Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
March-2018 Volume 17 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
March-2018 Volume 17 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Liraglutide repairs the infarcted heart: The role of the SIRT1/Parkin/mitophagy pathway

Retraction in: /10.3892/mmr.2024.13192
  • Authors:
    • Huiying Qiao
    • Haiyan Ren
    • He Du
    • Minfang Zhang
    • Xiaofang Xiong
    • Rong Lv
  • View Affiliations / Copyright

    Affiliations: Department of Geriatric, Wujiang District No. 1 People's Hospital, Suzhou, Jiangsu 215200, P.R. China, Central Laboratory of Xinjiang Medical University, Urumqi, Xinjiang 830011, P.R. China, Department of Pulmonary Circulation, Shanghai Pulmonary Hospital of Tongji University, Shanghai 200433, P.R. China, Department of Cardiovascular Medicine, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, Hubei 430000, P.R. China
    Copyright: © Qiao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3722-3734
    |
    Published online on: January 2, 2018
       https://doi.org/10.3892/mmr.2018.8371
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Liraglutide is glucagon‑like peptide‑1 receptor agonist used for treating patients with type 2 diabetes mellitus. The present study aimed to investigate the role and mechanism of liraglutide in repairing the infarcted heart following myocardial infarction. The results of the present study demonstrated that amplification of the dose of liraglutide for ~28 days was able to reduce cardiac fibrosis, inflammatory responses and myocardial death in the post‑infarcted heart. In vitro, liraglutide protected cardiomyocyte mitochondria against the chronic hypoxic damage, inhibiting the mitochondrial apoptosis pathways. Mechanistically, liraglutide elevated the expression of NAD‑dependent protein deacetylase sirtuin‑1 (SIRT1), which increased the expression of Parkin, leading to mitophagy activation. Protective mitophagy reversed cellular adenosine 5'‑triphosphate production, reduced cellular oxidative stress and balanced the redox response, sustaining mitochondrial homeostasis. Notably, following blockade of glucagon‑like peptide 1 receptor or knockdown of Parkin, the beneficial effects of liraglutide on mitochondria disappeared. In conclusion, the results of the present study illustrated the protective role of liraglutide in repairing the infarcted heart via regulation of the SIRT1/Parkin/mitophagy pathway.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

View References

1 

Bae S, Park M, Kang C, Dilmen S, Kang TH, Kang DG, Ke Q, Lee SU, Lee D and Kang PM: Hydrogen peroxide-responsive nanoparticle reduces myocardial ischemia/reperfusion injury. J Am Heart Assoc. 5:2016. View Article : Google Scholar : PubMed/NCBI

2 

Stähli BE, Gebhard C, Duchatelle V, Cournoyer D, Petroni T, Tanguay JF, Robb S, Mann J, Guertin MC, Wright RS, et al: Effects of the P-selectin antagonist inclacumab on myocardial damage after percutaneous coronary intervention according to timing of infusion: Insights from the SELECT-ACS trial. J Am Heart Assoc. 5:2016. View Article : Google Scholar

3 

Han D, Huang W, Li X, Gao L, Su T, Li X, Ma S, Liu T, Li C, Chen J, et al: Melatonin facilitates adipose-derived mesenchymal stem cells to repair the murine infarcted heart via the SIRT1 signaling pathway. J Pineal Res. 60:178–192. 2016. View Article : Google Scholar : PubMed/NCBI

4 

de Souza P, Guarido KL, Scheschowitsch K, da Silva LM, Werner MF, Assreuy J and da Silva-Santos JE: Impaired vascular function in sepsis-surviving rats mediated by oxidative stress and Rho-Kinase pathway. Redox Biol. 10:140–147. 2016. View Article : Google Scholar : PubMed/NCBI

5 

Zhu R, Sun H, Yu K, Zhong Y, Shi H, Wei Y, Su X, Xu W, Luo Q, Zhang F, et al: Interleukin-37 and dendritic cells treated with interleukin-37 plus troponin I ameliorate cardiac remodeling after myocardial infarction. J Am Heart Assoc. 5:2016. View Article : Google Scholar

6 

Nishikido T, Oyama J, Shiraki A, Komoda H and Node K: Deletion of apoptosis inhibitor of macrophage (AIM)/CD5L attenuates the inflammatory response and infarct size in acute myocardial infarction. J Am Heart Assoc. 5:e0028632016. View Article : Google Scholar : PubMed/NCBI

