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Article

Effect of Wnt1 and Wnt5a on the development of dopaminergic neurons, and toxicity induced by combined exposure to paraquat and maneb during gestation and lactation

  • Authors:
    • Jing Ma
    • Cui Huang
    • Kun Ma
    • Yan‑Ping Wu
    • Bai‑Xiang Li
    • Yan Sun
  • View Affiliations / Copyright

    Affiliations: Department of Toxicology, School of Public Health, Harbin Medical University, Harbin, Heilongjiang 150081, P.R. China
  • Pages: 9721-9728
    |
    Published online on: October 19, 2017
       https://doi.org/10.3892/mmr.2017.7833
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Abstract

Paraquat (PQ) and maneb (MB) are widely used herbicides. Wingless (Wnt) proteins serve a role in the development and differentiation of dopaminergic neurons. Previous studies demonstrated that combined exposure to PQ and MB damages dopaminergic neurons in the midbrain. Effects of PQ and MB exposure on midbrain Wnt proteins have also been previously reported. In the present study, from the 5th day of gestation to weaning of the offspring, pregnant Sprague‑Dawley rats were administrated saline, or PQ and MB at two different doses: high, 15 mg/kg body weight PQ + 45 mg/kg body weight MB; or low, 10 mg/kg body weight PQ + 30 mg/kg body weight MB. Dopamine content in the striatum was examined by high performance liquid chromatography with a fluorescence detector and mRNA and protein expression of Wnt1, Wnt5a, nuclear receptor related factor 1 (Nurr1) and tyrosine hydroxylase (TH) in the midbrain was examined by reverse transcription‑quantitative polymerase chain reaction and western blotting. Combined exposure to PQ and MB during development decreased mRNA and protein expression of Wnt1, TH and Nurr1 and increased expression of Wnt5a in the offspring.
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1 

Hauser RA, Heritier S, Rowse GJ, Hewitt LA and Isaacson SH: Droxidopa and reduced falls in a trial of parkinson disease patients with neurogenic orthostatic hypotension. Clin Neuropharmacol. 39:220–226. 2016. View Article : Google Scholar : PubMed/NCBI

2 

Goldman JG: Neuropsychiatric issues in Parkinson disease. Continuum. 22:1086–1103. 2016.PubMed/NCBI

3 

Savica R, Grossardt BR, Bower JH, Ahlskog JE and Rocca WA: Time trends in the incidence of parkinson disease. JAMA Neurol. 73:981–989. 2016. View Article : Google Scholar : PubMed/NCBI

4 

Pathak K and Akhtar N: Nose to brain delivery of nanoformulations for neurotherapeutics in parkinson's disease: Defining the preclinical, clinical and toxicity issues. Curr Drug Deliv. 2016. View Article : Google Scholar : PubMed/NCBI

5 

Ritz B and Yu F: Parkinson's disease mortality and pesticide exposure in California 1984–1994. Int J Epidemiol. 29:323–329. 2000. View Article : Google Scholar : PubMed/NCBI

6 

Shimizu K, Matsubara K, Ohtaki K and Shiono H: Paraquat leads to dopaminergic neural vulnerability in organotypic midbrain culture. Neurosci Res. 46:523–532. 2003. View Article : Google Scholar : PubMed/NCBI

7 

Finkbeiner S, Tavazoie SF, Maloratsky A, Jacobs KM, Harris KM and Greenberg ME: CREB: A major mediator of neuronal neurotrophin responses. Neuron. 19:1031–1047. 1997. View Article : Google Scholar : PubMed/NCBI

8 

Thiruchelvam M, Prokopenko O, Cory-Slechta DA, Buckley B and Mirochnitchenko O: Overexpression of superoxide dismutase or glutathione peroxidase protects against the paraquat + maneb-induced Parkinson disease phenotype. J Biol Chem. 280:22530–22539. 2005. View Article : Google Scholar : PubMed/NCBI

9 

Prakash J, Yadav SK, Chouhan S and Singh SP: Neuroprotective role of Withania somnifera root extract in maneb-paraquat induced mouse model of parkinsonism. Neurochem Res. 38:972–980. 2013. View Article : Google Scholar : PubMed/NCBI

10 

Kumari R, Jha RR, Singh MP and Patel DK: Whirling agitated single drop microextraction technique for the simultaneous analysis of paraquat and maneb in tissue samples of treated mice. J Sep Sci. 39:1725–1733. 2016. View Article : Google Scholar : PubMed/NCBI

