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Article

Overexpression of septin-7 inhibits melatonin-induced cell apoptosis in human fetal osteoblastic cells via suppression of endoplasmic reticulum stress

Corrigendum in: /10.3892/mmr.2021.12538
  • Authors:
    • Xiaotong Meng
    • Yue Zhu
    • Lin Tao
    • Sichao Zhao
    • Shui Qiu
  • View Affiliations / Copyright

    Affiliations: Department of Orthopaedics, First Affiliated Hospital of China Medical University, Shenyang, Liaoning 110001, P.R. China
  • Pages: 4817-4822
    |
    Published online on: January 17, 2018
       https://doi.org/10.3892/mmr.2018.8449
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Abstract

Our previous study demonstrated that melatonin could induce apoptosis in the human fetal osteoblastic (hFOB) 1.19 cell line via induction of endoplasmic reticulum stress (ERS), and recent studies have demonstrated that the expression of septin‑7 (SEPT7) exhibits a positive correlation with the concentration of melatonin. Western blotting demonstrated the expression level of SEPT7 was significantly upregulated in a dose‑dependent manner following treatment with differing concentrations of melatonin compared with the control groups, which did not receive any treatment. The expression of proteins associated with cell apoptosis and endoplasmic reticulum stress (ERS; pro-caspase‑3, cleaved caspase‑3, C/EBP‑homologous protein, 78 kDa glucose‑regulated protein and phosphorylated‑eukaryotic translation initiation factor 2α) were decreased following transfection with SEPT7 overexpression plasmid and increased following transfection with SEPT7 small interfering RNA compared with the control groups. The results of the present study suggest that SEPT7 inhibits melatonin‑induced cell apoptosis via suppression of ERS.
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1 

Beites CL, Xie H, Bowser R and Trimble WS: The septin CDCrel-1 binds syntaxin and inhibits exocytosis. Nat Neurosci. 2:434–439. 1999. View Article : Google Scholar : PubMed/NCBI

2 

Field CM and Kellogg D: Septins: Cytoskeletal polymers or signalling GTPases? Trends Cell Biol. 9:387–394. 1999. View Article : Google Scholar : PubMed/NCBI

3 

Larisch S, Yi Y, Lotan R, Kerner H, Eimerl S, Tony Parks W, Gottfried Y, Birkey Reffey S, de Caestecker MP, Danielpour D, et al: A novel mitochondrial septin-like protein, ARTS, mediates apoptosis dependent on its P-loop motif. Nat Cell Biol. 2:915–921. 2000. View Article : Google Scholar : PubMed/NCBI

4 

Kartmann B and Roth D: Novel roles for mammalian septins: From vesicle trafficking to oncogenesis. J Cell Sci. 114:839–844. 2001.PubMed/NCBI

5 

Hou MS, Liu XB, Cao J and Chen B: SEPT7 overexpression inhibits glioma cell migration by targeting the actin cytoskeleton pathway. Oncol Rep. 35:2003–2010. 2016. View Article : Google Scholar : PubMed/NCBI

6 

Jia ZF, Pu PY, Kang CS, Wang GX, Zhang ZY, Qiu MZ and Huang Q: Influence of SEPT7 on biological characters of glioma cell line TJ905. Zhonghua Wai Ke Za Zhi. 45:1420–1423. 2007.(In Chinese). PubMed/NCBI

7 

Zhang NZ, Liu L, Fan N, Zhang Q, Wang W, Zheng M, Ma L, Li Y and Shi L: The requirement of SEPT2 and SEPT7 for migration and invasion in human breast cancer via MEK/ERK activation. Oncotarget. 7:61587–61600. 2016.PubMed/NCBI

8 

Zhou J, Lu S, Yang S, Chen H, Shi H, Miao M and Jiao B: MicroRNA-127 post-transcriptionally downregulates Sept7 and suppresses cell growth in hepatocellular carcinoma cells. Cell Physiol Biochem. 33:1537–1546. 2014. View Article : Google Scholar : PubMed/NCBI

