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Article Open Access

CXCR7 regulates breast tumor metastasis and angiogenesis in vivo and in vitro

  • Authors:
    • Tingting Qian
    • Yancheng Liu
    • Yan Dong
    • Lei Zhang
    • Yining Dong
    • Yanhui Sun
    • Dongmei Sun
  • View Affiliations / Copyright

    Affiliations: Laboratory Animal Centre, Bengbu Medical College, Bengbu, Anhui 233000, P.R. China, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, P.R. China, College of Biology and Food Engineering, Chuzhou University, Chuzhou, Anhui 239000, P.R. China, School of Life Sciences and Technology, Tongji University, Shanghai 200092, P.R. China
    Copyright: © Qian et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3633-3639
    |
    Published online on: December 15, 2017
       https://doi.org/10.3892/mmr.2017.8286
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Abstract

The chemokine receptor CXCR7 is regarded as a scavenger receptor for CXCL12, and induces numerous key steps in tumor growth and metastasis. However, the exact molecular mechanism of CXCR7 regulation in breast tumor angiogenesis remains unknown. In the present study, the function of CXCR7 in breast tumors was investigated in vitro and in vivo. The breast cancer MDA‑MB‑231 cell line was used. Pharmacological inhibition of CXCR7 by CCX771 reduced breast tumor invasion, adhesion and metastasis. Furthermore, CXCR7 was essential for the tube formation of HUVECs in vitro, and for blood vessel formation in a Matrigel plug assay in vivo. In addition, vascular endothelial growth factor expression was also decreased in CCX771‑treated MDA‑MB‑231 cells, indicating that CCX771 regulates tumor angiogenesis. The present results indicated that CXCR7 regulated breast cancer metastasis at multiple stages; additional understanding of CXCR7 in tumor environments may develop anti‑metastatic therapy.
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Copy and paste a formatted citation
Spandidos Publications style
Qian T, Liu Y, Dong Y, Zhang L, Dong Y, Sun Y and Sun D: CXCR7 regulates breast tumor metastasis and angiogenesis in vivo and in vitro. Mol Med Rep 17: 3633-3639, 2018.
APA
Qian, T., Liu, Y., Dong, Y., Zhang, L., Dong, Y., Sun, Y., & Sun, D. (2018). CXCR7 regulates breast tumor metastasis and angiogenesis in vivo and in vitro. Molecular Medicine Reports, 17, 3633-3639. https://doi.org/10.3892/mmr.2017.8286
MLA
Qian, T., Liu, Y., Dong, Y., Zhang, L., Dong, Y., Sun, Y., Sun, D."CXCR7 regulates breast tumor metastasis and angiogenesis in vivo and in vitro". Molecular Medicine Reports 17.3 (2018): 3633-3639.
Chicago
Qian, T., Liu, Y., Dong, Y., Zhang, L., Dong, Y., Sun, Y., Sun, D."CXCR7 regulates breast tumor metastasis and angiogenesis in vivo and in vitro". Molecular Medicine Reports 17, no. 3 (2018): 3633-3639. https://doi.org/10.3892/mmr.2017.8286
Copy and paste a formatted citation
x
Spandidos Publications style
Qian T, Liu Y, Dong Y, Zhang L, Dong Y, Sun Y and Sun D: CXCR7 regulates breast tumor metastasis and angiogenesis in vivo and in vitro. Mol Med Rep 17: 3633-3639, 2018.
APA
Qian, T., Liu, Y., Dong, Y., Zhang, L., Dong, Y., Sun, Y., & Sun, D. (2018). CXCR7 regulates breast tumor metastasis and angiogenesis in vivo and in vitro. Molecular Medicine Reports, 17, 3633-3639. https://doi.org/10.3892/mmr.2017.8286
MLA
Qian, T., Liu, Y., Dong, Y., Zhang, L., Dong, Y., Sun, Y., Sun, D."CXCR7 regulates breast tumor metastasis and angiogenesis in vivo and in vitro". Molecular Medicine Reports 17.3 (2018): 3633-3639.
Chicago
Qian, T., Liu, Y., Dong, Y., Zhang, L., Dong, Y., Sun, Y., Sun, D."CXCR7 regulates breast tumor metastasis and angiogenesis in vivo and in vitro". Molecular Medicine Reports 17, no. 3 (2018): 3633-3639. https://doi.org/10.3892/mmr.2017.8286
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