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Article

Inhibitory effect of 1‑tetradecanol on Helicobacter pylori‑induced production of interleukin‑8 and vascular endothelial growth factor in gastric epithelial cells

  • Authors:
    • Green Kim
    • Jae‑Eun Kim
    • Min‑Jung Kang
    • Ah‑Ra Jang
    • Young Ran Kim
    • Sunoh Kim
    • Kyu‑Tae Chang
    • Jung Joo Hong
    • Jong‑Hwan Park
  • View Affiliations / Copyright

    Affiliations: Laboratory Animal Medicine, College of Veterinary Medicine, Chonnam National University, Gwangju 61186, Republic of Korea, Jeonnam Biopharmaceutical Research Center, Hwasun 58141, Republic of Korea, College of Pharmacy and Research Institute of Drug Development, Chonnam National University, Gwangju 61186, Republic of Korea, B&Tech Co., Ltd., R&D Center, Gwangju 61239, Republic of Korea, National Primate Research Center, Korea Research Institute of Bioscience and Biotechnology, Cheongju, Chungbuk 28116, Republic of Korea
  • Pages: 9573-9578
    |
    Published online on: October 13, 2017
       https://doi.org/10.3892/mmr.2017.7793
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Abstract

Helicobacter pylori (H. pylori) infection activates pro‑inflammatory mediators, including interleukin (IL)‑8 and vascular endothelial growth factor (VEGF) in gastric epithelial cells. 1‑Tetradecanol (1‑TD) has been purified from Dendropanax morbifera Leveille; its physiological activities are poorly understood. The present study assessed whether 1‑TD has an effect on H. pylori‑mediated inflammation in AGS gastric epithelial cells. 1‑TD reduced IL‑8 production by AGS cells in response to H. pylori in a significant and dose‑dependent manner, as measured by ELISA. Western blot analysis demonstrated that 1‑TD also suppressed the activation of nuclear factor‑κB, and two mitogen activated protein kinase species (p38 and extracellular signal‑regulated kinase 1/2), but not c‑Jun N‑terminal kinase in H. pylori‑infected AGS cells. As predicted, VEGF expression and hypoxia inducible factor‑1α stabilization induced by H. pylori in AGS cells were inhibited by 1‑TD. In addition, 1‑TD directly inhibited the growth of H. pylori in a dose‑dependent manner, as investigated by measuring the optical density. These findings indicated that 1‑TD may be a potential preventive or therapeutic agent for H. pylori‑induced gastric inflammation.
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Copy and paste a formatted citation
Spandidos Publications style
Kim G, Kim JE, Kang MJ, Jang AR, Kim YR, Kim S, Chang KT, Hong JJ and Park JH: Inhibitory effect of 1‑tetradecanol on Helicobacter pylori‑induced production of interleukin‑8 and vascular endothelial growth factor in gastric epithelial cells. Mol Med Rep 16: 9573-9578, 2017.
APA
Kim, G., Kim, J., Kang, M., Jang, A., Kim, Y.R., Kim, S. ... Park, J. (2017). Inhibitory effect of 1‑tetradecanol on Helicobacter pylori‑induced production of interleukin‑8 and vascular endothelial growth factor in gastric epithelial cells. Molecular Medicine Reports, 16, 9573-9578. https://doi.org/10.3892/mmr.2017.7793
MLA
Kim, G., Kim, J., Kang, M., Jang, A., Kim, Y. R., Kim, S., Chang, K., Hong, J. J., Park, J."Inhibitory effect of 1‑tetradecanol on Helicobacter pylori‑induced production of interleukin‑8 and vascular endothelial growth factor in gastric epithelial cells". Molecular Medicine Reports 16.6 (2017): 9573-9578.
Chicago
Kim, G., Kim, J., Kang, M., Jang, A., Kim, Y. R., Kim, S., Chang, K., Hong, J. J., Park, J."Inhibitory effect of 1‑tetradecanol on Helicobacter pylori‑induced production of interleukin‑8 and vascular endothelial growth factor in gastric epithelial cells". Molecular Medicine Reports 16, no. 6 (2017): 9573-9578. https://doi.org/10.3892/mmr.2017.7793
Copy and paste a formatted citation
x
Spandidos Publications style
Kim G, Kim JE, Kang MJ, Jang AR, Kim YR, Kim S, Chang KT, Hong JJ and Park JH: Inhibitory effect of 1‑tetradecanol on Helicobacter pylori‑induced production of interleukin‑8 and vascular endothelial growth factor in gastric epithelial cells. Mol Med Rep 16: 9573-9578, 2017.
APA
Kim, G., Kim, J., Kang, M., Jang, A., Kim, Y.R., Kim, S. ... Park, J. (2017). Inhibitory effect of 1‑tetradecanol on Helicobacter pylori‑induced production of interleukin‑8 and vascular endothelial growth factor in gastric epithelial cells. Molecular Medicine Reports, 16, 9573-9578. https://doi.org/10.3892/mmr.2017.7793
MLA
Kim, G., Kim, J., Kang, M., Jang, A., Kim, Y. R., Kim, S., Chang, K., Hong, J. J., Park, J."Inhibitory effect of 1‑tetradecanol on Helicobacter pylori‑induced production of interleukin‑8 and vascular endothelial growth factor in gastric epithelial cells". Molecular Medicine Reports 16.6 (2017): 9573-9578.
Chicago
Kim, G., Kim, J., Kang, M., Jang, A., Kim, Y. R., Kim, S., Chang, K., Hong, J. J., Park, J."Inhibitory effect of 1‑tetradecanol on Helicobacter pylori‑induced production of interleukin‑8 and vascular endothelial growth factor in gastric epithelial cells". Molecular Medicine Reports 16, no. 6 (2017): 9573-9578. https://doi.org/10.3892/mmr.2017.7793
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