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Article

Effects of icariside II ameliorates diabetic cardiomyopathy in streptozotocin-induced diabetic rats by activating Akt/NOS/NF-κB signaling

  • Authors:
    • Lu Yang
    • Chaosheng Peng
    • Jing Xia
    • Wenluo Zhang
    • Li Tian
    • Yuhong Tian
    • Xiaobin Yang
    • Yuean Cao
  • View Affiliations / Copyright

    Affiliations: Special Care Medical Center, Navy General Hospital of PLA, Beijing 100048, P.R. China
  • Pages: 4099-4105
    |
    Published online on: December 22, 2017
       https://doi.org/10.3892/mmr.2017.8342
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Abstract

Icariside II is a flavonoid extracted from Epimedium that has antioxidant, anti‑inflammatory and antiapoptotic effects. The aim of the present study was to evaluate the effects icariside II on diabetic cardiomyopathy in streptozotocin-induced diabetic rats. Icariside II treatment improved body weight, heart/body weight ratio and fasting blood glucose in diabetic model rats. Icariside II was demonstrated to reduce the expression levels of creatine kinase and lactate dehydrogenase in serum, and to lower cardiac oxidative stress, inflammation and apoptosis levels in diabetic rats. Icariside II treatment induced phosphoinositide 3‑kinase and phosphorylated‑Akt expression, and suppressed inducible nitric oxide synthase (iNOS) and nuclear factor (NF)‑κB protein expression in diabetic rat. Results from the present study suggested that treatment with icariside II improved diabetic cardiomyopathy in streptozotocin‑induced diabetic rats by activating the Akt/NOS/NF‑κB pathway.
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1 

Agrawal V, Agrawal A, Dwivedi AN and Tripathi K: Correlation between 2D echocardiography and multidetector row CT for early detection of diastolic dysfunction in normotensive diabetic patients. J Clin Diagn Res. 10:OC27–30. 2016.PubMed/NCBI

2 

Ding Y, Wang Y, Chen J, Hu Y, Cao Z, Ren P and Zhang Y: p21 overexpression sensitizes osteosarcoma U2OS cells to cisplatin via evoking caspase-3 and Bax/Bcl-2 cascade. Tumour Biol. 35:3119–3123. 2014. View Article : Google Scholar : PubMed/NCBI

3 

Pham I, Cosson E, Nguyen MT, Banu I, Genevois I, Poignard P and Valensi P: Evidence for a specific diabetic cardiomyopathy: An observational retrospective echocardiographic study in 656 asymptomatic type 2 diabetic patients. Int J Endocrinol. 7435032015.PubMed/NCBI

4 

Zhuo C, Jiang R, Lin X and Shao M: LncRNA H19 inhibits autophagy by epigenetically silencing of DIRAS3 in diabetic cardiomyopathy. Oncotarget. 8:1429–1437. 2017. View Article : Google Scholar : PubMed/NCBI

5 

Holscher ME, Bode C and Bugger H: Diabetic Cardiomyopathy: Does the type of diabetes matter? Int J Mol Sci. 17:21362016. View Article : Google Scholar :

6 

Xu G, Kuang G, Jiang W, Jiang R and Jiang D: Polydatin promotes apoptosis through upregulation the ratio of Bax/Bcl-2 and inhibits proliferation by attenuating the beta-catenin signaling in human osteosarcoma cells. Am J Transl Res. 8:922–931. 2016.PubMed/NCBI

7 

Li Z, Zhang J, Mulholland M and Zhang W: mTOR activation protects liver from ischemia/reperfusion-induced injury through NF-kappaB pathway. FASEB J. 31:3016–3026. 2017. View Article : Google Scholar

8 

Korkmaz-Icöz S, Al Said S, Radovits T, Li S, Brune M, Hegedűs P, Atmanli A, Ruppert M, Brlecic P, Lehmann LH, et al: Oral treatment with a zinc complex of acetylsalicylic acid prevents diabetic cardiomyopathy in a rat model of type-2 diabetes: activation of the Akt pathway. Cardiovasc Diabetol. 15:752016. View Article : Google Scholar : PubMed/NCBI

9 

Zhang H, Xiong Z, Wang J, Zhang S, Lei L, Yang L and Zhang Z: Glucagon-like peptide-1 protects cardiomyocytes from advanced oxidation protein product-induced apoptosis via the PI3K/Akt/Bad signaling pathway. Mol Med Rep. 13:1593–1601. 2016. View Article : Google Scholar : PubMed/NCBI

10 

He H, Qiao X and Wu S: Carbamylated erythropoietin attenuates cardiomyopathy via PI3K/Akt activation in rats with diabetic cardiomyopathy. Exp Ther Med. 6:567–573. 2013. View Article : Google Scholar : PubMed/NCBI

11 

Thomas CM, Yong QC, Rosa RM, Seqqat R, Gopal S, Casarini DE, Jones WK, Gupta S, Baker KM and Kumar R: Cardiac-specific suppression of NF-kappaB signaling prevents diabetic cardiomyopathy via inhibition of the renin-angiotensin system. Am J Physiol Heart Circ Physiol. 307:H1036–1045. 2014. View Article : Google Scholar : PubMed/NCBI

