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Article

Suppression of human breast cancer cells by tectorigenin through downregulation of matrix metalloproteinases and MAPK signaling in vitro

  • Authors:
    • Linwen Zeng
    • Shaofeng Yuan
    • Jianliang Shen
    • Ming Wu
    • Liangming Pan
    • Xiangdong Kong
  • View Affiliations / Copyright

    Affiliations: Department of Surgery, Tinglin Hospital of Jinshan District, Shanghai 201505, P.R. China
  • Pages: 3935-3943
    |
    Published online on: December 19, 2017
       https://doi.org/10.3892/mmr.2017.8313
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Abstract

Breast cancer is a major life‑threatening malignancy and is the second highest cause of mortality. The aim of the present study was to investigate the effects of tectorigenin (Tec), a Traditional Chinese Medicine, against human breast cancer cells in vitro. MDA‑MB‑231 and MCF‑7 human breast cancer cells were treated with various concentrations of Tec. Cell proliferation was evaluated using the Cell Counting kit‑8 assay, and apoptosis and the cell cycle were examined by flow cytometry. The migratory and invasive abilities of these cells were detected by Transwell and Matrigel assays, respectively. Metastasis‑, apoptosis‑ and survival‑related gene expression levels were measured by reverse transcription‑quantitative polymerase chain reaction and western blotting. The results indicated that Tec was able to inhibit the proliferation of MDA‑MB‑231 and MCF‑7 cells in a dose‑ and time‑dependent manner. Furthermore, Tec treatment induced apoptosis and G0/G1‑phase arrest, and inhibited cell migration and invasion. Tec treatment decreased the expression of matrix metalloproteinase (MMP)‑2, MMP9, BCL‑2, phosphorylated‑AKT and components of the mitogen‑activated protein kinase (MAPK) signaling pathway, and increased the expression of BCL‑2‑associated X, cleaved poly [ADP‑ribose] polymerase and cleaved caspase‑3. In conclusion, Tec treatment suppressed human breast cancer cells through the downregulation of AKT and MAPK signaling and the upregulated expression and/or activity of the caspase family in vitro. Therefore, Tec may be a potential therapeutic drug to treat human breast cancer.
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View References

1 

Kwak JH, Park JY, Lee D, Kwak JY, Park EH, Kim KH, Park HJ, Kim HY, Jang HJ, Ham J, et al: Inhibitory effects of ginseng sapogenins on the proliferation of triple negative breast cancer MDA-MB-231 cells. Bioorg Med Chem Lett. 24:5409–5412. 2014. View Article : Google Scholar : PubMed/NCBI

2 

Wang P, Du X, Xiong M, Cui J, Yang Q, Wang W, Chen Y and Zhang T: Ginsenoside Rd attenuates breast cancer metastasis implicating derepressing microRNA-18a-regulated Smad2 expression. Sci Rep. 6:337092016. View Article : Google Scholar : PubMed/NCBI

3 

Jia Y, Wang X, Liu Q, Leung AW, Wang P and Xu C: Sonodynamic action of hypocrellin B triggers cell apoptosis of breast cancer cells involving caspase pathway. Ultrasonics. 73:154–161. 2017. View Article : Google Scholar : PubMed/NCBI

4 

Qiao H, Wang TY, Yan W, Qin A, Fan QM, Han XG, Wang YG and Tang TT: Synergistic suppression of human breast cancer cells by combination of plumbagin and zoledronic acid in vitro. Acta Pharmacol Sin. 36:1085–1098. 2015. View Article : Google Scholar : PubMed/NCBI

5 

He J, Du L, Bao M, Zhang B, Qian H, Zhou Q and Cao Z: Oroxin A inhibits breast cancer cell growth by inducing robust endoplasmic reticulum stress and senescence. Anti-cancer Drugs. 27:204–215. 2016. View Article : Google Scholar : PubMed/NCBI

6 

Liedtke C, Mazouni C, Hess KR, André F, Tordai A, Mejia JA, Symmans WF, Gonzalez-Angulo AM, Hennessy B, Green M, et al: Response to neoadjuvant therapy and long-term survival in patients with triple-negative breast cancer. J Clin Oncol. 26:1275–1281. 2008. View Article : Google Scholar : PubMed/NCBI

