Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
April-2018 Volume 17 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
April-2018 Volume 17 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

AMPK/SIRT1/p38 MAPK signaling pathway regulates alcohol‑induced neurodegeneration by resveratrol

  • Authors:
    • Xinyi Gu
    • Zhengxu Cai
    • Ming Cai
    • Kun Liu
    • Dan Liu
    • Qinsong Zhang
    • Jing Tan
    • Qiang Ma
  • View Affiliations / Copyright

    Affiliations: Department of Neurology, The Affiliated Zhongshan Hospital of Dalian University, Dalian, Liaoning 116001, P.R. China, Department of Neurology, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116001, P.R. China
  • Pages: 5402-5408
    |
    Published online on: January 25, 2018
       https://doi.org/10.3892/mmr.2018.8482
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Resveratrol has also been approved for use in enhancing plant disease resistance and reducing pesticide use. A number of studies have shown that the disease resistance of crops treated with resveratrol is markedly improved. The aim of the present study was to examine the protective effect of resveratrol against alcohol‑induced neurodegeneration occurred and its association with AMP‑activated protein kinase (AMPK)/sirtuin 1 (SIRT1)/p38 in rats and humans. ELISA, caspase‑3 activity and western blot analyses were employed in the present study. Sprague‑Dawley rats and human neuroblastoma SH‑SY5Y cells were treated with alcohol to establish the alcohol‑induced model. Resveratrol protected against alcohol‑induced neuron damage in the hippocampus of the rats. Treatment with resveratrol also inhibited the alcohol‑induced inflammatory response, oxidative stress, caspase‑3 activities and B‑cell lymphoma (Bcl‑2)‑associated X protein/Bcl‑2 in the alcohol‑induced rat. Resveratrol also reduced the upregulated protein expression of AMPK and SIRT1, preventing the pro‑apoptotic alcohol‑induced protein expression of p38 in the rats exposed to alcohol. The downregulation of AMPK suppressed the expression of SIRT1 and activated the expression of p38 in the SH‑SY5Y cell model. Taken together, the data obtained suggested that resveratrol protected against alcohol‑induced neurodegeneration via the AMPK/SIRT1/p38 pathway in rats and humans.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

Figure 8

Figure 9

Figure 10

View References

1 

Goodlett CR and Eilers AT: Alcohol-induced Purkinje cell loss with a single binge exposure in neonatal rats: A stereological study of temporal windows of vulnerability. Alcohol Clin Exp Res. 21:738–744. 1997. View Article : Google Scholar : PubMed/NCBI

2 

Qin L and Crews FT: NADPH oxidase and reactive oxygen species contribute to alcohol-induced microglial activation and neurodegeneration. J Neuroinflammation. 9:52012. View Article : Google Scholar : PubMed/NCBI

3 

Takeuchi M and Saito T: Cytotoxicity of acetaldehyde-derived advanced glycation end-products (AA-AGE) in alcoholic-induced neuronal degeneration. Alcohol Clin Exp Res. 29 12 Suppl:220S–224S. 2005. View Article : Google Scholar : PubMed/NCBI

4 

Weiss B: The first 83 and the next 83: Perspectives on neurotoxicology. Neurotoxicology. 30:832–850. 2009. View Article : Google Scholar : PubMed/NCBI

5 

Myers J, London L and Lucchini RG: Neurotoxicology and development: Human, environmental and social impacts. Neurotoxicology. 45:217–219. 2014. View Article : Google Scholar : PubMed/NCBI

6 

Berman JW, Carson MJ, Chang L, Cox BM, Fox HS, Gonzalez RG, Hanson GR, Hauser KF, Ho WZ, Hong JS, et al: NeuroAIDS, drug abuse, and inflammation: Building collaborative research activities. J Neuroimmune Pharmacol. 1:351–399. 2006. View Article : Google Scholar : PubMed/NCBI

7 

Trickler WJ, Lantz SM, Murdock RC, Schrand AM, Robinson BL, Newport GD, Schlager JJ, Oldenburg SJ, Paule MG, Slikker W Jr, et al: Silver nanoparticle induced blood-brain barrier inflammation and increased permeability in primary rat brain microvessel endothelial cells. Toxicol Sci. 118:160–170. 2010. View Article : Google Scholar : PubMed/NCBI

