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Oxidized low density lipoprotein facilitates tumor necrosis factor‑α mediated chondrocyte death via autophagy pathway

  • Authors:
    • Pengcheng Shen
    • Yu Zhu
    • Lifan Zhu
    • Fengbiao Weng
    • Xiaolin Li
    • Yaozeng Xu
  • View Affiliations / Copyright

    Affiliations: Department of Orthopaedics, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, P.R. China, Department of Orthopaedics, Suzhou Hospital of Traditional Chinese Medicine, Suzhou, Jiangsu 215100, P.R. China, Department of Orthopaedics, The First People's Hospital of Wujiang District, Suzhou, Jiangsu 215200, P.R. China, Department of Orthopaedics, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiaotong University, Shanghai 200233, P.R. China
    Copyright: © Shen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 9449-9456
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    Published online on: October 13, 2017
       https://doi.org/10.3892/mmr.2017.7786
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Abstract

We aimed to investigate the role of oxidized low density lipoprotein (ox‑LDL) in tumor necrosis factor‑α (TNF‑α) mediated chondrocyte death and explore the mechanisms. Ten osteoarthritis (OA) and normal control cartilage tissue and synovial fluid (SF) samples were collected, and the expression of lectin‑like ox‑LDL receptor‑1 (LOX‑1) and ox‑LDL level was examined by real time quantitative PCR and enzyme‑linked immunosorbent assay (ELISA). An in vitro chondrocyte model was established by the introduction of TNF‑α and ox‑LDL, cell death was analyzed by trypan blue assay and the mechanisms were explored based on the apoptosis related pathway and autophagy pathway. Significantly increased ox‑LDL level (70.30±17.83 vs. 37.22±19.97, P<0.05) in SF sample and LOX‑1 expression level (0.51±0.10 vs. 0.32±0.04, P<0.05) in cartilage tissue was found in OA patients compared to those corresponding samples from control subjects. Ox‑LDL could facilitate TNF‑α mediated chondrocyte death and this effect could be blocked by LOX‑1 antibody neutralization. Autophagy inhibition by 3‑MA and Atg‑5 siRNA could reverse the cell death effect mediated by TNF‑α and ox‑LDL co‑treatment on chondrocytes. Oxidized low density lipoprotein facilitates tumor necrosis factor‑α mediated chondrocyte death via its interaction with LOX‑1, and autophagy is involved in the mechanisms.
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1 

Palazzo C, Nguyen C, Lefevre-Colau MM, Rannou F and Poiraudeau S: Risk factors and burden of osteoarthritis. Ann Phys Rehabil Med. 59:134–138. 2016. View Article : Google Scholar : PubMed/NCBI

2 

Prieto-Alhambra D, Judge A, Javaid MK, Cooper C, Diez-Perez A and Arden NK: Incidence and risk factors for clinically diagnosed knee, hip and hand osteoarthritis: Influences of age, gender and osteoarthritis affecting other joints. Ann Rheum Dis. 73:1659–1664. 2014. View Article : Google Scholar : PubMed/NCBI

3 

Lohmander LS and Roos EM: Clinical update: Treating osteoarthritis. Lancet. 370:2082–2084. 2007. View Article : Google Scholar : PubMed/NCBI

4 

Loeser RF, Goldring SR, Scanzello CR and Goldring MB: Osteoarthritis: A disease of the joint as an organ. Arthritis Rheum. 64:1697–1707. 2012. View Article : Google Scholar : PubMed/NCBI

5 

Zhang M, Mani SB, He Y, Hall AM, Xu L, Li Y, Zurakowski D, Jay GD and Warman ML: Induced superficial chondrocyte death reduces catabolic cartilage damage in murine posttraumatic osteoarthritis. J Clin Invest. 126:2893–2902. 2016. View Article : Google Scholar : PubMed/NCBI

6 

Zhou Q, Sun Y, Zhang P and Zheng J: Simultaneously blocking necrosis and apoptosis to protect TMJ chondrocytes from TNF-alpha induced death: A preliminary study. Int J Clin Experiment Med. 9:2202–2210. 2016.

7 

Jang KW, Buckwalter JA and Martin JA: Inhibition of cell-matrix adhesions prevents cartilage chondrocyte death following impact injury. J Orthop Res. 32:448–454. 2014. View Article : Google Scholar : PubMed/NCBI

8 

Intekhab-Alam NY, White OB, Getting SJ, Petsa A, Knight RA, Chowdrey HS, Townsend PA, Lawrence KM and Locke IC: Urocortin protects chondrocytes from NO-induced apoptosis: A future therapy for osteoarthritis? Cell Death Dis. 4:e7172013. View Article : Google Scholar : PubMed/NCBI

