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Article

Vildagliptin prevents cognitive deficits and neuronal apoptosis in a rat model of Alzheimer's disease

  • Authors:
    • Qing‑Hua Ma
    • Liu‑Fang Jiang
    • Jian‑Liang Mao
    • Wen‑Xin Xu
    • Min Huang
  • View Affiliations / Copyright

    Affiliations: Department of Preventive Health, The 3rd People's Hospital of Xiangcheng District, Suzhou, Jiangsu 215134, P.R. China, Department of Basic Courses, Computer Teaching and Research Section, Suzhou Vocational Health College, Suzhou, Jiangsu 215009, P.R. China, Department of General Medicine, Suzhou Municipal Hospital, Suzhou, Jiangsu 215001, P.R. China
  • Pages: 4113-4119
    |
    Published online on: December 18, 2017
       https://doi.org/10.3892/mmr.2017.8289
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Abstract

Diabetes has been identified to be a risk factor for Alzheimer's disease (AD). Vildagliptin, a novel oral hypoglycemic agent, has been demonstrated to exert protective effects on the pancreas and cardiovascular system. The present study examined the potential protective effects of vildagliptin on neurons in an AD rat model. Treatment with vildagliptin improved memory deficits and decreased neuronal apoptosis in the hippocampus. The expression levels of B cell lymphoma 2 (Bcl‑2) were increased, and the expression levels of caspase‑3, Bcl‑2 associated X protein and AD‑associated proteins were decreased in the hippocampus following treatment with vildagliptin. Additionally, the AD model‑induced decrease in phosphorylated (p) protein kinase B (p‑Akt), p‑glycogen synthase kinase 3β (p‑GSK3β), post‑synaptic density 95 and synaptophysin expression was reversed. These results indicate that vildagliptin administration exerts a protective effect against cognitive deficits by reducing tau phosphorylation and increasing the expression of proteins associated with synaptic plasticity in the hippocampus. Targeting of the Akt/GSK3β signaling pathway may be a key mechanism in preventing the disease progression of AD.
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Copy and paste a formatted citation
Spandidos Publications style
Ma QH, Jiang LF, Mao JL, Xu WX and Huang M: Vildagliptin prevents cognitive deficits and neuronal apoptosis in a rat model of Alzheimer's disease. Mol Med Rep 17: 4113-4119, 2018.
APA
Ma, Q., Jiang, L., Mao, J., Xu, W., & Huang, M. (2018). Vildagliptin prevents cognitive deficits and neuronal apoptosis in a rat model of Alzheimer's disease. Molecular Medicine Reports, 17, 4113-4119. https://doi.org/10.3892/mmr.2017.8289
MLA
Ma, Q., Jiang, L., Mao, J., Xu, W., Huang, M."Vildagliptin prevents cognitive deficits and neuronal apoptosis in a rat model of Alzheimer's disease". Molecular Medicine Reports 17.3 (2018): 4113-4119.
Chicago
Ma, Q., Jiang, L., Mao, J., Xu, W., Huang, M."Vildagliptin prevents cognitive deficits and neuronal apoptosis in a rat model of Alzheimer's disease". Molecular Medicine Reports 17, no. 3 (2018): 4113-4119. https://doi.org/10.3892/mmr.2017.8289
Copy and paste a formatted citation
x
Spandidos Publications style
Ma QH, Jiang LF, Mao JL, Xu WX and Huang M: Vildagliptin prevents cognitive deficits and neuronal apoptosis in a rat model of Alzheimer's disease. Mol Med Rep 17: 4113-4119, 2018.
APA
Ma, Q., Jiang, L., Mao, J., Xu, W., & Huang, M. (2018). Vildagliptin prevents cognitive deficits and neuronal apoptosis in a rat model of Alzheimer's disease. Molecular Medicine Reports, 17, 4113-4119. https://doi.org/10.3892/mmr.2017.8289
MLA
Ma, Q., Jiang, L., Mao, J., Xu, W., Huang, M."Vildagliptin prevents cognitive deficits and neuronal apoptosis in a rat model of Alzheimer's disease". Molecular Medicine Reports 17.3 (2018): 4113-4119.
Chicago
Ma, Q., Jiang, L., Mao, J., Xu, W., Huang, M."Vildagliptin prevents cognitive deficits and neuronal apoptosis in a rat model of Alzheimer's disease". Molecular Medicine Reports 17, no. 3 (2018): 4113-4119. https://doi.org/10.3892/mmr.2017.8289
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