Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
March-2018 Volume 17 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
March-2018 Volume 17 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

The role of ursodeoxycholic acid on cholestatic hepatic fibrosis in infant rats

  • Authors:
    • Ning Tang
    • Yaping Zhang
    • Qinghong Liang
    • Zeyu Liu
    • Yingping Shi
  • View Affiliations / Copyright

    Affiliations: Department of Pediatrics, Third Hospital of Hebei Medical University, Shijiazhuang, Hebei 050051, P.R. China, Department of Pathology, Tianjin Nankai Hospital, Tianjin 300100, P.R. China
  • Pages: 3837-3844
    |
    Published online on: December 15, 2017
       https://doi.org/10.3892/mmr.2017.8284
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The aim of the present study was to identify the impact of ursodeoxycholic acid (UDCA) on liver function and fibrosis markers in infant rats by establishing a cholestatic‑induced hepatic fibrosis model. α‑naphthylisothiocyanate (ANIT) was administrated by gavage to induce cholestatic hepatic fibrosis in infant rats. UCDA treatment was performed to assess its impact on biochemical indicators of liver function, four serum biomarkers of hepatic fibrosis, hepatic fibrosis indices in liver tissues and the pathology of liver tissues. Colorimetric assays and biochemical assays based on the initial rate method were performed to determine the levels of liver function markers in the serum, whereas the serum biomarkers of hepatic fibrosis were measured via radioimmunoassay. Sections of liver tissue were harvested and stained with hematoxylin‑eosin or picric acid‑Sirius red, and subjected to immunohistochemical staining to analyze liver pathology. All indicators of liver function, except for cholinesterase, were significantly higher in the ANIT model than in the control group (P<0.01). γ‑glutamyl transpeptidase and total bile acids of the UDCA treatment group were significantly lower than the ANIT model (P<0.05); whereas no significant differences were observed in alanine aminotransferase, aspartate aminotransferase, total bilirubin, direct bilirubin and indirect bilirubin between the two groups. Serum laminin protein (LN) and type‑IV collagen (cIV) in the UDCA treatment group were significantly lower than in the ANIT model (P<0.01); whereas no significant differences were observed in hyaluronic acid and type‑III procollagen between the two groups. Liver LN and cIV in the UDCA treatment group were significantly lower than in the ANIT model (P<0.01). The degree of hepatic fibrosis in the UDCA treatment group was significantly lower than in the ANIT model (P<0.01). The results of the present study demonstrated that UDCA is able to reduce LN and cIV in serum and protect liver tissues against hepatic fibrosis.
View Figures

Figure 1

Figure 2

Figure 3

View References

1 

Fischler B and Lamireau T: Cholestasis in the newborn and infant. Clin Res Hepatol Gastroenterol. 38:263–267. 2014. View Article : Google Scholar : PubMed/NCBI

2 

Catzola A and Vajro P: Management options for cholestatic liver disease in children. Expert Rev Gastroenterol Hepatol. 11:1019–1030. 2017. View Article : Google Scholar : PubMed/NCBI

3 

Hernandez-Gea V and Friedman SL: Pathogenesis of liver fibrosis. Annu Rev Pathol. 6:425–456. 2011. View Article : Google Scholar : PubMed/NCBI

4 

Lindor KD, Gershwin ME, Poupon R, Kaplan M, Bergasa NV and Heathcote EJ; American Association for Study of Liver Diseases, : Primary biliary cirrhosis. Hepatology. 50:291–308. 2009. View Article : Google Scholar : PubMed/NCBI

5 

European Association for the Study of the Liver, . EASL clinical practice guidelines: Management of cholestatic liver diseases. J Hepatol. 51:237–267. 2009. View Article : Google Scholar : PubMed/NCBI

6 

Orso G, Mandato C, Veropalumbo C, Cecchi N, Garzi A and Vajro P: Pediatric parenteral nutrition-associated liver disease and cholestasis: Novel advances in pathomechanisms-based prevention and treatment. Dig Liver Dis. 48:215–222. 2016. View Article : Google Scholar : PubMed/NCBI

7 

Qiu YL, Gong JY, Feng JY, Wang RX, Han J, Liu T, Lu Y, Li LT, Zhang MH, Sheps JA, et al: Defects in myosin VB are associated with a spectrum of previously undiagnosed low γ-glutamyltransferase cholestasis. Hepatology. 65:1655–1669. 2017. View Article : Google Scholar : PubMed/NCBI