7 

Koenitzer JR, Bonacci G, Woodcock SR, Chen CS, Cantu-Medellin N, Kelley EE and Schopfer FJ: Fatty acid nitroalkenes induce resistance to ischemic cardiac injury by modulating mitochondrial respiration at complex II. Redox Biol. 8:1–10. 2016. View Article : Google Scholar : PubMed/NCBI

8 

He B, Zhao Y, Xu L, Gao L, Su Y, Lin N and Pu J: The nuclear melatonin receptor RORa is a novel endogenous defender against myocardial ischemia/reperfusion injury. J Pineal Res. 60:313–326. 2016. View Article : Google Scholar : PubMed/NCBI

9 

Quijano C, Trujillo M, Castro L and Trostchansky A: Interplay between oxidant species and energy metabolism. Redox Biol. 8:28–42. 2016. View Article : Google Scholar : PubMed/NCBI

10 

Hu SY, Zhang Y, Zhu PJ, Zhou H and Chen YD: Liraglutide directly protects cardiomyocytes against reperfusion injury possibly via modulation of intracellular calcium homeostasis. J Geriatr Cardiol. 14:57–66. 2017.PubMed/NCBI

11 

Zhang W, Ren H, Xu C, Zhu C, Wu H, Liu D, Wang J, Liu L, Li W, Ma Q, et al: Hypoxic mitophagy regulates mitochondrial quality and platelet activation and determines severity of I/R heart injury. Elife. 5:2016. View Article : Google Scholar

12 

Zhou H, Li D, Zhu P, Hu S, Hu N, Ma S, Zhang Y, Han T, Ren J, Cao F and Chen Y: Melatonin suppresses platelet activation and function against cardiac ischemia/reperfusion injury via PPARγ/FUNDC1/mitophagy pathways. J Pineal Res. 63:2017. View Article : Google Scholar :

13 

Zhou H, Zhang Y, Hu S, Shi C, Zhu P, Ma Q, Jin Q, Cao F, Tian F and Chen Y: Melatonin protects cardiac microvasculature against ischemia/reperfusion injury via suppression of mitochondrial fission-VDAC1-HK2-mPTP-mitophagy axis. J Pineal Res. 63:2017. View Article : Google Scholar :

14 

Zhou H, Zhu P, Guo J, Hu N, Wang S, Li D, Hu S, Ren J, Cao F and Chen Y: Ripk3 induces mitochondrial apoptosis via inhibition of FUNDC1 mitophagy in cardiac IR injury. Redox Biol. 13:498–507. 2017. View Article : Google Scholar : PubMed/NCBI

15 

Wu H, Wei H, Sehgal SA, Liu L and Chen Q: Mitophagy receptors sense stress signals and couple mitochondrial dynamic machinery for mitochondrial quality control. Free Radic Biol Med. 100:199–209. 2016. View Article : Google Scholar : PubMed/NCBI

16 

Mouton-Liger F, Jacoupy M, Corvol JC and Corti O: PINK1/Parkin-dependent mitochondrial surveillance: From Pleiotropy to Parkinson's disease. Front Mol Neurosci. 10:1202017. View Article : Google Scholar : PubMed/NCBI

17 

McWilliams TG and Muqit MM: PINK1 and Parkin: Emerging themes in mitochondrial homeostasis. Curr Opin Cell Biol. 45:83–91. 2017. View Article : Google Scholar : PubMed/NCBI

18 

Rodriguez V, Weiss MC, Weintraub H, Goldberg IJ and Schwartzbard A: Cardiovascular disease leads to a new algorithm for diabetes treatment. J Clin Lipidol. 11:1126–1133. 2017. View Article : Google Scholar : PubMed/NCBI

19 

Levin PA, Nguyen H, Wittbrodt ET and Kim SC: Glucagon-like peptide-1 receptor agonists: A systematic review of comparative effectiveness research. Diabetes Metab Syndr Obes. 10:123–139. 2017. View Article : Google Scholar : PubMed/NCBI

20 

Chen WR, Tian F, Chen YD, Wang J, Yang JJ, Wang ZF, Da Wang J and Ning QX: Effects of liraglutide on no-reflow in patients with acute ST-segment elevation myocardial infarction. Int J Cardiol. 208:109–114. 2016. View Article : Google Scholar : PubMed/NCBI

21 

Chen WR, Chen YD, Tian F, Yang N, Cheng LQ, Hu SY, Wang J, Yang JJ, Wang SF and Gu XF: Effects of liraglutide on reperfusion injury in patients with ST-segment-elevation myocardial infarction. Circ Cardiovasc Imaging. 9:2016. View Article : Google Scholar :