12 

Wang ZQ, Chen MT, Zhang R, Zhang Y, Li W and Li YG: Docosahexaenoic acid attenuates doxorubicin-induced cytotoxicity and inflammation by suppressing NF-kappaB/iNOS/NO signaling pathway activation in H9C2 cardiac cells. J Cardiovasc Pharmacol. 67:283–289. 2016. View Article : Google Scholar : PubMed/NCBI

13 

Ren XM, Zuo GF, Wu W, Luo J, Ye P, Chen SL and Hu ZY: Atorvastatin alleviates experimental diabetic cardiomyopathy by regulating the GSK-3beta-PP2Ac-NF-kappaB signaling axis. PLoS One. 11:e01667402016. View Article : Google Scholar : PubMed/NCBI

14 

Yin C, Deng Y, Gao J, Li X, Liu Y and Gong Q: Icariside II, a novel phosphodiesterase-5 inhibitor, attenuates streptozotocin-induced cognitive deficits in rats. Neuroscience. 328:69–79. 2016. View Article : Google Scholar : PubMed/NCBI

15 

Tian W, Lei H, Guan R, Xu Y, Li H, Wang L, Yang B, Gao Z and Xin Z: Icariside II ameliorates diabetic nephropathy in streptozotocin-induced diabetic rats. Drug Des Devel Ther. 9:5147–5157. 2015.PubMed/NCBI

16 

Frustaci A, Ciccosanti F, Chimenti C, Nardacci R, Corazzari M, Verardo R, Ippolito G, Petrosillo N, Fimia GM and Piacentini M: Histological and proteomic profile of diabetic versus non-diabetic dilated cardiomyopathy. Int J Cardiol. 203:282–289. 2016. View Article : Google Scholar : PubMed/NCBI

17 

Zhu Z and Hu X: HMGB1 induced endothelial permeability promotes myocardial fibrosis in diabetic cardiomyopathy. Int J Cardiol. 227:8752017. View Article : Google Scholar : PubMed/NCBI

18 

Lebeche D: Diabetic cardiomyopathy: is resistin a culprit? Cardiovasc Diagn Ther. 5:387–393. 2015.PubMed/NCBI

19 

Wu H, Sheng ZQ, Xie J, Li R, Chen L, Li GN, Wang L and Xu B: Reduced HMGB 1-mediated pathway and oxidative stress in resveratrol-treated diabetic mice: A possible mechanism of cardioprotection of resveratrol in diabetes mellitus. Oxid Med Cell Longev. 2016:98368602016. View Article : Google Scholar : PubMed/NCBI

20 

Kuo WW, Wang WJ, Tsai CY, Way CL, Hsu HH and Chen LM: Diallyl trisufide (DATS) suppresses high glucose-induced cardiomyocyte apoptosis by inhibiting JNK/NFkappaB signaling via attenuating ROS generation. Int J Cardiol. 168:270–280. 2013. View Article : Google Scholar : PubMed/NCBI

21 

Varga ZV, Giricz Z, Liaudet L, Hasko G, Ferdinandy P and Pacher P: Interplay of oxidative, nitrosative/nitrative stress, inflammation, cell death and autophagy in diabetic cardiomyopathy. Biochim Biophys Acta. 1852:232–242. 2015. View Article : Google Scholar : PubMed/NCBI

22 

Suzuki H, Kayama Y, Sakamoto M, Iuchi H, Shimizu I, Yoshino T, Katoh D, Nagoshi T, Tojo K, Minamino T, et al: Arachidonate 12/15-lipoxygenase-induced inflammation and oxidative stress are involved in the development of diabetic cardiomyopathy. Diabetes. 64:618–630. 2015. View Article : Google Scholar : PubMed/NCBI

23 

Zhao YZ, Zhang M, Wong HL, Tian XQ, Zheng L, Yu XC, Tian FR, Mao KL, Fan ZL, Chen PP, et al: Prevent diabetic cardiomyopathy in diabetic rats by combined therapy of aFGF-loaded nanoparticles and ultrasound-targeted microbubble destruction technique. J Control Release. 223:11–21. 2016. View Article : Google Scholar : PubMed/NCBI

24 

Yu W, Zha W, Guo S, Cheng H, Wu J and Liu C: Flos Puerariae extract prevents myocardial apoptosis via attenuation oxidative stress in streptozotocin-induced diabetic mice. PLoS One. 9:e980442014. View Article : Google Scholar : PubMed/NCBI

25 

Zhang L, Ding WY, Wang ZH, Tang MX, Wang F, Li Y, Zhong M, Zhang Y and Wei Zhang: Erratum to: Early administration of trimetazidine attenuates diabetic cardiomyopathy in rats by alleviating fibrosis, reducing apoptosis and enhancing autophagy. J Transl Med. 14:3092016. View Article : Google Scholar : PubMed/NCBI

