Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
December-2017 Volume 16 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
December-2017 Volume 16 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Elaidic acid induces cell apoptosis through induction of ROS accumulation and endoplasmic reticulum stress in SH‑SY5Y cells

  • Authors:
    • Wei‑Wei Ma
    • Lei Zhao
    • Lin‑Hong Yuan
    • Huan‑Ling Yu
    • Hui Wang
    • Xin‑Yuan Gong
    • Feng Wei
    • Rong Xiao
  • View Affiliations / Copyright

    Affiliations: Department of Nutrition and Food Hygiene, School of Public Health, Beijing Key Laboratory of Environmental Toxicology, Capital Medical University, Beijing 100069, P.R. China, Department of Molecular Physiology and Biophysics, Holden Comprehensive Cancer Center, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA
    Copyright: © Ma et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 9337-9346
    |
    Published online on: October 19, 2017
       https://doi.org/10.3892/mmr.2017.7830
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Elaidic acid, which is a major trans fatty acid, has been reported to be involved in neurotoxicity; however, the underlying molecular mechanisms underlying its neurotoxic effects remain largely unknown. Therefore, the present study aimed to investigate the potential mechanisms underlying elaidic acid‑induced neuronal damage in vitro. The SH‑SY5Y neuroblastoma cell line was used as a model in the present study. Following treatment of cells with various concentrations of elaidic acid or with vehicle for 24 h, cell viability was measured using the MTT assay. Mitochondrial membrane potential (MMP) and reactive oxygen species (ROS) release were measured using flow cytometry. Cell apoptosis was measured by Annexin V‑fluorescein isothiocyanate/propidium iodide double staining, and cellular redox status was determined using ELISA analysis. Furthermore, western blotting was used to detect the protein expression levels of factors associated with oxidative damage and components of the endoplasmic reticulum (ER) stress/unfolded protein response (UPR) signaling pathways. The results demonstrated that elaidic acid treatment inhibited cell viability, elevated cell apoptosis and resulted in a loss of MMP. In addition, elaidic acid induced marked alterations in cellular redox status. Treatment with high doses of elaidic acid treatment also enhanced the release of ROS, and upregulated lipid peroxide and malondialdehyde levels; however, it reduced superoxide dismutase and glutathione peroxidase activities. Furthermore, elaidic acid resulted in upregulation of nuclear factor erythroid 2‑related factor 2 and downregulation of heme oxygenase 1, which are two key antioxidative factors. Elaidic acid treatment also induced or inhibited the expression of numerous ER stress/UPR‑associated molecules. It induced glucose‑regulated protein 78 (GRP78) expression, whereas the expression levels of activating transcription factor 4 (ATF4) and CCAAT/enhancer‑binding protein homologous protein (CHOP) were upregulated and then downregulated following treatment with various doses of elaidic acid. These results indicated that elaidic acid inhibited SH‑SY5Y cell growth and induced apoptosis by enhancing oxidative stress and activating the ER stress/UPR signaling pathway and the GRP78/ATF4/CHOP pathway.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

View References

1 

Forman MS, Trojanowski JQ and Lee VM: Neurodegenerative diseases: A decade of discoveries paves the way for therapeutic breakthroughs. Nat Med. 10:1055–1063. 2004. View Article : Google Scholar : PubMed/NCBI

2 

Brown RC, Lockwood AH and Sonawane BR: Neurodegenerative diseases: An overview of environmental risk factors. Environ Health Perspect. 113:1250–1256. 2005. View Article : Google Scholar : PubMed/NCBI

3 

Rozpedek W, Markiewicz L, Diehl JA, Pytel D and Majsterek I: Unfolded protein response and PERK kinase as a new therapeutic target in the pathogenesis of alzheimer's disease. Curr Med Chem. 22:3169–3184. 2015. View Article : Google Scholar : PubMed/NCBI

4 

Volgyi K, Juhász G, Kovacs Z and Penke B: Dysfunction of endoplasmic reticulum (ER) and mitochondria (MT) in Alzheimer's disease: The role of the ER-MT cross-talk. Curr Alzheimer Res. 12:655–672. 2015. View Article : Google Scholar : PubMed/NCBI

5 

Castellani R, Hirai K, Aliev G, Drew KL, Nunomura A, Takeda A, Cash AD, Obrenovich ME, Perry G and Smith MA: Role of mitochondrial dysfunction in Alzheimer's disease. J Neurosci Res. 70:357–360. 2002. View Article : Google Scholar : PubMed/NCBI

6 

Blesa J, Trigo-Damas I, Quiroga-Varela A and Jackson-Lewis VR: Oxidative stress and Parkinson's disease. Front Neuroanat. 9:912015. View Article : Google Scholar : PubMed/NCBI

