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Article

TGF‑β1 expression in adults with non‑traumatic osteonecrosis of the femoral head

  • Authors:
    • Jun Tao
    • Bin Dong
    • Li‑Xin Yang
    • Ke‑Qing Xu
    • Shuai Ma
    • Jun Lu
  • View Affiliations / Copyright

    Affiliations: Department of Orthopaedics, Huainan No. 1 People's Hospital, Huainan, Anhui 232007, P.R. China, Department of Pathogen Biology and Immunology, School of Medicine, Anhui University of Science and Technology, Huainan, Anhui 232001, P.R. China
  • Pages: 9539-9544
    |
    Published online on: October 19, 2017
       https://doi.org/10.3892/mmr.2017.7817
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Abstract

Non-traumatic osteonecrosis of the femoral head (NONFH) is a common clinical osteoarthropathy. The present study aimed to investigate the association between transforming growth factor β1 (TGF‑β1) and NONFH. Femoral head specimens were collected from patients with NONFH. Patients with traumatic osteonecrosis served as the control. Hematoxylin and eosin (H&E) staining was used to visualize the bone tissue architecture. Immunohistochemistry and densitometry were performed to quantify TGF‑β1 expression in tissues. Flow cytometry was used to detect cluster of differentiation (CD)3+, CD4+ and CD8+ cells, and the ratio of CD4+ to CD8+ T cells in the peripheral blood. H&E staining revealed osteonecrosis, disintegration of osteocytes with karyopyknosis and karyorrhexis, loss of osteocyte lacunae, aberrantly arranged circumferential lamellae, as well as dissolution of the lamellae and subtle osteogenesis in the experimental group, as opposed to the control group. Immunohistochemistry revealed that the expression of TGF‑β1 was significantly reduced in the experimental group (P<0.01). Further, the NONFH group had a decrease in the CD3+ and CD4+ cell populations (P<0.05 and P<0.01, respectively), an increase in the CD8+ cell population (P<0.05), as well as a reduction in the ratio of CD4+ to CD8+ cells (P<0.01). The present study indicated that TGF‑β1 expression was reduced in NONFH. This was associated with impaired repairing capacity of the femoral head and dysregulated subsets of T‑lymphocytes and possible immune functions.
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1 

Mont MA, Jones LC and Hungerford DS: Nontraumatic osteonecrosis of the femoral head: Ten years later. J Bone Joint Surg Am. 88:1117–1132. 2006. View Article : Google Scholar : PubMed/NCBI

2 

Mont MA, Cherian JJ, Sierra RJ, Jones LC and Lieberman JR: Nontraumatic osteonecrosis of the femoral head: Where do we stand today? A ten-year update. J Bone Joint Surg Am. 97:1604–1627. 2015. View Article : Google Scholar : PubMed/NCBI

3 

Zhao DW, Yu M, Hu K, Wang W, Yang L, Wang BJ, Gao XH, Guo YM, Xu YQ, Wei YS, et al: Prevalence of nontraumatic osteonecrosis of the femoral head and its associated risk factors in the Chinese population: Results from a nationally representative survey. Chin Med J (Engl). 128:2843–2850. 2015. View Article : Google Scholar : PubMed/NCBI

4 

Tan G, Kang PD and Pei FX: Glucocorticoids affect the metabolism of bone marrow stromal cells and lead to osteonecrosis of the femoral head: A review. Chin Med J (Engl). 125:134–139. 2012. View Article : Google Scholar : PubMed/NCBI

5 

Zalavras CG and Lieberman JR: Osteonecrosis of the femoral head: Evaluation and treatment. J Am Acad Orthop Surg. 22:455–464. 2014. View Article : Google Scholar : PubMed/NCBI

6 

Pouya F and Kerachian MA: Avascular necrosis of the femoral head: Are any genes involved? Arch Bone Jt Surg. 3:149–155. 2015.PubMed/NCBI

7 

Gómez-Mont Landerreche JG, Gil-Orbezo F, Morales-Dominguez H, Navarrete-Álvarez M, Trueba-Davalillo C and Capuano-Tripp P: Nontraumatic causes of bilateral avascular necrosis of the femoral head: Link between hepatitis C and pegylated interferon. Acta Ortop Mex Mex and pegylated interferon. Acta Ortop Mex. 29:172–175. 2015.(In Spanish). PubMed/NCBI

