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Article

Resveratrol alleviates lysophosphatidylcholine-induced damage and inflammation in vascular endothelial cells

  • Authors:
    • Jinsong Chen
    • Xiaocheng Cao
    • Yonghong Cui
    • Gaofeng Zeng
    • Jiaxian Chen
    • Guogang Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Cardiovascular Medicine, Xiangya Hospital, Central South University, Kaifu, Changsha, Hunan 410008, P.R. China, Laboratory of Medicine, Medical College, Hunan Normal University, Changsha, Hunan 410016, P.R. China, Department of Cardiovascular Medicine, The Second Affiliated Hospital of South China University, Hengyang, Hunan 421001, P.R. China
  • Pages: 4011-4018
    |
    Published online on: December 18, 2017
       https://doi.org/10.3892/mmr.2017.8300
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Abstract

The role of resveratrol (trans-3,5,4'-trihydroxystilbene; RES) in lysophosphatidylcholine (LPC)‑induced injury and inflammation in endothelial cells (regarded as an early event in arteriosclerosis) is unclear. The present study investigated whether RES reduces lactate dehydrogenase (LDH) activity and secretion of inflammatory cytokines such asinterleukin‑6 and tumor necrosis factor‑α, via the Toll‑like receptor (TLR)‑4/myeloid differentiation primary response gene 88 (MyD88)/nuclear factor (NF)‑κB signal transduction pathway in LPC‑induced damage and inflammation in human umbilical vein endothelial‑12 (HUVE‑12) cells. Using an ELISA and western blotting, the present study investigated the effects of RES on LDH activity and cytokine secretion. The effects of TLR‑4 short hairpin (sh)RNA and TLR‑4 cDNA transfection on NF‑κB activation during LPC‑induced damage and inflammation was also investigated in HUVE‑12 cells. The results demonstrated that RES significantly inhibited the effect of LPC on enzyme activity, pro‑inflammatory cytokine secretion, and expression of TLR‑4, MyD88 and NF‑κBp65 expression. In addition, RES and TLR‑4 shRNA transfection suppressed LPC‑induced injury and inflammation by blocking the TLR‑4/MyD88/NF‑κB signaling pathway Conversely, transfection with TLR‑4 cDNA enhanced LPC‑induced injury and inflammation, which abrogated the protective effects of RES. These data suggested that RES significantly suppressed LPC‑induced damage and inflammation, via suppression of the TLR‑4/MyD88/NF‑κB signaling pathway, which may provide a new mechanistic evidence for the treatment of arteriosclerosis by RES.
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1 

Domeij H, Hua X, Su J, Bäcklund A, Yan Z, Frostegard AG, Haeggström JZ, Modéer T and Frostegard J: Annexin A5 inhibits atherogenic and pro-inflammatory effects of lysophosphatidylcholine. Prostaglandins Other Lipid Mediat. 106:72–78. 2013. View Article : Google Scholar : PubMed/NCBI

2 

Sheldon IM, Cronin JG, Healey GD, Gabler C, Heuwieser W, Streyl D, Bromfield JJ, Miyamoto A, Fergani C and Dobson H: Innate immunity and inflammation of the bovine female reproductive tract in health and disease. Reproduction. 148:R41–R51. 2014. View Article : Google Scholar : PubMed/NCBI

3 

Gao W, Zhou Y, Li Q, Zhou Q, Tan L, Song Y, Zhao X, Yu M, Zheng S, Ye H, et al: Analysis of global gene expression profiles suggests a role of acute inflammation in type 3C diabetes mellitus caused by pancreatic ductal adenocarcinoma. Diabetologia. 58:835–844. 2015. View Article : Google Scholar : PubMed/NCBI

4 

Coussens LM and Werb Z: Inflammation and cancer. Nature. 420:860–867. 2002. View Article : Google Scholar : PubMed/NCBI

5 

Strowig T, Henao-Mejia J, Elinav E and Flavell R: Inflammasomes in health and disease. Nature. 481:278–286. 2012. View Article : Google Scholar : PubMed/NCBI

6 

Bradamante S, Barenghi L and Villa A: Cardiovascular protective effects of resveratrol. Cardiovasc Drug Rev. 22:169–188. 2004. View Article : Google Scholar : PubMed/NCBI

7 

Libby P, Ridker PM and Maseri A: Inflammation and atherosclerosis. Circulation. 105:1135–1143. 2002. View Article : Google Scholar : PubMed/NCBI

