Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
April-2018 Volume 17 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
April-2018 Volume 17 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Qiyusanlong decoction suppresses lung cancer in mice via Wnt/β-catenin pathway

  • Authors:
    • Jia‑Bing Tong
    • Xing‑Xing Zhang
    • Xin‑Heng Wang
    • Shi‑Jie Zeng
    • Dan‑Yang Wang
    • Zhi‑Qiang Zhang
    • Jian Hu
    • Chen Yang
    • Ze‑Geng Li
  • View Affiliations / Copyright

    Affiliations: Department of Respiratory, The First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, Anhui 230031, P.R. China, Key Laboratory of Xin An Medicine, Ministry of Education, Anhui University of Chinese Medicine, Hefei, Anhui 230012, P.R. China
  • Pages: 5320-5327
    |
    Published online on: January 24, 2018
       https://doi.org/10.3892/mmr.2018.8478
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Lung cancer is one of the most fatal cancers due to its high metastatic rate. Traditional Chinese medicine has been used in cancer patients for decades to improve quality of life and prolong survival time. The present study used a novel Qiyusanlong (QYSL) decoction composed of 10 kinds of Chinese medicine including astragalus membranaceus (Huangqi), polygonatumod oratum (yuzu), scolopendra (tianlong), pberetima (dilong), solanum nigrum (longkui), herbahedyotis (baihushecao), semen coicis (yiyiren), euphorbia helioscopia (zeqi), curcuma longa (eshu) and tendril-leaved fritillary bulb (chuanbei). The effects and function of the QYSL decoction remain to be elucidated. The present study established a mouse xenograft model using Lewis lung carcinoma cell injection and administered different doses of QYSL decoction to the mice. It was demonstrated that the chemotherapy drug Cisplatin (DDP) and QYSL decoction repressed lung tumor growth, and the inhibitory effect of DDP was more significant. Furthermore, QYSL decoction and DDP modulated the expression of regulatory proteins in the Wnt/β‑catenin pathway, including Wnt1, Wnt2, Wnt5a and glycogen synthase kinase 3β, detected by western blotting, and affected the signals of cluster of differentiation 44 variation 6 and Survivin in tumor tissues, examined via immunohistochemistry. The combination of QYSL decoction and DDP enhanced the inhibitory effect. These data demonstrated that the QYSL decoction repressed lung tumor development via the Wnt/β‑catenin pathway. The therapeutic effect of QYSL decoction alone was milder compared with DDP, however the combination of QYSL decoction and chemotherapy exhibited an increased the rapeutic effect compared with the treatments administered alone. These findings revealed the function of QYSL decoction as a lung cancer treatment and provided insight for a novel lung cancer therapy.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J and Jemal A: Global cancer statistics, 2012. CA Cancer J Clin. 65:87–108. 2015. View Article : Google Scholar : PubMed/NCBI

2 

Hwang KE and Kim HR: Response evaluation of chemotherapy for lung cancer. Tuberc Respir Dis (Seoul). 80:136–142. 2017. View Article : Google Scholar : PubMed/NCBI

3 

Yu N, Xiong Y and Wang C: Bu-Zhong-Yi-Qi decoction, the water extract of chinese traditional herbal medicine, enhances cisplatin cytotoxicity in A549/DDP cells through induction of apoptosis and autophagy. Biomed Res Int. 2017:36927972017. View Article : Google Scholar : PubMed/NCBI

4 

Somasundaram A and Burns TF: The next generation of immunotherapy: Keeping lung cancer in check. J Hematol Oncol. 10:872017. View Article : Google Scholar : PubMed/NCBI

5 

Ou Y, Zhai D, Wu N and Li X: Downregulation of miR-363 increases drug resistance in cisplatin-treated HepG2 by dysregulating Mcl-1. Gene. 572:116–122. 2015. View Article : Google Scholar : PubMed/NCBI

6 

Lin HQ, Gong AG, Wang HY, Duan R, Dong TT, Zhao KJ and Tsim KW: Danggui Buxue Tang (Astragali Radix and Angelicae Sinensis Radix) for menopausal symptoms: A review. J Ethnopharmacol. 199:205–210. 2017. View Article : Google Scholar : PubMed/NCBI

7 

Liu Z, Chen S, Cai J, Zhang E, Lan L, Zheng J, Liao L, Yang X, Zhou C and Du J: Traditional Chinese medicine syndrome-related herbal prescriptions in treatment of malignant tumors. J Tradit Chin Med. 33:19–26. 2013. View Article : Google Scholar : PubMed/NCBI

8 

Zhang X, Tong J and Li Z: Qiyusanlong decoction inhibits the level of PD-1/PD-L1 in mice bearing Lewis lung carcinoma. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 32:770–774. 2016.(In Chinese). PubMed/NCBI