8 

Farrier AJ, Franco LC Sanchez, Shoaib A, Gulati V, Johnson N, Uzoigwe CE and Choudhury MZ: New anti-resorptives and antibody mediated anti-resorptive therapy. Bone Joint J. 98-B:1–165. 2016. View Article : Google Scholar :

9 

Mont MA, Jones LC, Einhorn TA, Hungerford DS and Reddi AH: Osteonecrosis of the femoral head. Potential treatment with growth and differentiation factors. Clin Orthop Relat Res. (355 Suppl): S314–S335. 1998. View Article : Google Scholar : PubMed/NCBI

10 

Letterio JJ and Roberts AB: Regulation of immune responses by TGF-beta. Annu Rev Immunol. 16:137–161. 1998. View Article : Google Scholar : PubMed/NCBI

11 

Massagué J: TGF-beta signal transduction. Annu Rev Biochem. 67:753–791. 1998. View Article : Google Scholar : PubMed/NCBI

12 

Schultze-Mosgau S, Lehner B, Rödel F, Wehrhan F, Amann K, Kopp J, Thorwarth M, Nkenke E and Grabenbauer G: Expression of bone morphogenic protein 2/4, transforming growth factor-beta1, and bone matrix protein expression in healing area between vascular tibia grafts and irradiated bone-experimental model of osteonecrosis. Int J Radiat Oncol Biol Phys. 61:1189–1196. 2005. View Article : Google Scholar : PubMed/NCBI

13 

Mouzas OD, Zibis AH, Bonotis KS, Katsimagklis CD, Hadjigeorgiou GM, Papaliaga MN, Dimitroulias AP and Malizos KN: Psychological distress, personality traits and functional disability in patients with osteonecrosis of the femoral head. J Clin Med Res. 6:336–344. 2014.PubMed/NCBI

14 

Ficat RP: Idiopathic bone necrosis of the femoral head. Early diagnosis and treatment. J Bone Joint Surg Br. 67:3–9. 1985.PubMed/NCBI

15 

Zhang H, Xiao F, Liu Y, Zhao D, Shan Y and Jiang Y: A higher frequency of peripheral blood activated B cells in patients with non-traumatic osteonecrosis of the femoral head. Int Immunopharmacol. 20:95–100. 2014. View Article : Google Scholar : PubMed/NCBI

16 

Zheng L, Wang W, Ni J, Li Z and Xiao T: The association of eNOS gene polymorphism with avascular necrosis of femoral head. PLoS One. 9:e875832014. View Article : Google Scholar : PubMed/NCBI

17 

Hong YC, Luo RB, Lin T, Zhong HM and Shi JB: Efficacy of alendronate for preventing collapse of femoral head in adult patients with nontraumatic osteonecrosis. Biomed Res Int. 2014:7165382014. View Article : Google Scholar : PubMed/NCBI

18 

Sakaguchi M, Tanaka T, Fukushima W, Kubo T and Hirota Y; Idiopathic ONF Multicenter Case-Control Study Group, : Impact of oral corticosteroid use for idiopathic osteonecrosis of the femoral head: A nationwide multicenter case-control study in Japan. J Orthop Sci. 15:185–191. 2010. View Article : Google Scholar : PubMed/NCBI

19 

Lykissas MG, Gelalis ID, Kostas-Agnantis IP, Vozonelos G and Korompilias AV: The role of hypercoagulability in the development of osteonecrosis of the femoral head. Orthop Rev (Pavia). 4:e172012. View Article : Google Scholar : PubMed/NCBI

20 

Kapoor M, Martel-Pelletier J, Lajeunesse D, Pelletier JP and Fahmi H: Role of proinflammatory cytokines in the pathophysiology of osteoarthritis. Nat Rev Rheumatol. 7:33–42. 2011. View Article : Google Scholar : PubMed/NCBI

21 

Hong JM, Kim TH, Kim HJ, Park EK, Yang EK and Kim SY: Genetic association of angiogenesis- and hypoxia-related gene polymorphisms with osteonecrosis of the femoral head. Exp Mol Med. 42:376–385. 2010. View Article : Google Scholar : PubMed/NCBI

22 

Seamon J, Keller T, Saleh J and Cui Q: The pathogenesis of nontraumatic osteonecrosis. Arthritis. 2012:6017632012. View Article : Google Scholar : PubMed/NCBI

23 

Plaas A, Velasco J, Gorski DJ, Li J, Cole A, Christopherson K and Sandy JD: The relationship between fibrogenic TGFβ1 signaling in the joint and cartilage degradation in post-injury osteoarthritis. Osteoarthritis Cartilage. 19:1081–1090. 2011. View Article : Google Scholar : PubMed/NCBI