7 

Malhotra JD and Kaufman RJ: Endoplasmic reticulum stress and oxidative stress: A vicious cycle or a double-edged sword? Antioxid Redox Signal. 9:2277–2293. 2007. View Article : Google Scholar : PubMed/NCBI

8 

Barnard ND, Bunner AE and Agarwal U: Saturated and trans fats and dementia: A systematic review. Neurobiol Aging. 35 Suppl 2:S65–S73. 2014. View Article : Google Scholar : PubMed/NCBI

9 

Morris MC and Tangney CC: Dietary fat composition and dementia risk. Neurobiol Aging. 35 Suppl 2:S59–S64. 2014. View Article : Google Scholar : PubMed/NCBI

10 

Lichtenstein AH: Dietary trans fatty acids and cardiovascular disease risk: Past and present. Curr Atheroscler Rep. 16:4332014. View Article : Google Scholar : PubMed/NCBI

11 

Nielsen L Vendel, Krogager TP, Young C, Ferreri C, Chatgilialoglu C, Nørregaard Jensen O and Enghild JJ: Effects of elaidic acid on lipid metabolism in HepG2 cells, investigated by an integrated approach of lipidomics, transcriptomics and proteomics. PLoS One. 8:e742832013. View Article : Google Scholar : PubMed/NCBI

12 

Perova NV, Metel'skaia VA and Boĭtsov SA: Trans isomers of unsaturated fatty acids increase the risk of atherosclerosis-related circulatory system diseases. Ter Arkh. 85:113–117. 2013.(In Russian). PubMed/NCBI

13 

de Souza RJ, Mente A, Maroleanu A, Cozma AI, Ha V, Kishibe T, Uleryk E, Budylowski P, Schünemann H, Beyene J and Anand SS: Intake of saturated and trans unsaturated fatty acids and risk of all cause mortality, cardiovascular disease, and type 2 diabetes: Systematic review and meta-analysis of observational studies. BMJ. 351:h39782015. View Article : Google Scholar : PubMed/NCBI

14 

Morris MC, Evans DA, Bienias JL, Tangney CC, Bennett DA, Aggarwal N, Schneider J and Wilson RS: Dietary fats and the risk of incident Alzheimer disease. Arch Neurol. 60:194–200. 2003. View Article : Google Scholar : PubMed/NCBI

15 

Engelhart MJ, Geerlings MI, Ruitenberg A, Van Swieten JC, Hofman A, Witteman JC and Breteler MM: Diet and risk of dementia: Does fat matter? The rotterdam study. Neurology. 59:1915–1921. 2002. View Article : Google Scholar : PubMed/NCBI

16 

Grimm MO, Rothhaar TL, Grösgen S, Burg VK, Hundsdörfer B, Haupenthal VJ, Friess P, Kins S, Grimm HS and Hartmann T: Trans fatty acids enhance amyloidogenic processing of the Alzheimer amyloid precursor protein (APP). J Nutr Biochem. 23:1214–1223. 2012. View Article : Google Scholar : PubMed/NCBI

17 

Morinaga M, Kon K, Saito H, Arai K, Kusama H, Uchiyama A, Yamashina S, Ikejima K and Watanabe S: Sodium 4-phenylbutyrate prevents murine dietary steatohepatitis caused by trans-fatty acid plus fructose. J Clin Biochem Nutr. 57:183–191. 2015. View Article : Google Scholar : PubMed/NCBI

18 

Cassagno N, Palos-Pinto A, Costet P, Breilh D, Darmon M and Bérard AM: Low amounts of trans 18:1 fatty acids elevate plasma triacylglycerols but not cholesterol and alter the cellular defence to oxidative stress in mice. Br J Nutr. 94:346–352. 2005. View Article : Google Scholar : PubMed/NCBI

19 

Starr TK, Scott PM, Marsh BM, Zhao L, Than BL, O'Sullivan MG, Sarver AL, Dupuy AJ, Largaespada DA and Cormier RT: A sleeping beauty transposon-mediated screen identifies murine susceptibility genes for adenomatous polyposis coli (Apc)-dependent intestinal tumorigenesis. Proc Natl Acad Sci USA. 108:pp. 5765–5770. 2011; View Article : Google Scholar : PubMed/NCBI

20 

Sakitani K, Hirata Y, Hikiba Y, Hayakawa Y, Ihara S, Suzuki H, Suzuki N, Serizawa T, Kinoshita H, Sakamoto K, et al: Inhibition of autophagy exerts anti-colon cancer effects via apoptosis induced by p53 activation and ER stress. BMC Cancer. 15:7952015. View Article : Google Scholar : PubMed/NCBI

21 

Sui C, Ma Q, Nan K, Xiao J, Suo A, Sha H and Zhao L: hSSTR2 expression and octreotide treatment reverses multidrug resistance of BxPC-3 human pancreatic cancer cells. Oncol Rep. 22:1391–1396. 2009.PubMed/NCBI

