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Article

Protective effects of osthole against inflammation induced by lipopolysaccharide in BV2 cells

  • Authors:
    • Yuxin Bao
    • Xiaolin Meng
    • Fangning Liu
    • Fei Wang
    • Jinhui Yang
    • Haiyu Wang
    • Guanghong Xie
  • View Affiliations / Copyright

    Affiliations: Department of Clinical Veterinary Medicine, College of Veterinary Medicine, Jilin University, Changchun, Jilin 130062, P.R. China
  • Pages: 4561-4566
    |
    Published online on: January 17, 2018
       https://doi.org/10.3892/mmr.2018.8447
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Abstract

Inflammation and oxidative stress are implicated in the development of neurodegenerative diseases. Osthole is a compound that is extracted from She Chuang Zi, which is a type of traditional Chinese medicine. Osthole has previously been demonstrated to exhibit anticancer activities and has a low toxicity. However, to the best of our knowledge, the anti‑inflammatory effects of osthole in microglial cells have not been investigated extensively. The aim of the present study was to investigate the potential protective effects of osthole against inflammation induced by lipopolysaccharide (LPS) in microglial cells. The present study employed LPS‑stimulated BV2 mouse microglia to establish an inflammatory cell model and to investigate the anti‑inflammatory effects of osthole. Cells were pretreated with osthole for 1 h prior to LPS (10 µg/ml) stimulation. At 6 h after the addition of LPS, alterations in the levels of inflammatory factors, including tumor necrosis factor (TNF)‑α, interleukin (IL)‑6 and IL‑1β, were determined by ELISA. Furthermore, at 24 h after the addition of LPS, western blot analysis was performed to analyze the alterations in the protein expression of nuclear factor‑κB (NF‑κB) p65, phosphorylated‑NF‑κB p65, nuclear factor erythroid 2‑related factor 2 (Nrf2) and heme oxygenase (HO)‑1. The results demonstrated that the secretion of the inflammatory cytokines TNF‑α, IL‑6 and IL‑1β by LPS‑stimulated BV2 cells was significantly reduced by osthole treatment. Simultaneously, osthole treatment inhibited the LPS‑induced activation of the NF‑κB signaling pathway. In addition, osthole upregulated the expression of Nrf2 and HO‑1 in a dose‑dependent manner. Based on these results, osthole may exhibit anti‑inflammatory effects via the NF‑κB and Nrf2 pathways, indicating that osthole has the potential to be developed into an effective anti-inflammatory drug.
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1 

Liu WB, Zhou J, Qu Y, Li X, Lu CT, Xie KL, Sun XL and Fei Z: Neuroprotective effect of osthole on MPP+-induced cytotoxicity in PC12 cells via inhibition of mitochondrial dysfunction and ROS production. Neurochem Int. 57:206–215. 2010. View Article : Google Scholar : PubMed/NCBI

2 

Ogawa H, Sasai N, Kamisako T and Baba K: Effects of osthol on blood pressure and lipid metabolism in stroke-prone spontaneously hypertensive rats. J Ethnopharmacol. 112:26–31. 2007. View Article : Google Scholar : PubMed/NCBI

3 

Zhou F, Zhong W, Xue J, Gu ZL and Xie ML: Reduction of rat cardiac hypertrophy by osthol is related to regulation of cardiac oxidative stress and lipid metabolism. Lipids. 47:987–994. 2012. View Article : Google Scholar : PubMed/NCBI

4 

Liu J, Xu R and Zhao X: Mechanisms for effect of osthole on inhibiting the growth and invasion of bladder cancer cells. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 41:345–352. 2016.(In Chinese). PubMed/NCBI

5 

Pan Z, Fang Z, Lu W, Liu X and Zhang Y: Osthole, a coumadin analog from Cnidium monnieri (L.) Cusson, stimulates corticosterone secretion by increasing steroidogenic enzyme expression in mouse Y1 adrenocortical tumor cells. J Ethnopharmacol. 175:456–462. 2015. View Article : Google Scholar : PubMed/NCBI

6 

Chun J, Tosun A and Kim YS: Anti-inflammatory effect of corymbocoumarin from Seseli gummiferum subsp. corymbosum through suppression of NF-κB signaling pathway and induction of HO-1 expression in LPS-stimulated RAW 264.7 cells. Int Immunopharmacol. 31:207–215. 2016. View Article : Google Scholar : PubMed/NCBI