9 

Jiang Q, He M, Guan S, Ma M, Wu H, Yu Z, Jiang L, Wang Y, Zong X, Jin F and Wei M: MicroRNA-100 suppresses the migration and invasion of breast cancer cells by targeting FZD-8 and inhibiting Wnt/β-catenin signaling pathway. Tumour Biol. 37:5001–5011. 2016. View Article : Google Scholar : PubMed/NCBI

10 

Zhan P, Zhang B, Xi GM, Wu Y, Liu HB, Liu YF, Xu WJ, Zhu QQ, Cai F, Zhou ZJ, et al: PRC1 contributes to tumorigenesis of lung adenocarcinoma in association with the Wnt/β-catenin signaling pathway. Mol Cancer. 16:1082017. View Article : Google Scholar : PubMed/NCBI

11 

Hu T and Li C: Convergence between Wnt-β-catenin and EGFR signaling in cancer. Mol Cancer. 9:2362010. View Article : Google Scholar : PubMed/NCBI

12 

Shang S, Hua F and Hu ZW: The regulation of β-catenin activity and function in cancer: Therapeutic opportunities. Oncotarget. 8:33972–33989. 2017. View Article : Google Scholar : PubMed/NCBI

13 

Salahshor S, Naidoo R, Serra S, Shih W, Tsao MS, Chetty R and Woodgett JR: Frequent accumulation of nuclear E-cadherin and alterations in the Wnt signaling pathway in esophageal squamous cell carcinomas. Mod Pathol. 21:271–281. 2008. View Article : Google Scholar : PubMed/NCBI

14 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

15 

Ponta H, Sherman L and Herrlich PA: CD44: From adhesion molecules to signalling regulators. Nat Rev Mol Cell Biol. 4:33–45. 2003. View Article : Google Scholar : PubMed/NCBI

16 

Wang S, Zhu L, Zuo W, Zeng Z, Huang L, Lin F, Lin R, Wang J, Lu J, Wang Q, et al: MicroRNA-mediated epigenetic targeting of survivin significantly enhances the antitumor activity of paclitaxel against non-small cell lung cancer. Oncotarget. 7:37693–37713. 2016.PubMed/NCBI

17 

Zhuang B, Du L, Xu H, Xu X, Wang C, Fan Y, Cong M, Yin J, Li H and Guan H: Self-assembled Micelle Loading Cabazitaxel for therapy of Lung Cancer. Int J Pharm. 499:146–155. 2016. View Article : Google Scholar : PubMed/NCBI

18 

Taixiang W, Munro AJ and Guanjian L: Chinese medical herbs for chemotherapy side effects in colorectal cancer patients. Cochrane Database Syst Rev: CD004540. 2005.

19 

Xiao WL, Motley TJ, Unachukwu UJ, Lau CB, Jiang B, Hong F, Leung PC, Wang QF, Livingston PO, Cassileth BR and Kennelly EJ: Chemical and genetic assessment of variability in commercial Radix Astragali (Astragalus spp.) by ion trap LC-MS and nuclear ribosomal DNA barcoding sequence analyses. J Agric Food Chem. 59:1548–1556. 2011. View Article : Google Scholar : PubMed/NCBI

20 

Tai Y, Sun YM, Zou X, Pan Q, Lan YD, Huo Q, Zhu JW, Guo F, Zheng CQ, Wu CZ and Liu H: Effect of Polygonatum odoratum extract on human breast cancer MDA-MB-231 cell proliferation and apoptosis. Exp Ther Med. 12:2681–2687. 2016. View Article : Google Scholar : PubMed/NCBI

21 

Wu L, Liu T, Xiao Y, Li X, Zhu Y, Zhao Y, Bao J and Wu C: Polygonatum odoratum lectin induces apoptosis and autophagy by regulation of microRNA-1290 and microRNA-15a-3p in human lung adenocarcinoma A549 cells. Int J Biol Macromol. 85:217–226. 2016. View Article : Google Scholar : PubMed/NCBI

22 

Ma W, Liu R, Qi J and Zhang Y: Extracts of centipede Scolopendra subspinipes mutilans induce cell cycle arrest and apoptosis in A375 human melanoma cells. Oncol Lett. 8:414–420. 2014. View Article : Google Scholar : PubMed/NCBI

23 

Yang MY, Hung CH, Chang CH, Tseng TH and Wang CJ: Solanum nigrum suppress angiogenesis-mediated tumor growth through inhibition of the AKT/mTOR pathway. Am J Chin Med. 44:1273–1288. 2016. View Article : Google Scholar : PubMed/NCBI

24 

Liu X, Xu F, Wang G, Diao X and Li Y: Kanglaite injection plus chemotherapy versus chemotherapy alone for non-small cell lung cancer patients: A systematic review and meta-analysis. Curr Ther Res Clin Exp. 69:381–411. 2008. View Article : Google Scholar : PubMed/NCBI

