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Article

Homocysteine-induced proliferation of vascular smooth muscle cells occurs via PTEN hypermethylation and is mitigated by Resveratrol

  • Authors:
    • Sheng‑Chao Ma
    • Hui‑Ping Zhang
    • Yun Jiao
    • Yan‑Hua Wang
    • Hui Zhang
    • Xiao‑Ling Yang
    • An‑Ning Yang
    • Yi‑Deng Jiang
  • View Affiliations / Copyright

    Affiliations: Department of Basic Medicine, Ningxia Medical University, Yinchuan, Ningxia 750004, P.R. China, Department of Prenatal Diagnosis Center, General Hospital of Ningxia Medical University, Yinchuan, Ningxia 750004, P.R. China, Department of Infectious Disease, General Hospital of Ningxia Medical University, Yinchuan, Ningxia 750004, P.R. China
  • Pages: 5312-5319
    |
    Published online on: January 24, 2018
       https://doi.org/10.3892/mmr.2018.8471
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Abstract

Vascular smooth muscle cell (VSMC) proliferation is a primary pathological event in the development of atherosclerosis (AS), and the presence of homocysteine (Hcy) acts as an independent risk factor for AS. However, the underlying mechanisms remain to be elucidated. Phosphatase and tensin homologue on chromosome 10 (PTEN), is endogenously expressed in VSMCs and induces multiple signaling networks involved in cell proliferation, survival and inflammation, however, the specific role of PTEN is still unknown. The present study detected the proliferation ratio of VSMCs following treatment with Hcy and Resveratrol (RSV). In the 100 µM Hcy group, the proliferation ratio increased, and treatment with RSV decreased the proliferation ratio induced by Hcy. Reverse transcription‑quantitative polymerase chain reaction and western blotting were used to analyze PTEN expression, RSV treatment was associated with decreased PTEN expression levels in VSMCs. PTEN levels were decreased in Hcy treated cells, and the proliferation ratio of VSMCs were increased following treated with Hcy. To study the mechanism of regulation of PTEN by Hcy, the present study detected PTEN methylation levels in VSMCs, and PTEN DNA methylation levels were demonstrated to be increased in the 100 µM Hcy group, whereas treatment with RSV decreased the methylation status. DNA methyltransferase 1 is important role in the regulation of PTEN methylation. Overall, Hcy impacts the methylation status of PTEN, which is involved in cell proliferation, and induces the proliferation of VSMCs. This effect is alleviated by treatment with RSV, which exhibits an antagonistic mechanism against Hcy.
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1 

Devasia AJ, Joy B and Tarey SD: Serum homocysteine as a risk factor for carotid intimal thickening in acute stroke: A cross sectional observational study. Ann Indian Acad Neurol. 19:48–51. 2016. View Article : Google Scholar : PubMed/NCBI

2 

Liu T, Lin J, Ju T, Chu L and Zhang L: Vascular smooth muscle cell differentiation to an osteogenic phenotype involves matrix metalloproteinase-2 modulation by homocysteine. Mol Cell Biochem. 406:139–149. 2015. View Article : Google Scholar : PubMed/NCBI

3 

Liu X, Shen J, Zhan R, Wang X, Wang X, Zhang Z, Leng X, Yang Z and Qian L: Proteomic analysis of homocysteine induced proliferation of cultured neonatal rat vascular smooth muscle cells. Biochim Biophys Acta. 1794:177–184. 2009. View Article : Google Scholar : PubMed/NCBI

4 

Han XB, Zhang HP, Cao CJ, Wang YH, Tian J, Yang XL, Yang AN, Wang J, Jiang YD and Xu H: Aberrant DNA methylation of the PDGF gene in homocysteine-mediated VSMC proliferation and its underlying mechanism. Mol Med Rep. 10:947–954. 2014. View Article : Google Scholar : PubMed/NCBI

5 

Taysi S, Keles MS, Gumustekin K, Akyuz M, Boyuk A, Cikman O and Bakan N: Plasma homocysteine and liver tissue S-adenosylmethionine, S-adenosylhomocysteine status in vitamin B6-deficient rats. Eur Rev Med Pharmacol Sci. 19:154–160. 2015.PubMed/NCBI

