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Elevated pentose phosphate pathway is involved in the recovery of hypoxia‑induced erythrocytosis

  • Authors:
    • Chang Liu
    • Bao Liu
    • Er‑Long Zhang
    • Wen‑Ting Liao
    • Jie Liu
    • Bing‑Da Sun
    • Gang Xu
    • Jian Chen
    • Yu‑Qi Gao
  • View Affiliations / Copyright

    Affiliations: Institute of Medicine and Hygienic Equipment for High Altitude Region, College of High Altitude Military Medicine, Third Military Medical University, Chongqing 400038, P.R. China
    Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 9441-9448
    |
    Published online on: October 17, 2017
       https://doi.org/10.3892/mmr.2017.7801
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Abstract

As a typical model of hypoxia‑induced excessive erythrocytosis, high altitude polycythemia (HAPC) results in microcirculation disturbance, aggravates tissue hypoxia and results in a severe clinical outcome, without any effective intervention methods except for returning to an oxygen‑rich environment. The present study aimed to explore potential therapeutic targets which may participate in the recovery of HAPC by studying the mechanisms of reducing the hemoglobin (HB) concentration during re‑oxygenation. A total of 14 and 13 subjects were recruited over a 5,300 m distance and 5,170 m area. The patients were classified into HAPC or control groups based on their HB value. Plasma samples were collected on the day when they finished their stay in plateau for a year, and on the 180th day following their reaching in plain. Metabolic profiling was conducted by UPLC‑QTOF/MS. MetaboAnalyst platform was performed to explore the most perturbed metabolic pathways. A panel of differential metabolites were obtained in the recovery phase of HAPC and control groups. The present study identified the uniquely upregulated pentose phosphate pathway in HAPC subjects, along with a significantly decreased HB level. The findings were verified via a direct comparison between HAPC and control subjects at a high altitude. An increased pentose phosphate pathway was identified in control groups compared with HAPC subjects. An elevated pentose phosphate pathway may therefore participate in the recovery of HAPC, whereas a downregulated pentose phosphate pathway may contribute to hypoxia‑induced erythrocytosis. The results of the present study provide potential therapeutic strategies and novel insights into the pathogenesis of hypoxia‑induced polycythemia.
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View References

1 

Chen Y, Jiang C, Luo Y, Liu F and Gao Y: Interaction of CARD14, SENP1 and VEGFA polymorphisms on susceptibility to high altitude polycythemia in the Han Chinese population at the Qinghai-Tibetan Plateau. Blood Cells Mol Dis. 57:13–22. 2016. View Article : Google Scholar : PubMed/NCBI

2 

Tashi T, Feng T, Koul P, Amaru R, Hussey D, Lorenzo FR, RiLi G and Prchal JT: High altitude genetic adaptation in Tibetans: No role of increased hemoglobin-oxygen affinity. Blood Cells Mol Dis. 53:27–29. 2014. View Article : Google Scholar : PubMed/NCBI

3 

Al-Sheikh M, Moradkhani K, Lopez M, Wajcman H and Préhu C: Disturbance in the HIF-1alpha pathway associated with erythrocytosis: Further evidences brought by frameshift and nonsense mutations in the prolyl hydroxylase domain protein 2 (PHD2) gene. Blood Cells Mol Dis. 40:160–165. 2008. View Article : Google Scholar : PubMed/NCBI

4 

Frey H, Moreth K, Hsieh LT, Zeng-Brouwers J, Rathkolb B, Fuchs H, Gailus-Durner V, Iozzo RV, de Angelis MH and Schaefer L: A novel biological function of soluble biglycan: Induction of erythropoietin production and polycythemia. Glycoconj J. 34:393–404. 2017. View Article : Google Scholar : PubMed/NCBI

5 

Azad P, Zhao HW, Cabrales PJ, Ronen R, Zhou D, Poulsen O, Appenzeller O, Hsiao YH, Bafna V and Haddad GG: Senp1 drives hypoxia-induced polycythemia via GATA1 and Bcl-xL in subjects with Monge's disease. J Exp Med. 213:2729–2744. 2016. View Article : Google Scholar : PubMed/NCBI

6 

Jiang C, Cui J, Liu F, Gao L, Luo Y, Li P, Guan L and Gao Y: Mitochondrial DNA 10609T promotes hypoxia-induced increase of intracellular ROS and is a risk factor of high altitude polycythemia. PLoS One. 9:e877752014. View Article : Google Scholar : PubMed/NCBI

7 

Köhler D and Dellweg D: Polycythemia. Dtsch Med Wochenschr. 135:2300–2303. 2010.(In German). View Article : Google Scholar : PubMed/NCBI

8 

Tian H, Lam SM and Shui G: Metabolomics, a powerful tool for agricultural research. Int J Mol Sci. 17:pii: E18712016. View Article : Google Scholar