11 

Caputi FF, Carretta D, Lattanzio F, Palmisano M, Candeletti S and Romualdi P: Proteasome subunit and opioid receptor gene expression down-regulation induced by paraquat and maneb in human neuroblastoma SH-SY5Y cells. Environ Toxicol Pharmacol. 40:895–900. 2015. View Article : Google Scholar : PubMed/NCBI

12 

Ni W, Zeng S, Li W, Chen Y, Zhang S, Tang M, Sun S, Chai R and Li H: Wnt activation followed by Notch inhibition promotes mitotic hair cell regeneration in the postnatal mouse cochlea. Oncotarget. 7:66754–66768. 2016. View Article : Google Scholar : PubMed/NCBI

13 

Kriks S, Shim JW, Piao J, Ganat YM, Wakeman DR, Xie Z, Carrillo-Reid L, Auyeung G, Antonacci C, Buch A, et al: Dopamine neurons derived from human ES cells efficiently engraft in animal models of Parkinson's disease. Nature. 480:547–551. 2011.PubMed/NCBI

14 

Alavian KN, Jeddi S, Naghipour SI, Nabili P, Licznerski P and Tierney TS: The lifelong maintenance of mesencephalic dopaminergic neurons by Nurr1 and engrailed. J Biomed Sci. 21:272014. View Article : Google Scholar : PubMed/NCBI

15 

Kitagawa H, Ray WJ, Glantschnig H, Nantermet PV, Yu Y, Leu CT, Harada S, Kato S and Freedman LP: A regulatory circuit mediating convergence between Nurr1 transcriptional regulation and Wnt signaling. Mol Cell Biol. 27:7486–7496. 2007. View Article : Google Scholar : PubMed/NCBI

16 

Lee PC, Bordelon Y, Bronstein J and Ritz B: Traumatic brain injury, paraquat exposure and their relationship to Parkinson disease. Neurology. 79:2061–2066. 2012. View Article : Google Scholar : PubMed/NCBI

17 

Yuan JS, Reed A, Chen F and Stewart CN Jr: Statistical analysis of real-time PCR data. BMC Bioinformatics. 7:852006. View Article : Google Scholar : PubMed/NCBI

18 

Schober A: Classic toxin-induced animal models of Parkinson's disease: 6-OHDA and MPTP. Cell Tissue Res. 318:215–224. 2004. View Article : Google Scholar : PubMed/NCBI

19 

L'Episcopo F, Tirolo C, Testa N, Caniglia S, Morale MC, Deleidi M, Serapide MF, Pluchino S and Marchetti B: Plasticity of subventricular zone neuroprogenitors in MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) mouse model of Parkinson's disease involves cross talk between inflammatory and Wnt/β-catenin signaling pathways: Functional consequences for neuroprotection and repair. J Neurosci. 32:2062–2085. 2012. View Article : Google Scholar : PubMed/NCBI

20 

Gollamudi S, Johri A, Calingasan NY, Yang L, Elemento O and Beal MF: Concordant signaling pathways produced by pesticide exposure in mice correspond to pathways identified in human Parkinson's disease. PloS One. 7:e361912012. View Article : Google Scholar : PubMed/NCBI

21 

Desplats P, Patel P, Kosberg K, Mante M, Patrick C, Rockenstein E, Fujita M, Hashimoto M and Masliah E: Combined exposure to Maneb and Paraquat alters transcriptional regulation of neurogenesis-related genes in mice models of Parkinson's disease. Mol Neurodegener. 7:492012. View Article : Google Scholar : PubMed/NCBI

22 

Barlow BK, Thiruchelvam MJ, Bennice L, Cory-Slechta DA, Ballatori N and Richfield EK: Increased synaptosomal dopamine content and brain concentration of paraquat produced by selective dithiocarbamates. J Neurochem. 85:1075–1086. 2003. View Article : Google Scholar : PubMed/NCBI

23 

Yan M, Wang X, Zhao L, Chang X and Zhou Z: The effect of Wnt signaling pathway on paraquat induced PC12 cells damage. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 33:806–811. 2015.(In Chinese). PubMed/NCBI

24 

Kumar A, Leinisch F, Kadiiska MB, Corbett J and Mason RP: Formation and implications of alpha-synuclein radical in maneb- and paraquat-induced models of Parkinson's disease. Mol Neurobiol. 53:2983–2994. 2016. View Article : Google Scholar : PubMed/NCBI

25 

Sousa KM, Villaescusa JC, Cajanek L, Ondr JK, Castelo-Branco G, Hofstra W, Bryja V, Palmberg C, Bergman T, Wainwright B, et al: Wnt2 regulates progenitor proliferation in the developing ventral midbrain. J Biol Chem. 285:7246–7253. 2010. View Article : Google Scholar : PubMed/NCBI

