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Article

Possible role of miR-204 in optic nerve injury through the regulation of GAP-43

  • Authors:
    • Nanye Wang
    • Wenyan Yang
    • Tingting Xiao
    • Zhenzhong Miao
    • Wenbin Luo
    • Zhipeng You
    • Guodong Li
  • View Affiliations / Copyright

    Affiliations: Department of Ophthalmology, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, P.R. China, Department of Ophthalmology, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650034, P.R. China
  • Pages: 3891-3897
    |
    Published online on: December 22, 2017
       https://doi.org/10.3892/mmr.2017.8341
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Abstract

Optic nerve injury is a common disease. The present study aimed to examine the possible role of microRNA‑204 (miR‑204) in optic nerve injury through the regulation of growth‑associated protein-43 (GAP‑43). Initially, optic nerve injury models were established in Sprague‑Dawley (SD) rats, and the function of miR‑204 was either enhanced or inhibited through injection of miR‑204 mimic and inhibitor, respectively. Subsequently, the mRNA and protein levels of miR‑204, GAP‑43, toll‑like receptor 4 (TLR4), myeloid differentiation factor 88 (MyD88) and nuclear factor‑κB (NF‑κB) were examined in retinal tissues using reverse transcription‑quantitative polymerase chain reaction and western blot analyses. The apoptosis of retinal tissue cells was also detected using a terminal deoxynucleotidyl transferase mediated dUTP nick end labeling assay. There was a significant increase in the level of miR‑204 in retinal blood vessels of the model SD rats, compared with that in the normal SD rats (P<0.05), and the expression of GAP‑43 was significantly decreased (P<0.05). The results confirmed that the expression of GAP‑43 was significantly reduced, compared with that in the normal control group when the rats were treated with miR‑204 mimic (P<0.05), which was similar to the result in the model group. By contrast, its expression of GAP‑43 was significantly increased when treated with the miR‑204 inhibitor (P<0.05). Compared with the normal control group, the expression levels of TLR4, MyD88 and NF‑κB were significantly increased in the miR‑204 mimic group and model group (P<0.05), whereas the same three factors in the miR‑204 inhibitor group were effectively inhibited, compared with those in the model group, and showed similar results to the normal control group. The apoptotic rates of retinal cells in the miR‑204 mimic group and model group were significantly increased, compared with that in the normal control group (P<0.05), whereas miR‑204 inhibitor effectively reversed the effects on apoptotic rate observed in the model group, showing similar results to those in the normal control group. Taken together, miR‑204 promoted the apoptosis of retinal cells through inhibiting GAP‑43, providing theoretical guidance for the function of GAP‑43 in retinal injury.
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1 

Balla L, Ianovici N and Costin D: Pathology of the optic nerve injury. Rev Med Chir Soc Med Nat Iasi. 116:1087–1090. 2012.PubMed/NCBI

2 

Xue F, Wu K, Wang T, Cheng Y, Jiang M and Ji J: Morphological and functional changes of the optic nerve following traumatic optic nerve injuries in rabbits. Biomed Rep. 4:188–192. 2016. View Article : Google Scholar : PubMed/NCBI

3 

Maxwell WL, Bartlett E and Morgan H: Wallerian degeneration in the optic nerve stretch-injury model of traumatic brain injury: A stereological analysis. J Neurotrauma. 32:780–790. 2015. View Article : Google Scholar : PubMed/NCBI

4 

Grasselli G and Strata P: Structural plasticity of climbing fibers and the growth-associated protein GAP-43. Front Neural Circuits. 7:252013. View Article : Google Scholar : PubMed/NCBI

5 

Liu F, Liao F, Li W, Han Y and Liao D: Progesterone alters Nogo-A, GFAP and GAP-43 expression in a rat model of traumatic brain injury. Mol Med Rep. 9:1225–1231. 2014. View Article : Google Scholar : PubMed/NCBI

6 

Zhao JC, Zhang LX, Zhang Y and Shen YF: The differential regulation of Gap43 gene in the neuronal differentiation of P19 cells. J Cell Physiol. 227:2645–2653. 2012. View Article : Google Scholar : PubMed/NCBI