22 

Gong X, Zhang L, Jiang R, Ye M, Yin X and Wan J: Anti-inflammatory effects of mangiferin on sepsis-induced lung injury in mice via up-regulation of heme oxygenase-1. J Nutr Biochem. 24:1173–1181. 2013. View Article : Google Scholar : PubMed/NCBI

23 

Takahashi T, Shimizu H, Morimatsu H, Maeshima K, Inoue K, Akagi R, Matsumi M, Katayama H and Morita K: Heme Oxygenase-1 is an essential cytoprotective component in oxidative tissue injury induced by hemorrhagic shock. J Clin Biochem Nutr. 44:28–40. 2009. View Article : Google Scholar : PubMed/NCBI

24 

van Poppel G: Intake of trans fatty acids in western Europe: The TRANSFAIR study. Lancet. 351:10991998. View Article : Google Scholar : PubMed/NCBI

25 

Jokela H, Kalela A, Lilja M, Salmi M, Lehtimäki T, Kunnas T, Teisala K, Punnonen R and Nikkari ST: Sequentially combined estradiol valerate plus levonorgestrel therapy decreases 18:1 trans-fatty acid content of plasma lipids in healthy postmenopausal women. Gynecol Endocrinol. 21:360–365. 2005. View Article : Google Scholar : PubMed/NCBI

26 

Svahn JC, Feldl F, Räihä NC, Koletzko B and Axelsson IE: Different quantities and quality of fat in milk products given to young children: Effects on long chain polyunsaturated fatty acids and trans fatty acids in plasma. Acta Paediatr. 91:20–29. 2002. View Article : Google Scholar : PubMed/NCBI

27 

Abraham RA, Bahl VK, Parshad R, Seenu V, Roy A, Golandaz S, Dorairaj P and Ramakrishnan L: Content of trans fatty acids in human cheek epithelium: Comparison with serum and adipose tissue. Biomed Res Int. 2013:2761742013. View Article : Google Scholar : PubMed/NCBI

28 

Sun Q, Ma J, Campos H, Hankinson SE, Manson JE, Stampfer MJ, Rexrode KM, Willett WC and Hu FB: A prospective study of trans fatty acids in erythrocytes and risk of coronary heart disease. Circulation. 115:1858–1865. 2007. View Article : Google Scholar : PubMed/NCBI

29 

Burdge GC, Tricon S, Morgan R, Kliem KE, Childs C, Jones E, Russell JJ, Grimble RF, Williams CM, Yaqoob P and Calder PC: Incorporation of cis-9, trans-11 conjugated linoleic acid and vaccenic acid (trans-11 18:1) into plasma and leucocyte lipids in healthy men consuming dairy products naturally enriched in these fatty acids. Br J Nutr. 94:237–243. 2005. View Article : Google Scholar : PubMed/NCBI

30 

Itoh K, Tong KI and Yamamoto M: Molecular mechanism activating Nrf2-Keap1 pathway in regulation of adaptive response to electrophiles. Free Radic Biol Med. 36:1208–1213. 2004. View Article : Google Scholar : PubMed/NCBI

31 

Henderson MJ, Baldwin HA, Werley CA, Boccardo S, Whitaker LR, Yan X, Holt GT, Schreiter ER, Looger LL, Cohen AE, et al: A low affinity GCaMP3 variant (GCaMPer) for imaging the endoplasmic reticulum calcium store. PLoS One. 10:e01392732015. View Article : Google Scholar : PubMed/NCBI

32 

Schwarz DS and Blower MD: The endoplasmic reticulum: Structure, function and response to cellular signaling. Cell Mol Life Sci. 73:79–94. 2016. View Article : Google Scholar : PubMed/NCBI

33 

Bakhshi J, Weinstein L, Poksay KS, Nishinaga B, Bredesen DE and Rao RV: Coupling endoplasmic reticulum stress to the cell death program in mouse melanoma cells: Effect of curcumin. Apoptosis. 13:904–914. 2008. View Article : Google Scholar : PubMed/NCBI

34 

Xu D, Perez RE, Rezaiekhaligh MH, Bourdi M and Truog WE: Knockdown of ERp57 increases BiP/GRP78 induction and protects against hyperoxia and tunicamycin-induced apoptosis. Am J Physiol Lung Cell Mol Physiol. 297:L44–L51. 2009. View Article : Google Scholar : PubMed/NCBI

35 

Feng J, Chen X and Sun X, Wang F and Sun X: Expression of endoplasmic reticulum stress markers GRP78 and CHOP induced by oxidative stress in blue light-mediated damage of A2E-containing retinal pigment epithelium cells. Ophthalmic Res. 52:224–233. 2014. View Article : Google Scholar : PubMed/NCBI