9 

Niu J, Clancy M, Aliabadi P, Vasan R and Felson DT: Metabolic syndrome, its components, and knee osteoarthritis: The framingham Osteoarthritis study. Arthritis Rheumatol. 69:1194–1203. 2017. View Article : Google Scholar : PubMed/NCBI

10 

Haugen IK, Ramachandran VS, Misra D, Neogi T, Niu J, Yang T, Zhang Y and Felson DT: Hand osteoarthritis in relation to mortality and incidence of cardiovascular disease: Data from the Framingham Heart Study. Ann Rheum Dis. 74:74–81. 2015. View Article : Google Scholar : PubMed/NCBI

11 

Hussain S Monira, Wang Y, Cicuttini FM, Simpson JA, Giles GG, Graves S and Wluka AE: Incidence of total knee and hip replacement for osteoarthritis in relation to the metabolic syndrome and its components: A prospective cohort study. Semin Arthritis Rheum. 43:429–436. 2014. View Article : Google Scholar : PubMed/NCBI

12 

Bellamy N, Buchanan WW, Goldsmith CH, Campbell J and Stitt LW: Validation study of WOMAC: A health status instrument for measuring clinically important patient relevant outcomes to antirheumatic drug therapy in patients with osteoarthritis of the hip or knee. J Rheumatol. 15:1833–1840. 1988.PubMed/NCBI

13 

Roorda LD, Jones CA, Waltz M, Lankhorst GJ, Bouter LM, Van der Eijken JW, Willems WJ, Heyligers IC, Voaklander DC, Kelly KD and Suarez-Almazor ME: Satisfactory cross cultural equivalence of the Dutch WOMAC in patients with hip osteoarthritis waiting for arthroplasty. Ann Rheum Dis. 63:36–42. 2004. View Article : Google Scholar : PubMed/NCBI

14 

Ji Y, Strawn TL, Grunz EA, Stevenson MJ, Lohman AW, Lawrence DA and Fay WP: Multifaceted role of plasminogen activator inhibitor-1 in regulating early remodeling of vein bypass grafts. Arterioscler Thromb Vasc Biol. 31:1781–1787. 2011. View Article : Google Scholar : PubMed/NCBI

15 

Goldring MB and Otero M: Inflammation in osteoarthritis. Curr Opin Rheumatol. 23:471–478. 2011. View Article : Google Scholar : PubMed/NCBI

16 

Almonte-Becerril M, Navarro-Garcia F, Gonzalez-Robles A, Vega-Lopez MA, Lavalle C and Kouri JB: Cell death of chondrocytes is a combination between apoptosis and autophagy during the pathogenesis of Osteoarthritis within an experimental model. Apoptosis. 15:631–638. 2010. View Article : Google Scholar : PubMed/NCBI

17 

Balci B: The modification of serum lipids after acute coronary syndrome and importance in clinical practice. Curr Cardiol Rev. 7:272–276. 2011. View Article : Google Scholar : PubMed/NCBI

18 

Libby P and Hansson GK: Inflammation and immunity in diseases of the arterial tree: Players and layers. Circ Res. 116:307–311. 2015. View Article : Google Scholar : PubMed/NCBI

19 

Perrins CJ and Bobryshev YV: Current advances in understanding of immunopathology of atherosclerosis. Virchows Archiv. 458:117–123. 2011. View Article : Google Scholar : PubMed/NCBI

20 

Twardowski L, Cheng F, Michaelsen J, Winter S, Hofmann U, Schaeffeler E, Müller S, Sonnenberg M, Steuer K, Ott G, et al: Enzymatically modified low-density lipoprotein is present in all stages of aortic valve sclerosis: Implications for pathogenesis of the disease. J Am Heart Assoc. 4:e0021562015. View Article : Google Scholar : PubMed/NCBI

21 

Sawamura T, Kume N, Aoyama T, Moriwaki H, Hoshikawa H, Aiba Y, Tanaka T, Miwa S, Katsura Y, Kita T and Masaki T: An endothelial receptor for oxidized low-density lipoprotein. Nature. 386:73–77. 1997. View Article : Google Scholar : PubMed/NCBI

22 

Xu S, Ogura S, Chen J, Little PJ, Moss J and Liu P: LOX-1 in atherosclerosis: Biological functions and pharmacological modifiers. Cell Mol Life Sci. 70:2859–2872. 2013. View Article : Google Scholar : PubMed/NCBI

23 

Misaka T, Suzuki S, Sakamoto N, Yamaki T, Sugimoto K, Kunii H, Nakazato K, Saitoh S, Sawamura T, Ishibashi T and Takeishi Y: Significance of soluble lectin-like oxidized LDL receptor-1 levels in systemic and coronary circulation in acute coronary syndrome. Biomed Res Int. 2014:6491852014. View Article : Google Scholar : PubMed/NCBI

