Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
March-2018 Volume 17 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
March-2018 Volume 17 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Role of miR-34c in the cognitive function of epileptic rats induced by pentylenetetrazol

  • Authors:
    • Yiqing Huang
    • Xixia Liu
    • Yuhan Liao
    • Yayun Liao
    • Donghua Zou
    • Xing Wei
    • Qi Huang
    • Yuan Wu
  • View Affiliations / Copyright

    Affiliations: Department of Neurology, The First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi 530021, P.R. China
    Copyright: © Huang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 4173-4180
    |
    Published online on: January 17, 2018
       https://doi.org/10.3892/mmr.2018.8441
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Studies suggest that microRNA (miR)‑34c may serve a role in cognitive function in rodent and primate groups. A previous study demonstrated an increase in miR‑34c expression in chronic epileptic rats with memory disorders, induced by pentylenetetrazol (PTZ). However, the mechanism underlying the effects of miR‑34c on cognitive function in epileptic rats remains unclear. Therefore, the present study investigated alterations in cognitive function in temporal lobe epileptic rats, induced by repeated injections of PTZ, following treatment with an miR‑34c agomir compared with a scramble group. Increased expression of miR‑34c was observed in the agomir group, in addition to an increased deficit in learning and memory function in the Morris water maze test. Glutamate receptor ionotropic N‑methyl‑D‑aspartate (NMDA) 2B (NR2B), phosphorylated (p)‑reduced nicotinamide‑adenine dinucleotide phosphate‑dependent diflavin oxidoreductase 1 (NR1) and p‑glutamate receptor 1 (GluR1) protein expression was detected in the hippocampus using western blotting. Additionally, the downregulation of NR2B, p‑NR1 and p‑GluR1 in the miR‑34c agomir group demonstrated that miR‑34c may serve a negative role in cognitive function in epileptic seizures, by dysregulating NMDA and α-amino-3-hydroxy-5‑methyl‑4‑isoxazolepropionic acid receptors, which are associated with long‑term potentiation.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

Fineberg SK, Kosik KS and Davidson BL: MicroRNAs potentiate neural development. Neuron. 64:303–309. 2009. View Article : Google Scholar : PubMed/NCBI

2 

Smalheiser NR and Lugli G: microRNA regulation of synaptic plasticity. Neuromolecular Med. 11:133–140. 2009. View Article : Google Scholar : PubMed/NCBI

3 

Ouellet DL, Perron MP, Gobeil LA, Plante P and Provost P: MicroRNAs in gene regulation: When the smallest governs it all. J Biomed Biotechnol. 2006:696162006. View Article : Google Scholar : PubMed/NCBI

4 

Parsons MJ, Grimm CH, Paya-Cano JL, Sugden K, Nietfeld W, Lehrach H and Schalkwyk LC: Using hippocampal microRNA expression differences between mouse inbred strains to characterise miRNA function. Mamm Genome. 19:552–560. 2008. View Article : Google Scholar : PubMed/NCBI

5 

Haramati S, Navon I, Issler O, Ezra-Nevo G, Gil S, Zwang R, Hornstein E and Chen A: MicroRNA as repressors of stress-induced anxiety: The case of amygdalar miR-34. J Neurosci. 31:14191–14203. 2011. View Article : Google Scholar : PubMed/NCBI

6 

Zovoilis A, Agbemenyah HY, Agis-Balboa RC, Stilling RM, Edbauer D, Rao P, Farinelli L, Delalle I, Schmitt A, Falkai P, et al: microRNA-34c is a novel target to treat dementias. EMBO J. 30:4299–4308. 2011. View Article : Google Scholar : PubMed/NCBI

7 

Cao SE, Tian J, Chen S, Zhang X and Zhang Y: Role of miR-34c in ketamine-induced neurotoxicity in neonatal mice hippocampus. Cell Biol Int. 39:164–168. 2015. View Article : Google Scholar : PubMed/NCBI

8 

Ryan B, Joilin G and Williams JM: Plasticity-related microRNA and their potential contribution to the maintenance of long-term potentiation. Front Mol Neurosci. 8:42015. View Article : Google Scholar : PubMed/NCBI

9 

Stepan J, Dine J and Eder M: Functional optical probing of the hippocampal trisynaptic circuit in vitro: Network dynamics, filter properties, and polysynaptic induction of CA1 LTP. Front Neurosci. 9:1602015. View Article : Google Scholar : PubMed/NCBI

10 

Bowden JB, Abraham WC and Harris KM: Differential effects of strain, circadian cycle, and stimulation pattern on LTP and concurrent LTD in the dentate gyrus of freely moving rats. Hippocampus. 22:1363–1370. 2012. View Article : Google Scholar : PubMed/NCBI