24 

Finnson KW, McLean S, Di Guglielmo GM and Philip A: Dynamics of transforming growth factor beta signaling in wound healing and scarring. Adv Wound Care (New Rochelle). 2:195–214. 2013. View Article : Google Scholar : PubMed/NCBI

25 

Penn JW, Grobbelaar AO and Rolfe KJ: The role of the TGF-β family in wound healing, burns and scarring: A review. Int J Burns Trauma. 2:18–28. 2012.PubMed/NCBI

26 

Bastian O, Pillay J, Alblas J, Leenen L, Koenderman L and Blokhuis T: Systemic inflammation and fracture healing. J Leukoc Biol. 89:669–673. 2011. View Article : Google Scholar : PubMed/NCBI

27 

Yang H, Gao F, Li X, Wang J, Liu H and Zheng Z: TGF-β1 antagonizes TNF-α induced up-regulation of matrix metalloproteinase 3 in nucleus pulposus cells: Role of the ERK1/2 pathway. Connect Tissue Res. 56:461–468. 2015. View Article : Google Scholar : PubMed/NCBI

28 

Rivas M Noval, Weatherly K, Hazzan M, Vokaer B, Dremier S, Gaudray F, Goldman M, Salmon I and Braun MY: Reviving function in CD4+ T cells adapted to persistent systemic antigen. J Immunol. 183:4284–4291. 2009. View Article : Google Scholar : PubMed/NCBI

29 

Kumarasinghe DD, Sullivan T, Kuliwaba JS, Fazzalari NL and Atkins GJ: Evidence for the dysregulated expression of TWIST1, TGFβ1 and SMAD3 in differentiating osteoblasts from primary hip osteoarthritis patients. Osteoarthritis Cartilage. 20:1357–1366. 2012. View Article : Google Scholar : PubMed/NCBI

30 

Feng W, Ying WZ, Aaron KJ and Sanders PW: Transforming growth factor-β mediates endothelial dysfunction in rats during high salt intake. Am J Physiol Renal Physiol. 309:F1018–F1025. 2015. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Tao J, Dong B, Yang LX, Xu KQ, Ma S and Lu J: TGF‑β1 expression in adults with non‑traumatic osteonecrosis of the femoral head. Mol Med Rep 16: 9539-9544, 2017.
APA
Tao, J., Dong, B., Yang, L., Xu, K., Ma, S., & Lu, J. (2017). TGF‑β1 expression in adults with non‑traumatic osteonecrosis of the femoral head. Molecular Medicine Reports, 16, 9539-9544. https://doi.org/10.3892/mmr.2017.7817
MLA
Tao, J., Dong, B., Yang, L., Xu, K., Ma, S., Lu, J."TGF‑β1 expression in adults with non‑traumatic osteonecrosis of the femoral head". Molecular Medicine Reports 16.6 (2017): 9539-9544.
Chicago
Tao, J., Dong, B., Yang, L., Xu, K., Ma, S., Lu, J."TGF‑β1 expression in adults with non‑traumatic osteonecrosis of the femoral head". Molecular Medicine Reports 16, no. 6 (2017): 9539-9544. https://doi.org/10.3892/mmr.2017.7817
Copy and paste a formatted citation
x
Spandidos Publications style
Tao J, Dong B, Yang LX, Xu KQ, Ma S and Lu J: TGF‑β1 expression in adults with non‑traumatic osteonecrosis of the femoral head. Mol Med Rep 16: 9539-9544, 2017.
APA
Tao, J., Dong, B., Yang, L., Xu, K., Ma, S., & Lu, J. (2017). TGF‑β1 expression in adults with non‑traumatic osteonecrosis of the femoral head. Molecular Medicine Reports, 16, 9539-9544. https://doi.org/10.3892/mmr.2017.7817
MLA
Tao, J., Dong, B., Yang, L., Xu, K., Ma, S., Lu, J."TGF‑β1 expression in adults with non‑traumatic osteonecrosis of the femoral head". Molecular Medicine Reports 16.6 (2017): 9539-9544.
Chicago
Tao, J., Dong, B., Yang, L., Xu, K., Ma, S., Lu, J."TGF‑β1 expression in adults with non‑traumatic osteonecrosis of the femoral head". Molecular Medicine Reports 16, no. 6 (2017): 9539-9544. https://doi.org/10.3892/mmr.2017.7817
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