7 

Qu Z, Cui J, Harata-Lee Y, Aung TN, Feng Q, Raison JM, Kortschak RD and Adelson DL: Identification of candidate anti-cancer molecular mechanisms of compound kushen injection using functional genomics. Oncotarget. 7:66003–66019. 2016. View Article : Google Scholar : PubMed/NCBI

8 

Zhang Y, He L, Yue S, Huang Q, Zhang Y and Yang J: Characterization and evaluation of a self-microemulsifying drug delivery system containing tectorigenin, an isoflavone with low aqueous solubility and poor permeability. Drug Deliv. 24:632–640. 2017. View Article : Google Scholar : PubMed/NCBI

9 

Guo Y, Chen YH, Cheng ZH, Ou-Yang HN, Luo C and Guo ZL: Tectorigenin inhibits osteosarcoma cell migration through downregulation of matrix metalloproteinases in vitro. Anticancer Drugs. 27:540–546. 2016. View Article : Google Scholar : PubMed/NCBI

10 

Yang YI, Lee KT, Park HJ, Kim TJ, Choi YS, Shih Ie M and Choi JH: Tectorigenin sensitizes paclitaxel-resistant human ovarian cancer cells through downregulation of the Akt and NFκB pathway. Carcinogenesis. 33:2488–2498. 2012. View Article : Google Scholar : PubMed/NCBI

11 

Amin A, Mokhdomi TA, Bukhari S, Wani SH, Wafai AH, Lone GN, Qadri A and Qadri RA: Tectorigenin ablates the inflammation-induced epithelial-mesenchymal transition in a co-culture model of human lung carcinoma. Pharmacol Rep. 67:382–387. 2015. View Article : Google Scholar : PubMed/NCBI

12 

Jiang CP, Ding H, Shi DH, Wang YR, Li EG and Wu JH: Pro-apoptotic effects of tectorigenin on human hepatocellular carcinoma HepG2 cells. World J Gastroenterol. 18:1753–1764. 2012. View Article : Google Scholar : PubMed/NCBI

13 

Lee KT, Sohn IC, Kim YK, Choi JH, Choi JW, Park HJ, Itoh Y and Miyamoto K: Tectorigenin, an isoflavone of Pueraria thunbergiana Benth., induces differentiation and apoptosis in human promyelocytic leukemia HL-60 cells. Biol Pharm Bull. 24:1117–1121. 2001. View Article : Google Scholar : PubMed/NCBI

14 

Li QY, Chen L, Yan MM, Shi XJ and Zhong MK: Tectorigenin regulates adipogenic differentiation and adipocytokines secretion via PPARγ and IKK/NF-κB signaling. Pharm Biol. 53:1567–1575. 2015. View Article : Google Scholar : PubMed/NCBI

15 

Monthakantirat O, De-Eknamkul W, Umehara K, Yoshinaga Y, Miyase T, Warashina T and Noguchi H: Phenolic constituents of the rhizomes of the Thai medicinal plant Belamcanda chinensis with proliferative activity for two breast cancer cell lines. J Nat Prod. 68:361–364. 2005. View Article : Google Scholar : PubMed/NCBI

16 

Umehara K, Nemoto K, Matsushita A, Terada E, Monthakantirat O, De-Eknamkul W, Miyase T, Warashina T, Degawa M and Noguchi H: Flavonoids from the heartwood of the Thai medicinal plant Dalbergia parviflora and their effects on estrogenic-responsive human breast cancer cells. J Nat Prod. 72:2163–2168. 2009. View Article : Google Scholar : PubMed/NCBI

17 

Han XG, Li Y, Mo HM, Li K, Lin D, Zhao CQ, Zhao J and Tang TT: TIMP3 regulates osteosarcoma cell migration, invasion and chemotherapeutic resistances. Tumour Biol. 37:8857–8867. 2016. View Article : Google Scholar : PubMed/NCBI

18 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

19 

Fang C, Wang FB, Li Y and Zeng XT: Down-regulation of miR-199b-5p is correlated with poor prognosis for breast cancer patients. Biomed Pharmacother. 84:1189–1193. 2016. View Article : Google Scholar : PubMed/NCBI

20 

Chlebowski RT, Pan K and Col NF: Ovarian suppression in combination endocrine adjuvant therapy in premenopausal women with early breast cancer. Breast Cancer Res Treat. 161:185–190. 2017. View Article : Google Scholar : PubMed/NCBI

