Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
March-2018 Volume 17 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
March-2018 Volume 17 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Protection against monocrotaline-induced pulmonary arterial hypertension and caveolin-1 downregulation by fluvastatin in rats

  • Authors:
    • Shaoping Zhu
    • Junyu Wang
    • Xianguo Wang
    • Jinping Zhao
  • View Affiliations / Copyright

    Affiliations: Department of Cardiothoracic Surgery, Zhongnan Hospital of Wuhan University, Wuhan, Hubei 430071, P.R. China, Department of Oncology, Hubei Provincial Hospital of Integrated Chinese and Western Medicine, Wuhan, Hubei 430015, P.R. China
  • Pages: 3944-3950
    |
    Published online on: December 22, 2017
       https://doi.org/10.3892/mmr.2017.8345
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Statins are Hydroxymethylglutaryl-coenzyme A reductase inhibitors, which are typically used to lower blood cholesterol. Additional beneficial effects, including improvement to pulmonary arterial hypertension (PAH), have also been confirmed. However, the mechanisms underlying this improvement have not yet been clarified. The present study was conducted to determine if fluvastatin was protective against experimental PAH development and to investigate the potential effects of fluvastatin on caveolin‑1 (cav‑1) expression. Rats were randomized to either receive a single subcutaneous injection of monocrotaline (MCT; 60 mg/kg; MCT group) or a single subcutaneous injection of MCT (60 mg/kg) followed by an oral gavage of fluvastatin (10 mg/kg) once daily until day 42 (M + F group). Rats in the MCT group received an equivalent volume of saline following the MCT injection. Six additional rats were given an equivalent volume of saline throughout as a control measure. PAH associated variables and cav‑1 protein expression were measured in each group at various times during the experimental period. Hemodynamic and morphometric analysis revealed that M + F rats developed moderate, delayed PAH. Cav‑1 western blot analysis demonstrated that cav‑1 expression was not significantly different in fluvastatin treated rats; however, MCT injured rats given saline had markedly reduced cav‑1 expression. It was concluded that fluvastatin may protect against PAH development and ameliorate MCT induced inhibition of cav‑1 expression in rats.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

Kanemoto N: Natural history of primary pulmonary hypertension elucidated by pulmonary hemodynamics. J Cardiol. 18:757–763. 1988.(In Japanese). PubMed/NCBI

2 

Larsen CM, McCully RB, Murphy JG, Kushwaha SS, Frantz RP and Kane GC: Usefulness of high-density lipoprotein cholesterol to predict survival in pulmonary arterial hypertension. Am J Cardiol. 118:292–297. 2016. View Article : Google Scholar : PubMed/NCBI

3 

Chen D, Zhou D, Qian J, Chen F, Guan L, Dong L and Ge J: Atorvastatin prevents dehydromonocrotaline-induced pulmonary hypertension in beagles. Exp Lung Res. 38:333–343. 2012. View Article : Google Scholar : PubMed/NCBI

4 

Maron DJ, Fazio S and Linton MF: Current perspectives on statins. Circulation. 101:207–213. 2000. View Article : Google Scholar : PubMed/NCBI

5 

Li XL, Guan RJ and Li JJ: Attenuation of monocrotaline-induced pulmonary arterial hypertension in rats by rosuvastatin. J Cardiovasc Pharmacol. 60:219–226. 2012. View Article : Google Scholar : PubMed/NCBI

6 

Nishimura T, Vaszar LT, Faul JL, Zhao G, Berry GJ, Shi L, Qiu D, Benson G, Pearl RG and Kao PN: Simvastatin rescues rats from fatal pulmonary hypertension by inducing apoptosis of neointimal smooth muscle cells. Circulation. 108:1640–1645. 2003. View Article : Google Scholar : PubMed/NCBI

7 

Murata T, Kinoshita K, Hori M, Kuwahara M, Tsubone H, Karaki H and Ozaki H: Statin protects endothelial nitric oxide synthase activity in hypoxia-induced pulmonary hypertension. Arterioscler Thromb Vasc Biol. 25:2335–2342. 2005. View Article : Google Scholar : PubMed/NCBI

8 

Mason RP, Walter MF, Day CA and Jacob RF: Intermolecular differences of 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitors contribute to distinct pharmacologic and pleiotropic actions. Am J Cardiol. 96:11F–23F. 2005. View Article : Google Scholar : PubMed/NCBI

