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Article

Oxymatrine protects against the effects of cardiopulmonary resuscitation via modulation of the TGF-β1/Smad3 signaling pathway

  • Authors:
    • Dawei Wang
    • Xiao Qian Lou
    • Xiao‑Ming Jiang
    • Chenxi Yang
    • Xiao‑Liang Liu
    • Nan Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Emergency, The First Hospital of Jilin University, Chaoyang, Changchun, Jilin 130000, P.R. China, Department of Endocrinology, Second Department, The First Hospital of Jilin University, Chaoyang, Changchun, Jilin 130000, P.R. China, Centre for Heart and Lung Innovation University of British Columbia, Vancouver, BC V6P 2G9, Canada
  • Pages: 4747-4752
    |
    Published online on: January 4, 2018
       https://doi.org/10.3892/mmr.2018.8373
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Abstract

Previous studies have demonstrated that oxymatrine may inhibit ventricular remodeling and serves an important role in the treatment of cardiovascular disease. The present study investigated whether oxymatrine treatment protects against the effects of cardiopulmonary resuscitation (CPR) via regulation of the transforming growth factor‑β1 (TGF‑β1)/mothers against decapentaplegic (Smad) signaling pathway. A CPR model was established in Sprague‑Dawley (SD) rats by asphyxiation, and rats were subsequently anaesthetized by intraperitoneal injection of chloral hydrate. SD rats were then administered 25 or 50 mg/kg oxymatrine once a day for 4 weeks. Oxymatrine treatment significantly improved troponin I levels, the ejection fraction, hydroxyproline content and the myocardial performance index in model rats. However, treatment with oxymatrine significantly reduced arterial oxygen tension, arterial lactate levels and oxygen extraction. Treatment with oxymatrine following CPR significantly inhibited the protein expression levels of TGF‑β1, TGF‑β1 receptor type 1 and Smad homolog 3 (Smad3) in model rats. The results of this research indicated that oxymatrine treatment may protect against the effects of CPR via regulation of the TGF‑β1/Smad3 signaling pathway and may be a novel drug for CPR in a clinical setting.
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View References

1 

Takahashi K, Sasanuma N, Itani Y, Tanaka T, Domen K, Masuyama T, Ohyanagi M and Suzuki K: Impact of early interventions by a cardiac rehabilitation team on the social rehabilitation of patients resuscitated from cardiogenic out-of-hospital cardiopulmonary arrest. Intern Med. 54:133–139. 2015. View Article : Google Scholar : PubMed/NCBI

2 

Blomberg H, Gedeborg R, Berglund L, Karlsten R and Johansson J: Poor chest compression quality with mechanical compressions in simulated CPR: A randomized, cross-over manikin study. Resuscitation. 82:1332–1337. 2011. View Article : Google Scholar : PubMed/NCBI

3 

Chung TN, Kim SW, You JS, Cho YS, Chung SP, Park I and Kim SH: The specific effect of metronome guidance on the quality of one-person CPR and rescuer fatigue. J Emerg Med. 43:1049–1054. 2012. View Article : Google Scholar : PubMed/NCBI

4 

Ducros L, Vicaut E, Soleil C, Le Guen M, Gueye P, Poussant T, Mebazaa A, Payen D and Plaisance P: Effect of the addition of vasopressin or vasopressin plus nitroglycerin to epinephrine on arterial blood pressure during CPR in humans. J Emerg Med. 41:453–459. 2011. View Article : Google Scholar : PubMed/NCBI

5 

Jones CM, Thorne CJ, Colter PS, Macrae A, Brown GA and Hulme J: Rescuers may vary their side of approach to a casualty without impact on cardiopulmonary resuscitation performance. Emerg Med J. 30:74–75. 2013. View Article : Google Scholar : PubMed/NCBI

6 

Maitra SR, Bhaduri S, El-Maghrabi MR and Shapiro MJ: Inhibition of matrix metalloproteinase on hepatic transforming growth factor beta1 and caspase-3 activation in hemorrhage. Acad Emerg Med. 12:797–803. 2005. View Article : Google Scholar : PubMed/NCBI

7 

Wang X, Qu X, Zhong Q, Li Q and Wang D: Expression of transforming growth factor beta 1 in lung tissue during cardiopulmonary bypass-induced lung injury in dogs. Thorac Cardiovasc Surg. 61:747–753. 2013. View Article : Google Scholar : PubMed/NCBI

8 

Hutcheson JD, Ryzhova LM, Setola V and Merryman WD: 5-HT(2B) antagonism arrests non-canonical TGF-β1-induced valvular myofibroblast differentiation. J Mol Cell Cardiol. 53:707–714. 2012. View Article : Google Scholar : PubMed/NCBI

