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Hydrogen sulfide regulates bone remodeling and promotes orthodontic tooth movement

  • Authors:
    • Haiya Pu
    • Yongmei Hua
  • View Affiliations / Copyright

    Affiliations: Department of Orthodontics, School of Dentistry, Tongji University, Shanghai Engineering Research Center of Tooth Restoration and Regeneration, Shanghai 200233, P.R. China
    Copyright: © Pu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 9415-9422
    |
    Published online on: October 17, 2017
       https://doi.org/10.3892/mmr.2017.7813
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Abstract

Hydrogen sulfide (H2S) is a gas signaling molecule that has multiple influences on physiological and pathological processes in the mammalian body, including vasodilation, neurotransmission, inflammation, hypoxia sensing and bone remodeling. Our previous studies suggested that H2S might be involved in the periodontal tissue remodeling during the orthodontic tooth movement (OTM) via increasing periodontal ligament cell differentiation, tissue mineralization, bone formation and collagen synthesis. The aim of the present study was to investigate the effects of H2S on alveolar bone remodeling that is associated with tooth movement. Experiments were performed in an OTM mouse model. Sodium hydrosulfide (NaHS), which is a donor of H2S and DL-propargylglycine (PAG) and a cystathionine-γ-lyase (CSE) inhibitor, which could also decrease H2S expression, were administered intraperitoneally and respectively. A total of 60 male C57BL6/J mice were divided into 4 groups; Control, NaHS, PAG and combination (PAG+NaHS). The rate of OTM and the bone mineral density (BMD) of alveolar bone were scanned and measured by micro-computed tomography (micro-CT). The number of osteoclasts and expression of the tumor necrosis factor ligand superfamily member-11 (RANKL), alkaline phosphatase (ALP), osteocalcin (OCN) and osteoprotegerin (OPG) in alveolar bone were accessed to evaluate the osteoclastic activity and osteogenesis with histochemistry of tartrate-resistant acid phosphatase staining, immunohistochemistry and reverse transcription-quantitative polymerase chain reaction. In the alveolar bone, NaHS increased the OTM and decreased the BMD, respectively. PAG significantly decrease OTM and increased the BMD. NaHS combined with PAG rescued the PAG-induced changes in the OTM and the BMD. Additionally, the number of osteoclasts, the expression of RANKL, ALP, OCN and the ratio of RANKL/OPG were significantly up-regulated in the NaHS group. In contrast, PAG down-regulated the number of osteoclasts, the expression of RANKL, ALP, OCN and the ratio of RANKL/OPG. These findings suggested that H2S might facilitate the OTM by enhancing alveolar bone remodeling as a result of an increased osteoclastic activity and osteogenesis.
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View References

1 

Melsen B: Biological reaction of alveolar bone to orthodontic tooth movement. Angle Orthod. 69:151–158. 1999.PubMed/NCBI

2 

Krishnan V and Davidovitch Z: Cellular, molecular, and tissue-level reactions to orthodontic force. Am J Orthod Dentofacial Orthop. 129:469.e1–32. 2006. View Article : Google Scholar

3 

Masella RS and Meister M: Current concepts in the biology of orthodontic tooth movement. Am J Orthod Dentofacial Orthop. 129:458–468. 2006. View Article : Google Scholar : PubMed/NCBI

4 

Zahrowski JJ: Optimizing orthodontic treatment in patients taking bisphosphonates for osteoporosis. Am Orthod Dentofacial Orthop. 135:361–374. 2009. View Article : Google Scholar

5 

Pichler K, Loreto C, Leonardi R, Reuber T, Weinberg AM and Musumeci G: RANKL is downregulated in bone cells by physical activity (treadmill and vibration stimulation training) in rat with glucocorticoid-induced osteoporosis. Histol Histopathol. 28:1185–1196. 2013.PubMed/NCBI