7 

Williams KR, McAninch DS, Stefanovic S, Xing L, Allen M, Li W, Feng Y, Mihailescu MR and Bassell GJ: hnRNP-Q1 represses nascent axon growth in cortical neurons by inhibiting Gap-43 mRNA translation. Mol Biol Cell. 27:518–534. 2016. View Article : Google Scholar : PubMed/NCBI

8 

Zhu Q, Liu Z, Wang C, Nie L, He Y, Zhang Y, Liu X and Su G: Lentiviral-mediated growth-associated protein-43 modification of bone marrow mesenchymal stem cells improves traumatic optic neuropathy in rats. Mol Med Rep. 12:5691–5700. 2015. View Article : Google Scholar : PubMed/NCBI

9 

Tan H, Kang X, Lu S and Liu L: The therapeutic effects of bone marrow mesenchymal stem cells after optic nerve damage in the adult rat. Clin Interv Aging. 10:487–490. 2015.PubMed/NCBI

10 

Kaneda M, Nagashima M, Mawatari K, Nunome T, Muramoto K, Sugitani K and Kato S: Growth-associated protein43 (GAP43) is a biochemical marker for the whole period of fish optic nerve regeneration. Adv Exp Med Biol. 664:97–104. 2010. View Article : Google Scholar : PubMed/NCBI

11 

Guarnieri S, Morabito C, Paolini C, Boncompagni S, Pilla R, Fanò-Illic G and Mariggiò MA: Growth associated protein 43 is expressed in skeletal muscle fibers and is localized in proximity of mitochondria and calcium release units. PloS One. 8:e532672013. View Article : Google Scholar : PubMed/NCBI

12 

Takei H, Buckleair LW, Rivera A and Powell SZ: Brain tissue microarrays in neurodegenerative diseases: Validation of methodology and immunohistochemical study of growth-associated protein-43 and calretinin. Pathol Int. 57:775–783. 2007. View Article : Google Scholar : PubMed/NCBI

13 

Lucas SM, Rothwell NJ and Gibson RM: The role of inflammation in CNS injury and disease. Br J Pharmacol. 147 Suppl 1:S232–S240. 2006. View Article : Google Scholar : PubMed/NCBI

14 

DeFrancesco-Lisowitz A, Lindborg JA, Niemi JP and Zigmond RE: The neuroimmunology of degeneration and regeneration in the peripheral nervous system. Neuroscience. 302:174–203. 2015. View Article : Google Scholar : PubMed/NCBI

15 

Lin S, Liang Y, Zhang J, Bian C, Zhou H, Guo Q, Xiong Y, Li S and Su B: Microglial TIR-domain-containing adapter-inducing interferon-β (TRIF) deficiency promotes retinal ganglion cell survival and axon regeneration via nuclear factor-κB. J Neuroinflammation. 9:392012. View Article : Google Scholar : PubMed/NCBI

16 

Qi M, Zheng L, Qi Y, Han X, Xu Y, Xu L, Yin L, Wang C, Zhao Y, Sun H, et al: Dioscin attenuates renal ischemia/reperfusion injury by inhibiting the TLR4/MyD88 signaling pathway via up-regulation of HSP70. Pharmacol Res. 100:341–352. 2015. View Article : Google Scholar : PubMed/NCBI

17 

Chen M, Xiang Z and Cai J: The anti-apoptotic and neuro-protective effects of human umbilical cord blood mesenchymal stem cells (hUCB-MSCs) on acute optic nerve injury is transient. Brain Res. 1532:63–75. 2013. View Article : Google Scholar : PubMed/NCBI

18 

Latchney SE, Masiulis I, Zaccaria KJ, Lagace DC, Powell CM, McCasland JS and Eisch AJ: Developmental and adult GAP-43 deficiency in mice dynamically alters hippocampal neurogenesis and mossy fiber volume. Dev Neurosci. 36:44–63. 2014. View Article : Google Scholar : PubMed/NCBI

19 

Bertoli G, Cava C and Castiglioni I: MicroRNAs: New biomarkers for diagnosis, prognosis, therapy prediction and therapeutic tools for breast cancer. Theranostics. 5:1122–1143. 2015. View Article : Google Scholar : PubMed/NCBI

