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The roles of TRIO and F-actin-binding protein in glioblastoma cells

  • Authors:
    • Hyunji Lee
    • Minhee Kim
    • Jisoo Park
    • Quangdon Tran
    • Youngeun Hong
    • Hyeonjeong Cho
    • Sungjin Park
    • Suntaek Hong
    • Derek P. Brazil
    • Seon‑Hwan Kim
    • Jongsun Park
  • View Affiliations / Copyright

    Affiliations: Department of Pharmacology and Medical Science, Metabolic Syndrome and Cell Signaling Laboratory, Research Institute for Medical Sciences, College of Medicine, Chungnam National University, Daejeon, Chungcheongnam‑do 35015, Republic of Korea, Laboratory of Cancer Cell Biology, Department of Biochemistry, School of Medicine, Gachon University, Incheon, Gyeonggi‑do 21999, Republic of Korea, Centre for Experimental Medicine, Queen's University Belfast, Belfast BT9 7BL, UK, Department of Neurosurgery, Institute for Cancer Research, College of Medicine, Chungnam National University, Daejeon, Chungcheongnam‑do 35015, Republic of Korea
    Copyright: © Lee et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 4540-4546
    |
    Published online on: January 18, 2018
       https://doi.org/10.3892/mmr.2018.8458
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Abstract

TRIO and F-actin-binding protein (TrioBP), which was initially discovered as a binding partner of Trio and F‑actin, is a critical factor associated with hearing loss in humans. However, the function of TrioBP in cancer has not been investigated. In the present study, TrioBP expression was indicated to be highly elevated in U87‑MG and U343‑MG cells. Furthermore, the TrioBP mRNA expression level was markedly increased in U87‑MG and U251‑MG cells compared with that in cerebral cortex cells, as determined by deep sequencing. Comprehensive analysis of a public TCGA dataset confirmed that TrioBP expression is elevated in patients with glioblastoma. In summary, the present data indicate that TrioBP expression is increased in glioblastoma cell lines and in patients with glioma, suggesting that TrioBP has potential as a diagnostic marker or therapeutic agent for glioma.
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1 

Glaser T, Han I, Wu L and Zeng X: Targeted nanotechnology in glioblastoma multiforme. Front Pharmacol. 8:1662017. View Article : Google Scholar : PubMed/NCBI

2 

Arif SH, Pandith AA, Bhat AR, Ramzan AU, Malik Nk, Chibber SS, Wani AA, Tabasum R and Altaf Kirmani A: EGFR and PTEN Gene Mutation Status in Glioblastoma Patients and their Prognostic Impact on Patient's Survival. J Carcinog Mutagen. 6:2182015.

3 

Virk SM, Gibson RM, Quinones-Mateu ME and Barnholtz-Sloan JS: Identification of variants in primary and recurrent glioblastoma using a cancer-specific gene panel and whole exome sequencing. PLoS One. 10:e01241782015. View Article : Google Scholar : PubMed/NCBI

4 

Bergers G and Benjamin LE: Tumorigenesis and the angiogenic switch. Nat Rev Cancer. 3:401–410. 2003. View Article : Google Scholar : PubMed/NCBI

5 

Wesseling P, Ruiter DJ and Burger PC: Angiogenesis in brain tumors; pathobiological and clinical aspects. J Neurooncol. 32:253–265. 1997. View Article : Google Scholar : PubMed/NCBI

6 

Das S and Marsden PA: Angiogenesis in glioblastoma. N Engl J Med. 369:1561–1563. 2013. View Article : Google Scholar : PubMed/NCBI

7 

Carmeliet P and Jain RK: Molecular mechanisms and clinical applications of angiogenesis. Nature. 473:298–307. 2011. View Article : Google Scholar : PubMed/NCBI

8 

Norden AD, Drappatz J and Wen PY: Novel anti-angiogenic therapies for malignant gliomas. Lancet Neurol. 7:1152–1160. 2008. View Article : Google Scholar : PubMed/NCBI

