Gonzalez-Rubio ML, Herraiz M, Manzarbeitia F, Fortes
J, Fernandez-Cruz A and Egido J: Long-term organ protection by
doxazosin and/or quinapril as antihypertensive therapy. J Nephrol.
19:588–598. 2006.PubMed/NCBI
|
|
49
|
Perlini S, Palladini G, Ferrero I, Tozzi
R, Fallarini S, Facoetti A, Nano R, Clari F, Busca G, Fogari R and
Ferrari AU: Sympathectomy or doxazosin, but not propranolol, blunt
myocardial interstitial fibrosis in pressure-overload hypertrophy.
Hypertension. 46:1213–1218. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
50
|
Pawluczyk IZ, Patel SR and Harris KP: The
role of the alpha-1 adrenoceptor in modulating human mesangial cell
matrix production. Nephrol Dial Transplant. 21:2417–2424. 2006.
View Article : Google Scholar : PubMed/NCBI
|
|
51
|
Oben JA, Roskams T, Yang S, Lin H, Sinelli
N, Torbenson M, Smedh U, Moran TH, Li Z, Huang J, et al: Hepatic
fibrogenesis requires sympathetic neurotransmitters. Gut.
53:438–445. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
52
|
Oben JA, Roskams T, Yang S, Lin H, Sinelli
N, Li Z, Torbenson M, Huang J, Guarino P, Kafrouni M and Diehl AM:
Sympathetic nervous system inhibition increases hepatic progenitors
and reduces liver injury. Hepatology. 38:664–673. 2003. View Article : Google Scholar : PubMed/NCBI
|
|
53
|
Sugimoto H, Yang C, LeBleu VS, Soubasakos
MA, Giraldo M, Zeisberg M and Kalluri R: BMP-7 functions as a novel
hormone to facilitate liver regeneration. FASEB J. 21:256–264.
2007. View Article : Google Scholar : PubMed/NCBI
|
|
54
|
Jirouskova M, Zbodakova O, Gregor M,
Chalupsky K, Sarnova L, Hajduch M, Ehrmann J, Jirkovska M and
Sedlacek R: Hepatoprotective effect of MMP-19 deficiency in a mouse
model of chronic liver fibrosis. PLoS One. 7:e462712012. View Article : Google Scholar : PubMed/NCBI
|
|
55
|
Arendt E, Ueberham U, Bittner R, Gebhardt
R and Ueberham E: Enhanced matrix degradation after withdrawal of
TGF-beta1 triggers hepatocytes from apoptosis to proliferation and
regeneration. Cell Prolif. 38:287–299. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
56
|
Yang J, Zheng J, Wu L, Shi M, Zhang H,
Wang X, Xia N, Wang D, Liu X, Yao L, et al: NDRG2 ameliorates
hepatic fibrosis by inhibiting the TGF-β1/Smad pathway and altering
the MMP2/TIMP2 ratio in rats. PLoS One. 6:e277102011. View Article : Google Scholar : PubMed/NCBI
|
