Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
March-2018 Volume 17 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
March-2018 Volume 17 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Perioperative oral supplementation with fish oil promotes liver regeneration following partial hepatectomy in mice via AMPK activation

  • Authors:
    • Hui Yao
    • Xiao Fu
    • Xuejian Zi
    • Wenjun Jia
    • Yudong Qiu
  • View Affiliations / Copyright

    Affiliations: Department of Hepatopancreatobiliary Surgery, Nanjing Drum Tower Hospital, Medical School of Nanjing University, Nanjing, Jiangsu 210008, P.R. China, Department of Hepatopancreatobiliary Surgery, Nanjing Drum Tower Hospital, Clinical College of Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. China
  • Pages: 3905-3911
    |
    Published online on: December 27, 2017
       https://doi.org/10.3892/mmr.2017.8362
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The present study aimed to observe the effects of perioperative oral supplementation with fish oil (FO) on liver regeneration in mice and examine the potential mechanism. A total of 120 male ICR mice were randomly divided into 5 groups: Sham, Control, fish oil (FO), Compound C [the AMP‑activated protein kinase (AMPK) inhibitor dorsomorphin], and Compound C + FO. Changes in liver function, alterations in hepatocyte proliferation and in the expression of polarization markers, and activation of AMPK signaling were examined following partial hepatectomy (PH). The results demonstrated that restoration of serum alanine aminotransferase (ALT) and total bilirubin (TBIL) levels were significantly faster in FO‑treated mice compared with Control mice, and this effect was suppressed by treatment with Compound C. FO‑treated mice exhibited increased numbers of Ki‑67 positive hepatocytes and their postoperative liver‑to‑body weight ratio was significantly increased compared with the Control mice, which was also suppressed by co‑treatment with the AMPK inhibitor. Furthermore, protein expression of Occludin, Claudin‑3, tight junction protein 1 and bile salt export pump was gradually increased in FO‑treated mice compared with Control, whereas Compound C treatment reversed this effect. Therefore, the present study revealed that perioperative oral supplementation with FO may promote liver regeneration and improved liver function in mice following PH through AMPK activation.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

Ding BS, Cao Z, Lis R, Nolan DJ, Guo P, Simons M, Penfold ME, Shido K, Rabbany SY and Rafii S: Divergent angiocrine signals from vascular niche balance liver regeneration and fibrosis. Nature. 505:97–102. 2014. View Article : Google Scholar : PubMed/NCBI

2 

Willenbring H and Grompe M: A therapy for liver failure found in the JNK yard. Cell. 153:283–284. 2013. View Article : Google Scholar : PubMed/NCBI

3 

Fausto N, Campbell JS and Riehle KJ: Liver regeneration. Hepatology. 43 2 Suppl 1:S45–S53. 2006. View Article : Google Scholar : PubMed/NCBI

4 

Wuestefeld T, Pesic M, Rudalska R, Dauch D, Longerich T, Kang TW, Yevsa T, Heinzmann F, Hoenicke L, Hohmeyer A, et al: A direct in vivo RNAi screen identifies MKK4 as a key regulator of liver regeneration. Cell. 153:389–401. 2013. View Article : Google Scholar : PubMed/NCBI

5 

Taub R: Liver regeneration: From myth to mechanism. Nat Rev Mol Cell Biol. 5:836–847. 2004. View Article : Google Scholar : PubMed/NCBI

6 

Michalopoulos GK: Principles of liver regeneration and growth homeostasis. Compr Physiol. 3:485–513. 2013.PubMed/NCBI

7 

He VJ: Professor Norbert Hüser: The function of immune cells for liver regeneration after partial hepatectomy. Hepatobiliary Surg Nutr. 3:52–54. 2014.PubMed/NCBI

8 

Svegliati-Baroni G, Candelaresi C, Saccomanno S, Ferretti G, Bachetti T, Marzioni M, De Minicis S, Nobili L, Salzano R, Omenetti A, et al: A model of insulin resistance and nonalcoholic steatohepatitis in rats: Role of peroxisome proliferator-activated receptor-alpha and n-3 polyunsaturated fatty acid treatment on liver injury. Am J Pathol. 169:846–860. 2006. View Article : Google Scholar : PubMed/NCBI