26 

Zhang J, Götz S, Weisenhorn DM Vogt, Simeone A, Wurst W and Prakash N: A WNT1-regulated developmental gene cascade prevents dopaminergic neurodegeneration in adult En1(+/-) mice. Neurobiol Dis. 82:32–45. 2015. View Article : Google Scholar : PubMed/NCBI

27 

Barlow BK, Lee DW, Cory-Slechta DA and Opanashuk LA: Modulation of antioxidant defense systems by the environmental pesticide maneb in dopaminergic cells. Neurotoxicology. 26:63–75. 2005. View Article : Google Scholar : PubMed/NCBI

28 

Andersson ER, Prakash N, Cajanek L, Minina E, Bryja V, Bryjova L, Yamaguchi TP, Hall AC, Wurst W and Arenas E: Wnt5a regulates ventral midbrain morphogenesis and the development of A9-A10 dopaminergic cells in vivo. PloS One. 3:e35172008. View Article : Google Scholar : PubMed/NCBI

29 

Andersson ER, Saltó C, Villaescusa JC, Cajanek L, Yang S, Bryjova L, Nagy II, Vainio SJ, Ramirez C, Bryja V and Arenas E: Wnt5a cooperates with canonical Wnts to generate midbrain dopaminergic neurons in vivo and in stem cells. Proc Natl Acad Sci U S A. 110:pp. E602–E610. 2013; View Article : Google Scholar : PubMed/NCBI

30 

Fischer T, Guimera J, Wurst W and Prakash N: Distinct but redundant expression of the Frizzled Wnt receptor genes at signaling centers of the developing mouse brain. Neuroscience. 147:693–711. 2007. View Article : Google Scholar : PubMed/NCBI

31 

Gao H, Sun B, Fu H, Chi X, Wang F, Qi X, Hu J and Shao S: PDIA6 promotes the proliferation of HeLa cells through activating the Wnt/β-catenin signaling pathway. Oncotarget. 7:53289–53298. 2016. View Article : Google Scholar : PubMed/NCBI

32 

Zetterstrom RH, Solomin L, Jansson L, Hoffer BJ, Olson L and Perlmann T: Dopamine neuron agenesis in Nurr1-deficient mice. Science. 276:248–250. 1997. View Article : Google Scholar : PubMed/NCBI

33 

Saucedo-Cardenas O, Quintana-Hau JD, Le WD, Smidt MP, Cox JJ, De Mayo F, Burbach JP and Conneely OM: Nurr1 is essential for the induction of the dopaminergic phenotype and the survival of ventral mesencephalic late dopaminergic precursor neurons. Proc Natl Acad Sci USA. 95:pp. 4013–4018. 1998; View Article : Google Scholar : PubMed/NCBI

34 

Castillo SO, Baffi JS, Palkovits M, Goldstein DS, Kopin IJ, Witta J, Magnuson MA and Nikodem VM: Dopamine biosynthesis is selectively abolished in substantia nigra/ventral tegmental area but not in hypothalamic neurons in mice with targeted disruption of the Nurr1 gene. Mol Cell Neurosci. 11:36–46. 1998. View Article : Google Scholar : PubMed/NCBI

35 

Xiao Q, Castillo SO and Nikodem VM: Distribution of messenger RNAs for the orphan nuclear receptors Nurr1 and Nur77 (NGFI-B) in adult rat brain using in situ hybridization. Neuroscience. 75:221–230. 1996. View Article : Google Scholar : PubMed/NCBI

36 

Hermanson E, Joseph B, Castro D, Lindqvist E, Aarnisalo P, Wallén A, Benoit G, Hengerer B, Olson L and Perlmann T: Nurr1 regulates dopamine synthesis and storage in MN9D dopamine cells. Exp Cell Res. 288:324–34. 2003. View Article : Google Scholar : PubMed/NCBI

37 

Ding Y, Zhang Z, Ma J, Xia H, Wang Y, Liu Y, Ma Q, Sun T and Liu J: Directed differentiation of postnatal hippocampal neural stem cells generates nuclear receptor related1 protein and tyrosine hydroxylaseexpressing cells. Mol Med Rep. 14:1993–1999. 2016. View Article : Google Scholar : PubMed/NCBI

38 

Kim KS, Kim CH, Hwang DY, Seo H, Chung S, Hong SJ, Lim JK, Anderson T and Isacson O: Orphan nuclear receptor Nurr1 directly transactivates the promoter activity of the tyrosine hydroxylase gene in a cell-specific manner. J Neurochem. 85:622–634. 2003. View Article : Google Scholar : PubMed/NCBI