8 

Kim D, Nguyen MD, Dobbin MM, Fischer A, Sananbenesi F, Rodgers JT, Delalle I, Baur JA, Sui G, Armour SM, et al: SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis. EMBO J. 26:3169–3179. 2007. View Article : Google Scholar : PubMed/NCBI

9 

Youn HS, Lee JY, Fitzgerald KA, Young HA, Akira S and Hwang DH: Specific inhibition of MyD88-independent signaling pathways of TLR3 and TLR4 by resveratrol: Molecular targets are TBK1 and RIP1 in TRIF complex. J Immunol. 175:3339–3346. 2005. View Article : Google Scholar : PubMed/NCBI

10 

Apetoh L, Ghiringhelli F, Tesniere A, Obeid M, Ortiz C, Criollo A, Mignot G, Maiuri MC, Ullrich E, Saulnier P, et al: Toll-like receptor 4-dependent contribution of the immune system to anticancer chemotherapy and radiotherapy. Nat Med. 13:1050–1059. 2007. View Article : Google Scholar : PubMed/NCBI

11 

Huang RL, Yuan Y, Zou GM, Liu G, Tu J and Li Q: LPS-stimulated inflammatory environment inhibits BMP-2-induced osteoblastic differentiation through crosstalk between TLR4/MyD88/NF-kB and BMP/Smad signaling. Stem Cells Dev. 23:277–289. 2014. View Article : Google Scholar : PubMed/NCBI

12 

Augoff K, Hryniewicz-Jankowska A and Tabola R: Lactate dehydrogenase 5: An old friend and a new hope in the war on cancer. Cancer Lett. 358:1–7. 2015. View Article : Google Scholar : PubMed/NCBI

13 

Aiyar N, Disa J, Ao Z, Ju H, Nerurkar S, Willette RN, Macphee CH, Johns DG and Douglas SA: Lysophosphatidylcholine induces inflammatory activation of human coronary artery smooth muscle cells. Mol Cell Biochem. 295:113–120. 2007. View Article : Google Scholar : PubMed/NCBI

14 

Qin X, Qiu C and Zhao L: Lysophosphatidylcholine perpetuates macrophage polarization toward classically activated phenotype in inflammation. Cell Immunol. 289:185–190. 2014. View Article : Google Scholar : PubMed/NCBI

15 

Li JZ, Wu JH, Yu SY, Shao QR and Dong XM: Inhibitory effects of paeoniflorin on lysophosphatidylcholine-induced inflammatory factor production in human umbilical vein endothelial cells. Int J Mol Med. 31:493–497. 2013. View Article : Google Scholar : PubMed/NCBI

16 

Tsou TC, Liou SH, Yeh SC, Tsai FY and Chao HR: Crucial role of Toll-like receptors in the zinc/nickel-induced inflammatory response in vascular endothelial cells. Toxicol Appl Pharmacol. 273:492–499. 2013. View Article : Google Scholar : PubMed/NCBI

17 

Wang Y, Tu Q, Yan W, Xiao D, Zeng Z, Ouyang Y, Huang L, Cai J, Zeng X, Chen YJ and Liu A: CXC195 suppresses proliferation and inflammatory response in LPS-induced human hepatocellular carcinoma cells via regulating TLR4-MyD88-TAK1-mediated NF-kB and MAPK pathway. Biochem Biophys Res Commun. 456:373–379. 2015. View Article : Google Scholar : PubMed/NCBI

18 

Bomfim GF, Echem C, Martins CB, Costa TJ, Sartoretto SM, Dos Santos RA, Oliveira MA, Akamine EH, Fortes ZB, Tostes RC, et al: Toll-like receptor 4 inhibition reduces vascular inflammation in spontaneously hypertensive rats. Life Sci. 122:1–7. 2015. View Article : Google Scholar : PubMed/NCBI

19 

Bucci M, Vellecco V, Harrington L, Brancaleone V, Roviezzo F, Mattace Raso G, Ianaro A, Lungarella G, De Palma R, Meli R and Cirino G: Cross-talk between Toll-like receptor 4 (TLR4) and proteinase-activated receptor 2 (PAR (2)) is involved in vascular function. Br J Pharmacol. 168:411–420. 2013. View Article : Google Scholar : PubMed/NCBI