6 

Leonardi R, Loreto C, Talic N, Caltabiano R and Musumeci G: Immunolocalization of lubricin in the rat periodontal ligament during experimental tooth movement. Acta Histochem. 114:700–704. 2012. View Article : Google Scholar : PubMed/NCBI

7 

Cardile V, Musumeci G, Sicurezza E, Caggia S, Rusu MC, Leonardi R and Loreto C: Expression of TRAIL and its receptors DR5 and DcR2 in orthodontic tooth movement. Histol Histopathol. 28:933–940. 2013.PubMed/NCBI

8 

Kabil O, Motl N and Banerjee R: H2S and its role in redox signaling. Biochim Biophys Acta. 1844:1355–1366. 2014. View Article : Google Scholar : PubMed/NCBI

9 

Shibuya N, Tanaka M, Yoshida M, Ogasawara Y, Togawa T, Ishii K and Kimura H: 3-Mercaptopyruvate sulfurtransferase produces hydrogen sulfide and bound sulfane sulfur in the brain. Antioxid Redox Signal. 11:703–714. 2009. View Article : Google Scholar : PubMed/NCBI

10 

Yang G, Wu L, Jiang B, Yang W, Qi J, Cao K, Meng Q, Mustafa AK, Mu W, Zhang S, et al: H2S as a physiologic vasorelaxant: Hypertension in mice with deletion of cystathionine gamma-lyase. Science. 322:587–590. 2008. View Article : Google Scholar : PubMed/NCBI

11 

Abe K and Kimura H: The possible role of hydrogen sulfide as an endogenous neuromodulator. J Neurosci. 16:1066–1071. 1996.PubMed/NCBI

12 

Papapetropoulos A, Pyriochou A, Altaany Z, Yang G, Marazioti A, Zhou Z, Jeschke MG, Branski LK, Herndon DN, Wang R and Szabó C: Hydrogen sulfide is an endogenous stimulator of angiogenesis. Proc Natl Acad Sci USA. 106:pp. 21972–21977. 2009; View Article : Google Scholar : PubMed/NCBI

13 

Li L, Bhatia M, Zhu YZ, Zhu YC, Ramnath RD, Wang ZJ, Anuar FB, Whiteman M, Salto-Tellez M and Moore PK: Hydrogen sulfide is a novel mediator of lipopolysaccharide-induced inflammation in the mouse. FASEB J. 19:1196–1198. 2005.PubMed/NCBI

14 

Olson KR, Healy MJ, Qin Z, Skovgaard N, Vulesevic B, Duff DW, Whitfield NL, Yang G, Wang R and Perry SF: Hydrogen sulfide as an oxygen sensor in trout gill chemoreceptors. Am J Physiol Regul Integr Comp Physiol. 295:R669–R680. 2008. View Article : Google Scholar : PubMed/NCBI

15 

Irie K, Ekuni D, Tomofuji T, Endo Y, Kasuyama K, Yaegaki K and Morita M: Combined effects of hydrogen sulfide and lipopolysaccharide on osteoclast differentiation in rats. J Periodontol. 83:522–527. 2012. View Article : Google Scholar : PubMed/NCBI

16 

Irie K, Ekuni D, Yamamoto T, Morita M, Yaegaki K, Ii H and Imai T: A single application of hydrogen sulphide induces a transient osteoclast differentiation with RANKL expression in the rat model. Arch Oral Biol. 54:723–729. 2009. View Article : Google Scholar : PubMed/NCBI

17 

Su Y, Liu D, Liu Y, Zhang C, Wang J and Wang S: Physiologic levels of endogenous hydrogen sulfide maintain the proliferation and differentiation capacity of periodontal ligament stem cells. J Periodontol. 86:1276–1286. 2015. View Article : Google Scholar : PubMed/NCBI

18 

Liao C and Hua Y: Effect of hydrogen sulphide on the expression of osteoprotegerin and receptor activator of NF-κB ligand in human periodontal ligament cells induced by tension-force stimulation. Arch Oral Biol. 58:1784–1790. 2013. View Article : Google Scholar : PubMed/NCBI