26 

Wu MP, Zhang YS, Zhou QM, Xiong J, Dong YR and Yan C: Higenamine protects ischemia/reperfusion induced cardiac injury and myocyte apoptosis through activation of beta2-AR/PI3K/AKT signaling pathway. Pharmacol Res. 104:115–123. 2016. View Article : Google Scholar : PubMed/NCBI

27 

Wang J, Ji SY, Liu SZ, Jing R and Lou WJ: Cardioprotective effect of breviscapine: Inhibition of apoptosis in H9c2 cardiomyocytes via the PI3K/Akt/eNOS pathway following simulated ischemia/reperfusion injury. Pharmazie. 70:593–597. 2015.PubMed/NCBI

28 

Liu W, Mao L, Ji F, Chen F, Wang S and Xie Y: Icariside II activates EGFR-Akt-Nrf2 signaling and protects osteoblasts from dexamethasone. Oncotarget. 8:2594–2603. 2017.PubMed/NCBI

29 

Jiang C, Tong YL, Zhang D, Liu LZ and Wang JF: Sinomenine prevents the development of cardiomyopathy in diabetic rats by inhibiting inflammatory responses and blocking activation of NF-kappaB. Gen Physiol Biophys. 36:65–74. 2017. View Article : Google Scholar : PubMed/NCBI

30 

Song J, Feng L, Zhong R, Xia Z, Zhang L, Cui L, Yan H, Jia X and Zhang Z: Icariside II inhibits the EMT of NSCLC cells in inflammatory microenvironment via down-regulation of Akt/NF-kappaB signaling pathway. Mol Carcinog. 56:36–48. 2017. View Article : Google Scholar : PubMed/NCBI

31 

Lee KS, Lee HJ, Ahn KS and Kim SH, Nam D, Kim DK, Choi DY, Ahn KS, Lu J and Kim SH: Cyclooxygenase-2/prostaglandin E2 pathway mediates icariside II induced apoptosis in human PC-3 prostate cancer cells. Cancer Lett. 280:93–100. 2009. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Yang L, Peng C, Xia J, Zhang W, Tian L, Tian Y, Yang X and Cao Y: Effects of icariside II ameliorates diabetic cardiomyopathy in streptozotocin-induced diabetic rats by activating Akt/NOS/NF-κB signaling. Mol Med Rep 17: 4099-4105, 2018.
APA
Yang, L., Peng, C., Xia, J., Zhang, W., Tian, L., Tian, Y. ... Cao, Y. (2018). Effects of icariside II ameliorates diabetic cardiomyopathy in streptozotocin-induced diabetic rats by activating Akt/NOS/NF-κB signaling. Molecular Medicine Reports, 17, 4099-4105. https://doi.org/10.3892/mmr.2017.8342
MLA
Yang, L., Peng, C., Xia, J., Zhang, W., Tian, L., Tian, Y., Yang, X., Cao, Y."Effects of icariside II ameliorates diabetic cardiomyopathy in streptozotocin-induced diabetic rats by activating Akt/NOS/NF-κB signaling". Molecular Medicine Reports 17.3 (2018): 4099-4105.
Chicago
Yang, L., Peng, C., Xia, J., Zhang, W., Tian, L., Tian, Y., Yang, X., Cao, Y."Effects of icariside II ameliorates diabetic cardiomyopathy in streptozotocin-induced diabetic rats by activating Akt/NOS/NF-κB signaling". Molecular Medicine Reports 17, no. 3 (2018): 4099-4105. https://doi.org/10.3892/mmr.2017.8342
Copy and paste a formatted citation
x
Spandidos Publications style
Yang L, Peng C, Xia J, Zhang W, Tian L, Tian Y, Yang X and Cao Y: Effects of icariside II ameliorates diabetic cardiomyopathy in streptozotocin-induced diabetic rats by activating Akt/NOS/NF-κB signaling. Mol Med Rep 17: 4099-4105, 2018.
APA
Yang, L., Peng, C., Xia, J., Zhang, W., Tian, L., Tian, Y. ... Cao, Y. (2018). Effects of icariside II ameliorates diabetic cardiomyopathy in streptozotocin-induced diabetic rats by activating Akt/NOS/NF-κB signaling. Molecular Medicine Reports, 17, 4099-4105. https://doi.org/10.3892/mmr.2017.8342
MLA
Yang, L., Peng, C., Xia, J., Zhang, W., Tian, L., Tian, Y., Yang, X., Cao, Y."Effects of icariside II ameliorates diabetic cardiomyopathy in streptozotocin-induced diabetic rats by activating Akt/NOS/NF-κB signaling". Molecular Medicine Reports 17.3 (2018): 4099-4105.
Chicago
Yang, L., Peng, C., Xia, J., Zhang, W., Tian, L., Tian, Y., Yang, X., Cao, Y."Effects of icariside II ameliorates diabetic cardiomyopathy in streptozotocin-induced diabetic rats by activating Akt/NOS/NF-κB signaling". Molecular Medicine Reports 17, no. 3 (2018): 4099-4105. https://doi.org/10.3892/mmr.2017.8342
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