21 

Kong X, Li Z and Li X: GSTP1, GSTM1 and GSTT1 polymorphisms as predictors of response to chemotherapy in patients with breast cancer: A meta-analysis. Cancer Chemother Pharmacol. 78:1163–1173. 2016. View Article : Google Scholar : PubMed/NCBI

22 

Sun S, Wang F, Dou H, Zhang L and Li J: Preventive effect of zoledronic acid on aromatase inhibitor-associated bone loss for postmenopausal breast cancer patients receiving adjuvant letrozole. Onco Targets Ther. 9:6029–6036. 2016. View Article : Google Scholar : PubMed/NCBI

23 

Meng L, Xu Y, Xu C and Zhang W: Biomarker discovery to improve prediction of breast cancer survival: Using gene expression profiling, meta-analysis and tissue validation. Onco Targets Ther. 9:6177–6185. 2016. View Article : Google Scholar : PubMed/NCBI

24 

Fleisher B, Clarke C and Ait-Oudhia S: Current advances in biomarkers for targeted therapy in triple-negative breast cancer. Breast Cancer (Dove Med Press). 8:183–197. 2016.PubMed/NCBI

25 

Wang X, Xia X, Leung AW, Xiang J, Jiang Y, Wang P, Xu J, Yu H, Bai D and Xu C: Ultrasound induces cellular destruction of nasopharyngeal carcinoma cells in the presence of curcumin. Ultrasonics. 51:165–170. 2011. View Article : Google Scholar : PubMed/NCBI

26 

Tan XL, Guo L and Wang GH: Polyporus umbellatus inhibited tumor cell proliferation and promoted tumor cell apoptosis by down-regulating AKT in breast cancer. Biomed Pharmacother. 83:526–535. 2016. View Article : Google Scholar : PubMed/NCBI

27 

Iwanowycz S, Wang J, Hodge J, Wang Y, Yu F and Fan D: Emodin inhibits breast cancer growth by blocking the tumor-promoting feedforward loop between cancer cells and macrophages. Mol Cancer Ther. 15:1931–1942. 2016. View Article : Google Scholar : PubMed/NCBI

28 

Kapoor S: Tectorigenin and its inhibitory effects on tumor growth in systemic malignancies. Immunopharmacol Immunotoxicol. 35:5332013. View Article : Google Scholar : PubMed/NCBI

29 

Ha le M, Que do TN, Huyen do TT, Long PQ and Dat NT: Toxicity, analgesic and anti-inflammatory activities of tectorigenin. Immunopharmacol Immunotoxicol. 35:336–340. 2013. View Article : Google Scholar : PubMed/NCBI

30 

Thelen P, Scharf JG, Burfeind P, Hemmerlein B, Wuttke W, Spengler B, Christoffel V, Ringert RH and Seidlová-Wuttke D: Tectorigenin and other phytochemicals extracted from leopard lily Belamcanda chinensis affect new and established targets for therapies in prostate cancer. Carcinogenesis. 26:1360–1367. 2005. View Article : Google Scholar : PubMed/NCBI

31 

Ho JY, Hsu RJ, Liu JM, Chen SC, Liao GS, Gao HW and Yu CP: MicroRNA-382-5p aggravates breast cancer progression by regulating the RERG/Ras/ERK signaling axis. Oncotarget. 8:22443–22459. 2017. View Article : Google Scholar : PubMed/NCBI

32 

Wang D, Wu P, Wang H, Zhu L, Zhao W and Lu Y: SIN1 promotes the proliferation and migration of breast cancer cells by Akt activation. Biosci Rep. 36:e004242016. View Article : Google Scholar : PubMed/NCBI

33 

Wang H, Jia XH, Chen JR, Yi YJ, Wang JY, Li YJ and Xie SY: HOXB4 knockdown reverses multidrug resistance of human myelogenous leukemia K562/ADM cells by downregulating P-gp, MRP1 and BCRP expression via PI3K/Akt signaling pathway. Int J Oncol. 49:2529–2537. 2016. View Article : Google Scholar : PubMed/NCBI

34 

Aghazadeh S and Yazdanparast R: Mycophenolic acid potentiates HER2-overexpressing SKBR3 breast cancer cell line to induce apoptosis: Involvement of AKT/FOXO1 and JAK2/STAT3 pathways. Apoptosis. 21:1302–1314. 2016. View Article : Google Scholar : PubMed/NCBI