22 

Paneni F and Lüscher TF: Cardiovascular protection in the treatment of type 2 diabetes: A review of clinical trial results across drug classes. Am J Med. 130:S18–S29. 2017. View Article : Google Scholar : PubMed/NCBI

23 

Chen WR, Shen XQ, Zhang Y, Chen YD, Hu SY, Qian G, Wang J, Yang JJ, Wang ZF and Tian F: Effects of liraglutide on left ventricular function in patients with non-ST-segment elevation myocardial infarction. Endocrine. 52:516–526. 2016. View Article : Google Scholar : PubMed/NCBI

24 

Chen WR, Hu SY, Chen YD, Zhang Y, Qian G, Wang J, Yang JJ, Wang ZF, Tian F and Ning QX: Effects of liraglutide on left ventricular function in patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention. Am Heart J. 170:845–854. 2015. View Article : Google Scholar : PubMed/NCBI

25 

Zhang W, Huang Q, Zeng Z, Wu J, Zhang Y and Chen Z: Sirt1 inhibits oxidative stress in vascular endothelial cells. Oxid Med Cell Longev. 2017:75439732017. View Article : Google Scholar : PubMed/NCBI

26 

D'Onofrio N, Servillo L, Giovane A, Casale R, Vitiello M, Marfella R, Paolisso G and Balestrieri ML: Ergothioneine oxidation in the protection against high-glucose induced endothelial senescence: Involvement of SIRT1 and SIRT6. Free Radic Biol Med. 96:211–222. 2016. View Article : Google Scholar : PubMed/NCBI

27 

Mayo JC, Sainz RM, González Menéndez P, Cepas V, Tan DX and Reiter RJ: Melatonin and sirtuins: A ‘not-so unexpected’ relationship. J Pineal Res. 62:2017

28 

Zhang C, Qu S, Wei X, Feng Y, Zhu H, Deng J, Wang K, Liu K, Liu M, Zhang H and Xiao X: HSP25 down-regulation enhanced p53 acetylation by dissociation of SIRT1 from p53 in doxorubicin-induced H9c2 cell apoptosis. Cell Stress Chaperones. 21:251–260. 2016. View Article : Google Scholar : PubMed/NCBI

29 

Tong W, Ju L, Qiu M, Xie Q, Chen Y, Shen W, Sun W, Wang W and Tian J: Liraglutide ameliorates non-alcoholic fatty liver disease by enhancing mitochondrial architecture and promoting autophagy through the SIRT1/SIRT3-FOXO3a pathway. Hepatol Res. 46:933–943. 2016. View Article : Google Scholar : PubMed/NCBI

30 

Prieto-Domínguez N, Ordóñez R, Fernández A, Méndez-Blanco C, Baulies A, Garcia-Ruiz C, Fernández-Checa JC, Mauriz JL and González-Gallego J: Melatonin-induced increase in sensitivity of human hepatocellular carcinoma cells to sorafenib is associated with reactive oxygen species production and mitophagy. J Pineal Res. 61:396–407. 2016. View Article : Google Scholar : PubMed/NCBI

31 

Ho HY, Lin CW, Chien MH, Reiter RJ, Su SC, Hsieh YH and Yang SF: Melatonin suppresses TPA-induced metastasis by downregulating matrix metalloproteinase-9 expression through JNK/SP-1 signaling in nasopharyngeal carcinoma. J Pineal Res. 61:479–492. 2016. View Article : Google Scholar : PubMed/NCBI

32 

Zhang Y, Zhou H, Wu W, Shi C, Hu S, Yin T, Ma Q, Han T, Zhang Y, Tian F and Chen Y: Liraglutide protects cardiac microvascular endothelial cells against hypoxia/reoxygenation injury through the suppression of the SR-Ca(2+)-XO-ROS axis via activation of the GLP-1R/PI3K/Akt/survivin pathways. Free Radic Biol Med. 95:278–292. 2016. View Article : Google Scholar : PubMed/NCBI

33 

Xu S, Pi H, Zhang L, Zhang N, Li Y, Zhang H, Tang J, Li H, Feng M, Deng P, et al: Melatonin prevents abnormal mitochondrial dynamics resulting from the neurotoxicity of cadmium by blocking calcium-dependent translocation of Drp1 to the mitochondria. J Pineal Res. 60:291–302. 2016. View Article : Google Scholar : PubMed/NCBI

34 

Quintana C, Cabrera J, Perdomo J, Estévez F, Loro JF, Reiter RJ and Quintana J: Melatonin enhances hyperthermia-induced apoptotic cell death in human leukemia cells. J Pineal Res. 61:381–395. 2016. View Article : Google Scholar : PubMed/NCBI