8 

Tang N, Zhang Y, Liu Z, Fu T, Liang Q and Ai X: Correlation analysis between four serum biomarkers of liver fibrosis and liver function in infants with cholestasis. Biomed Rep. 5:107–112. 2016. View Article : Google Scholar : PubMed/NCBI

9 

Fang YQ, Lv DX, Jia W, Li J, Deng YQ, Wang Y, Yu M and Wang GQ: Case-control study on prednisolone combined with ursodeoxycholic acid and azathioprine in pure primary biliary cirrhosis with high levels of immunoglobulin G and transaminases: Efficacy and safety analysis. Medicine (Baltimore). 93:e1042014. View Article : Google Scholar : PubMed/NCBI

10 

Rudic JS, Poropat G, Krstic MN, Bjelakovic G and Gluud C: Ursodeoxycholic acid for primary biliary cirrhosis. Cochrane Database Syst Rev. 12:CD0005512012.PubMed/NCBI

11 

Simić D, Milojević I, Bogićević D, Milenović M, Radlović V, Drasković B, Benka AU, Sindjić S and Maksimović R: Preventive effect of ursodeoxycholic acid on parenteral nutrition-associated liver disease in infants. Srp Arh Celok Lek. 142:184–188. 2014. View Article : Google Scholar : PubMed/NCBI

12 

Hatano R, Kawaguchi K, Togashi F, Sugata M, Masuda S and Asano S: Ursodeoxycholic acid ameliorates intrahepatic cholestasis independent of biliary bicarbonate secretion in Vil2kd/kd mice. Biol Pharm Bull. 40:34–42. 2017. View Article : Google Scholar : PubMed/NCBI

13 

Zhou WC, Zhang QB and Qiao L: Pathogenesis of liver cirrhosis. World J Gastroenterol. 20:7312–7324. 2014. View Article : Google Scholar : PubMed/NCBI

14 

Mizuochi T, Kimura A, Suzuki M, Ueki I, Takei H, Nittono H, Kakiuchi T, Shigeta T, Sakamoto S, Fukuda A, et al: Successful heterozygous living donor liver transplantation for an oxysterol 7α-hydroxylase deficiency in a Japanese patient. Liver Transpl. 17:1059–1065. 2011.PubMed/NCBI

15 

Wang L, Wu G, Wu F, Jiang N and Lin Y: Geniposide attenuates ANIT-induced cholestasis through regulation of transporters and enzymes involved in bile acids homeostasis in rats. J Ethnopharmacol. 20:178–185. 2017. View Article : Google Scholar

16 

Tang N, Zhang Y, Liu Z, Ai X and Liang Q: Correlation of four potential biomarkers of liver fibrosis with liver function and grade of hepatic fibrosis in a neonatal cholestatic rat model. Mol Med Rep. 16:415–421. 2017. View Article : Google Scholar : PubMed/NCBI

17 

Knodell RG, Ishak KG, Black WC, Chen TS, Craig R, Kaplowitz N, Kiernan TW and Wollman J: Formulation and application of a numerical scoring system for assessing histological activity in asymptomatic chronic active hepatitis. Hepatology. 1:431–435. 1981. View Article : Google Scholar : PubMed/NCBI

18 

Wang T, Zhou ZX, Sun LX, Li X, Xu ZM, Chen M, Zhao GL, Jiang ZZ and Zhang LY: Resveratrol effectively attenuates α-naphthyl-isothiocyanate-induced acute cholestasis and liver injury through choleretic and anti-inflammatory mechanisms. Acta Pharmacol Sin. 35:1527–1536. 2014. View Article : Google Scholar : PubMed/NCBI

19 

Connolly AK, Price SC, Connelly JC and Hinton RH: Early changes in bile duct lining cells and hepatocytes in rats treated with alpha-naphthylisothiocyanate. Toxicol Appl Pharmacol. 93:208–219. 1988. View Article : Google Scholar : PubMed/NCBI

20 

Kossor DC, Meunier PC, Handler JA, Sozio RS and Goldstein RS: Temporal relationship of changes in hepatobiliary function and morphology in rats following alpha-naphthylisothiocyanate (ANIT) administration. Toxico1 Appl Pharmacol. 119:108–114. 1993. View Article : Google Scholar

21 

Golbar HM, Izawa T, Yano R, Ichikawa C, Sawamoto O, Kuwamura M, Lamarre J and Yamate J: Immunohistochemical characterization of macrophages and myofibroblasts in α-Naphthylisoth-iocyanate (ANIT)-induced bile duct injury and subsequent fibrogenesis in rats. Toxicol Pathol. 39:795–808. 2011. View Article : Google Scholar : PubMed/NCBI