39 

Huang L, Deng M, He Y, Lu S, Liu S and Fang Y: β-asarone increases MEF2D and TH levels and reduces α-synuclein level in 6-OHDA-induced rats via regulating the HSP70/MAPK/MEF2D/Beclin-1 pathway: Chaperone-mediated autophagy activation, macroautophagy inhibition and HSP70 up-expression. Behav Brain Res. 313:370–379. 2016. View Article : Google Scholar : PubMed/NCBI

40 

Medeiros HH, Santana MA, Leite MD, Aquino LA, de Barros MA, Galvão NT, Ladd FV, Cavalcante JC, Costa MS, Cavalcante JS and Nascimento ES Jr: The cytoarchitectonic and TH-immunohistochemical characterization of the dopamine cell groups in the substantia nigra, ventral tegmental area and retrorubral field in a bat (Artibeus planirostris). Neurosci Res. 112:37–46. 2016. View Article : Google Scholar : PubMed/NCBI

41 

Nagatsu T and Nagatsu I: Tyrosine hydroxylase (TH), its cofactor tetrahydrobiopterin (BH4), other catecholamine-related enzymes and their human genes in relation to the drug and gene therapies of Parkinson's disease (PD): Historical overview and future prospects. J Neural Transm (Vienna). 123:1255–1278. 2016. View Article : Google Scholar : PubMed/NCBI

42 

Yu J, Li X, Yang J, Wu Y and Li B: Effects of simazine exposure on neuronal development-related factors in mn9d cells. Med Sci Monit. 22:2831–2838. 2016. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Ma J, Huang C, Ma K, Wu YP, Li BX and Sun Y: Effect of Wnt1 and Wnt5a on the development of dopaminergic neurons, and toxicity induced by combined exposure to paraquat and maneb during gestation and lactation. Mol Med Rep 16: 9721-9728, 2017.
APA
Ma, J., Huang, C., Ma, K., Wu, Y., Li, B., & Sun, Y. (2017). Effect of Wnt1 and Wnt5a on the development of dopaminergic neurons, and toxicity induced by combined exposure to paraquat and maneb during gestation and lactation. Molecular Medicine Reports, 16, 9721-9728. https://doi.org/10.3892/mmr.2017.7833
MLA
Ma, J., Huang, C., Ma, K., Wu, Y., Li, B., Sun, Y."Effect of Wnt1 and Wnt5a on the development of dopaminergic neurons, and toxicity induced by combined exposure to paraquat and maneb during gestation and lactation". Molecular Medicine Reports 16.6 (2017): 9721-9728.
Chicago
Ma, J., Huang, C., Ma, K., Wu, Y., Li, B., Sun, Y."Effect of Wnt1 and Wnt5a on the development of dopaminergic neurons, and toxicity induced by combined exposure to paraquat and maneb during gestation and lactation". Molecular Medicine Reports 16, no. 6 (2017): 9721-9728. https://doi.org/10.3892/mmr.2017.7833
Copy and paste a formatted citation
x
Spandidos Publications style
Ma J, Huang C, Ma K, Wu YP, Li BX and Sun Y: Effect of Wnt1 and Wnt5a on the development of dopaminergic neurons, and toxicity induced by combined exposure to paraquat and maneb during gestation and lactation. Mol Med Rep 16: 9721-9728, 2017.
APA
Ma, J., Huang, C., Ma, K., Wu, Y., Li, B., & Sun, Y. (2017). Effect of Wnt1 and Wnt5a on the development of dopaminergic neurons, and toxicity induced by combined exposure to paraquat and maneb during gestation and lactation. Molecular Medicine Reports, 16, 9721-9728. https://doi.org/10.3892/mmr.2017.7833
MLA
Ma, J., Huang, C., Ma, K., Wu, Y., Li, B., Sun, Y."Effect of Wnt1 and Wnt5a on the development of dopaminergic neurons, and toxicity induced by combined exposure to paraquat and maneb during gestation and lactation". Molecular Medicine Reports 16.6 (2017): 9721-9728.
Chicago
Ma, J., Huang, C., Ma, K., Wu, Y., Li, B., Sun, Y."Effect of Wnt1 and Wnt5a on the development of dopaminergic neurons, and toxicity induced by combined exposure to paraquat and maneb during gestation and lactation". Molecular Medicine Reports 16, no. 6 (2017): 9721-9728. https://doi.org/10.3892/mmr.2017.7833
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