7 

Menden HL, Xia S, Mabry SM, Navarro A, Nyp MF and Sampath V: Nicotinamide adenine dinucleotide phosphate oxidase 2 regulates LPS-induced inflammation and alveolar remodeling in the developing lung. Am J Respir Cell Mol Biol. 55:767–778. 2016. View Article : Google Scholar : PubMed/NCBI

8 

Bozic I, Savic S, Laketa D, Bjelobaba I, Milenkovic I, Pekovic S, Nedeljkovic N and Lavrnja I: Benfotiamine attenuates inflammatory response in LPS stimulated BV-2 microglia. PLoS One. 10:e01183722015. View Article : Google Scholar : PubMed/NCBI

9 

Yang L, Guo H and Jin X, Meng X, Yan L, Dan Z, Wu S, Zhou H, Peng L, Xie Q and Jin X: Oleoylethanolamide exerts anti-inflammatory effects on LPS-induced THP-1 cells by enhancing PPARα signaling and inhibiting the NF-κB and ERK1/2/AP-1/STAT3 pathways. Sci Rep. 6:346112016. View Article : Google Scholar : PubMed/NCBI

10 

Shi J, Shan S, Li H, Song G and Li Z: Anti-inflammatory effects of millet bran derived-bound polyphenols in LPS-induced HT-29 cell via ROS/miR-149/Akt/NF-κB signaling pathway. Oncotarget. 8:74582–74594. 2017.PubMed/NCBI

11 

Fan C, Wu L, Zhang G, Xu F, Zhang S, Zhang X, Sun L, Yu Y, Zhang Y and Ye RD: 4′-Hydroxywogonin suppresses lipopolysaccharide-induced inflammatory responses in RAW 264.7 macrophages and acute lung injury mice. PLoS One. 12:e01811912017. View Article : Google Scholar : PubMed/NCBI

12 

Minagar A, Shapshak P, Fujimura R, Ownby R, Heyes M and Eisdorfer C: The role of macrophage/microglia and astrocytes in the pathogenesis of three neurologic disorders: HIV-associated dementia, Alzheimer disease, and multiple sclerosis. J Neurol Sci. 202:13–23. 2002. View Article : Google Scholar : PubMed/NCBI

13 

Gasparini C, Celeghini C, Monasta L and Zauli G: NF-kappaB pathways in hematological malignancies. Cell Mol Life Sci. 71:2083–2102. 2014. View Article : Google Scholar : PubMed/NCBI

14 

Shih RH, Wang CY and Yang CM: NF-kappaB signaling pathways in neurological inflammation: A mini review. Front Mol Neurosci. 8:772015. View Article : Google Scholar : PubMed/NCBI

15 

Brambilla R, Bracchi-Ricard V, Hu WH, Frydel B, Bramwell A, Karmally S, Green EJ and Bethea JR: Inhibition of astroglial nuclear factor kappaB reduces inflammation and improves functional recovery after spinal cord injury. J Exp Med. 202:145–156. 2005. View Article : Google Scholar : PubMed/NCBI

16 

Noort AR, Tak PP and Tas SW: Non-canonical NF-κB signaling in rheumatoid arthritis: Dr Jekyll and Mr Hyde? Arthritis Res Ther. 17:152015. View Article : Google Scholar : PubMed/NCBI

17 

Duh EJ, Maury WJ, Folks TM, Fauci AS and Rabson AB: Tumor necrosis factor alpha activates human immunodeficiency virus type 1 through induction of nuclear factor binding to the NF-kappa B sites in the long terminal repeat. Proc Natl Acad Sci USA. 86:pp. 5974–5978. 1989; View Article : Google Scholar : PubMed/NCBI

18 

Khodir AE, Atef H, Said E, ElKashef HA and Salem HA: Implication of Nrf2/HO-1 pathway in the coloprotective effect of coenzyme Q10 against experimentally induced ulcerative colitis. Inflammopharmacology. 25:119–135. 2017. View Article : Google Scholar : PubMed/NCBI

19 

Cao S, Du J and Hei Q: Lycium barbarum polysaccharide protects against neurotoxicity via the Nrf2-HO-1 pathway. Exp Ther Med. 14:4919–4927. 2017.PubMed/NCBI

20 

Kwon YW, Cheon SY, Park SY, Song J and Lee JH: Tryptanthrin suppresses the activation of the LPS-treated BV2 microglial cell line via Nrf2/HO-1 antioxidant signaling. Front Cell Neurosci. 11:182017. View Article : Google Scholar : PubMed/NCBI