24 

Nakagawa T, Akagi M, Hoshikawa H, Chen M, Yasuda T, Mukai S, Ohsawa K, Masaki T, Nakamura T and Sawamura T: Lectin-like oxidized low-density lipoprotein receptor 1 mediates leukocyte infiltration and articular cartilage destruction in rat zymosan-induced arthritis. Arthritis Rheum. 46:2486–2494. 2002. View Article : Google Scholar : PubMed/NCBI

25 

Nishimura S, Akagi M, Yoshida K, Hayakawa S, Sawamura T, Munakata H and Hamanishi C: Oxidized low-density lipoprotein (ox-LDL) binding to lectin-like ox-LDL receptor-1 (LOX-1) in cultured bovine articular chondrocytes increases production of intracellular reactive oxygen species (ROS) resulting in the activation of NF-kappaB. Osteoarthritis Cartilage. 12:568–576. 2004. View Article : Google Scholar : PubMed/NCBI

26 

Yumoto K, Nifuji A, Rittling SR, Tsuchiya Y, Kon S, Uede T, Denhardt DT, Hemmi H, Notomi T, Hayata T, et al: Osteopontin deficiency suppresses tumor necrosis factor-α-induced apoptosis in chondrocytes. Cartilage. 3:79–85. 2012. View Article : Google Scholar : PubMed/NCBI

27 

Kim J, Xu M, Xo R, Mates A, Wilson GL, AW IV Pearsall and Grishko V: Mitochondrial DNA damage is involved in apoptosis caused by pro-inflammatory cytokines in human OA chondrocytes. Osteoarthritis Cartilage. 18:424–432. 2010. View Article : Google Scholar : PubMed/NCBI

28 

Csaki C, Mobasheri A and Shakibaei M: Synergistic chondroprotective effects of curcumin and resveratrol in human articular chondrocytes: Inhibition of IL-1beta-induced NF-kappaB-mediated inflammation and apoptosis. Arthritis Res Ther. 11:R1652009. View Article : Google Scholar : PubMed/NCBI

29 

Caramés B, López-Armada MJ, Cillero-Pastor B, Lires-Dean M, Vaamonde C, Galdo F and Blanco FJ: Differential effects of tumor necrosis factor-alpha and interleukin-1beta on cell death in human articular chondrocytes. Osteoarthritis Cartilage. 16:715–722. 2008. View Article : Google Scholar : PubMed/NCBI

30 

López-Armada MJ, Caramés B, Lires-Deán M, Cillero-Pastor B, Ruiz-Romero C, Galdo F and Blanco FJ: Cytokines, tumor necrosis factor-alpha and interleukin-1beta, differentially regulate apoptosis in osteoarthritis cultured human chondrocytes. Osteoarthritis Cartilage. 14:660–669. 2006. View Article : Google Scholar : PubMed/NCBI

31 

Lee SW, Song YS, Lee SY, Yoon YG, Lee SH, Park BS, Yun I, Choi H, Kim K, Chung WT and Yoo YH: Downregulation of protein kinase CK2 activity facilitates tumor necrosis factor-α-mediated chondrocyte death through apoptosis and autophagy. PLoS One. 6:e191632011. View Article : Google Scholar : PubMed/NCBI

32 

Jiang LB, Meng DH, Lee SM, Liu SH, Xu QT, Wang Y and Zhang J: Dihydroartemisinin inhibits catabolism in rat chondrocytes by activating autophagy via inhibition of the NF-κB pathway. Sci Rep. 6:389792016. View Article : Google Scholar : PubMed/NCBI

33 

Wang K: Autophagy and apoptosis in liver injury. Cell Cycle. 14:1631–1642. 2015. View Article : Google Scholar : PubMed/NCBI

34 

Jia J, Yao W, Guan M, Dai W, Shahnazari M, Kar R, Bonewald L, Jiang JX and Lane NE: Glucocorticoid dose determines osteocyte cell fate. FASEB J. 25:3366–3376. 2011. View Article : Google Scholar : PubMed/NCBI

35 

Mizushima N: Physiological functions of autophagy. Curr Top Microbiol Immunol. 335:71–84. 2009.PubMed/NCBI

36 

Shapiro IM, Layfield R, Lotz M, Settembre C and Whitehouse C: Boning up on autophagy: The role of autophagy in skeletal biology. Autophagy. 10:7–19. 2014. View Article : Google Scholar : PubMed/NCBI

37 

Sasaki H, Takayama K, Matsushita T, Ishida K, Kubo S, Matsumoto T, Fujita N, Oka S, Kurosaka M and Kuroda R: Autophagy modulates osteoarthritis-related gene expression in human chondrocytes. Arthritis Rheum. 64:1920–1928. 2012. View Article : Google Scholar : PubMed/NCBI

