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Article

The effects of interleukin 2 and rAd-p53 as a treatment for glioblastoma

  • Authors:
    • Hai‑Bo Qiao
    • Jia Li
    • Lian‑Jie Lv
    • Ben‑Jin Nie
    • Peng Lu
    • Feng Xue
    • Zhi‑Ming Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery, Tianjin Nankai Hospital, Tianjin 300100, P.R. China
  • Pages: 4853-4859
    |
    Published online on: January 9, 2018
       https://doi.org/10.3892/mmr.2018.8408
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Abstract

Interleukin 2 (IL-2) is an anti-cancer cytokine that stimulates T cell propagation, triggering innate and adaptive immunity. IL-2 has been used for cancer therapy and has achieved curative effects. Recombinant adenovirus p53 injection (rAd‑p53) is a gene therapeutic agent that may improve the prognosis of patients with glioblastoma (GBM). In the present study, the effect of combined IL‑2 and rAd‑p53 treatment was studied. The ability of IL‑2 to stimulate immunoregulation and the ability of p53 to induce apoptosis for GBM was researched in the GBM tumor model. In addition, the activity of IL‑2 was analyzed. The antitumor potential of IL‑2 and rAd‑p53 was studied using xenograph mice carrying GBM cells. Tumor‑specific CD4+ and CD8+ T cells were also analyzed in the GBM‑bearing models. The results demonstrated that IL‑2 and rAd‑p53 not only stimulated tumor‑specific cytotoxic T‑lymphocyte responses and increased regulatory CD4+ and cytotoxic CD8+ T cell proliferation, however additionally increased expression of apoptosis‑associated genes. The treatment with IL‑2 and rAd‑p53 resulted in tumor regression and prolonged the survival of glioma‑bearing mice. Taken together, a combination of IL‑2 and rAd‑p53 treatment combines the effects of immunotherapy and oncolytic therapy and may be a comprehensive therapeutic schedule for clinical application in future cancer therapies.
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Copy and paste a formatted citation
Spandidos Publications style
Qiao HB, Li J, Lv LJ, Nie BJ, Lu P, Xue F and Zhang ZM: The effects of interleukin 2 and rAd-p53 as a treatment for glioblastoma. Mol Med Rep 17: 4853-4859, 2018.
APA
Qiao, H., Li, J., Lv, L., Nie, B., Lu, P., Xue, F., & Zhang, Z. (2018). The effects of interleukin 2 and rAd-p53 as a treatment for glioblastoma. Molecular Medicine Reports, 17, 4853-4859. https://doi.org/10.3892/mmr.2018.8408
MLA
Qiao, H., Li, J., Lv, L., Nie, B., Lu, P., Xue, F., Zhang, Z."The effects of interleukin 2 and rAd-p53 as a treatment for glioblastoma". Molecular Medicine Reports 17.3 (2018): 4853-4859.
Chicago
Qiao, H., Li, J., Lv, L., Nie, B., Lu, P., Xue, F., Zhang, Z."The effects of interleukin 2 and rAd-p53 as a treatment for glioblastoma". Molecular Medicine Reports 17, no. 3 (2018): 4853-4859. https://doi.org/10.3892/mmr.2018.8408
Copy and paste a formatted citation
x
Spandidos Publications style
Qiao HB, Li J, Lv LJ, Nie BJ, Lu P, Xue F and Zhang ZM: The effects of interleukin 2 and rAd-p53 as a treatment for glioblastoma. Mol Med Rep 17: 4853-4859, 2018.
APA
Qiao, H., Li, J., Lv, L., Nie, B., Lu, P., Xue, F., & Zhang, Z. (2018). The effects of interleukin 2 and rAd-p53 as a treatment for glioblastoma. Molecular Medicine Reports, 17, 4853-4859. https://doi.org/10.3892/mmr.2018.8408
MLA
Qiao, H., Li, J., Lv, L., Nie, B., Lu, P., Xue, F., Zhang, Z."The effects of interleukin 2 and rAd-p53 as a treatment for glioblastoma". Molecular Medicine Reports 17.3 (2018): 4853-4859.
Chicago
Qiao, H., Li, J., Lv, L., Nie, B., Lu, P., Xue, F., Zhang, Z."The effects of interleukin 2 and rAd-p53 as a treatment for glioblastoma". Molecular Medicine Reports 17, no. 3 (2018): 4853-4859. https://doi.org/10.3892/mmr.2018.8408
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