21 

Bachewal P, Gundu C, Yerra VG, Kalvala AK, Areti A and Kumar A: Morin exerts neuroprotection via attenuation of ROS induced oxidative damage and neuroinflammation in experimental diabetic neuropathy. Biofactors. Nov 28–2017.(Epub ahead of print). View Article : Google Scholar : PubMed/NCBI

22 

Truong VL, Jun M and Jeong WS: Role of resveratrol in regulation of cellular defense systems against oxidative stress. Biofactors. Nov 28–2017.(Epub ahead of print). PubMed/NCBI

23 

Chen QM and Maltagliati AJ: Nrf2 at the heart of oxidative stress and cardiac protection. Physiol Genomics. Nov 29–2017.(Epub ahead of print).

24 

Aldaba-Muruato LR, Muñoz-Ortega MH, Macías-Pérez JR, Pulido-Ortega J, Martínez-Hernández SL and Ventura-Juárez J: Adrenergic regulation during acute hepatic infection with Entamoeba histolytica in the hamster: Involvement of oxidative stress, Nrf2 and NF-KappaB. Parasite. 24:462017. View Article : Google Scholar : PubMed/NCBI

25 

Hao Y and Liu Y: Osthole alleviates bleomycin-induced pulmonary fibrosis via modulating angiotensin-converting enzyme 2/angiotensin-(1–7) axis and decreasing inflammation responses in rats. Biol Pharm Bull. 39:457–465. 2016. View Article : Google Scholar : PubMed/NCBI

26 

Chen Z, Mao X, Liu A, Gao X, Chen X, Ye M, Ye J, Liu P, Xu S, Liu J, et al: Osthole, a natural coumarin improves cognitive impairments and BBB dysfunction after transient global brain ischemia in C57 BL/6J mice: Involvement of Nrf2 pathway. Neurochem Res. 40:186–194. 2015. View Article : Google Scholar : PubMed/NCBI

27 

Wu SJ: Osthole attenuates inflammatory responses and regulates the expression of inflammatory mediators in HepG2 cells grown in differentiated medium from 3T3-L1 preadipocytes. J Med Food. 18:972–979. 2015. View Article : Google Scholar : PubMed/NCBI

28 

Wang XL, Shang X, Cui Y, Zhao X, Zhang Y and Xie ML: Osthole inhibits inflammatory cytokine release through PPARα/γ-mediated mechanisms in LPS-stimulated 3T3-L1 adipocytes. Immunopharmacol Immunotoxicol. 37:185–192. 2015. View Article : Google Scholar : PubMed/NCBI

29 

Huang T and Dong Z: Osthole protects against inflammation in a rat model of chronic kidney failure via suppression of nuclear factor-κB, transforming growth factor-β1 and activation of phosphoinositide 3-kinase/protein kinase B/nuclear factor (erythroid-derived 2)-like 2 signaling. Mol Med Rep. 16:4915–4921. 2017. View Article : Google Scholar : PubMed/NCBI

30 

Hao Y and Liu Y: Osthole alleviates bleomycin-induced pulmonary fibrosis via modulating angiotensin-converting enzyme 2/angiotensin-(1–7) axis and decreasing inflammation responses in rats. Biol Pharm Bull. 39:457–465. 2016. View Article : Google Scholar : PubMed/NCBI

31 

Lee HH, Shin JS, Lee WS, Ryu B, Jang DS and Lee KT: Biflorin, isolated from the flower buds of syzygium aromaticum L., suppresses LPS-induced inflammatory mediators via STAT1 inactivation in macrophages and protects mice from endotoxin shock. J Nat Prod. 79:711–720. 2016. View Article : Google Scholar : PubMed/NCBI

32 

Cho N, Moon EH, Kim HW, Hong J, Beutler JA and Sung SH: Inhibition of nitric oxide production in BV2 microglial cells by triterpenes from tetrapanax papyriferus. Molecules. 21:4592016. View Article : Google Scholar : PubMed/NCBI

33 

Sun Y and Shang D: Inhibitory effects of antimicrobial peptides on lipopolysaccharide-induced inflammation. Mediators Inflamm. 2015:1675722015. View Article : Google Scholar : PubMed/NCBI

34 

Tai Y, Qiu Y and Bao Z: Magnesium lithospermate B suppresses lipopolysaccharide-induced neuroinflammation in BV2 microglial cells and attenuates neurodegeneration in lipopolysaccharide-injected mice. J Mol Neurosci. Dec 1–2017.(Epub ahead of print). PubMed/NCBI

35 

He Y, She H, Zhang T, Xu H, Cheng L, Yepes M, Zhao Y and Mao Z: p38 MAPK inhibits autophagy and promotes microglial inflammatory responses by phosphorylating ULK1. J Cell Biol. Dec 1–2017.(Epub ahead of print).