6 

Elshorbagy AK, Jernerén F, Samocha-Bonet D, Refsum H and Heilbronn LK: Serum S-adenosylmethionine, but not methionine, increases in response to overfeeding in humans. Nutr Diabetes. 6:e1922016. View Article : Google Scholar : PubMed/NCBI

7 

Wang L, Fu X, Peng X, Xiao Z, Li Z, Chen G and Wang X: DNA methylation profiling reveals correlation of differential methylation patterns with gene expression in human epilepsy. J Mol Neurosci. 59:68–77. 2016. View Article : Google Scholar : PubMed/NCBI

8 

Yang AN, Zhang HP, Sun Y, Yang XL, Wang N, Zhu G, Zhang H, Xu H, Ma SC, Zhang Y, et al: High-methionine diets accelerate atherosclerosis by HHcy-mediated FABP4 gene demethylation pathway via DNMT1 in ApoE(−/−) mice. FEBS Lett. 589:3998–4009. 2015. View Article : Google Scholar : PubMed/NCBI

9 

Yideng J, Zhihong L, Jiantuan X, Jun C, Guizhong L and Shuren W: Homocysteine-mediated PPARalpha, gamma DNA methylation and its potential pathogenic mechanism in monocytes. DNA Cell Biol. 27:143–150. 2008. View Article : Google Scholar : PubMed/NCBI

10 

Chen WJ, Lin KH, Lai YJ, Yang SH and Pang JH: Protective effect of propylthiouracil independent of its hypothyroid effect on atherogenesis in cholesterol-fed rabbits: PTEN induction and inhibition of vascular smooth muscle cell proliferation and migration. Circulation. 110:1313–1319. 2004. View Article : Google Scholar : PubMed/NCBI

11 

Sedding DG, Widmer-Teske R, Mueller A, Stieger P, Daniel JM, Gündüz D, Pullamsetti S, Nef H, Moellmann H, Troidl C, et al: Role of the phosphatase PTEN in early vascular remodeling. PLoS One. 8:e554452013. View Article : Google Scholar : PubMed/NCBI

12 

Rice KM, Uddemarri S, Desai DH, Morrison RG, Harris R, Wright GL and Blough ER: PGF2alpha-associated vascular smooth muscle hypertrophy is ROS dependent and involves the activation of mTOR, p70S6k, and PTEN. Prostaglandins Other Lipid Mediat. 85:49–57. 2008. View Article : Google Scholar : PubMed/NCBI

13 

Hu C, Liu S, Sun Y, Shi G and Li Y: Effect of recombinant hPTEN gene expression on PDGF induced VSMC proliferation. Cell Biochem Biophys. 70:1185–1190. 2014. View Article : Google Scholar : PubMed/NCBI

14 

Moradi H and Vaziri ND: Effect of Resveratrol on progression of polycystic kidney disease: A case of cautious optimism. Nephrol Dial Transplant. 31:1755–1758. 2016. View Article : Google Scholar : PubMed/NCBI

15 

Pieszka M, Szczurek P, Ropka-Molik K, Oczkowicz M and Pieszka M: The role of Resveratrol in the regulation of cell metabolism-a review. Postepy Hig Med Dosw (Online). 70:117–123. 2016.(In Polish). View Article : Google Scholar : PubMed/NCBI

16 

Fišar Z, Hroudová J, Singh N, Kopřivová A and Macečková D: Effect of simvastatin, coenzyme Q10, Resveratrol, acetylcysteine and acetylcarnitine on mitochondrial respiration. Folia Biol (Praha). 62:53–66. 2016.PubMed/NCBI

17 

Ma SC, Cao JC, Zhang HP, Jiao Y, Zhang H, He YY, Wang YH, Yang XL, Yang AN, Tian J, et al: Aberrant promoter methylation of multiple genes in VSMC proliferation induced by Hcy. Mol Med Rep. Sep 19–2017.(Epub ahead of print). View Article : Google Scholar

18 

Hu C, Liu S, Sun Y, Shi G and Li Y: Effect of recombinant hPTEN gene expression on PDGF induced VSMC proliferation. Cell Biochem Biophys. 70:1185–1190. 2014. View Article : Google Scholar : PubMed/NCBI

