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Age‑dependent alteration in the expression of oligodendrocyte‑specific protein in the gerbil hippocampus

  • Authors:
    • Hyang‑Ah Lee
    • Joon Ha Park
    • Dae Won Kim
    • Choong‑Hyun Lee
    • In Koo Hwang
    • Hyeyoung Kim
    • Myoung Cheol Shin
    • Jun Hwi Cho
    • Jae‑Chul Lee
    • Yoohun Noh
    • Sung‑Su Kim
    • Moo‑Ho Won
    • Ji Hyeon Ahn
  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics and Gynecology, School of Medicine, Kangwon National University, Chuncheon, Gangwon 24341, Republic of Korea, Department of Biomedical Science and Research Institute for Bioscience and Biotechnology, Hallym University, Chuncheon, Gangwon 24252, Republic of Korea, Department of Biochemistry and Molecular Biology, and Research Institute of Oral Sciences, College of Dentistry, Kangnung‑Wonju National University, Gangneung, Gangwon 25457, Republic of Korea, Department of Pharmacy, College of Pharmacy, Dankook University, Cheonan, Chungcheongnam 31116, Republic of Korea, Department of Anatomy and Cell Biology, College of Veterinary Medicine, and Research Institute for Veterinary Science, Seoul National University, Seoul 08826, Republic of Korea, Department of Anesthesiology and Pain Medicine, Chungju Hospital, Konkuk University School of Medicine, Chungju, Chungcheongbuk 27376, Republic of Korea, Department of Emergency Medicine and Institute of Medical Sciences, Kangwon National University Hospital, Chuncheon, Gangwon 24341, Republic of Korea, Department of Neurobiology, School of Medicine, Kangwon National University, Chuncheon, Gangwon 24341, Republic of Korea, Famenity Biomedical Research Center, Famenity, Inc., Youngin, Gyeonggi 13837, Republic of Korea
    Copyright: © Lee et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3615-3620
    |
    Published online on: December 20, 2017
       https://doi.org/10.3892/mmr.2017.8337
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Abstract

Oligodendrocytes are myelin-forming cells in the central nervous system. Research into the effects of aging on oligodendrocyte protein expression remains limited. The present study aimed to determine the alterations in oligodendrocyte‑specific protein (OSP) expression in the gerbil hippocampus at 1, 2, 3, 4, 6 and 24 months of age with western blot and immunohistochemistry analyses. OSP expression levels in the hippocampus were highest at 6 months of age. OSP immunoreactivity was identified in numerous cell bodies at 1 month, although the number of OSP immunoreactive cells was different according to hippocampal subregion. The number of OSP immunoreactive cells significantly decreased at 2 months and, thereafter, numbers decreased gradually. The detection of OSP immunoreactive fibers was negligible in all layers in the hippocampal subregions until 4 months. OSP immunoreactive fibers were abundant at 6 and 24 months, although the fiber distribution patterns in the CA1‑3 areas and dentate gyrus were different. The results demonstrated that OSP expression in the gerbil hippocampus was age‑dependent. The detection of OSP immunoreactive cell bodies and fibers was significantly different according to the layers of hippocampal subregions, indicating that myelination may be continuously altered in the hippocampus during normal aging.
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Copy and paste a formatted citation
Spandidos Publications style
Lee HA, Park JH, Kim DW, Lee CH, Hwang IK, Kim H, Shin MC, Cho JH, Lee JC, Noh Y, Noh Y, et al: Age‑dependent alteration in the expression of oligodendrocyte‑specific protein in the gerbil hippocampus. Mol Med Rep 17: 3615-3620, 2018.
APA
Lee, H., Park, J.H., Kim, D.W., Lee, C., Hwang, I.K., Kim, H. ... Ahn, J.H. (2018). Age‑dependent alteration in the expression of oligodendrocyte‑specific protein in the gerbil hippocampus. Molecular Medicine Reports, 17, 3615-3620. https://doi.org/10.3892/mmr.2017.8337
MLA
Lee, H., Park, J. H., Kim, D. W., Lee, C., Hwang, I. K., Kim, H., Shin, M. C., Cho, J. H., Lee, J., Noh, Y., Kim, S., Won, M., Ahn, J. H."Age‑dependent alteration in the expression of oligodendrocyte‑specific protein in the gerbil hippocampus". Molecular Medicine Reports 17.3 (2018): 3615-3620.
Chicago
Lee, H., Park, J. H., Kim, D. W., Lee, C., Hwang, I. K., Kim, H., Shin, M. C., Cho, J. H., Lee, J., Noh, Y., Kim, S., Won, M., Ahn, J. H."Age‑dependent alteration in the expression of oligodendrocyte‑specific protein in the gerbil hippocampus". Molecular Medicine Reports 17, no. 3 (2018): 3615-3620. https://doi.org/10.3892/mmr.2017.8337
Copy and paste a formatted citation
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Spandidos Publications style
Lee HA, Park JH, Kim DW, Lee CH, Hwang IK, Kim H, Shin MC, Cho JH, Lee JC, Noh Y, Noh Y, et al: Age‑dependent alteration in the expression of oligodendrocyte‑specific protein in the gerbil hippocampus. Mol Med Rep 17: 3615-3620, 2018.
APA
Lee, H., Park, J.H., Kim, D.W., Lee, C., Hwang, I.K., Kim, H. ... Ahn, J.H. (2018). Age‑dependent alteration in the expression of oligodendrocyte‑specific protein in the gerbil hippocampus. Molecular Medicine Reports, 17, 3615-3620. https://doi.org/10.3892/mmr.2017.8337
MLA
Lee, H., Park, J. H., Kim, D. W., Lee, C., Hwang, I. K., Kim, H., Shin, M. C., Cho, J. H., Lee, J., Noh, Y., Kim, S., Won, M., Ahn, J. H."Age‑dependent alteration in the expression of oligodendrocyte‑specific protein in the gerbil hippocampus". Molecular Medicine Reports 17.3 (2018): 3615-3620.
Chicago
Lee, H., Park, J. H., Kim, D. W., Lee, C., Hwang, I. K., Kim, H., Shin, M. C., Cho, J. H., Lee, J., Noh, Y., Kim, S., Won, M., Ahn, J. H."Age‑dependent alteration in the expression of oligodendrocyte‑specific protein in the gerbil hippocampus". Molecular Medicine Reports 17, no. 3 (2018): 3615-3620. https://doi.org/10.3892/mmr.2017.8337
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