11 

Joilin G, Guévremont D, Ryan B, Claudianos C, Cristino AS, Abraham WC and Williams JM: Rapid regulation of microRNA following induction of long-term potentiation in vivo. Front Mol Neurosci. 7:982014. View Article : Google Scholar : PubMed/NCBI

12 

Cercato MC, Colettis N, Snitcofsky M, Aguirre AI, Kornisiuk EE, Baez MV and Jerusalinsky DA: Hippocampal NMDA receptors and the previous experience effect on memory. J Physiol Paris. 108:263–269. 2014. View Article : Google Scholar : PubMed/NCBI

13 

Liu X, Wu Y, Huang Q, Zou D, Qin W and Chen Z: Grouping pentylenetetrazol-induced epileptic rats according to memory impairment and MicroRNA expression profiles in the hippocampus. PLoS One. 10:e01261232015. View Article : Google Scholar : PubMed/NCBI

14 

Paxinos G, Watson CR and Emson PC: AChE-stained horizontal sections of the rat brain in stereotaxic coordinates. J Neurosci Methods. 3:129–149. 1980. View Article : Google Scholar : PubMed/NCBI

15 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

16 

Sayin U, Sutula TP and Stafstrom CE: Seizures in the developing brain cause adverse long-term effects on spatial learning and anxiety. Epilepsia. 45:1539–1548. 2004. View Article : Google Scholar : PubMed/NCBI

17 

Kerchner GA and Nicoll RA: Silent synapses and the emergence of a postsynaptic mechanism for LTP. Nat Rev Neurosci. 9:813–825. 2008. View Article : Google Scholar : PubMed/NCBI

18 

Pierrefiche O: Long term depression in rat hippocampus and the effect of ethanol during fetal life. Brain Sci. 7:pii: E1572017. View Article : Google Scholar

19 

Ramachandran B, Ahmed S and Dean C: Long-term depression is differentially expressed in distinct lamina of hippocampal CA1 dendrites. Front Cell Neurosci. 9:232015. View Article : Google Scholar : PubMed/NCBI

20 

Izumi Y, O'Dell KA and Zorumski CF: Corticosterone enhances the potency of ethanol against hippocampal long-term potentiation via local neurosteroid synthesis. Front Cell Neurosci. 9:2542015. View Article : Google Scholar : PubMed/NCBI

21 

Liao Y, Huang Y, Liu X, Luo C, Zou D, Wei X, Huang Q and Wu Y: MicroRNA-328a regulates water maze performance in PTZ-kindled rats. Brain Res Bull. 125:205–210. 2016. View Article : Google Scholar : PubMed/NCBI

22 

Tabassum H and Frey JU: The effect of acute swim stress and training in the water maze on hippocampal synaptic activity as well as plasticity in the dentate gyrus of freely moving rats: Revisiting swim-induced LTP reinforcement. Hippocampus. 23:1291–1298. 2013. View Article : Google Scholar : PubMed/NCBI

23 

Cui Y, Jin J, Zhang X, Xu H, Yang L, Du D, Zeng Q, Tsien JZ, Yu H and Cao X: Forebrain NR2B overexpression facilitating the prefrontal cortex long-term potentiation and enhancing working memory function in mice. PLoS One. 6:e203122011. View Article : Google Scholar : PubMed/NCBI

24 

Szczurowska E and Mareš P: NMDA and AMPA receptors: Development and status epilepticus. Physiol Res. 62 Suppl 1:S21–S38. 2013.PubMed/NCBI

25 

Traynelis SF, Wollmuth LP, McBain CJ, Menniti FS, Vance KM, Ogden KK, Hansen KB, Yuan H, Myers SJ and Dingledine R: Glutamate receptor ion channels: Structure, regulation, and function. Pharmacol Rev. 62:405–496. 2010. View Article : Google Scholar : PubMed/NCBI

26 

Niewoehner B, Single FN, Hvalby Ø, Jensen V, Meyer zum Alten Borgloh S, Seeburg PH, Rawlins JN, Sprengel R and Bannerman DM: Impaired spatial working memory but spared spatial reference memory following functional loss of NMDA receptors in the dentate gyrus. Eur J Neurosci. 25:837–846. 2007. View Article : Google Scholar : PubMed/NCBI

27 

Watson DJ, Herbert MR and Stanton ME: NMDA receptor involvement in spatial delayed alternation in developing rats. Behav Neurosci. 123:44–53. 2009. View Article : Google Scholar : PubMed/NCBI