9 

Meng X, Zhu Y, Tao L, Zhao S and Qiu S: Periostin has a protective role in melatonin-induced cell apoptosis by inhibiting the eIF2α-ATF4 pathway in human osteoblasts. Int J Mol Med. 41:1003–1012. 2018.PubMed/NCBI

10 

Subramaniam M, Jalal SM, Rickard DJ, Harris SA, Bolander ME and Spelsberg TC: Further characterization of human fetal osteoblastic hFOB 1.19 and hFOB/ER alpha cells: Bone formation in vivo and karyotype analysis using multicolor fluorescent in situ hybridization. J Cell Biochem. 87:9–15. 2002. View Article : Google Scholar : PubMed/NCBI

11 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative P C R and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

12 

Reiter RJ, Tan DX and Fuentes-Broto L: Melatonin: A multi-tasking molecule. Prog Brain Res. 181:127–151. 2010. View Article : Google Scholar : PubMed/NCBI

13 

Akbarzadeh M, Rahbarghazi R, Nabat E, Movassaghpour AA, Shanehbandi D, Faramarzian Azimi Maragheh B, Matluobi D, Barazvan B, Kazemi M, Samadi N and Nouri M: The impact of different extracellular matrices on melatonin effect in proliferation and stemness properties of ovarian cancer cells. Biomed Pharmacother. 87:288–295. 2017. View Article : Google Scholar : PubMed/NCBI

14 

Bavithra S, Selvakumar K, Sundareswaran L and Arunakaran J: Neuroprotective effect of melatonin against PCBs induced behavioural, molecular and histological changes in cerebral cortex of adult male wistar rats. Neurochem Res. 42:428–438. 2017. View Article : Google Scholar : PubMed/NCBI

15 

Mostowy S and Cossart P: Septins: The forth component of the cytoskeleton. Nat Rev Mol Cell Biol. 13:183–194. 2012. View Article : Google Scholar : PubMed/NCBI

16 

Weirich CS, Erzberger JP and Barral Y: The septin family of GTPases: Architecture and dynamics. Nat Rev Mol Cell Biol. 9:478–489. 2008. View Article : Google Scholar : PubMed/NCBI

17 

Kremer BE, Haystead T and Macara IG: Mammalian septins regulate microtubule stability through interaction with the micro tubule-binding protein MAP4. Mol Biol Cell. 16:4648–4659. 2005. View Article : Google Scholar : PubMed/NCBI

18 

Nagata K and Inagaki M: Cytoskeletal modification of Rho guanine nucleotide exchange factor activity: Identification of a Rho guanine nucleotide exchange factor as a binding partner for Sept9b, a mammalian septin. Oncogene. 24:65–76. 2005. View Article : Google Scholar : PubMed/NCBI

19 

Wloka C, Nishihama R, Onishi M, Oh Y, Hanna J, Pringle JR, Krauss M and Bi E: Evidence that a septin diffusion barrier is dispensable for cytokinesis in budding yeast. Biol Chem. 392:813–829. 2011. View Article : Google Scholar : PubMed/NCBI

20 

Kim MS, Froese CD, Xie H and Trimble WS: Uncovering priciples that control septin-septin interactions. J Biol Chem. 287:30406–30413. 2012. View Article : Google Scholar : PubMed/NCBI

21 

Shehadeh L, Mitsi G, Adi N, Bishopric N and Papapetropoulos S: Expression of lewy body protein septin 4 in postmortem brain of Parkinson's disease and contro subjects. Mov Disord. 24:204–210. 2009. View Article : Google Scholar : PubMed/NCBI

22 

Scott M, Hyland P, McGregor G, Hillan KJ, Russell SE and Hall PA: Multimodality expression profiling shows SEPT9 to be overexpressed in a wide range of human tumours. Oncogene. 24:4688–4700. 2005. View Article : Google Scholar : PubMed/NCBI

23 

Amir S, Wang R, Matzkin H, Simons JW and Mabjeesh NJ: MSF-A interacts with hypoxia-inducible factor-1alpha and augments hypoxia-inducible factor transcriptional activation to affect tumorigenicity and angiogenesis. Cancer Res. 66:856–866. 2006. View Article : Google Scholar : PubMed/NCBI