35 

Pariente R, Pariente JA, Rodríguez AB and Espino J: Melatonin sensitizes human cervical cancer HeLa cells to cisplatin-induced cytotoxicity and apoptosis: Effects on oxidative stress and DNA fragmentation. J Pineal Res. 60:55–64. 2016. View Article : Google Scholar : PubMed/NCBI

36 

Kitsati N, Mantzaris MD and Galaris D: Hydroxytyrosol inhibits hydrogen peroxide-induced apoptotic signaling via labile iron chelation. Redox Biol. 10:233–242. 2016. View Article : Google Scholar : PubMed/NCBI

37 

Lin YW, Lee LM, Lee WJ, Chu CY, Tan P, Yang YC, Chen WY, Yang SF, Hsiao M and Chien MH: Melatonin inhibits MMP-9 transactivation and renal cell carcinoma metastasis by suppressing Akt-MAPKs pathway and NF-κB DNA-binding activity. J Pineal Res. 60:277–290. 2016. View Article : Google Scholar : PubMed/NCBI

38 

Ursini F, Maiorino M and Forman HJ: Redox homeostasis: The Golden Mean of healthy living. Redox Biol. 8:205–215. 2016. View Article : Google Scholar : PubMed/NCBI

39 

Du K, Ramachandran A and Jaeschke H: Oxidative stress during acetaminophen hepatotoxicity: Sources, pathophysiological role and therapeutic potential. Redox Biol. 10:148–156. 2016. View Article : Google Scholar : PubMed/NCBI

40 

Rizzo NR, Hank NC and Zhang J: Detecting presence of cardiovascular disease through mitochondria respiration as depicted through biophotonic emission. Redox Biol. 8:11–17. 2016. View Article : Google Scholar : PubMed/NCBI

41 

Singh AK and Singh R: SAVOR-TIMI to SUSTAIN-6: A critical comparison of cardiovascular outcome trials of antidiabetic drugs. Expert Rev Clin Pharmacol. 10:429–442. 2017. View Article : Google Scholar : PubMed/NCBI

42 

Mailloux RJ and Treberg JR: Protein S-glutathionlyation links energy metabolism to redox signaling in mitochondria. Redox Biol. 8:110–118. 2016. View Article : Google Scholar : PubMed/NCBI

43 

Caja S and Enríquez JA: Mitochondria in endothelial cells: Sensors and integrators of environmental cues. Redox Biol. 12:821–827. 2017. View Article : Google Scholar : PubMed/NCBI

44 

Zhang W, Siraj S, Zhang R and Chen Q: Mitophagy receptor FUNDC1 regulates mitochondrial homeostasis and protects the heart from I/R injury. Autophagy. 13:1080–1081. 2017. View Article : Google Scholar : PubMed/NCBI

45 

Qiu S, Zhu S, Xu S, Han Y, Liu W and Zuo J: Molecular dynamics simulations of human E3 ubiquitin ligase Parkin. Mol Med Rep. 16:4561–4568. 2017. View Article : Google Scholar : PubMed/NCBI

46 

Shida M, Kitajima Y, Nakamura J, Yanagihara K, Baba K, Wakiyama K and Noshiro H: Impaired mitophagy activates mtROS/HIF-1α interplay and increases cancer aggressiveness in gastric cancer cells under hypoxia. Int J Oncol. 48:1379–1390. 2016. View Article : Google Scholar : PubMed/NCBI

47 

Díaz-Casado ME, Lima E, García JA, Doerrier C, Aranda P, Sayed RK, Guerra-Librero A, Escames G, López LC and Acuña-Castroviejo D: Melatonin rescues zebrafish embryos from the parkinsonian phenotype restoring the parkin/PINK1/DJ-1/MUL1 network. J Pineal Res Res Pineal Res. 61:96–107. 2016. View Article : Google Scholar

48 

Mendivil-Perez M, Soto-Mercado V, Guerra-Librero A, Fernandez-Gil BI, Florido J, Shen YQ, Tejada MA, Capilla-Gonzalez V, Rusanova I, Garcia-Verdugo JM, et al: Melatonin enhances neural stem cell differentiation and engraftment by increasing mitochondrial function. J Pineal Res. 63:2017. View Article : Google Scholar : PubMed/NCBI

49 

Bravo-San Pedro JM, Kroemer G and Galluzzi L: Autophagy and mitophagy in cardiovascular disease. Circ Res. 120:1812–1824. 2017. View Article : Google Scholar : PubMed/NCBI