9 

Liu XN, Wang S, Yang Q, Wang YJ, Chen DX and Zhu XX: ESC reverses epithelial mesenchymal transition induced by transforming growth factor-β via inhibition of Smad signal pathway in HepG2 liver cancer cells. Cancer Cell Int. 15:1142015. View Article : Google Scholar : PubMed/NCBI

10 

He M, Wu Y, Wang M, Chen W, Yuan W and Jiang J: The clinical value of oxymatrine in preventing lamivudine induced YMDD mutation: A Meta-analysis. Evid Based Complement Alternat Med. 2015:9716162015. View Article : Google Scholar : PubMed/NCBI

11 

Jiang G, Liu X, Wang M, Chen H, Chen Z and Qiu T: Oxymatrine ameliorates renal ischemia-reperfusion injury from oxidative stress through Nrf2/HO-1 pathway. Acta Cir Bras. 30:422–429. 2015. View Article : Google Scholar : PubMed/NCBI

12 

Zhang Y, Yan R and Hu Y: Oxymatrine inhibits lipopolysaccharide-induced inflammation by down-regulating Toll-like receptor 4/nuclear factor-kappa B in macrophages. Can J Physiol Pharmacol. 93:253–260. 2015. View Article : Google Scholar : PubMed/NCBI

13 

Shen XC, Yang YP, Xiao TT, Peng J and Liu XD: Protective effect of oxymatrine on myocardial fibrosis induced by acute myocardial infarction in rats involved in TGF-β1-Smads signal pathway. J Asian Nat Prod Res. 13:215–224. 2011. View Article : Google Scholar : PubMed/NCBI

14 

Ye S, Weng Y, Sun S, Chen W, Wu X, Li Z, Weil MH and Tang W: Comparison of the durations of mild therapeutic hypothermia on outcome after CPR in the rat. Circulation. 125:123–129. 2012. View Article : Google Scholar : PubMed/NCBI

15 

Edelson DP, Call SL, Yuen TC and Vanden Hoek TL: The impact of a step stool on CPR: A cross-over mannequin study. Resuscitation. 83:874–878. 2012. View Article : Google Scholar : PubMed/NCBI

16 

Zhao S, Qian J, Wang J, Tang G, Zhengfei Y, Jena C, Xiaobo WU, Neil D, Caijing L and Wanchun T: Effects of oxygen concentrations on postresuscitation myocardial oxidative stress and myocardial function in a rat model of Cardiopulmonary Resuscitation. Crit Care Med. 43:e560–e566. 2015. View Article : Google Scholar : PubMed/NCBI

17 

Kruzliak P, Pechanova O and Kara T: New perspectives of nitric oxide donors in cardiac arrest and CPR treatment. Heart Fail Rev. 19:383–390. 2014. View Article : Google Scholar : PubMed/NCBI

18 

Xue M, McKelvey K, Shen K, Minhas N, March L, Park SY and Jackson CJ: Endogenous MMP-9 and not MMP-2 promotes rheumatoid synovial fibroblast survival, inflammation and cartilage degradation. Rheumatology (Oxford). 53:2270–2279. 2014. View Article : Google Scholar : PubMed/NCBI

19 

Kim BJ, Hur JW, Park JS, Kim JH, Kwon TH, Park YK and Moon HJ: Expression of matrix metalloproteinase-2 and −9 in human ligamentum flavum cells treated with tumor necrosis factor-α and interleukin-1β. J Neurosurg Spine. 24:428–435. 2016. View Article : Google Scholar : PubMed/NCBI

20 

Stan MS, Sima C, Cinteza LO and Dinischiotu A: Silicon-based quantum dots induce inflammation in human lung cells and disrupt extracellular matrix homeostasis. FEBS J. 282:2914–2929. 2015. View Article : Google Scholar : PubMed/NCBI

21 

Tuuminen R, Nykänen AI, Krebs R, Soronen J, Pajusola K, Keränen MA, Koskinen PK, Alitalo K and Lemström KB: PDGF-A, -C, and -D but not PDGF-B increase TGF-beta1 and chronic rejection in rat cardiac allografts. Arterioscler Thromb Vasc Biol. 29:691–698. 2009. View Article : Google Scholar : PubMed/NCBI

22 

Wang J, Yu J, Ding CP, Han SP, Zeng XY and Wang JY: Transforming growth factor-beta in the red nucleus plays antinociceptive effect under physiological and pathological pain conditions. Neuroscience. 291:37–45. 2015. View Article : Google Scholar : PubMed/NCBI