19 

Jiang Z and Hua Y: Hydrogen sulfide promotes osteogenic differentiation of human periodontal ligament cells via p38-MAPK signaling pathway under proper tension stimulation. Arch Oral Biol. 72:8–13. 2016. View Article : Google Scholar : PubMed/NCBI

20 

Cao H, Kou X, Yang R, Liu D, Wang X, Song Y, Feng L, He D, Gan Y and Zhou Y: Force-induced Adrb2 in periodontal ligament cells promotes tooth movement. J Dent Res. 93:1163–1169. 2014. View Article : Google Scholar : PubMed/NCBI

21 

Yan Y, Liu F, Kou X, Liu D, Yang R, Wang X, Song Y, He D, Gan Y and Zhou Y: T cells are required for orthodontic tooth movement. J Dent Res. 94:1463–1470. 2015. View Article : Google Scholar : PubMed/NCBI

22 

Schmittgen TD and Livak KJ: Analyzing real-time PCR data by the comparative C(T) method. Nat Protoc. 3:1101–1108. 2008. View Article : Google Scholar : PubMed/NCBI

23 

Long H, Pyakurel U, Wang Y, Liao L, Zhou Y and Lai W: Interventions for accelerating orthodontic tooth movement: A systematic review. Angle Orthod. 83:164–171. 2013. View Article : Google Scholar : PubMed/NCBI

24 

Nimeri G, Kau CH, Abou-Kheir NS and Corona R: Acceleration of tooth movement during orthodontic treatment-a frontier in orthodontics. Prog Orthod. 14:422013. View Article : Google Scholar : PubMed/NCBI

25 

Kau CH, Kantarci A, Shaughnessy T, Vachiramon A, Santiwong P, de la Fuente A, Skrenes D, Ma D and Brawn P: Photobiomodulation accelerates orthodontic alignment in the early phase of treatment. Prog Orthod. 14:302013. View Article : Google Scholar : PubMed/NCBI

26 

Kau CH: A radiographic analysis of tooth morphology following the use of a novel cyclical force device in orthodontics. Head Face Med. 7:142011. View Article : Google Scholar : PubMed/NCBI

27 

Nishimura M, Chiba M, Ohashi T, Sato M, Shimizu Y, Igarashi K and Mitani H: Periodontal tissue activation by vibration: Intermittent stimulation by resonance vibration accelerates experimental tooth movement in rats. Am J Orthod Dentofacial Orthop. 133:572–583. 2008. View Article : Google Scholar : PubMed/NCBI

28 

Wilcko WM, Wilcko T, Bouquot JE and Ferguson DJ: Rapid orthodontics with alveolar reshaping: Two case reports of decrowding. Int J Periodontics Restorative Dent. 21:9–19. 2001.PubMed/NCBI

29 

Ciacli C and Puşchiţă M: RANKL/RANK/OPG molecular complex-control factors in bone remodeling in psoriatic arthritis. Rev Med Chir Soc Med Nat Iasi. 115:354–360. 2011.PubMed/NCBI

30 

Simonet WS, Lacey DL, Dunstan CR, Kelley M, Chang MS, Lüthy R, Nguyen HQ, Wooden S, Bennett L, Boone T, et al: Osteoprotegerin: A novel secreted protein involved in the regulation of bone density. Cell. 89:309–319. 1997. View Article : Google Scholar : PubMed/NCBI

31 

Karsenty G: The genetic transformation of bone biology. Genes Dev. 13:3037–3051. 1999. View Article : Google Scholar : PubMed/NCBI

32 

Souza LK, Araújo TS, Sousa NA, Sousa FB, Nogueira KM, Nicolau LA and Medeiros JV: Evidence that d-cysteine protects mice from gastric damage via hydrogen sulfide produced by d-amino acid oxidase. Nitric Oxide. 64:1–6. 2017. View Article : Google Scholar : PubMed/NCBI