36 

Xu L, Zheng X, Wang Y, Fan Q, Zhang M, Li R, Ye J, Wu X, Zhao W and Zhang Y: Berberine protects acute liver failure in mice through inhibiting inflammation and mitochondria-dependent apoptosis. Eur J Pharmacol. 819:161–168. 2017. View Article : Google Scholar : PubMed/NCBI

37 

Wang S, Zhang Z, Wang Y, Gadahi JA, Xie Q, Xu L, Yan R, Song X and Li X: Toxoplasma gondii excretory/secretory antigens (TgESAs) suppress pro-inflammatory cytokine secretion by inhibiting TLR-induced NF-κB activation in LPS-stimulated murine macrophages. Oncotarget. 8:88351–88359. 2017.PubMed/NCBI

38 

Chen XJ, Zhang B, Hou SJ, Shi Y, Xu DQ, Wang YX, Liu ML, Dong HY, Sun RH, Bao ND, Jin FG and Li ZC: Osthole improves acute lung injury in mice by up-regulating Nrf-2/thioredoxin 1. Respir Physiol Neurobiol. 188:214–222. 2013. View Article : Google Scholar : PubMed/NCBI

39 

Tursun X, Zhao Y, Alat Z, Xin X, Tursun A, Abdulla R and AkberAisa H: Anti-inflammatory effect of rosa rugosa flower extract in lipopolysaccharide-stimulated RAW264.7 macrophages. Biomol Ther (Seoul). 24:184–190. 2016. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Bao Y, Meng X, Liu F, Wang F, Yang J, Wang H and Xie G: Protective effects of osthole against inflammation induced by lipopolysaccharide in BV2 cells. Mol Med Rep 17: 4561-4566, 2018.
APA
Bao, Y., Meng, X., Liu, F., Wang, F., Yang, J., Wang, H., & Xie, G. (2018). Protective effects of osthole against inflammation induced by lipopolysaccharide in BV2 cells. Molecular Medicine Reports, 17, 4561-4566. https://doi.org/10.3892/mmr.2018.8447
MLA
Bao, Y., Meng, X., Liu, F., Wang, F., Yang, J., Wang, H., Xie, G."Protective effects of osthole against inflammation induced by lipopolysaccharide in BV2 cells". Molecular Medicine Reports 17.3 (2018): 4561-4566.
Chicago
Bao, Y., Meng, X., Liu, F., Wang, F., Yang, J., Wang, H., Xie, G."Protective effects of osthole against inflammation induced by lipopolysaccharide in BV2 cells". Molecular Medicine Reports 17, no. 3 (2018): 4561-4566. https://doi.org/10.3892/mmr.2018.8447
Copy and paste a formatted citation
x
Spandidos Publications style
Bao Y, Meng X, Liu F, Wang F, Yang J, Wang H and Xie G: Protective effects of osthole against inflammation induced by lipopolysaccharide in BV2 cells. Mol Med Rep 17: 4561-4566, 2018.
APA
Bao, Y., Meng, X., Liu, F., Wang, F., Yang, J., Wang, H., & Xie, G. (2018). Protective effects of osthole against inflammation induced by lipopolysaccharide in BV2 cells. Molecular Medicine Reports, 17, 4561-4566. https://doi.org/10.3892/mmr.2018.8447
MLA
Bao, Y., Meng, X., Liu, F., Wang, F., Yang, J., Wang, H., Xie, G."Protective effects of osthole against inflammation induced by lipopolysaccharide in BV2 cells". Molecular Medicine Reports 17.3 (2018): 4561-4566.
Chicago
Bao, Y., Meng, X., Liu, F., Wang, F., Yang, J., Wang, H., Xie, G."Protective effects of osthole against inflammation induced by lipopolysaccharide in BV2 cells". Molecular Medicine Reports 17, no. 3 (2018): 4561-4566. https://doi.org/10.3892/mmr.2018.8447
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