28 

Watson DJ and Stanton ME: Intrahippocampal administration of an NMDA-receptor antagonist impairs spatial discrimination reversal learning in weanling rats. Neurobiol Learn Mem. 92:89–98. 2009. View Article : Google Scholar : PubMed/NCBI

29 

Hawasli AH, Benavides DR, Nguyen C, Kansy JW, Hayashi K, Chambon P, Greengard P, Powell CM, Cooper DC and Bibb JA: Cyclin-dependent kinase 5 governs learning and synaptic plasticity via control of NMDAR degradation. Nat Neurosci. 10:880–886. 2007. View Article : Google Scholar : PubMed/NCBI

30 

von Engelhardt J, Doganci B, Jensen V, Hvalby Ø, Göngrich C, Taylor A, Barkus C, Sanderson DJ, Rawlins JN, Seeburg PH, et al: Contribution of hippocampal and extra-hippocampal NR2B-containing NMDA receptors to performance on spatial learning tasks. Neuron. 60:846–860. 2008. View Article : Google Scholar : PubMed/NCBI

31 

Ghersi MS, Gabach LA, Buteler F, Vilcaes AA, Schiöth HB, Perez MF and de Barioglio SR: Ghrelin increases memory consolidation through hippocampal mechanisms dependent on glutamate release and NR2B-subunits of the NMDA receptor. Psychopharmacology (Berl). 232:1843–1857. 2015. View Article : Google Scholar : PubMed/NCBI

32 

Sanderson DJ, Good MA, Seeburg PH, Sprengel R, Rawlins JN and Bannerman DM: The role of the GluR-A (GluR1) AMPA receptor subunit in learning and memory. Prog Brain Res. 169:159–178. 2008. View Article : Google Scholar : PubMed/NCBI

33 

Balu DT and Coyle JT: Glutamate receptor composition of the post-synaptic density is altered in genetic mouse models of NMDA receptor hypo- and hyperfunction. Brain Res. 1392:1–7. 2011. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Huang Y, Liu X, Liao Y, Liao Y, Zou D, Wei X, Huang Q and Wu Y: Role of miR-34c in the cognitive function of epileptic rats induced by pentylenetetrazol. Mol Med Rep 17: 4173-4180, 2018.
APA
Huang, Y., Liu, X., Liao, Y., Liao, Y., Zou, D., Wei, X. ... Wu, Y. (2018). Role of miR-34c in the cognitive function of epileptic rats induced by pentylenetetrazol. Molecular Medicine Reports, 17, 4173-4180. https://doi.org/10.3892/mmr.2018.8441
MLA
Huang, Y., Liu, X., Liao, Y., Liao, Y., Zou, D., Wei, X., Huang, Q., Wu, Y."Role of miR-34c in the cognitive function of epileptic rats induced by pentylenetetrazol". Molecular Medicine Reports 17.3 (2018): 4173-4180.
Chicago
Huang, Y., Liu, X., Liao, Y., Liao, Y., Zou, D., Wei, X., Huang, Q., Wu, Y."Role of miR-34c in the cognitive function of epileptic rats induced by pentylenetetrazol". Molecular Medicine Reports 17, no. 3 (2018): 4173-4180. https://doi.org/10.3892/mmr.2018.8441
Copy and paste a formatted citation
x
Spandidos Publications style
Huang Y, Liu X, Liao Y, Liao Y, Zou D, Wei X, Huang Q and Wu Y: Role of miR-34c in the cognitive function of epileptic rats induced by pentylenetetrazol. Mol Med Rep 17: 4173-4180, 2018.
APA
Huang, Y., Liu, X., Liao, Y., Liao, Y., Zou, D., Wei, X. ... Wu, Y. (2018). Role of miR-34c in the cognitive function of epileptic rats induced by pentylenetetrazol. Molecular Medicine Reports, 17, 4173-4180. https://doi.org/10.3892/mmr.2018.8441
MLA
Huang, Y., Liu, X., Liao, Y., Liao, Y., Zou, D., Wei, X., Huang, Q., Wu, Y."Role of miR-34c in the cognitive function of epileptic rats induced by pentylenetetrazol". Molecular Medicine Reports 17.3 (2018): 4173-4180.
Chicago
Huang, Y., Liu, X., Liao, Y., Liao, Y., Zou, D., Wei, X., Huang, Q., Wu, Y."Role of miR-34c in the cognitive function of epileptic rats induced by pentylenetetrazol". Molecular Medicine Reports 17, no. 3 (2018): 4173-4180. https://doi.org/10.3892/mmr.2018.8441
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team