33 

Ivanciuc T, Sbrana E, Ansar M, Bazhanov N, Szabo C, Casola A and Garofalo RP: Hydrogen sulfide is an antiviral and antiinflammatory endogenous gasotransmitter in the airways. Role in respiratory syncytial virus infection. Am J Respir Cell Mol Biol. 55:684–696. 2016. View Article : Google Scholar : PubMed/NCBI

34 

Liu Y, Yang R, Liu X, Zhou Y, Qu C, Kikuiri T, Wang S, Zandi E, Du J, Ambudkar IS and Shi S: Hydrogen sulfide maintains mesenchymal stem cell function and bone homeostasis via regulation of Ca(2+) channel sulfhydration. Cell Stem Cell. 15:66–78. 2014. View Article : Google Scholar : PubMed/NCBI

35 

Qin J and Hua Y: Effects of hydrogen sulfide on the expression of alkaline phosphatase, osteocalcin and collagen type I in human periodontal ligament cells induced by tension force stimulation. Mol Med Rep. 14:3871–3877. 2016. View Article : Google Scholar : PubMed/NCBI

36 

Itou T, Maldonado N, Yamada I, Goettsch C, Matsumoto J, Aikawa M, Singh S and Aikawa E: Cystathionine γ-lyase accelerates osteoclast differentiation: Identification of a novel regulator of osteoclastogenesis by proteomic analysis. Arterioscler Thromb Vasc Biol. 34:626–634. 2014. View Article : Google Scholar : PubMed/NCBI

37 

Viecilli RF, Katona TR, Chen J, Hartsfield JK Jr and Roberts WE: Orthodontic mechanotransduction and the role of the P2X7 receptor. Am J Orthod Dentofacial Orthop. 135:694.e1–16; discussion 694–695. 2009. View Article : Google Scholar

38 

Krishnan V and Davidovitch Z: On a path to unfolding the biological mechanisms of orthodontic tooth movement. J Dent Res. 88:597–608. 2009. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Pu H and Hua Y: Hydrogen sulfide regulates bone remodeling and promotes orthodontic tooth movement. Mol Med Rep 16: 9415-9422, 2017.
APA
Pu, H., & Hua, Y. (2017). Hydrogen sulfide regulates bone remodeling and promotes orthodontic tooth movement. Molecular Medicine Reports, 16, 9415-9422. https://doi.org/10.3892/mmr.2017.7813
MLA
Pu, H., Hua, Y."Hydrogen sulfide regulates bone remodeling and promotes orthodontic tooth movement". Molecular Medicine Reports 16.6 (2017): 9415-9422.
Chicago
Pu, H., Hua, Y."Hydrogen sulfide regulates bone remodeling and promotes orthodontic tooth movement". Molecular Medicine Reports 16, no. 6 (2017): 9415-9422. https://doi.org/10.3892/mmr.2017.7813
Copy and paste a formatted citation
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Spandidos Publications style
Pu H and Hua Y: Hydrogen sulfide regulates bone remodeling and promotes orthodontic tooth movement. Mol Med Rep 16: 9415-9422, 2017.
APA
Pu, H., & Hua, Y. (2017). Hydrogen sulfide regulates bone remodeling and promotes orthodontic tooth movement. Molecular Medicine Reports, 16, 9415-9422. https://doi.org/10.3892/mmr.2017.7813
MLA
Pu, H., Hua, Y."Hydrogen sulfide regulates bone remodeling and promotes orthodontic tooth movement". Molecular Medicine Reports 16.6 (2017): 9415-9422.
Chicago
Pu, H., Hua, Y."Hydrogen sulfide regulates bone remodeling and promotes orthodontic tooth movement". Molecular Medicine Reports 16, no. 6 (2017): 9415-9422. https://doi.org/10.3892/mmr.2017.7813
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