9 

Lima AR, Mde L Bastos, Carvalho M and de Pinho P Guedes: Biomarker discovery in human prostate cancer: An update in metabolomics studies. Transl Oncol. 9:357–370. 2016. View Article : Google Scholar : PubMed/NCBI

10 

McClain DA, Abuelgasim KA, Nouraie M, Salomon-Andonie J, Niu X, Miasnikova G, Polyakova LA, Sergueeva A, Okhotin DJ, Cherqaoui R, et al: Decreased serum glucose and glycosylated hemoglobin levels in patients with Chuvash polycythemia: A role for HIF in glucose metabolism. J Mol Med (Berl). 91:59–67. 2013. View Article : Google Scholar : PubMed/NCBI

11 

Liao WT, Liu B, Chen J, Cui JH, Gao YX, Liu FY, Xu G, Sun BD, Zhang EL, Yuan ZB, et al: Metabolite modulation in human plasma in the early phase of acclimatization to hypobaric hypoxia. Sci Rep. 6:225892016. View Article : Google Scholar : PubMed/NCBI

12 

Smith CA, O'Maille G, Want EJ, Qin C, Trauger SA, Brandon TR, Custodio DE, Abagyan R and Siuzdak G: METLIN: A metabolite mass spectral database. Ther Drug Monit. 27:747–751. 2005. View Article : Google Scholar : PubMed/NCBI

13 

Wishart DS, Jewison T, Guo AC, Wilson M, Knox C, Liu Y, Djoumbou Y, Mandal R, Aziat F, Dong E, et al: HMDB 3.0-the human metabolome database in 2013. Nucleic Acids Res. 41(Database Issue): D801–D807. 2013.PubMed/NCBI

14 

Xia J, Sinelnikov IV, Han B and Wishart DS: MetaboAnalyst 3.0-making metabolomics more meaningful. Nucleic Acids Res. 43(W1): W251–W257. 2015. View Article : Google Scholar : PubMed/NCBI

15 

Riganti C, Gazzano E, Polimeni M, Aldieri E and Ghigo D: The pentose phosphate pathway: An antioxidant defense and a crossroad in tumor cell fate. Free Radic Biol Med. 53:421–436. 2012. View Article : Google Scholar : PubMed/NCBI

16 

van Zwieten R, Verhoeven AJ and Roos D: Inborn defects in the antioxidant systems of human red blood cells. Free Radic Biol Med. 67:377–386. 2014. View Article : Google Scholar : PubMed/NCBI

17 

Karasawa T, Saito T, Ueno Y, Sugimoto M and Soga T: Metabolome analysis of erythrocytes from patients with chronic hepatitis C reveals the etiology of ribavirin-induced hemolysis. Int J Med Sci. 10:1575–1577. 2013. View Article : Google Scholar : PubMed/NCBI

18 

D'Alessandro A, Gevi F and Zolla L: Red blood cell metabolism under prolonged anaerobic storage. Mol Biosyst. 9:1196–1209. 2013. View Article : Google Scholar : PubMed/NCBI

19 

Zhou L, Chen P, Peng Y and Ouyang R: Role of oxidative stress in the neurocognitive dysfunction of obstructive sleep apnea syndrome. Oxid Med Cell Longev. 2016:96268312016. View Article : Google Scholar : PubMed/NCBI

20 

Kim M, Han CH and Lee MY: NADPH oxidase and the cardiovascular toxicity associated with smoking. Toxicol Res. 30:149–157. 2014. View Article : Google Scholar : PubMed/NCBI

21 

Rauchová H, Vokurková M and Koudelová J: Hypoxia-induced lipid peroxidation in the brain during postnatal ontogenesis. Physiol Res. 61 Suppl 1:S89–S101. 2012.PubMed/NCBI

22 

Gostner JM, Becker K, Kurz K and Fuchs D: Disturbed amino acid metabolism in HIV: Association with neuropsychiatric symptoms. Front Psychiatry. 6:972015. View Article : Google Scholar : PubMed/NCBI

23 

Lin X, Zhao L, Tang S, Zhou Q, Lin Q, Li X, Zheng H and Gao H: Metabolic effects of basic fibroblast growth factor in streptozotocin-induced diabetic rats: A 1H NMR-based metabolomics investigation. Sci Rep. 6:364742016. View Article : Google Scholar : PubMed/NCBI

24 

Kim YW and Byzova TV: Oxidative stress in angiogenesis and vascular disease. Blood. 123:625–631. 2014. View Article : Google Scholar : PubMed/NCBI

25 

Stevens JP, Churchill T, Fokkelman K, Haase E, Idikio H, Korbutt G, Bigam DL and Cheung PY: Oxidative stress and matrix metalloproteinase-9 activity in the liver after hypoxia and reoxygenation with 21% or 100% oxygen in newborn piglets. Eur J Pharmacol. 580:385–393. 2008. View Article : Google Scholar : PubMed/NCBI