20 

Riccioni G, Gammone MA, Tettamanti G, Bergante S, Pluchinotta FR and D'Orazio N: Resveratrol and anti-atherogenic effects. Int J Food Sci Nutr. 66:603–610. 2015. View Article : Google Scholar : PubMed/NCBI

21 

Zhang C, Lin G, Wan W, Li X, Zeng B, Yang B and Huang C: Resveratrol, a polyphenol phytoalexin, protects cardiomyocytes against anoxia/reoxygenation injury via the TLR4/NF-κB signaling pathway. Int J Mol Med. 29:557–563. 2012. View Article : Google Scholar : PubMed/NCBI

22 

Li J, Xie C, Zhuang J, Li H, Yao Y, Shao C and Wang H: Resveratrol attenuates inflammation in the rat heart subjected to ischemia-reperfusion: Role of the TLR4/NF-κB signaling pathway. Mol Med Rep. 11:1120–1126. 2015.PubMed/NCBI

23 

Feng Y and Longmore GD: The LIM protein Ajuba influences interleukin-1-induced NF-kappaB activation by affecting the assembly and activity of the protein kinase Czeta/p62/TRAF6 signaling complex. Mol Cell Biol. 25:4010–4022. 2005. View Article : Google Scholar : PubMed/NCBI

24 

Deng YH, Alex D, Huang HQ, Wang N, Yu N, Wang YT, Leung GP and Lee SM: Inhibition of TNF-α-mediated endothelial cell-monocyte cell adhesion and adhesion molecules expression by the resveratrol derivative, trans-3,5,4′-trimethoxystilbene. Phytother Res. 25:451–457. 2011.PubMed/NCBI

25 

Bonnefont-Rousselot D: Resveratrol and cardiovascular diseases. Nutrients. 8:2502016. View Article : Google Scholar :

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Copy and paste a formatted citation
Spandidos Publications style
Chen J, Cao X, Cui Y, Zeng G, Chen J and Zhang G: Resveratrol alleviates lysophosphatidylcholine-induced damage and inflammation in vascular endothelial cells. Mol Med Rep 17: 4011-4018, 2018.
APA
Chen, J., Cao, X., Cui, Y., Zeng, G., Chen, J., & Zhang, G. (2018). Resveratrol alleviates lysophosphatidylcholine-induced damage and inflammation in vascular endothelial cells. Molecular Medicine Reports, 17, 4011-4018. https://doi.org/10.3892/mmr.2017.8300
MLA
Chen, J., Cao, X., Cui, Y., Zeng, G., Chen, J., Zhang, G."Resveratrol alleviates lysophosphatidylcholine-induced damage and inflammation in vascular endothelial cells". Molecular Medicine Reports 17.3 (2018): 4011-4018.
Chicago
Chen, J., Cao, X., Cui, Y., Zeng, G., Chen, J., Zhang, G."Resveratrol alleviates lysophosphatidylcholine-induced damage and inflammation in vascular endothelial cells". Molecular Medicine Reports 17, no. 3 (2018): 4011-4018. https://doi.org/10.3892/mmr.2017.8300
Copy and paste a formatted citation
x
Spandidos Publications style
Chen J, Cao X, Cui Y, Zeng G, Chen J and Zhang G: Resveratrol alleviates lysophosphatidylcholine-induced damage and inflammation in vascular endothelial cells. Mol Med Rep 17: 4011-4018, 2018.
APA
Chen, J., Cao, X., Cui, Y., Zeng, G., Chen, J., & Zhang, G. (2018). Resveratrol alleviates lysophosphatidylcholine-induced damage and inflammation in vascular endothelial cells. Molecular Medicine Reports, 17, 4011-4018. https://doi.org/10.3892/mmr.2017.8300
MLA
Chen, J., Cao, X., Cui, Y., Zeng, G., Chen, J., Zhang, G."Resveratrol alleviates lysophosphatidylcholine-induced damage and inflammation in vascular endothelial cells". Molecular Medicine Reports 17.3 (2018): 4011-4018.
Chicago
Chen, J., Cao, X., Cui, Y., Zeng, G., Chen, J., Zhang, G."Resveratrol alleviates lysophosphatidylcholine-induced damage and inflammation in vascular endothelial cells". Molecular Medicine Reports 17, no. 3 (2018): 4011-4018. https://doi.org/10.3892/mmr.2017.8300
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