22 

Tarantino G, Finelli C, Colao A, Capone D, Tarantino M, Grimaldi E, Chianese D, Gioia S, Pasanisi F, Contaldo F, et al: Are hepatic steatosis and carotid intima media thickness associated in obese patients with normal or slightly elevated gamma-glutamyl-transferase? J Transl Med. 10:502012. View Article : Google Scholar : PubMed/NCBI

23 

Tavian D, Degiorgio D, Roncaglia N, Vergani P, Cameroni I, Colombo R and Coviello DA: A new splicing site mutation of the ABCB4 gene in intrahepatic cholestasis of pregnancy with raised serum gamma-GT. Dig Liver Dis. 41:671–675. 2009. View Article : Google Scholar : PubMed/NCBI

24 

Lurie Y, Webb M, Cytter-Kuint R, Shteingart S and Lederkremer GZ: Non-invasive diagnosis of liver fibrosis and cirrhosis. World J Gastroenterol. 21:11567–11583. 2015. View Article : Google Scholar : PubMed/NCBI

25 

Matsui S, Yamane T, Takita T, Oishi Y and Kobayashi-Hattori K: The hypocholesterolemic activity of Momordica charantia fruit is mediated by the altered cholesterol- and bile acid-regulating gene expression in rat liver. Nutr Res. 33:580–585. 2013. View Article : Google Scholar : PubMed/NCBI

26 

Soroka CJ, Mennone A, Hagey LR, Ballatori N and Boyer JL: Mouse organic solute transporter alpha deficiency enhances renal excretion of bile acids and attenuates cholestasis. Hepatology. 51:181–190. 2010. View Article : Google Scholar : PubMed/NCBI

27 

Geenes V, Lövgren-Sandblom A, Benthin L, Lawrance D, Chambers J, Gurung V, Thornton J, Chappell L, Khan E, Dixon P, et al: The reversed feto-maternal bile acid gradient in intrahepatic cholestasis of pregnancy is corrected by ursodeoxycholic acid. PLoS One. 9:e838282014. View Article : Google Scholar : PubMed/NCBI

28 

Poupon R: Ursodeoxycholic acid and bile-acid mimetics as therapeutic agents for cholestatic liver diseases: An overview of their mechanisms of action. Clin Res Hepatol Gastroenterol. 36 Suppl 1:S3–S12. 2012. View Article : Google Scholar : PubMed/NCBI

29 

Ozel Coskun BD, Yucesoy M, Gursoy S, Baskol M, Yurci A, Yagbasan A, Doğan S and Baskol G: Effects of ursodeoxycholic acid therapy on carotid intima media thickness, apolipoprotein A1, apolipoprotein B, and apolipoprotein B/A1 ratio in nonalcoholic steatohepatitis. Eur J Gastroenterol Hepatol. 27:142–149. 2015. View Article : Google Scholar : PubMed/NCBI

30 

Kim MD, Kim SS, Cha HY, Jang SH, Chang DY, Kim W, Suh-Kim H and Lee JH: Therapeutic effect of hepatocyte growth factor-secreting mesenchymal stem cells in a rat model of liver fibrosis. Exp Mol Med. 46:e1102014. View Article : Google Scholar : PubMed/NCBI

31 

Friedman SL: Hepatic fibrosis-overview. Toxicology. 254:120–129. 2008. View Article : Google Scholar : PubMed/NCBI

32 

Suk KT, Kim DY, Sohn KM and Kim DJ: Biomarkers of liver fibrosis. Adv Clin Chem. 62:33–122. 2013. View Article : Google Scholar : PubMed/NCBI

33 

El-Mezayen HA, Habib S, Marzok HF and Saad MH: Diagnostic performance of collagen IV and laminin for the prediction of fibrosis and cirrhosis in chronic hepatitis C patients: A multicenter study. Eur J Gastroenterol Hepatol. 27:378–385. 2015. View Article : Google Scholar : PubMed/NCBI

34 

Lee HH, Seo YS, Um SH, Won NH, Yoo H, Jung ES, Kwon YD, Park S, Keum B, Kim YS, et al: Usefulness of non-invasive markers for predicting significant fibrosis in patients with chronic liver disease. J Korean Med Sci. 25:67–74. 2010. View Article : Google Scholar : PubMed/NCBI