9 

Rakotoniaina Z, Guerard P, Lirussi F, Goirand F, Rochette L, Dumas M and Bardou M: The protective effect of HMG-CoA reductase inhibitors against monocrotaline-induced pulmonary hypertension in the rat might not be a class effect: Comparison of pravastatin and atorvastatin. Naunyn Schmiedebergs Arch Pharmacol. 374:195–206. 2006. View Article : Google Scholar : PubMed/NCBI

10 

Satoh K, Fukumoto Y, Nakano M, Sugimura K, Nawata J, Demachi J, Karibe A, Kagaya Y, Ishii N, Sugamura K and Shimokawa H: Statin ameliorates hypoxia-induced pulmonary hypertension associated with down-regulated stromal cell-derived factor-1. Cardiovasc Res. 81:226–234. 2009. View Article : Google Scholar : PubMed/NCBI

11 

Achcar RO, Demura Y, Rai PR, Taraseviciene-Stewart L, Kasper M, Voelkel NF and Cool CD: Loss of caveolin and heme oxygenase expression in severe pulmonary hypertension. Chest. 129:696–705. 2006. View Article : Google Scholar : PubMed/NCBI

12 

Chan SY and Loscalzo J: Pathogenic mechanisms of pulmonary arterial hypertension. J Mol Cell Cardiol. 44:14–30. 2008. View Article : Google Scholar : PubMed/NCBI

13 

Wang L, Zhao B, Chen Y, Ma L, Chen EZ and Mao EQ: Inflammation and edema in the lung and kidney of hemorrhagic shock rats are alleviated by biliary tract external drainage via the heme oxygenase-1 pathway. Inflammation. 38:2242–2251. 2015. View Article : Google Scholar : PubMed/NCBI

14 

Zuckerbraun BS, Chin BY, Wegiel B, Billiar TR, Czsimadia E, Rao J, Shimoda L, Ifedigbo E, Kanno S and Otterbein LE: Carbon monoxide reverses established pulmonary hypertension. J Exp Med. 203:2109–2119. 2006. View Article : Google Scholar : PubMed/NCBI

15 

Adam O and Laufs U: Antioxidative effects of statins. Arch Toxicol. 82:885–892. 2008. View Article : Google Scholar : PubMed/NCBI

16 

Steinberg D: The statins in preventive cardiology. N Engl J Med. 359:1426–1427. 2008. View Article : Google Scholar : PubMed/NCBI

17 

Nishimura T, Faul JL, Berry GJ, Vaszar LT, Qiu D, Pearl RG and Kao PN: Simvastatin attenuates smooth muscle neointimal proliferation and pulmonary hypertension in rats. Am J Respir Crit Care Med. 166:1403–1408. 2002. View Article : Google Scholar : PubMed/NCBI

18 

Hu H, Sung A, Zhao G, Shi L, Qiu D, Nishimura T and Kao PN: Simvastatin enhances bone morphogenetic protein receptor type II expression. Biochem Biophys Res Commun. 339:59–64. 2006. View Article : Google Scholar : PubMed/NCBI

19 

Kao PN: Simvastatin treatment of pulmonary hypertension: An observational case series. Chest. 127:1446–1452. 2005. View Article : Google Scholar : PubMed/NCBI

20 

Pei Y, Ma P, Wang X, Zhang W, Zhang X, Zheng P, Yan L, Xu Q and Dai G: Rosuvastatin attenuates monocrotaline-induced pulmonary hypertension via regulation of Akt/eNOS signaling and asymmetric dimethylarginine metabolism. Eur J Pharmacol. 666:165–172. 2011. View Article : Google Scholar : PubMed/NCBI

21 

Yao J, Xiong M, Tang B, Chen G, Liang M, Ma X, Wang Z and Wu Z: Simvastatin attenuates pulmonary vascular remodelling by down-regulating matrix metalloproteinase-1 and −9 expression in a carotid artery-jugular vein shunt pulmonary hypertension model in rats. Eur J Cardiothorac Surg. 42:e121–e127. 2012. View Article : Google Scholar : PubMed/NCBI

22 

Carlin CM, Celnik DF, Pak O, Wadsworth R, Peacock AJ and Welsh DJ: Low-dose fluvastatin reverses the hypoxic pulmonary adventitial fibroblast phenotype in experimental pulmonary hypertension. Am J Respir Cell Mol Biol. 47:140–148. 2012. View Article : Google Scholar : PubMed/NCBI