20 

Adlakha YK and Neeru Saini: Brain microRNAs and insights into biological functions and therapeutic potential of brain enriched miRNA-128. Mol Cancer. 13:332014. View Article : Google Scholar : PubMed/NCBI

21 

Ouyang YB, Stary CM, White RE and Giffard RG: The use of microRNAs to modialate redox and immune response to stroke. Antioxid Redox Signal. 22:187–202. 2015. View Article : Google Scholar : PubMed/NCBI

22 

Li T, Pan H and Li R: The dual regulatory role of miR-204 in cancer. Tumor Biol. 37:11667–11677. 2016. View Article : Google Scholar

23 

Huang J, Zhao L, Xing L and Chen D: MicroRNA-204 regulates Runx2 protein expression and mesenchymal progenitor cell differentiation. Stem Cells. 28:357–364. 2010.PubMed/NCBI

24 

Zhao J, Wang C, Song Y and Fang B: Arsenic trioxide and microRNA-204 display contrary effects on regulating adipogenic and osteogenic differentiation of mesenchymal stem cells in aplastic anemia. Acta Biochim Biophys Sin (Shanghai). 46:885–893. 2014. View Article : Google Scholar : PubMed/NCBI

25 

Banaei-Esfahani A, Moazzeni H, Naseri Nosar P, Amin S, Arefian E, Soleimani M, Yazdani S and Elahi E: MicroRNAs that target RGS5. Iran J Basic Med Sci. 18:108–114. 2015.PubMed/NCBI

26 

Ohana R, Weiman-Kelman B, Raviv S, Tamm ER, Pasmanik-Chor M, Rinon A, Netanely D, Shamir R, Solomon AS and Ashery-Padan R: MicroRNAs are essential for differentiation of the retinal pigmented epithelium and maturation of adjacent photoreceptors. Development. 142:2487–2498. 2015. View Article : Google Scholar : PubMed/NCBI

27 

An J, Chen X, Chen W, Liang R, Reinach PS, Yan D and Tu L: MicroRNA expression profile and the role of miR-204 in corneal wound healing. Invest Ophthalmol Vis Sci. 56:3673–3683. 2015. View Article : Google Scholar : PubMed/NCBI

28 

Natera-Naranjo O, Aschrafi A, Gioio AE and Kaplan BB: Identification and quantitative analyses of microRNAs located in the distal axons of sympathetic neurons. RNA. 16:1516–1529. 2010. View Article : Google Scholar : PubMed/NCBI

29 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

30 

Kim J, Jo K, Lee IS, Kim CS and Kim JS: The extract of Aster koraiensis prevents retinal pericyte apoptosis in diabetic rats and its active compound, chlorogenic acid inhibits AGE formation and AGE/RAGE interaction. Nutrients. 8:E5852016. View Article : Google Scholar : PubMed/NCBI

31 

Morishita S, Oku H, Horie T, Tonari M, Kida T, Okubo A, Sugiyama T, Takai S, Hara H and Ikeda T: Systemic simvastatin rescues retinal ganglion cells from optic nerve injury possibly through suppression of astroglial NF-kB activation. PLoS One. 9:e843872014. View Article : Google Scholar : PubMed/NCBI

32 

Gupta SK, Mishra R, Kusum S, Spedding M, Meiri KF, Gressens P and Mani S: GAP-43 is essential for the neurotrophic effects of BDNF and positive AMPA receptor modulator S18986. Cell Death Differ. 16:624–637. 2009. View Article : Google Scholar : PubMed/NCBI

33 

Huang C, Cen LP, Liu L, Leaver SG, Harvey AR, Cui Q, Pang CP and Zhang M: Adeno-associated virus-mediated expression of growth-associated protein-43 aggravates retinal ganglion cell death in experimental chronic glaucomatous injury. Mol Vis. 19:1422–1432. 2013.PubMed/NCBI