35 

El-Shabrawi MH, Zein El Abedin MY, Omar N, Kamal NM, Elmakarem SA, Khattab S, El-Sayed HM, El-Hennawy A and Ali AS: Predictive accuracy of serum hyaluronic acid as a non-invasive marker of fibrosis in a cohort of multi-transfused Egyptian children with β-thalassaemia major. Arab J Gastroenterol. 13:45–48. 2012. View Article : Google Scholar : PubMed/NCBI

36 

Nath NC, Rahman MA, Khan MR, Hasan MS, Bhuiyan TM, Hoque MN, Kabir MM, Raha AK and Jahan B: Serum hyaluronic acid as a predictor of fibrosis in chronic hepatitis B and C virus infection. Mymensingh Med J. 20:614–619. 2011.PubMed/NCBI

37 

Nobili V, Alisi A, Torre G, De Vito R, Pietrobattista A, Morino G, De Ville De Goyet J, Bedogni G and Pinzani M: Hyaluronic acid predicts hepatic fibrosis in children with nonalcoholic fatty liver disease. Transl Res. 156:229–234. 2010. View Article : Google Scholar : PubMed/NCBI

38 

Li ZX, He Y, Wu J, Liang DM, Zhang BL, Yang H, Wang LL, Ma Y and Wei KL: Noninvasive evaluation of hepatic fibrosis in children with infant hepatitis syndrome. World J Gastroenterol. 12:7155–7160. 2006. View Article : Google Scholar : PubMed/NCBI

39 

Paumgartner G and Beuers U: Ursodeoxycholic acid in cholestatic liver disease: Mechanisms of action and therapeutic use revisited. Hepatology. 36:525–531. 2002. View Article : Google Scholar : PubMed/NCBI

40 

Alaca N, Özbeyli D, Uslu S, Şahin HH, Yiğittürk G, Kurtel H, Öktem G and Çağlayan Yeğen B: Treatment with milk thistle extract (Silybum marianum), ursodeoxycholic acid, or their combination attenuates cholestatic liver injury in rats: Role of the hepatic stem cells. Turk J Gastroenterol. 28:476–484. 2017. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Tang N, Zhang Y, Liang Q, Liu Z and Shi Y: The role of ursodeoxycholic acid on cholestatic hepatic fibrosis in infant rats. Mol Med Rep 17: 3837-3844, 2018.
APA
Tang, N., Zhang, Y., Liang, Q., Liu, Z., & Shi, Y. (2018). The role of ursodeoxycholic acid on cholestatic hepatic fibrosis in infant rats. Molecular Medicine Reports, 17, 3837-3844. https://doi.org/10.3892/mmr.2017.8284
MLA
Tang, N., Zhang, Y., Liang, Q., Liu, Z., Shi, Y."The role of ursodeoxycholic acid on cholestatic hepatic fibrosis in infant rats". Molecular Medicine Reports 17.3 (2018): 3837-3844.
Chicago
Tang, N., Zhang, Y., Liang, Q., Liu, Z., Shi, Y."The role of ursodeoxycholic acid on cholestatic hepatic fibrosis in infant rats". Molecular Medicine Reports 17, no. 3 (2018): 3837-3844. https://doi.org/10.3892/mmr.2017.8284
Copy and paste a formatted citation
x
Spandidos Publications style
Tang N, Zhang Y, Liang Q, Liu Z and Shi Y: The role of ursodeoxycholic acid on cholestatic hepatic fibrosis in infant rats. Mol Med Rep 17: 3837-3844, 2018.
APA
Tang, N., Zhang, Y., Liang, Q., Liu, Z., & Shi, Y. (2018). The role of ursodeoxycholic acid on cholestatic hepatic fibrosis in infant rats. Molecular Medicine Reports, 17, 3837-3844. https://doi.org/10.3892/mmr.2017.8284
MLA
Tang, N., Zhang, Y., Liang, Q., Liu, Z., Shi, Y."The role of ursodeoxycholic acid on cholestatic hepatic fibrosis in infant rats". Molecular Medicine Reports 17.3 (2018): 3837-3844.
Chicago
Tang, N., Zhang, Y., Liang, Q., Liu, Z., Shi, Y."The role of ursodeoxycholic acid on cholestatic hepatic fibrosis in infant rats". Molecular Medicine Reports 17, no. 3 (2018): 3837-3844. https://doi.org/10.3892/mmr.2017.8284
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team