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Review

Apolipoprotein status in type 2 diabetes mellitus and its complications (Review)

  • Authors:
    • Puhong Zhang
    • Jialin Gao
    • Chun Pu
    • Yao Zhang
  • View Affiliations / Copyright

    Affiliations: Anhui Province Key Laboratory of Biological Macromolecules Research, Wannan Medical College, Wuhu, Anhui 241002, P.R. China, Department of Endocrinology and Genetic Metabolism, Yijishan Hospital of Wannan Medical College, Wuhu, Anhui 241002, P.R. China, Clinical Laboratory, Yijishan Hospital of Wannan Medical College, Wuhu, Anhui 241002, P.R. China
  • Pages: 9279-9286
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    Published online on: October 19, 2017
       https://doi.org/10.3892/mmr.2017.7831
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Abstract

Dyslipidaemia in type 2 diabetes mellitus (T2DM) is characterized by high plasma triglyceride concentrations, reduced high‑density lipoprotein concentrations and increased small density low‑density lipoprotein concentrations. Dyslipidaemia may lead to cardiovascular disease (CVD) and other complications. Apolipoproteins mainly comprise six species, apolipoprotein (apo)A, apoB, apoC, apoD, apoE and apoM, which are important components of plasma lipoproteins that carry lipids and stabilize the structure of lipoproteins. Complex metabolic disorders of apolipoproteins are present in T2DM, such as high plasma apoB, apoC‑II, apoC‑III and apoE concentrations, and low plasma apoA‑I and apoM concentrations, which are associated with dyslipidaemia and interrelated complications. Plasma concentrations of some apolipoproteins are also altered in T2DM with CVD or other complications. Several apolipoprotein polymorphisms are associated with diabetes susceptibility and/or lipid metabolism. The present review described the metabolic disorders of apolipoproteins in T2DM and its complications, and the relationship between each major apolipoprotein and T2DM, as well as the effects of apolipoprotein polymorphisms on diabetic susceptibility.
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Copy and paste a formatted citation
Spandidos Publications style
Zhang P, Gao J, Pu C and Zhang Y: Apolipoprotein status in type 2 diabetes mellitus and its complications (Review). Mol Med Rep 16: 9279-9286, 2017.
APA
Zhang, P., Gao, J., Pu, C., & Zhang, Y. (2017). Apolipoprotein status in type 2 diabetes mellitus and its complications (Review). Molecular Medicine Reports, 16, 9279-9286. https://doi.org/10.3892/mmr.2017.7831
MLA
Zhang, P., Gao, J., Pu, C., Zhang, Y."Apolipoprotein status in type 2 diabetes mellitus and its complications (Review)". Molecular Medicine Reports 16.6 (2017): 9279-9286.
Chicago
Zhang, P., Gao, J., Pu, C., Zhang, Y."Apolipoprotein status in type 2 diabetes mellitus and its complications (Review)". Molecular Medicine Reports 16, no. 6 (2017): 9279-9286. https://doi.org/10.3892/mmr.2017.7831
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang P, Gao J, Pu C and Zhang Y: Apolipoprotein status in type 2 diabetes mellitus and its complications (Review). Mol Med Rep 16: 9279-9286, 2017.
APA
Zhang, P., Gao, J., Pu, C., & Zhang, Y. (2017). Apolipoprotein status in type 2 diabetes mellitus and its complications (Review). Molecular Medicine Reports, 16, 9279-9286. https://doi.org/10.3892/mmr.2017.7831
MLA
Zhang, P., Gao, J., Pu, C., Zhang, Y."Apolipoprotein status in type 2 diabetes mellitus and its complications (Review)". Molecular Medicine Reports 16.6 (2017): 9279-9286.
Chicago
Zhang, P., Gao, J., Pu, C., Zhang, Y."Apolipoprotein status in type 2 diabetes mellitus and its complications (Review)". Molecular Medicine Reports 16, no. 6 (2017): 9279-9286. https://doi.org/10.3892/mmr.2017.7831
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