25 

Cheng J, Han W, Wang Z, Shao Y, Wang Y and Zhang Y, Li Z, Xu X and Zhang Y: Hepatocellular carcinoma growth is inhibited by euphorbia helioscopia L. Extract in nude mice xenografts. Biomed Res Int. 2015:6010152015. View Article : Google Scholar : PubMed/NCBI

26 

Kocaadam B and Şanlier N: Curcumin, an active component of turmeric (Curcuma longa), and its effects on health. Crit Rev Food Sci Nutr. 57:2889–2895. 2017. View Article : Google Scholar : PubMed/NCBI

27 

MacDonald BT, Tamai K and He X: Wnt/beta-catenin signaling: Components, mechanisms, and diseases. Dev Cell. 17:9–26. 2009. View Article : Google Scholar : PubMed/NCBI

28 

Zhao Y, Yang ZQ, Wang Y, Miao Y, Liu Y, Dai SD, Han Y and Wang EH: Dishevelled-1 and dishevelled-3 affect cell invasion mainly through canonical and noncanonical Wnt pathway, respectively and associate with poor prognosis in nonsmall cell lung cancer. Mol Carcinog. 49:760–770. 2010.PubMed/NCBI

29 

Liu Y, Zhou Q, Zhou D, Huang C, Meng X and Li J: Secreted frizzled-related protein 2-mediated cancer events: Friend or foe? Pharmacol Rep. 69:403–408. 2017. View Article : Google Scholar : PubMed/NCBI

30 

Wang J, Xiao L, Luo CH, Zhou H, Zeng L, Zhong J, Tang Y, Zhao XH, Zhao M and Zhang Y: CD44v6 promotes β-catenin and TGF-β expression, inducing aggression in ovarian cancer cells. Mol Med Rep. 11:3505–3510. 2015. View Article : Google Scholar : PubMed/NCBI

31 

Sun W and Chen G: Impact and mechanism of non-steroidal anti-inflammatory drugs combined with chemotherapeutic drugs on human lung cancer-nude mouse transplanted tumors. Oncol Lett. 11:4193–4199. 2016. View Article : Google Scholar : PubMed/NCBI

32 

Garg H, Suri P, Gupta JC, Talwar GP and Dubey S: Survivin: A unique target for tumor therapy. Cancer Cell Int. 16:492016. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Tong JB, Zhang XX, Wang XH, Zeng SJ, Wang DY, Zhang ZQ, Hu J, Yang C and Li ZG: Qiyusanlong decoction suppresses lung cancer in mice via Wnt/β-catenin pathway. Mol Med Rep 17: 5320-5327, 2018.
APA
Tong, J., Zhang, X., Wang, X., Zeng, S., Wang, D., Zhang, Z. ... Li, Z. (2018). Qiyusanlong decoction suppresses lung cancer in mice via Wnt/β-catenin pathway. Molecular Medicine Reports, 17, 5320-5327. https://doi.org/10.3892/mmr.2018.8478
MLA
Tong, J., Zhang, X., Wang, X., Zeng, S., Wang, D., Zhang, Z., Hu, J., Yang, C., Li, Z."Qiyusanlong decoction suppresses lung cancer in mice via Wnt/β-catenin pathway". Molecular Medicine Reports 17.4 (2018): 5320-5327.
Chicago
Tong, J., Zhang, X., Wang, X., Zeng, S., Wang, D., Zhang, Z., Hu, J., Yang, C., Li, Z."Qiyusanlong decoction suppresses lung cancer in mice via Wnt/β-catenin pathway". Molecular Medicine Reports 17, no. 4 (2018): 5320-5327. https://doi.org/10.3892/mmr.2018.8478
Copy and paste a formatted citation
x
Spandidos Publications style
Tong JB, Zhang XX, Wang XH, Zeng SJ, Wang DY, Zhang ZQ, Hu J, Yang C and Li ZG: Qiyusanlong decoction suppresses lung cancer in mice via Wnt/β-catenin pathway. Mol Med Rep 17: 5320-5327, 2018.
APA
Tong, J., Zhang, X., Wang, X., Zeng, S., Wang, D., Zhang, Z. ... Li, Z. (2018). Qiyusanlong decoction suppresses lung cancer in mice via Wnt/β-catenin pathway. Molecular Medicine Reports, 17, 5320-5327. https://doi.org/10.3892/mmr.2018.8478
MLA
Tong, J., Zhang, X., Wang, X., Zeng, S., Wang, D., Zhang, Z., Hu, J., Yang, C., Li, Z."Qiyusanlong decoction suppresses lung cancer in mice via Wnt/β-catenin pathway". Molecular Medicine Reports 17.4 (2018): 5320-5327.
Chicago
Tong, J., Zhang, X., Wang, X., Zeng, S., Wang, D., Zhang, Z., Hu, J., Yang, C., Li, Z."Qiyusanlong decoction suppresses lung cancer in mice via Wnt/β-catenin pathway". Molecular Medicine Reports 17, no. 4 (2018): 5320-5327. https://doi.org/10.3892/mmr.2018.8478
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team