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Article Open Access

Prevalence of the CYP2C19*2 (681 G>A), *3 (636 G>A) and *17 (‑806 C>T) alleles among an Iranian population of different ethnicities

  • Authors:
    • Mahshid Dehbozorgi
    • Behnam Kamalidehghan
    • Iman Hosseini
    • Zahra Dehghanfard
    • Mohammad Hossein Sangtarash
    • Maryam Firoozi
    • Fatemeh Ahmadipour
    • Goh Yong Meng
    • Massoud Houshmand
  • View Affiliations / Copyright

    Affiliations: Department of Biology, University of Sistan and Baluchestan, Zahedan 98155‑987, Iran, Medical Genetics Department, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran 198396‑3113, Iran, Department of Cellular and Molecular Biology, Nourdanesh Institute of Higher Education, Isfahan 8351711111, Iran, Department of Medical Genetics, National Institute of Genetic Engineering and Biotechnology, Tehran 14965/161, Iran, Pharmacy Department, Faculty of Medicine, University of Malaya, Kuala Lumpur 50603, Malaysia, Department of Preclinical Sciences, Faculty of Veterinary Medicine, Universiti Putra Malaysia, Selangor 43400, Malaysia
    Copyright: © Dehbozorgi et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 4195-4202
    |
    Published online on: January 5, 2018
       https://doi.org/10.3892/mmr.2018.8377
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Abstract

Polymorphisms in the cytochrome P (CYP) 450 family may cause adverse drug responses in individuals. Cytochrome P450 2C19 (CYP2C19) is a member of the CYP family, where the presence of the 681 G>A, 636 G>A and 806 C>T polymorphisms result in the CYP2C19*2, CYP2C19*3 and CYP2C19*17 alleles, respectively. In the current study, the frequency of the CYP2C19*2, CYP2C19*3 and CYP2C19*17 alleles in an Iranian population cohort of different ethnicities were examined and then compared with previously published frequencies within other populations. Allelic and genotypic frequencies of the CYP2C19 alleles (*2, *3 and *17) were detected using polymerase chain reaction (PCR)‑restriction fragment length polymorphism analysis, PCR‑single‑strand conformation polymorphism analysis and DNA sequencing from blood samples of 1,229 unrelated healthy individuals from different ethnicities within the Iranian population. The CYP2C19 allele frequencies among the Iranian population were 21.4, 1.7, and 27.1% for the CYP2C19*2, CYP2C19*3 and CYP2C19*17 alleles, respectively. The frequency of the homozygous A/A variant of the CYP2C19*2 allele was significantly high and low in the Lur (P<0.001) and Caspian (P<0.001) ethnicities, respectively. However, the frequency of the homozygous A/A variant of the CYP2C19*3 allele was not detected in the Iranian cohort in the current study. The frequency of the heterozygous G/A variant of the CYP2C19*3 allele had the significantly highest and lowest frequency in the Fars (P<0.001) and Lur (P<0.001) groups, respectively. The allele frequency of the homozygous T/T variant of the CYP2C19*17 allele was significantly high in the Caspian (P<0.001) and low in the Kurd (P<0.05) groups. The frequency of the CYP2C19 alleles involved in drug metabolism, may improve the clinical understanding of the ethnic differences in drug responses, resulting in the advancement of the personalized medicine among the different ethnicities within the Iranian population.
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Copy and paste a formatted citation
Spandidos Publications style
Dehbozorgi M, Kamalidehghan B, Hosseini I, Dehghanfard Z, Sangtarash MH, Firoozi M, Ahmadipour F, Meng GY and Houshmand M: Prevalence of the CYP2C19*2 (681 G>A), *3 (636 G>A) and *17 (‑806 C>T) alleles among an Iranian population of different ethnicities. Mol Med Rep 17: 4195-4202, 2018.
APA
Dehbozorgi, M., Kamalidehghan, B., Hosseini, I., Dehghanfard, Z., Sangtarash, M.H., Firoozi, M. ... Houshmand, M. (2018). Prevalence of the CYP2C19*2 (681 G>A), *3 (636 G>A) and *17 (‑806 C>T) alleles among an Iranian population of different ethnicities. Molecular Medicine Reports, 17, 4195-4202. https://doi.org/10.3892/mmr.2018.8377
MLA
Dehbozorgi, M., Kamalidehghan, B., Hosseini, I., Dehghanfard, Z., Sangtarash, M. H., Firoozi, M., Ahmadipour, F., Meng, G. Y., Houshmand, M."Prevalence of the CYP2C19*2 (681 G>A), *3 (636 G>A) and *17 (‑806 C>T) alleles among an Iranian population of different ethnicities". Molecular Medicine Reports 17.3 (2018): 4195-4202.
Chicago
Dehbozorgi, M., Kamalidehghan, B., Hosseini, I., Dehghanfard, Z., Sangtarash, M. H., Firoozi, M., Ahmadipour, F., Meng, G. Y., Houshmand, M."Prevalence of the CYP2C19*2 (681 G>A), *3 (636 G>A) and *17 (‑806 C>T) alleles among an Iranian population of different ethnicities". Molecular Medicine Reports 17, no. 3 (2018): 4195-4202. https://doi.org/10.3892/mmr.2018.8377
Copy and paste a formatted citation
x
Spandidos Publications style
Dehbozorgi M, Kamalidehghan B, Hosseini I, Dehghanfard Z, Sangtarash MH, Firoozi M, Ahmadipour F, Meng GY and Houshmand M: Prevalence of the CYP2C19*2 (681 G>A), *3 (636 G>A) and *17 (‑806 C>T) alleles among an Iranian population of different ethnicities. Mol Med Rep 17: 4195-4202, 2018.
APA
Dehbozorgi, M., Kamalidehghan, B., Hosseini, I., Dehghanfard, Z., Sangtarash, M.H., Firoozi, M. ... Houshmand, M. (2018). Prevalence of the CYP2C19*2 (681 G>A), *3 (636 G>A) and *17 (‑806 C>T) alleles among an Iranian population of different ethnicities. Molecular Medicine Reports, 17, 4195-4202. https://doi.org/10.3892/mmr.2018.8377
MLA
Dehbozorgi, M., Kamalidehghan, B., Hosseini, I., Dehghanfard, Z., Sangtarash, M. H., Firoozi, M., Ahmadipour, F., Meng, G. Y., Houshmand, M."Prevalence of the CYP2C19*2 (681 G>A), *3 (636 G>A) and *17 (‑806 C>T) alleles among an Iranian population of different ethnicities". Molecular Medicine Reports 17.3 (2018): 4195-4202.
Chicago
Dehbozorgi, M., Kamalidehghan, B., Hosseini, I., Dehghanfard, Z., Sangtarash, M. H., Firoozi, M., Ahmadipour, F., Meng, G. Y., Houshmand, M."Prevalence of the CYP2C19*2 (681 G>A), *3 (636 G>A) and *17 (‑806 C>T) alleles among an Iranian population of different ethnicities". Molecular Medicine Reports 17, no. 3 (2018): 4195-4202. https://doi.org/10.3892/mmr.2018.8377
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