19 

Dong X, Yu LG, Sun R, Cheng YN, Cao H, Yang KM, Dong YN, Wu Y and Guo XL: Inhibition of PTEN expression and activity by angiotensin II induces proliferation and migration of vascular smooth muscle cells. J Cell Biochem. 114:174–182. 2013. View Article : Google Scholar : PubMed/NCBI

20 

Greißel A, Culmes M, Napieralski R, Wagner E, Gebhard H, Schmitt M, Zimmermann A, Eckstein HH, Zernecke A and Pelisek J: Alternation of histone and DNA methylation in human atherosclerotic carotid plaques. Thromb Haemost. 114:390–402. 2015. View Article : Google Scholar : PubMed/NCBI

21 

Meng L, Liu L, Zhou C, Pan S, Zhai X, Jiang C, Guo Y, Ji Z, Chi J, Peng F and Guo H: Polyphenols and polypeptides in Chinese rice wine inhibit homocysteine-induced proliferation and migration of vascular smooth muscle cells. J Cardiovasc Pharmacol. 67:482–490. 2016. View Article : Google Scholar : PubMed/NCBI

22 

Swiader A, Nahapetyan H, Faccini J, D'Angelo R, Mucher E, Elbaz M, Boya P and Vindis C: Mitophagy acts as a safeguard mechanism against human vascular smooth muscle cell apoptosis induced by atherogenic lipids. Oncotarget. 7:28821–28835. 2016. View Article : Google Scholar : PubMed/NCBI

23 

Chen WJ, Pang JH, Lin KH, Lee DY, Hsu LA and Kuo CT: Propylthiouracil, independent of its antithyroid effect, promotes vascular smooth muscle cells differentiation via PTEN induction. Basic Res Cardiol. 105:19–28. 2010. View Article : Google Scholar : PubMed/NCBI

24 

Chawla V, Simionescu A, Langan EM III and LaBerge M: Influence of clinically relevant mechanical forces on vascular smooth muscle cells under chronic high glucose: An in vitro dynamic disease model. Ann Vasc Surg. 34:212–226. 2016. View Article : Google Scholar : PubMed/NCBI

25 

Jiang C, Zhang H, Zhang W, Kong W, Zhu Y, Zhang H, Xu Q, Li Y and Wang X: Homocysteine promotes vascular smooth muscle cell migration by induction of the adipokine resistin. Am J Physiol Cell Physiol. 297:C1466–C1476. 2009. View Article : Google Scholar : PubMed/NCBI

26 

Bonnevaux H, Lemaitre O, Vincent L, Levit MN, Windenberger F, Halley F, Delorme C, Lengauer C, Garcia-Echeverria C and Virone-Oddos A: Concomitant inhibition of PI3Kβ and BRAF or MEK in PTEN-deficient/BRAF-mutant melanoma treatment: Preclinical assessment of SAR260301 oral PI3Kβ-selective inhibitor. Mol Cancer Ther. 15:1460–1471. 2016. View Article : Google Scholar : PubMed/NCBI

27 

Morais CL, Guedes LB, Hicks J, Baras AS, De Marzo AM and Lotan TL: ERG and PTEN status of isolated high-grade PIN occurring in cystoprostatectomy specimens without invasive prostatic adenocarcinoma. Hum Pathol. 55:117–125. 2016. View Article : Google Scholar : PubMed/NCBI

28 

Schwartzbauer G and Robbins J: The tumor suppressor gene PTEN can regulate cardiac hypertrophy and survival. J Biol Chem. 276:35786–35793. 2001. View Article : Google Scholar : PubMed/NCBI

29 

Tang F, Guo S, Liao H, Yu P, Wang L, Song X, Chen J and Yang Q: Resveratrol enhances neurite outgrowth and synaptogenesis via sonic hedgehog signaling following oxygen-glucose deprivation/reoxygenation injury. Cell Physiol Biochem. 43:852–869. 2017. View Article : Google Scholar : PubMed/NCBI

30 

Guo R, Li W, Liu B, Li S, Zhang B and Xu Y: Resveratrol protects vascular smooth muscle cells against high glucose-induced oxidative stress and cell proliferation in vitro. Med Sci Monit Basic Res. 20:82–92. 2014. View Article : Google Scholar : PubMed/NCBI

