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Role of protein delta homolog 1 in the proliferation and differentiation of ameloblasts

  • Authors:
    • Shengcai Qi
    • Xueqin Zhu
    • Xiaoning Wang
    • Fubo Chen
    • Yanhong Yan
    • Guangwei Shang
    • Wantao Chen
  • View Affiliations / Copyright

    Affiliations: Department of Oral and Maxillofacial‑Head and Neck Oncology, and Faculty of Oral and Maxillofacial Surgery, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, P.R. China, Department of Stomatology, Shanghai Tenth People's Hospital, Tongji University, Shanghai 200072, P.R. China, Department of Pediatric Dentistry, School and Hospital of Stomatology, Tongji University, Shanghai Engineering Research Center of Tooth Restoration and Regeneration, Shanghai 200072, P.R. China
    Copyright: © Qi et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3537-3544
    |
    Published online on: December 18, 2017
       https://doi.org/10.3892/mmr.2017.8290
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Abstract

Protein delta homolog 1 (DLK1) regulates the odontoblastic differentiation of human dental pulp stem cells. It was hypothesized that DLK1 may exert regulatory effects on epithelial‑mesenchymal interactions in tooth development. The present study investigated the expression of DLK1 during the development of mouse enamel and its role in the proliferation and differentiation of ameloblast‑lineage cells (ALCs). DLK1 expression was upregulated in ameloblasts in the first mandibular molar during the entire process of enamel development. The mRNA and protein levels of DLK1 were significantly upregulated following ameloblastic induction in ALCs. In addition, overexpression of DLK1 promoted the proliferation of ALCs, inhibited ameloblastic differentiation, upregulated the expression of amelogenin and enamelin, and downregulated the expression of odontogenic ameloblast‑associated protein and kallikrein 4. The results of the present study suggested that DLK1 may be a potent regulator of ameloblast proliferation and differentiation, and may regulate enamel formation during tooth development.
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Copy and paste a formatted citation
Spandidos Publications style
Qi S, Zhu X, Wang X, Chen F, Yan Y, Shang G and Chen W: Role of protein delta homolog 1 in the proliferation and differentiation of ameloblasts. Mol Med Rep 17: 3537-3544, 2018.
APA
Qi, S., Zhu, X., Wang, X., Chen, F., Yan, Y., Shang, G., & Chen, W. (2018). Role of protein delta homolog 1 in the proliferation and differentiation of ameloblasts. Molecular Medicine Reports, 17, 3537-3544. https://doi.org/10.3892/mmr.2017.8290
MLA
Qi, S., Zhu, X., Wang, X., Chen, F., Yan, Y., Shang, G., Chen, W."Role of protein delta homolog 1 in the proliferation and differentiation of ameloblasts". Molecular Medicine Reports 17.3 (2018): 3537-3544.
Chicago
Qi, S., Zhu, X., Wang, X., Chen, F., Yan, Y., Shang, G., Chen, W."Role of protein delta homolog 1 in the proliferation and differentiation of ameloblasts". Molecular Medicine Reports 17, no. 3 (2018): 3537-3544. https://doi.org/10.3892/mmr.2017.8290
Copy and paste a formatted citation
x
Spandidos Publications style
Qi S, Zhu X, Wang X, Chen F, Yan Y, Shang G and Chen W: Role of protein delta homolog 1 in the proliferation and differentiation of ameloblasts. Mol Med Rep 17: 3537-3544, 2018.
APA
Qi, S., Zhu, X., Wang, X., Chen, F., Yan, Y., Shang, G., & Chen, W. (2018). Role of protein delta homolog 1 in the proliferation and differentiation of ameloblasts. Molecular Medicine Reports, 17, 3537-3544. https://doi.org/10.3892/mmr.2017.8290
MLA
Qi, S., Zhu, X., Wang, X., Chen, F., Yan, Y., Shang, G., Chen, W."Role of protein delta homolog 1 in the proliferation and differentiation of ameloblasts". Molecular Medicine Reports 17.3 (2018): 3537-3544.
Chicago
Qi, S., Zhu, X., Wang, X., Chen, F., Yan, Y., Shang, G., Chen, W."Role of protein delta homolog 1 in the proliferation and differentiation of ameloblasts". Molecular Medicine Reports 17, no. 3 (2018): 3537-3544. https://doi.org/10.3892/mmr.2017.8290
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