9 

Pradelli L, Mayer K, Muscaritoli M and Heller AR: n-3 fatty acid-enriched parenteral nutrition regimens in elective surgical and ICU patients: A meta-analysis. Crit Care. 16:R1842012. View Article : Google Scholar : PubMed/NCBI

10 

Fu D, Wakabayashi Y, Lippincott-Schwartz J and Arias IM: Bile acid stimulates hepatocyte polarization through a cAMP-Epac-MEK-LKB1-AMPK pathway. Proc Natl Acad Sci USA. 108:pp. 1403–1408. 2011; View Article : Google Scholar : PubMed/NCBI

11 

International Transporter Consortium, ; Giacomini KM, Huang SM, Tweedie DJ, Benet LZ, Brouwer KL, Chu X, Dahlin A, Evers R, Fischer V, et al: Membrane transporters in drug development. Nat Rev Drug Discov. 9:215–236. 2010. View Article : Google Scholar : PubMed/NCBI

12 

Woods A, Heslegrave AJ, Muckett PJ, Levene AP, Clements M, Mobberley M, Ryder TA, Abu-Hayyeh S, Williamson C, Goldin RD, et al: LKB1 is required for hepatic bile acid transport and canalicular membrane integrity in mice. Biochem J. 434:49–60. 2011. View Article : Google Scholar : PubMed/NCBI

13 

Fu D, Wakabayashi Y, Ido Y, Lippincott-Schwartz J and Arias IM: Regulation of bile canalicular network formation and maintenance by AMP-activated protein kinase and LKB1. J Cell Sci. 123:3294–3302. 2010. View Article : Google Scholar : PubMed/NCBI

14 

Merlen G, Gentric G, Celton-Morizur S, Foretz M, Guidotti JE, Fauveau V, Leclerc J, Viollet B and Desdouets C: AMPKα1 controls hepatocyte proliferation independently of energy balance by regulating Cyclin A2 expression. J Hepatol. 60:152–159. 2014. View Article : Google Scholar : PubMed/NCBI

15 

Homolya L, Fu D, Sengupta P, Jarnik M, Gillet JP, Vitale-Cross L, Gutkind JS, Lippincott-Schwartz J and Arias IM: LKB1/AMPK and PKA control ABCB11 trafficking and polarization in hepatocytes. PLoS One. 9:e919212014. View Article : Google Scholar : PubMed/NCBI

16 

Stehr SN and Heller AR: Omega-3 fatty acid effects on biochemical indices following cancer surgery. Clin Chim Acta. 373:1–8. 2006. View Article : Google Scholar : PubMed/NCBI

17 

Zhu XH, Wu YF, Qiu YD, Jiang CP and Ding YT: Liver-protecting effects of omega-3 fish oil lipid emulsion in liver transplantation. World J Gastroenterol. 18:6141–6147. 2012. View Article : Google Scholar : PubMed/NCBI

18 

Yan XP, Wang S, Yang Y and Qiu YD: Effects of n-3 polyunsaturated fatty acids on rat livers after partial hepatectomy via LKB1-AMPK signaling pathway. Transplant Proc. 43:pp. 3604–3612. 2011; View Article : Google Scholar : PubMed/NCBI

19 

Qiu YD, Wang S, Yang Y and Yan XP: Omega-3 polyunsaturated fatty acids promote liver regeneration after 90% hepatectomy in rats. World J Gastroenterol. 18:3288–3295. 2012.PubMed/NCBI

20 

Grosse B, Degrouard J, Jaillard D and Cassio D: Build them up and break them down: Tight junctions of cell lines expressing typical hepatocyte polarity with a varied repertoire of claudins. Tissue Barriers. 1:e252102013. View Article : Google Scholar : PubMed/NCBI

21 

Son S, Kojima T, Decaens C, Yamaguchi H, Ito T, Imamura M, Murata M, Tanaka S, Chiba H, Hirate K and Sawada N: Knockdown of tight junction protein claudin-2 prevents bile canalicular formation in WIF-B9 cells. Histochem Cell Biol. 131:411–424. 2009. View Article : Google Scholar : PubMed/NCBI