31 

Ma SC, Zhang HP, Kong FQ, Zhang H, Yang C, He YY, Wang YH, Yang AN, Tian J, Yang XL, et al: Integration of gene expression and DNA methylation profiles provides a molecular subtype for risk assessment in atherosclerosis. Mol Med Rep. 13:4791–4799. 2016. View Article : Google Scholar : PubMed/NCBI

32 

Hai Z and Zuo W: Aberrant DNA methylation in the pathogenesis of atherosclerosis. Clin Chim Acta. 456:69–74. 2016. View Article : Google Scholar : PubMed/NCBI

33 

Grimaldi V, Vietri MT, Schiano C, Picascia A, De Pascale MR, Fiorito C, Casamassimi A and Napoli C: Epigenetic reprogramming in atherosclerosis. Curr Atheroscler Rep. 17:4762015. View Article : Google Scholar : PubMed/NCBI

34 

Benetatos L and Vartholomatos G: On the potential role of DNMT1 in acute myeloid leukemia and myelodysplastic syndromes: Not another mutated epigenetic driver. Ann Hematol. 95:1571–1582. 2016. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Ma SC, Zhang HP, Jiao Y, Wang YH, Zhang H, Yang XL, Yang AN and Jiang YD: Homocysteine-induced proliferation of vascular smooth muscle cells occurs via PTEN hypermethylation and is mitigated by Resveratrol. Mol Med Rep 17: 5312-5319, 2018.
APA
Ma, S., Zhang, H., Jiao, Y., Wang, Y., Zhang, H., Yang, X. ... Jiang, Y. (2018). Homocysteine-induced proliferation of vascular smooth muscle cells occurs via PTEN hypermethylation and is mitigated by Resveratrol. Molecular Medicine Reports, 17, 5312-5319. https://doi.org/10.3892/mmr.2018.8471
MLA
Ma, S., Zhang, H., Jiao, Y., Wang, Y., Zhang, H., Yang, X., Yang, A., Jiang, Y."Homocysteine-induced proliferation of vascular smooth muscle cells occurs via PTEN hypermethylation and is mitigated by Resveratrol". Molecular Medicine Reports 17.4 (2018): 5312-5319.
Chicago
Ma, S., Zhang, H., Jiao, Y., Wang, Y., Zhang, H., Yang, X., Yang, A., Jiang, Y."Homocysteine-induced proliferation of vascular smooth muscle cells occurs via PTEN hypermethylation and is mitigated by Resveratrol". Molecular Medicine Reports 17, no. 4 (2018): 5312-5319. https://doi.org/10.3892/mmr.2018.8471
Copy and paste a formatted citation
x
Spandidos Publications style
Ma SC, Zhang HP, Jiao Y, Wang YH, Zhang H, Yang XL, Yang AN and Jiang YD: Homocysteine-induced proliferation of vascular smooth muscle cells occurs via PTEN hypermethylation and is mitigated by Resveratrol. Mol Med Rep 17: 5312-5319, 2018.
APA
Ma, S., Zhang, H., Jiao, Y., Wang, Y., Zhang, H., Yang, X. ... Jiang, Y. (2018). Homocysteine-induced proliferation of vascular smooth muscle cells occurs via PTEN hypermethylation and is mitigated by Resveratrol. Molecular Medicine Reports, 17, 5312-5319. https://doi.org/10.3892/mmr.2018.8471
MLA
Ma, S., Zhang, H., Jiao, Y., Wang, Y., Zhang, H., Yang, X., Yang, A., Jiang, Y."Homocysteine-induced proliferation of vascular smooth muscle cells occurs via PTEN hypermethylation and is mitigated by Resveratrol". Molecular Medicine Reports 17.4 (2018): 5312-5319.
Chicago
Ma, S., Zhang, H., Jiao, Y., Wang, Y., Zhang, H., Yang, X., Yang, A., Jiang, Y."Homocysteine-induced proliferation of vascular smooth muscle cells occurs via PTEN hypermethylation and is mitigated by Resveratrol". Molecular Medicine Reports 17, no. 4 (2018): 5312-5319. https://doi.org/10.3892/mmr.2018.8471
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