34 

Conte I, Merella S, Garcia-Manteiga JM, Migliore C, Lazarevic D, Carrella S, Marco-Ferreres R, Avellino R, Davidson NP and Emmett W: The combination of transcriptomics and informatics identifies pathways targeted by miR-204 during neurogenesis and axon guidance. Nucleic Acids Res. 42:7793–7806. 2014. View Article : Google Scholar : PubMed/NCBI

35 

Ohana R, Weiman-Kelman B, Raviv S, Tamm ER, Pasmanik-Chor M, Rinon A, Netanely D, Shamir R, Solomon AS and Ashery-Padan R: MicroRNAs are essential for differentiation of the retinal pigmented epithelium and maturation of adjacent photoreceptors. Development. 142:2487–2498. 2015. View Article : Google Scholar : PubMed/NCBI

36 

Natera-Naranjo O, Aschrafi A, Gioio AE and Kaplan BB: Identification and quantitative analyses of microRNAs located in the distal axons of sympathetic neurons. RNA. 16:1516–1529. 2010. View Article : Google Scholar : PubMed/NCBI

37 

López-Costa JJ, Goldstein J, Mangeaud M and Saavedra JP: Expression of GAP-43 in the retina of rats following protracted illumination. Brain Res. 900:332–336. 2001. View Article : Google Scholar : PubMed/NCBI

38 

Ju WK, Gwon JS, Park SJ, Kim KY, Moon JI, Lee MY, Oh SJ and Chun MH: Growth-associated protein 43 is up-regulated in the ganglion cells of the ischemic rat retina. Neuroreport. 13:861–865. 2002. View Article : Google Scholar : PubMed/NCBI

39 

Alfonso-Loeches S, Pascual-Lucas M, Blanco AM, Sanchez-Vera I and Guerri C: Pivotal role of TLR4 receptors in alcohol-induced neuroinflammation and brain damage. J Neurosci. 30:8285–8295. 2010. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Wang N, Yang W, Xiao T, Miao Z, Luo W, You Z and Li G: Possible role of miR-204 in optic nerve injury through the regulation of GAP-43. Mol Med Rep 17: 3891-3897, 2018.
APA
Wang, N., Yang, W., Xiao, T., Miao, Z., Luo, W., You, Z., & Li, G. (2018). Possible role of miR-204 in optic nerve injury through the regulation of GAP-43. Molecular Medicine Reports, 17, 3891-3897. https://doi.org/10.3892/mmr.2017.8341
MLA
Wang, N., Yang, W., Xiao, T., Miao, Z., Luo, W., You, Z., Li, G."Possible role of miR-204 in optic nerve injury through the regulation of GAP-43". Molecular Medicine Reports 17.3 (2018): 3891-3897.
Chicago
Wang, N., Yang, W., Xiao, T., Miao, Z., Luo, W., You, Z., Li, G."Possible role of miR-204 in optic nerve injury through the regulation of GAP-43". Molecular Medicine Reports 17, no. 3 (2018): 3891-3897. https://doi.org/10.3892/mmr.2017.8341
Copy and paste a formatted citation
x
Spandidos Publications style
Wang N, Yang W, Xiao T, Miao Z, Luo W, You Z and Li G: Possible role of miR-204 in optic nerve injury through the regulation of GAP-43. Mol Med Rep 17: 3891-3897, 2018.
APA
Wang, N., Yang, W., Xiao, T., Miao, Z., Luo, W., You, Z., & Li, G. (2018). Possible role of miR-204 in optic nerve injury through the regulation of GAP-43. Molecular Medicine Reports, 17, 3891-3897. https://doi.org/10.3892/mmr.2017.8341
MLA
Wang, N., Yang, W., Xiao, T., Miao, Z., Luo, W., You, Z., Li, G."Possible role of miR-204 in optic nerve injury through the regulation of GAP-43". Molecular Medicine Reports 17.3 (2018): 3891-3897.
Chicago
Wang, N., Yang, W., Xiao, T., Miao, Z., Luo, W., You, Z., Li, G."Possible role of miR-204 in optic nerve injury through the regulation of GAP-43". Molecular Medicine Reports 17, no. 3 (2018): 3891-3897. https://doi.org/10.3892/mmr.2017.8341
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