26 

Fuchs JE, Huber RG, von Grafenstein S, Wallnoefer HG, Spitzer GM, Fuchs D and Liedl KR: Dynamic regulation of phenylalanine hydroxylase by simulated redox manipulation. PLoS One. 7:e530052012. View Article : Google Scholar : PubMed/NCBI

27 

Jiang W and Fang BS: Construction and evaluation of a novel bifunctional phenylalanine-formate dehydrogenase fusion protein for bienzyme system with cofactor regeneration. J Ind Microbiol Biotechnol. 43:577–584. 2016. View Article : Google Scholar : PubMed/NCBI

28 

Vilaseca MA, Farré C and Ramón F: Phenylalanine determined in plasma with use of phenylalanine dehydrogenase and a centrifugal analyzer. Clin Chem. 39:129–131. 1993.PubMed/NCBI

29 

Rocha JC and Martins MJ: Oxidative stress in phenylketonuria: Future directions. J Inherit Metab Dis. 35:381–398. 2012. View Article : Google Scholar : PubMed/NCBI

30 

Zhao G, Li Z and Gu T: Antihypertension and anti-cardiovascular remodeling by phenylalanine in spontaneously hypertensive rats: Effectiveness and mechanisms. Chin Med J (Engl). 114:270–274. 2001.PubMed/NCBI

31 

Førli L, Pedersen JI, Bjørtuft, Vatn M, Kofstad J and Boe J: Serum amino acids in relation to nutritional status, lung function and energy intake in patients with advanced pulmonary disease. Respir Med. 94:868–874. 2000. View Article : Google Scholar : PubMed/NCBI

32 

Molnár GA, Kun S, Sélley E, Kertész M, Szélig L, Csontos C, Böddi K, Bogár L, Miseta A and Wittmann I: Role of tyrosine isomers in acute and chronic diseases leading to oxidative stress-A Review. Curr Med Chem. 23:667–685. 2016. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Liu C, Liu B, Zhang EL, Liao WT, Liu J, Sun BD, Xu G, Chen J and Gao YQ: Elevated pentose phosphate pathway is involved in the recovery of hypoxia‑induced erythrocytosis. Mol Med Rep 16: 9441-9448, 2017.
APA
Liu, C., Liu, B., Zhang, E., Liao, W., Liu, J., Sun, B. ... Gao, Y. (2017). Elevated pentose phosphate pathway is involved in the recovery of hypoxia‑induced erythrocytosis. Molecular Medicine Reports, 16, 9441-9448. https://doi.org/10.3892/mmr.2017.7801
MLA
Liu, C., Liu, B., Zhang, E., Liao, W., Liu, J., Sun, B., Xu, G., Chen, J., Gao, Y."Elevated pentose phosphate pathway is involved in the recovery of hypoxia‑induced erythrocytosis". Molecular Medicine Reports 16.6 (2017): 9441-9448.
Chicago
Liu, C., Liu, B., Zhang, E., Liao, W., Liu, J., Sun, B., Xu, G., Chen, J., Gao, Y."Elevated pentose phosphate pathway is involved in the recovery of hypoxia‑induced erythrocytosis". Molecular Medicine Reports 16, no. 6 (2017): 9441-9448. https://doi.org/10.3892/mmr.2017.7801
Copy and paste a formatted citation
x
Spandidos Publications style
Liu C, Liu B, Zhang EL, Liao WT, Liu J, Sun BD, Xu G, Chen J and Gao YQ: Elevated pentose phosphate pathway is involved in the recovery of hypoxia‑induced erythrocytosis. Mol Med Rep 16: 9441-9448, 2017.
APA
Liu, C., Liu, B., Zhang, E., Liao, W., Liu, J., Sun, B. ... Gao, Y. (2017). Elevated pentose phosphate pathway is involved in the recovery of hypoxia‑induced erythrocytosis. Molecular Medicine Reports, 16, 9441-9448. https://doi.org/10.3892/mmr.2017.7801
MLA
Liu, C., Liu, B., Zhang, E., Liao, W., Liu, J., Sun, B., Xu, G., Chen, J., Gao, Y."Elevated pentose phosphate pathway is involved in the recovery of hypoxia‑induced erythrocytosis". Molecular Medicine Reports 16.6 (2017): 9441-9448.
Chicago
Liu, C., Liu, B., Zhang, E., Liao, W., Liu, J., Sun, B., Xu, G., Chen, J., Gao, Y."Elevated pentose phosphate pathway is involved in the recovery of hypoxia‑induced erythrocytosis". Molecular Medicine Reports 16, no. 6 (2017): 9441-9448. https://doi.org/10.3892/mmr.2017.7801
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