23 

Fan DL, Zhao WJ, Wang YX, Han SY and Guo S: Oxymatrine inhibits collagen synthesis in keloid fibroblasts via inhibition of transforming growth factor-β1/Smad signaling pathway. Int J Dermatol. 51:463–472. 2012. View Article : Google Scholar : PubMed/NCBI

24 

Yan X, Liao H, Cheng M, Shi X, Lin X, Feng XH and Chen YG: Smad7 Protein Interacts with Receptor-regulated Smads (R-Smads) to inhibit transforming growth factor-β (TGF-β)/Smad signaling. J Biol Chem. 291:382–392. 2016. View Article : Google Scholar : PubMed/NCBI

25 

Du S, Li H, Cui Y, Yang L, Wu J, Huang H, Chen Y, Huang W, Zhang R, Yang J, et al: Houttuynia cordata inhibits lipopolysaccharide-induced rapid pulmonary fibrosis by up-regulating IFN-γ and inhibiting the TGF-β1/Smad pathway. Int Immunopharmacol. 13:331–340. 2012. View Article : Google Scholar : PubMed/NCBI

26 

Xu Z, Ramachandran S, Gunasekaran M, Zhou F, Trulock E, Kreisel D, Hachem R and Mohanakumar T: MicroRNA-144 dysregulates the transforming growth factor-β signaling cascade and contributes to the development of bronchiolitis obliterans syndrome after human lung transplantation. J Heart Lung Transplant. 34:1154–1162. 2015. View Article : Google Scholar : PubMed/NCBI

27 

Guo C, Han F, Zhang C, Xiao W and Yang Z: Protective effects of oxymatrine on experimental diabetic nephropathy. Planta Med. 80:269–276. 2014. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Wang D, Lou XQ, Jiang XM, Yang C, Liu XL and Zhang N: Oxymatrine protects against the effects of cardiopulmonary resuscitation via modulation of the TGF-β1/Smad3 signaling pathway. Mol Med Rep 17: 4747-4752, 2018.
APA
Wang, D., Lou, X.Q., Jiang, X., Yang, C., Liu, X., & Zhang, N. (2018). Oxymatrine protects against the effects of cardiopulmonary resuscitation via modulation of the TGF-β1/Smad3 signaling pathway. Molecular Medicine Reports, 17, 4747-4752. https://doi.org/10.3892/mmr.2018.8373
MLA
Wang, D., Lou, X. Q., Jiang, X., Yang, C., Liu, X., Zhang, N."Oxymatrine protects against the effects of cardiopulmonary resuscitation via modulation of the TGF-β1/Smad3 signaling pathway". Molecular Medicine Reports 17.3 (2018): 4747-4752.
Chicago
Wang, D., Lou, X. Q., Jiang, X., Yang, C., Liu, X., Zhang, N."Oxymatrine protects against the effects of cardiopulmonary resuscitation via modulation of the TGF-β1/Smad3 signaling pathway". Molecular Medicine Reports 17, no. 3 (2018): 4747-4752. https://doi.org/10.3892/mmr.2018.8373
Copy and paste a formatted citation
x
Spandidos Publications style
Wang D, Lou XQ, Jiang XM, Yang C, Liu XL and Zhang N: Oxymatrine protects against the effects of cardiopulmonary resuscitation via modulation of the TGF-β1/Smad3 signaling pathway. Mol Med Rep 17: 4747-4752, 2018.
APA
Wang, D., Lou, X.Q., Jiang, X., Yang, C., Liu, X., & Zhang, N. (2018). Oxymatrine protects against the effects of cardiopulmonary resuscitation via modulation of the TGF-β1/Smad3 signaling pathway. Molecular Medicine Reports, 17, 4747-4752. https://doi.org/10.3892/mmr.2018.8373
MLA
Wang, D., Lou, X. Q., Jiang, X., Yang, C., Liu, X., Zhang, N."Oxymatrine protects against the effects of cardiopulmonary resuscitation via modulation of the TGF-β1/Smad3 signaling pathway". Molecular Medicine Reports 17.3 (2018): 4747-4752.
Chicago
Wang, D., Lou, X. Q., Jiang, X., Yang, C., Liu, X., Zhang, N."Oxymatrine protects against the effects of cardiopulmonary resuscitation via modulation of the TGF-β1/Smad3 signaling pathway". Molecular Medicine Reports 17, no. 3 (2018): 4747-4752. https://doi.org/10.3892/mmr.2018.8373
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