24 

Horowitz A, Lapointe JF, Eid R, Sheibani S, Gharib N, Jones NK, Vali H, Mandato CA and Greenwood MT: The human septin7 and the yeast CDC10 septin prevent Bax and copper mediated cell death in yeast. Biochim Biophys Acta. 1833:3186–3194. 2013. View Article : Google Scholar : PubMed/NCBI

25 

Jia ZF, Huang Q, Kang CS, Yang WD, Wang GX, Yu SZ, Jiang H and Pu PY: Overexpression of septin 7 suppresses glioma cell growth. J Neurooncol. 98:329–340. 2010. View Article : Google Scholar : PubMed/NCBI

26 

Pizarro JG, Yeste-Velasco M, Esparza JL, Verdaguer E, Pallàs M, Camins A and Folch J: The antiproliferative activity of melatonin in B65 rat dopaminergic neuroblastoma cells is related to the downregulation of cell cycle-related genes. J Pineal Res. 45:8–16. 2008. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Meng X, Zhu Y, Tao L, Zhao S and Qiu S: Overexpression of septin-7 inhibits melatonin-induced cell apoptosis in human fetal osteoblastic cells via suppression of endoplasmic reticulum stress Corrigendum in /10.3892/mmr.2021.12538. Mol Med Rep 17: 4817-4822, 2018.
APA
Meng, X., Zhu, Y., Tao, L., Zhao, S., & Qiu, S. (2018). Overexpression of septin-7 inhibits melatonin-induced cell apoptosis in human fetal osteoblastic cells via suppression of endoplasmic reticulum stress Corrigendum in /10.3892/mmr.2021.12538. Molecular Medicine Reports, 17, 4817-4822. https://doi.org/10.3892/mmr.2018.8449
MLA
Meng, X., Zhu, Y., Tao, L., Zhao, S., Qiu, S."Overexpression of septin-7 inhibits melatonin-induced cell apoptosis in human fetal osteoblastic cells via suppression of endoplasmic reticulum stress Corrigendum in /10.3892/mmr.2021.12538". Molecular Medicine Reports 17.3 (2018): 4817-4822.
Chicago
Meng, X., Zhu, Y., Tao, L., Zhao, S., Qiu, S."Overexpression of septin-7 inhibits melatonin-induced cell apoptosis in human fetal osteoblastic cells via suppression of endoplasmic reticulum stress Corrigendum in /10.3892/mmr.2021.12538". Molecular Medicine Reports 17, no. 3 (2018): 4817-4822. https://doi.org/10.3892/mmr.2018.8449
Copy and paste a formatted citation
x
Spandidos Publications style
Meng X, Zhu Y, Tao L, Zhao S and Qiu S: Overexpression of septin-7 inhibits melatonin-induced cell apoptosis in human fetal osteoblastic cells via suppression of endoplasmic reticulum stress Corrigendum in /10.3892/mmr.2021.12538. Mol Med Rep 17: 4817-4822, 2018.
APA
Meng, X., Zhu, Y., Tao, L., Zhao, S., & Qiu, S. (2018). Overexpression of septin-7 inhibits melatonin-induced cell apoptosis in human fetal osteoblastic cells via suppression of endoplasmic reticulum stress Corrigendum in /10.3892/mmr.2021.12538. Molecular Medicine Reports, 17, 4817-4822. https://doi.org/10.3892/mmr.2018.8449
MLA
Meng, X., Zhu, Y., Tao, L., Zhao, S., Qiu, S."Overexpression of septin-7 inhibits melatonin-induced cell apoptosis in human fetal osteoblastic cells via suppression of endoplasmic reticulum stress Corrigendum in /10.3892/mmr.2021.12538". Molecular Medicine Reports 17.3 (2018): 4817-4822.
Chicago
Meng, X., Zhu, Y., Tao, L., Zhao, S., Qiu, S."Overexpression of septin-7 inhibits melatonin-induced cell apoptosis in human fetal osteoblastic cells via suppression of endoplasmic reticulum stress Corrigendum in /10.3892/mmr.2021.12538". Molecular Medicine Reports 17, no. 3 (2018): 4817-4822. https://doi.org/10.3892/mmr.2018.8449
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