9 

Chinot OL, Wick W, Mason W, Henriksson R, Saran F, Nishikawa R, Carpentier AF, Hoang-Xuan K, Kavan P, Cernea D, et al: Bevacizumab plus radiotherapy-temozolomide for newly diagnosed glioblastoma. N Engl J Med. 370:709–722. 2014. View Article : Google Scholar : PubMed/NCBI

10 

Gilbert MR, Dignam JJ, Armstrong TS, Wefel JS, Blumenthal DT, Vogelbaum MA, Colman H, Chakravarti A, Pugh S, Won M, et al: A randomized trial of bevacizumab for newly diagnosed glioblastoma. N Engl J Med. 370:699–708. 2014. View Article : Google Scholar : PubMed/NCBI

11 

Seipel K, O'Brien SP, Iannotti E, Medley QG and Streuli M: Tara, a novel F-actin binding protein, associates with the Trio guanine nucleotide exchange factor and regulates actin cytoskeletal organization. J Cell Sci. 114:389–399. 2001.PubMed/NCBI

12 

Shahin H, Walsh T, Sobe T, Abu Sa'ed J, Abu Rayan A, Lynch ED, Lee MK, Avraham KB, King MC and Kanaan M: Mutations in a novel isoform of TRIOBP that encodes a filamentous-actin binding protein are responsible for DFNB28 recessive nonsyndromic hearing loss. Am J Hum Genet. 78:144–152. 2006. View Article : Google Scholar : PubMed/NCBI

13 

Riazuddin S, Khan SN, Ahmed ZM, Ghosh M, Caution K, Nazli S, Kabra M, Zafar AU, Chen K, Naz S, et al: Mutations in TRIOBP, which encodes a putative cytoskeletal-organizing protein, are associated with nonsyndromic recessive deafness. Am J Hum Genet. 78:137–143. 2006. View Article : Google Scholar : PubMed/NCBI

14 

Lenz DR and Avraham KB: Hereditary hearing loss: From human mutation to mechanism. Hear Res. 281:3–10. 2011. View Article : Google Scholar : PubMed/NCBI

15 

Kitajiri S, Sakamoto T, Belyantseva IA, Goodyear RJ, Stepanyan R, Fujiwara I, Bird JE, Riazuddin S, Riazuddin S, Ahmed ZM, et al: Actin-bundling protein TRIOBP forms resilient rootlets of hair cell stereocilia essential for hearing. Cell. 141:786–798. 2010. View Article : Google Scholar : PubMed/NCBI

16 

Salhia B, Tran NL, Chan A, Wolf A, Nakada M, Rutka F, Ennis M, McDonough WS, Berens ME, Symons M and Rutka JT: The guanine nucleotide exchange factors trio, Ect2 and Vav3 mediate the invasive behavior of glioblastoma. Am J Pathol. 173:1828–1838. 2008. View Article : Google Scholar : PubMed/NCBI

17 

Kim HB and Yoo BS: Propolis inhibits UVA-induced Apoptosis of human keratinocyte HaCaT cells by scavenging ROS. Toxicol Res. 32:345–351. 2016. View Article : Google Scholar : PubMed/NCBI

18 

Li Y, Park J, Piao L, Kong G, Kim Y, Park KA, Zhang T, Hong J, Hur GM, Seok JH, et al: PKB-mediated PHF20 phosphorylation on Ser291 is required for p53 function in DNA damage. Cell Signal. 25:74–84. 2013. View Article : Google Scholar : PubMed/NCBI

19 

Bioinformatics UG: The International Human Genome Sequencing Consortium. http://genome.ucsc.eduAccessed. 20:20162015.