35 

Zhang Z, Liu L, Liu C, Cao S, Zhu Y and Mei Q: TIPE2 suppresses the tumorigenesis, growth and metastasis of breast cancer via inhibition of the AKT and p38 signaling pathways. Oncol Rep. 36:3311–3316. 2016. View Article : Google Scholar : PubMed/NCBI

36 

Din TA, Seeni A, Yusoff MS, Shamsuddin S and Jaafar H: PF4-Induced apoptosis in breast cancer in vivo study: The role of the caspases family. Pathology. 48 Suppl 1:S1222016. View Article : Google Scholar

37 

Lazebnik YA, Kaufmann SH, Desnoyers S, Poirier GG and Earnshaw WC: Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE. Nature. 371:346–347. 1994. View Article : Google Scholar : PubMed/NCBI

38 

Soldani C and Scovassi AI: Poly(ADP-ribose) polymerase-1 cleavage during apoptosis: An update. Apoptosis. 7:321–328. 2002. View Article : Google Scholar : PubMed/NCBI

39 

Bhaskara VK, Panigrahi M, Challa S and Babu PP: Comparative status of activated ERK1/2 and PARP cleavage in human gliomas. Neuropathology. 25:48–53. 2005. View Article : Google Scholar : PubMed/NCBI

40 

Sharifi S, Barar J, Hejazi MS and Samadi N: Roles of the Bcl-2/Bax ratio, caspase-8 and 9 in resistance of breast cancer cells to paclitaxel. Asian Pac J Cancer Prev. 15:8617–8622. 2014. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Zeng L, Yuan S, Shen J, Wu M, Pan L and Kong X: Suppression of human breast cancer cells by tectorigenin through downregulation of matrix metalloproteinases and MAPK signaling in vitro. Mol Med Rep 17: 3935-3943, 2018.
APA
Zeng, L., Yuan, S., Shen, J., Wu, M., Pan, L., & Kong, X. (2018). Suppression of human breast cancer cells by tectorigenin through downregulation of matrix metalloproteinases and MAPK signaling in vitro. Molecular Medicine Reports, 17, 3935-3943. https://doi.org/10.3892/mmr.2017.8313
MLA
Zeng, L., Yuan, S., Shen, J., Wu, M., Pan, L., Kong, X."Suppression of human breast cancer cells by tectorigenin through downregulation of matrix metalloproteinases and MAPK signaling in vitro". Molecular Medicine Reports 17.3 (2018): 3935-3943.
Chicago
Zeng, L., Yuan, S., Shen, J., Wu, M., Pan, L., Kong, X."Suppression of human breast cancer cells by tectorigenin through downregulation of matrix metalloproteinases and MAPK signaling in vitro". Molecular Medicine Reports 17, no. 3 (2018): 3935-3943. https://doi.org/10.3892/mmr.2017.8313
Copy and paste a formatted citation
x
Spandidos Publications style
Zeng L, Yuan S, Shen J, Wu M, Pan L and Kong X: Suppression of human breast cancer cells by tectorigenin through downregulation of matrix metalloproteinases and MAPK signaling in vitro. Mol Med Rep 17: 3935-3943, 2018.
APA
Zeng, L., Yuan, S., Shen, J., Wu, M., Pan, L., & Kong, X. (2018). Suppression of human breast cancer cells by tectorigenin through downregulation of matrix metalloproteinases and MAPK signaling in vitro. Molecular Medicine Reports, 17, 3935-3943. https://doi.org/10.3892/mmr.2017.8313
MLA
Zeng, L., Yuan, S., Shen, J., Wu, M., Pan, L., Kong, X."Suppression of human breast cancer cells by tectorigenin through downregulation of matrix metalloproteinases and MAPK signaling in vitro". Molecular Medicine Reports 17.3 (2018): 3935-3943.
Chicago
Zeng, L., Yuan, S., Shen, J., Wu, M., Pan, L., Kong, X."Suppression of human breast cancer cells by tectorigenin through downregulation of matrix metalloproteinases and MAPK signaling in vitro". Molecular Medicine Reports 17, no. 3 (2018): 3935-3943. https://doi.org/10.3892/mmr.2017.8313
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