23 

Campian ME, Hardziyenka M, Michel MC and Tan HL: How valid are animal models to evaluate treatments for pulmonary hypertension? Naunyn Schmiedebergs Arch Pharmacol. 373:391–400. 2006. View Article : Google Scholar : PubMed/NCBI

24 

Jeffery TK and Morrell NW: Molecular and cellular basis of pulmonary vascular remodeling in pulmonary hypertension. Prog Cardiovasc Dis. 45:173–202. 2002. View Article : Google Scholar : PubMed/NCBI

25 

van Deurs B, Roepstorff K, Hommelgaard AM and Sandvig K: Caveolae: Anchored, multifunctional platforms in the lipid ocean. Trends Cell Biol. 13:92–100. 2003. View Article : Google Scholar : PubMed/NCBI

26 

Razani B, Engelman JA, Wang XB, Schubert W, Zhang XL, Marks CB, Macaluso F, Russell RG, Li M, Pestell RG, et al: Caveolin-1 null mice are viable but show evidence of hyperproliferative and vascular abnormalities. J Biol Chem. 276:38121–38138. 2001.PubMed/NCBI

27 

Mathew R, Huang J, Shah M, Patel K, Gewitz M and Sehgal PB: Disruption of endothelial-cell caveolin-1alpha/raft scaffolding during development of monocrotaline-induced pulmonary hypertension. Circulation. 110:1499–1506. 2004. View Article : Google Scholar : PubMed/NCBI

28 

Bouzas B and Gatzoulis MA: Pulmonary arterial hypertension in adults with congenital heart disease. Rev Esp Cardiol. 58:465–469. 2005.(In Spanish). View Article : Google Scholar : PubMed/NCBI

29 

Machado RF: Sickle cell anemia-associated pulmonary arterial hypertension. J Bras Pneumol. 33:583–591. 2007.(In English, Portuguese). View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Zhu S, Wang J, Wang X and Zhao J: Protection against monocrotaline-induced pulmonary arterial hypertension and caveolin-1 downregulation by fluvastatin in rats. Mol Med Rep 17: 3944-3950, 2018.
APA
Zhu, S., Wang, J., Wang, X., & Zhao, J. (2018). Protection against monocrotaline-induced pulmonary arterial hypertension and caveolin-1 downregulation by fluvastatin in rats. Molecular Medicine Reports, 17, 3944-3950. https://doi.org/10.3892/mmr.2017.8345
MLA
Zhu, S., Wang, J., Wang, X., Zhao, J."Protection against monocrotaline-induced pulmonary arterial hypertension and caveolin-1 downregulation by fluvastatin in rats". Molecular Medicine Reports 17.3 (2018): 3944-3950.
Chicago
Zhu, S., Wang, J., Wang, X., Zhao, J."Protection against monocrotaline-induced pulmonary arterial hypertension and caveolin-1 downregulation by fluvastatin in rats". Molecular Medicine Reports 17, no. 3 (2018): 3944-3950. https://doi.org/10.3892/mmr.2017.8345
Copy and paste a formatted citation
x
Spandidos Publications style
Zhu S, Wang J, Wang X and Zhao J: Protection against monocrotaline-induced pulmonary arterial hypertension and caveolin-1 downregulation by fluvastatin in rats. Mol Med Rep 17: 3944-3950, 2018.
APA
Zhu, S., Wang, J., Wang, X., & Zhao, J. (2018). Protection against monocrotaline-induced pulmonary arterial hypertension and caveolin-1 downregulation by fluvastatin in rats. Molecular Medicine Reports, 17, 3944-3950. https://doi.org/10.3892/mmr.2017.8345
MLA
Zhu, S., Wang, J., Wang, X., Zhao, J."Protection against monocrotaline-induced pulmonary arterial hypertension and caveolin-1 downregulation by fluvastatin in rats". Molecular Medicine Reports 17.3 (2018): 3944-3950.
Chicago
Zhu, S., Wang, J., Wang, X., Zhao, J."Protection against monocrotaline-induced pulmonary arterial hypertension and caveolin-1 downregulation by fluvastatin in rats". Molecular Medicine Reports 17, no. 3 (2018): 3944-3950. https://doi.org/10.3892/mmr.2017.8345
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team