20 

Kim D and Salzberg S: TopHat 2.1.0. https://ccb.jhu.edu/software/tophat/index.shtmlJuly 29–2015

21 

Na CH, Hong JH, Kim WS, Shanta SR, Bang JY, Park D, Kim HK and Kim KP: Identification of protein markers specific for papillary renal cell carcinoma using imaging mass spectrometry. Mol Cells. 38:624–629. 2015. View Article : Google Scholar : PubMed/NCBI

22 

van Rijssel J and van Buul JD: The many faces of the guanine-nucleotide exchange factor trio. Cell Adh Migr. 6:482–487. 2012. View Article : Google Scholar : PubMed/NCBI

23 

Fortin Ensign SP, Mathews IT, Symons MH, Berens ME and Tran NL: Implications of Rho GTPase signaling in glioma cell invasion and tumor progression. Front Oncol. 3:2412013. View Article : Google Scholar : PubMed/NCBI

24 

Li A, Dawson JC, Forero-Vargas M, Spence HJ, Yu X, König I, Anderson K and Machesky LM: The actin-bundling protein fascin stabilizes actin in invadopodia and potentiates protrusive invasion. Curr Biol. 20:339–345. 2010. View Article : Google Scholar : PubMed/NCBI

25 

Yun SP, Ryu JM, Jang MW and Han HJ: Interaction of profilin-1 and F-actin via a β-arrestin-1/JNK signaling pathway involved in prostaglandin E(2)-induced human mesenchymal stem cells migration and proliferation. J Cell physiol. 226:559–571. 2011. View Article : Google Scholar : PubMed/NCBI

26 

Bao J, Wang S, Gunther LK, Kitajiri S, Li C and Sakamoto T: The actin-bundling protein TRIOBP-4 and −5 promotes the motility of pancreatic cancer cells. Cancer Lett. 356:367–373. 2015. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Lee H, Kim M, Park J, Tran Q, Hong Y, Cho H, Park S, Hong S, Brazil DP, Kim SH, Kim SH, et al: The roles of TRIO and F-actin-binding protein in glioblastoma cells. Mol Med Rep 17: 4540-4546, 2018.
APA
Lee, H., Kim, M., Park, J., Tran, Q., Hong, Y., Cho, H. ... Park, J. (2018). The roles of TRIO and F-actin-binding protein in glioblastoma cells. Molecular Medicine Reports, 17, 4540-4546. https://doi.org/10.3892/mmr.2018.8458
MLA
Lee, H., Kim, M., Park, J., Tran, Q., Hong, Y., Cho, H., Park, S., Hong, S., Brazil, D. P., Kim, S., Park, J."The roles of TRIO and F-actin-binding protein in glioblastoma cells". Molecular Medicine Reports 17.3 (2018): 4540-4546.
Chicago
Lee, H., Kim, M., Park, J., Tran, Q., Hong, Y., Cho, H., Park, S., Hong, S., Brazil, D. P., Kim, S., Park, J."The roles of TRIO and F-actin-binding protein in glioblastoma cells". Molecular Medicine Reports 17, no. 3 (2018): 4540-4546. https://doi.org/10.3892/mmr.2018.8458
Copy and paste a formatted citation
x
Spandidos Publications style
Lee H, Kim M, Park J, Tran Q, Hong Y, Cho H, Park S, Hong S, Brazil DP, Kim SH, Kim SH, et al: The roles of TRIO and F-actin-binding protein in glioblastoma cells. Mol Med Rep 17: 4540-4546, 2018.
APA
Lee, H., Kim, M., Park, J., Tran, Q., Hong, Y., Cho, H. ... Park, J. (2018). The roles of TRIO and F-actin-binding protein in glioblastoma cells. Molecular Medicine Reports, 17, 4540-4546. https://doi.org/10.3892/mmr.2018.8458
MLA
Lee, H., Kim, M., Park, J., Tran, Q., Hong, Y., Cho, H., Park, S., Hong, S., Brazil, D. P., Kim, S., Park, J."The roles of TRIO and F-actin-binding protein in glioblastoma cells". Molecular Medicine Reports 17.3 (2018): 4540-4546.
Chicago
Lee, H., Kim, M., Park, J., Tran, Q., Hong, Y., Cho, H., Park, S., Hong, S., Brazil, D. P., Kim, S., Park, J."The roles of TRIO and F-actin-binding protein in glioblastoma cells". Molecular Medicine Reports 17, no. 3 (2018): 4540-4546. https://doi.org/10.3892/mmr.2018.8458
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