50 

Nan J, Zhu W, Rahman MS, Liu M, Li D, Su S, Zhang N, Hu X, Yu H, Gupta MP and Wang J: Molecular regulation of mitochondrial dynamics in cardiac disease. Biochim Biophys Acta. 1864:1260–1273. 2017. View Article : Google Scholar : PubMed/NCBI

51 

Vásquez-Trincado C, García-Carvajal I, Pennanen C, Parra V, Hill JA, Rothermel BA and Lavandero S: Mitochondrial dynamics, mitophagy and cardiovascular disease. J Physiol. 594:509–525. 2016. View Article : Google Scholar : PubMed/NCBI

52 

Shires SE and Gustafsson ÅB: Mitophagy and heart failure. J Mol Med (Berl). 93:253–262. 2015. View Article : Google Scholar : PubMed/NCBI

53 

Akkafa F, Halil Altiparmak I, Erkus ME, Aksoy N, Kaya C, Ozer A, Sezen H, Oztuzcu S, Koyuncu I and Umurhan B: Reduced SIRT1 expression correlates with enhanced oxidative stress in compensated and decompensated heart failure. Redox Biol. 6:169–173. 2015. View Article : Google Scholar : PubMed/NCBI

54 

Kozlov AV, Lancaster JR Jr, Meszaros AT and Weidinger A: Mitochondria-meditated pathways of organ failure upon inflammation. Redox Biol. 13:170–181. 2017. View Article : Google Scholar : PubMed/NCBI

55 

Dhingra A, Jayas R, Afshar P, Guberman M, Maddaford G, Gerstein J, Lieberman B, Nepon H, Margulets V, Dhingra R and Kirshenbaum LA: Ellagic acid antagonizes Bnip3-mediated mitochondrial injury and necrotic cell death of cardiac myocytes. Free Radic Biol Med. 112:411–422. 2017. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Qiao H, Ren H, Du H, Zhang M, Xiong X and Lv R: Liraglutide repairs the infarcted heart: The role of the SIRT1/Parkin/mitophagy pathway Retraction in /10.3892/mmr.2024.13192. Mol Med Rep 17: 3722-3734, 2018.
APA
Qiao, H., Ren, H., Du, H., Zhang, M., Xiong, X., & Lv, R. (2018). Liraglutide repairs the infarcted heart: The role of the SIRT1/Parkin/mitophagy pathway Retraction in /10.3892/mmr.2024.13192. Molecular Medicine Reports, 17, 3722-3734. https://doi.org/10.3892/mmr.2018.8371
MLA
Qiao, H., Ren, H., Du, H., Zhang, M., Xiong, X., Lv, R."Liraglutide repairs the infarcted heart: The role of the SIRT1/Parkin/mitophagy pathway Retraction in /10.3892/mmr.2024.13192". Molecular Medicine Reports 17.3 (2018): 3722-3734.
Chicago
Qiao, H., Ren, H., Du, H., Zhang, M., Xiong, X., Lv, R."Liraglutide repairs the infarcted heart: The role of the SIRT1/Parkin/mitophagy pathway Retraction in /10.3892/mmr.2024.13192". Molecular Medicine Reports 17, no. 3 (2018): 3722-3734. https://doi.org/10.3892/mmr.2018.8371
Copy and paste a formatted citation
x
Spandidos Publications style
Qiao H, Ren H, Du H, Zhang M, Xiong X and Lv R: Liraglutide repairs the infarcted heart: The role of the SIRT1/Parkin/mitophagy pathway Retraction in /10.3892/mmr.2024.13192. Mol Med Rep 17: 3722-3734, 2018.
APA
Qiao, H., Ren, H., Du, H., Zhang, M., Xiong, X., & Lv, R. (2018). Liraglutide repairs the infarcted heart: The role of the SIRT1/Parkin/mitophagy pathway Retraction in /10.3892/mmr.2024.13192. Molecular Medicine Reports, 17, 3722-3734. https://doi.org/10.3892/mmr.2018.8371
MLA
Qiao, H., Ren, H., Du, H., Zhang, M., Xiong, X., Lv, R."Liraglutide repairs the infarcted heart: The role of the SIRT1/Parkin/mitophagy pathway Retraction in /10.3892/mmr.2024.13192". Molecular Medicine Reports 17.3 (2018): 3722-3734.
Chicago
Qiao, H., Ren, H., Du, H., Zhang, M., Xiong, X., Lv, R."Liraglutide repairs the infarcted heart: The role of the SIRT1/Parkin/mitophagy pathway Retraction in /10.3892/mmr.2024.13192". Molecular Medicine Reports 17, no. 3 (2018): 3722-3734. https://doi.org/10.3892/mmr.2018.8371
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team