22 

Kojima T, Yamamoto T, Murata M, Chiba H, Kokai Y and Sawada N: Regulation of the blood-biliary barrier: Interaction between gap and tight junctions in hepatocytes. Med Electron Microsc. 36:157–164. 2003. View Article : Google Scholar : PubMed/NCBI

23 

Lee JH, Koh H, Kim M, Kim Y, Lee SY, Karess RE, Lee SH, Shong M, Kim JM, Kim J and Chung J: Energy-dependent regulation of cell structure by AMP-activated protein kinase. Nature. 447:1017–1020. 2007. View Article : Google Scholar : PubMed/NCBI

24 

Baas AF, Kuipers J, van der Wel NN, Batlle E, Koerten HK, Peters PJ and Clevers HC: Complete polarization of single intestinal epithelial cells upon activation of LKB1 by STRAD. Cell. 116:457–466. 2004. View Article : Google Scholar : PubMed/NCBI

25 

Zhang L, Li J, Young LH and Caplan MJ: AMP-activated protein kinase regulates the assembly of epithelial tight junctions. Proc Natl Acad Sci USA. 103:pp. 17272–17277. 2006; View Article : Google Scholar : PubMed/NCBI

26 

Zhang YL, Guo H, Zhang CS, Lin SY, Yin Z, Peng Y, Luo H, Shi Y, Lian G, Zhang C, et al: AMP as a low-energy charge signal autonomously initiates assembly of AXIN-AMPK-LKB1 complex for AMPK activation. Cell Metab. 18:546–555. 2013. View Article : Google Scholar : PubMed/NCBI

27 

Gowans GJ, Hawley SA, Ross FA and Hardie DG: AMP is a true physiological regulator of AMP-activated protein kinase by both allosteric activation and enhancing net phosphorylation. Cell Metab. 18:556–566. 2013. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Yao H, Fu X, Zi X, Jia W and Qiu Y: Perioperative oral supplementation with fish oil promotes liver regeneration following partial hepatectomy in mice via AMPK activation. Mol Med Rep 17: 3905-3911, 2018.
APA
Yao, H., Fu, X., Zi, X., Jia, W., & Qiu, Y. (2018). Perioperative oral supplementation with fish oil promotes liver regeneration following partial hepatectomy in mice via AMPK activation. Molecular Medicine Reports, 17, 3905-3911. https://doi.org/10.3892/mmr.2017.8362
MLA
Yao, H., Fu, X., Zi, X., Jia, W., Qiu, Y."Perioperative oral supplementation with fish oil promotes liver regeneration following partial hepatectomy in mice via AMPK activation". Molecular Medicine Reports 17.3 (2018): 3905-3911.
Chicago
Yao, H., Fu, X., Zi, X., Jia, W., Qiu, Y."Perioperative oral supplementation with fish oil promotes liver regeneration following partial hepatectomy in mice via AMPK activation". Molecular Medicine Reports 17, no. 3 (2018): 3905-3911. https://doi.org/10.3892/mmr.2017.8362
Copy and paste a formatted citation
x
Spandidos Publications style
Yao H, Fu X, Zi X, Jia W and Qiu Y: Perioperative oral supplementation with fish oil promotes liver regeneration following partial hepatectomy in mice via AMPK activation. Mol Med Rep 17: 3905-3911, 2018.
APA
Yao, H., Fu, X., Zi, X., Jia, W., & Qiu, Y. (2018). Perioperative oral supplementation with fish oil promotes liver regeneration following partial hepatectomy in mice via AMPK activation. Molecular Medicine Reports, 17, 3905-3911. https://doi.org/10.3892/mmr.2017.8362
MLA
Yao, H., Fu, X., Zi, X., Jia, W., Qiu, Y."Perioperative oral supplementation with fish oil promotes liver regeneration following partial hepatectomy in mice via AMPK activation". Molecular Medicine Reports 17.3 (2018): 3905-3911.
Chicago
Yao, H., Fu, X., Zi, X., Jia, W., Qiu, Y."Perioperative oral supplementation with fish oil promotes liver regeneration following partial hepatectomy in mice via AMPK activation". Molecular Medicine Reports 17, no. 3 (2018): 3905-3911. https://doi.org/10.3892/mmr.2017.8362
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team