38 

Hong D, Bai YP, Gao HC, Wang X, Li LF, Zhang GG and Hu CP: Ox-LDL induces endothelial cell apoptosis via the LOX-1-dependent endoplasmic reticulum stress pathway. Atherosclerosis. 235:310–317. 2014. View Article : Google Scholar : PubMed/NCBI

39 

Zheng H, Cui D, Quan X, Yang W, Li Y, Zhang L and Liu E: Lp-PLA2 silencing protects against ox-LDL-induced oxidative stress and cell apoptosis via Akt/mTOR signaling pathway in human THP1 macrophages. Biochem Biophys Res Commun. 477:1017–1023. 2016. View Article : Google Scholar : PubMed/NCBI

40 

Del Carlo M Jr and Loeser RF: Cell death in osteoarthritis. Curr Rheumatol Rep. 10:37–42. 2008. View Article : Google Scholar : PubMed/NCBI

41 

D'Lima D, Hermida J, Hashimoto S, Colwell C and Lotz M: Caspase inhibitors reduce severity of cartilage lesions in experimental osteoarthritis. Arthritis Rheum. 54:1814–1821. 2006. View Article : Google Scholar : PubMed/NCBI

42 

Kuhn K, D'Lima DD, Hashimoto S and Lotz M: Cell death in cartilage. Osteoarthritis Cartilage. 12:1–16. 2004. View Article : Google Scholar : PubMed/NCBI

43 

Mathew R and White E: Autophagy in tumorigenesis and energy metabolism: Friend by day, foe by night. Curr Opin Genet Dev. 21:113–119. 2011. View Article : Google Scholar : PubMed/NCBI

44 

Bhutia SK, Mukhopadhyay S, Sinha N, Das DN, Panda PK, Patra SK, Maiti TK, Mandal M, Dent P, Wang XY, et al: Autophagy: Cancer's friend or foe? Adv Cancer Res. 118:61–95. 2013. View Article : Google Scholar : PubMed/NCBI

45 

Marx J: Autophagy: Is it cancer's friend or foe? Science. 312:1160–1161. 2006. View Article : Google Scholar : PubMed/NCBI

46 

Lis K, Kuzawinska O and Bałkowiec-Iskra E: Tumor necrosis factor inhibitors-state of knowledge. Arch Med Sci. 10:1175–1185. 2014. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Shen P, Zhu Y, Zhu L, Weng F, Li X and Xu Y: Oxidized low density lipoprotein facilitates tumor necrosis factor‑α mediated chondrocyte death via autophagy pathway. Mol Med Rep 16: 9449-9456, 2017.
APA
Shen, P., Zhu, Y., Zhu, L., Weng, F., Li, X., & Xu, Y. (2017). Oxidized low density lipoprotein facilitates tumor necrosis factor‑α mediated chondrocyte death via autophagy pathway. Molecular Medicine Reports, 16, 9449-9456. https://doi.org/10.3892/mmr.2017.7786
MLA
Shen, P., Zhu, Y., Zhu, L., Weng, F., Li, X., Xu, Y."Oxidized low density lipoprotein facilitates tumor necrosis factor‑α mediated chondrocyte death via autophagy pathway". Molecular Medicine Reports 16.6 (2017): 9449-9456.
Chicago
Shen, P., Zhu, Y., Zhu, L., Weng, F., Li, X., Xu, Y."Oxidized low density lipoprotein facilitates tumor necrosis factor‑α mediated chondrocyte death via autophagy pathway". Molecular Medicine Reports 16, no. 6 (2017): 9449-9456. https://doi.org/10.3892/mmr.2017.7786
Copy and paste a formatted citation
x
Spandidos Publications style
Shen P, Zhu Y, Zhu L, Weng F, Li X and Xu Y: Oxidized low density lipoprotein facilitates tumor necrosis factor‑α mediated chondrocyte death via autophagy pathway. Mol Med Rep 16: 9449-9456, 2017.
APA
Shen, P., Zhu, Y., Zhu, L., Weng, F., Li, X., & Xu, Y. (2017). Oxidized low density lipoprotein facilitates tumor necrosis factor‑α mediated chondrocyte death via autophagy pathway. Molecular Medicine Reports, 16, 9449-9456. https://doi.org/10.3892/mmr.2017.7786
MLA
Shen, P., Zhu, Y., Zhu, L., Weng, F., Li, X., Xu, Y."Oxidized low density lipoprotein facilitates tumor necrosis factor‑α mediated chondrocyte death via autophagy pathway". Molecular Medicine Reports 16.6 (2017): 9449-9456.
Chicago
Shen, P., Zhu, Y., Zhu, L., Weng, F., Li, X., Xu, Y."Oxidized low density lipoprotein facilitates tumor necrosis factor‑α mediated chondrocyte death via autophagy pathway". Molecular Medicine Reports 16, no. 6 (2017): 9449-9456. https://doi.org/10.3892/mmr.2017.7786
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