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Article

KIF17 mediates the learning and memory impairment in offspring induced by maternal exposure to propofol during middle pregnancy

  • Authors:
    • Liuqing Wu
    • Shengqiang Wang
    • Yunlin Feng
    • Weihong Zhao
    • Wei Zuo
    • Liang Zhong
    • Jiamei Lin
    • Weilu Zhao
    • Foquan Luo
  • View Affiliations / Copyright

    Affiliations: Department of Anesthesiology, The First Affiliated Hospital, Nanchang University, Nanchang, Jiangxi 330006, P.R. China, Department of Pain Management, The People's Hospital of Jiujiang, Jiujiang, Jiangxi 332000, P.R. China, Department of Anesthesiology, The People's Hospital of Pingxiang, Pingxiang, Jiangxi 337000, P.R. China
  • Pages: 5428-5434
    |
    Published online on: January 24, 2018
       https://doi.org/10.3892/mmr.2018.8479
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Abstract

Preclinical studies suggest that propofol may cause neuronal injury to the developing brain. A previous study demonstrated that, in a rat model, maternal exposure to propofol during early or late pregnancy caused learning and memory impairment in the offspring. However, whether propofol exposure during middle pregnancy can cause long‑term behavioral deficits in the offspring remains to be elucidated. N‑methyl‑D‑aspartate receptor 2B subunit (NR2B) serves a critical role in memory modulation. To exert its function, NR2B must be transported to the neuronal membrane by kinesin family member 17 (KIF17). The aim of the present study was to investigate the role of KIF17 in learning and memory impairment in rat offspring caused by propofol exposure during middle pregnancy. Pregnant rats were exposed to propofol on gestational day 14 (G14) for 4 and 8 h, with control pregnant rats receiving an equal volume of normal saline. The learning and memory of the offspring was assessed using Morris water maze tests from postnatal day 30 (P30) to P36. The levels of KIF17 protein, total NR2B (T‑NR2B) and membrane NR2B (M‑NR2B) in the hippocampus were detected using western blotting. The results demonstrated that propofol exposure caused learning and memory deficits and decreased KIF17 and M‑NR2B protein levels in the hippocampus; however, no but changes in the expression of T‑NR2B were observed. These results indicate that maternal propofol exposure during middle pregnancy impairs learning and memory in offspring rats by suppressing the expression of KIF17 and inhibiting the translocation of NR2B to the neuronal membrane.
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Copy and paste a formatted citation
Spandidos Publications style
Wu L, Wang S, Feng Y, Zhao W, Zuo W, Zhong L, Lin J, Zhao W and Luo F: KIF17 mediates the learning and memory impairment in offspring induced by maternal exposure to propofol during middle pregnancy. Mol Med Rep 17: 5428-5434, 2018.
APA
Wu, L., Wang, S., Feng, Y., Zhao, W., Zuo, W., Zhong, L. ... Luo, F. (2018). KIF17 mediates the learning and memory impairment in offspring induced by maternal exposure to propofol during middle pregnancy. Molecular Medicine Reports, 17, 5428-5434. https://doi.org/10.3892/mmr.2018.8479
MLA
Wu, L., Wang, S., Feng, Y., Zhao, W., Zuo, W., Zhong, L., Lin, J., Zhao, W., Luo, F."KIF17 mediates the learning and memory impairment in offspring induced by maternal exposure to propofol during middle pregnancy". Molecular Medicine Reports 17.4 (2018): 5428-5434.
Chicago
Wu, L., Wang, S., Feng, Y., Zhao, W., Zuo, W., Zhong, L., Lin, J., Zhao, W., Luo, F."KIF17 mediates the learning and memory impairment in offspring induced by maternal exposure to propofol during middle pregnancy". Molecular Medicine Reports 17, no. 4 (2018): 5428-5434. https://doi.org/10.3892/mmr.2018.8479
Copy and paste a formatted citation
x
Spandidos Publications style
Wu L, Wang S, Feng Y, Zhao W, Zuo W, Zhong L, Lin J, Zhao W and Luo F: KIF17 mediates the learning and memory impairment in offspring induced by maternal exposure to propofol during middle pregnancy. Mol Med Rep 17: 5428-5434, 2018.
APA
Wu, L., Wang, S., Feng, Y., Zhao, W., Zuo, W., Zhong, L. ... Luo, F. (2018). KIF17 mediates the learning and memory impairment in offspring induced by maternal exposure to propofol during middle pregnancy. Molecular Medicine Reports, 17, 5428-5434. https://doi.org/10.3892/mmr.2018.8479
MLA
Wu, L., Wang, S., Feng, Y., Zhao, W., Zuo, W., Zhong, L., Lin, J., Zhao, W., Luo, F."KIF17 mediates the learning and memory impairment in offspring induced by maternal exposure to propofol during middle pregnancy". Molecular Medicine Reports 17.4 (2018): 5428-5434.
Chicago
Wu, L., Wang, S., Feng, Y., Zhao, W., Zuo, W., Zhong, L., Lin, J., Zhao, W., Luo, F."KIF17 mediates the learning and memory impairment in offspring induced by maternal exposure to propofol during middle pregnancy". Molecular Medicine Reports 17, no. 4 (2018): 5428-5434. https://doi.org/10.3892/mmr.2018.8479
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