36 

Ferreiro E, Baldeiras I, Ferreira IL, Costa RO, Rego AC, Pereira CF and Oliveira CR: Mitochondrial- and endoplasmic reticulum-associated oxidative stress in Alzheimer's disease: From pathogenesis to biomarkers. Int J Cell Biol. 2012:7352062012. View Article : Google Scholar : PubMed/NCBI

37 

Chen Y and Brandizzi F: AtIRE1A/AtIRE1B and AGB1 independently control two essential unfolded protein response pathways in Arabidopsis. Plant J. 69:266–277. 2012. View Article : Google Scholar : PubMed/NCBI

38 

Nagashima Y, Mishiba K, Suzuki E, Shimada Y, Iwata Y and Koizumi N: Arabidopsis IRE1 catalyses unconventional splicing of bZIP60 mRNA to produce the active transcription factor. Sci Rep. 1:292011. View Article : Google Scholar : PubMed/NCBI

39 

Kim I, Xu W and Reed JC: Cell death and endoplasmic reticulum stress: Disease relevance and therapeutic opportunities. Nat Rev Drug Discov. 7:1013–1030. 2008. View Article : Google Scholar : PubMed/NCBI

40 

Bertolotti A, Zhang Y, Hendershot LM, Harding HP and Ron D: Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response. Nat Cell Biol. 2:326–332. 2000. View Article : Google Scholar : PubMed/NCBI

41 

Szegezdi E, Logue SE, Gorman AM and Samali A: Mediators of endoplasmic reticulum stress-induced apoptosis. EMBO Rep. 7:880–885. 2006. View Article : Google Scholar : PubMed/NCBI

42 

Benham AM, van Lith M, Sitia R and Braakman I: Ero1-PDI interactions, the response to redox flux and the implications for disulfide bond formation in the mammalian endoplasmic reticulum. Philos Trans R Soc Lond B Biol Sci. 368:201104032013. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Ma WW, Zhao L, Yuan LH, Yu HL, Wang H, Gong XY, Wei F and Xiao R: Elaidic acid induces cell apoptosis through induction of ROS accumulation and endoplasmic reticulum stress in SH‑SY5Y cells. Mol Med Rep 16: 9337-9346, 2017.
APA
Ma, W., Zhao, L., Yuan, L., Yu, H., Wang, H., Gong, X. ... Xiao, R. (2017). Elaidic acid induces cell apoptosis through induction of ROS accumulation and endoplasmic reticulum stress in SH‑SY5Y cells. Molecular Medicine Reports, 16, 9337-9346. https://doi.org/10.3892/mmr.2017.7830
MLA
Ma, W., Zhao, L., Yuan, L., Yu, H., Wang, H., Gong, X., Wei, F., Xiao, R."Elaidic acid induces cell apoptosis through induction of ROS accumulation and endoplasmic reticulum stress in SH‑SY5Y cells". Molecular Medicine Reports 16.6 (2017): 9337-9346.
Chicago
Ma, W., Zhao, L., Yuan, L., Yu, H., Wang, H., Gong, X., Wei, F., Xiao, R."Elaidic acid induces cell apoptosis through induction of ROS accumulation and endoplasmic reticulum stress in SH‑SY5Y cells". Molecular Medicine Reports 16, no. 6 (2017): 9337-9346. https://doi.org/10.3892/mmr.2017.7830
Copy and paste a formatted citation
x
Spandidos Publications style
Ma WW, Zhao L, Yuan LH, Yu HL, Wang H, Gong XY, Wei F and Xiao R: Elaidic acid induces cell apoptosis through induction of ROS accumulation and endoplasmic reticulum stress in SH‑SY5Y cells. Mol Med Rep 16: 9337-9346, 2017.
APA
Ma, W., Zhao, L., Yuan, L., Yu, H., Wang, H., Gong, X. ... Xiao, R. (2017). Elaidic acid induces cell apoptosis through induction of ROS accumulation and endoplasmic reticulum stress in SH‑SY5Y cells. Molecular Medicine Reports, 16, 9337-9346. https://doi.org/10.3892/mmr.2017.7830
MLA
Ma, W., Zhao, L., Yuan, L., Yu, H., Wang, H., Gong, X., Wei, F., Xiao, R."Elaidic acid induces cell apoptosis through induction of ROS accumulation and endoplasmic reticulum stress in SH‑SY5Y cells". Molecular Medicine Reports 16.6 (2017): 9337-9346.
Chicago
Ma, W., Zhao, L., Yuan, L., Yu, H., Wang, H., Gong, X., Wei, F., Xiao, R."Elaidic acid induces cell apoptosis through induction of ROS accumulation and endoplasmic reticulum stress in SH‑SY5Y cells". Molecular Medicine Reports 16, no. 6 (2017): 9337-9346. https://doi.org/10.3892/mmr.2017.7830
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team