8 

Park I, Lee Y, Kim HD and Kim K: Effect of resveratrol, a SIRT1 activator, on the interactions of the CLOCK/BMAL1 complex. Endocrinol Metab (Seoul). 29:379–387. 2014. View Article : Google Scholar : PubMed/NCBI

9 

Sonnemann J, Kahl M, Siranjeevi PM, Blumrich A, Blümel L, Becker S, Wittig S, Winkler R, Krämer OH and Beck JF: Reverse chemomodulatory effects of the SIRT1 activators resveratrol and SRT1720 in Ewing's sarcoma cells: Resveratrol suppresses and SRT1720 enhances etoposide- and vincristine-induced anticancer activity. J Cancer Res Clin Oncol. 142:17–26. 2016. View Article : Google Scholar : PubMed/NCBI

10 

Allen JW, Mutkus LA and Aschner M: Chronic ethanol produces increased taurine transport and efflux in cultured astrocytes. Neurotoxicology. 23:693–700. 2002. View Article : Google Scholar : PubMed/NCBI

11 

Wan W and DePetrillo PB: Ritonavir protects hippocampal neurons against oxidative stress-induced apoptosis. Neurotoxicology. 23:301–306. 2002. View Article : Google Scholar : PubMed/NCBI

12 

Overstreet DH: Organophosphate pesticides, cholinergic function and cognitive performance in advanced age. Neurotoxicology. 21:75–81. 2000.PubMed/NCBI

13 

Polizzi S, Pira E, Ferrara M, Bugiani M, Papaleo A, Albera R and Palmi S: Neurotoxic effects of aluminium among foundry workers and Alzheimer's disease. Neurotoxicology. 23:761–774. 2002. View Article : Google Scholar : PubMed/NCBI

14 

Zhang LN, Hao L, Wang HY, Su HN, Sun YJ, Yang XY, Che B, Xue J and Gao ZB: Neuroprotective effect of resveratrol against glutamate-induced excitotoxicity. Adv Clin Exp Med. 24:161–165. 2015. View Article : Google Scholar : PubMed/NCBI

15 

Abengózar-Vela A, Calonge M, Stern ME, González-Garcia MJ and Enriquez-De-Salamanca A: Quercetin and resveratrol decrease the inflammatory and oxidative responses in human ocular surface epithelial cells. Invest Ophthalmol Vis Sci. 56:2709–2719. 2015. View Article : Google Scholar : PubMed/NCBI

16 

Leyton L, Hott M, Acuña F, Caroca J, Nuñez M, Martin C, Zambrano A, Concha MI and Otth C: Nutraceutical activators of AMPK/Sirt1 axis inhibit viral production and protect neurons from neurodegenerative events triggered during HSV-1 infection. Virus Res. 205:63–72. 2015. View Article : Google Scholar : PubMed/NCBI

17 

Choi JS, Park C and Jeong JW: AMP-activated protein kinase is activated in Parkinson's disease models mediated by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Biochem Biophys Res Commun. 391:147–151. 2010. View Article : Google Scholar : PubMed/NCBI

18 

Hao W, Takano T, Guillemette J, Papillon J, Ren G and Cybulsky AV: Induction of apoptosis by the Ste20-like kinase SLK, a germinal center kinase that activates apoptosis signal-regulating kinase and p38. J Biol Chem. 281:3075–3084. 2006. View Article : Google Scholar : PubMed/NCBI

19 

Liu K, Yang Y and Mansbridge J: Comparison of the stress response to cryopreservation in monolayer and three-dimensional human fibroblast cultures: Stress proteins, MAP kinases, and growth factor gene expression. Tissue Eng. 6:539–554. 2000. View Article : Google Scholar : PubMed/NCBI

20 

Guo S, Yao Q, Ke Z, Chen H, Wu J and Liu C: Resveratrol attenuates high glucose-induced oxidative stress and cardiomyocyte apoptosis through AMPK. Mol Cell Endocrinol. 412:85–94. 2015. View Article : Google Scholar : PubMed/NCBI

21 

Yoshida K, Bacal J, Desmarais D, Padioleau I, Tsaponina O, Chabes A, Pantesco V, Dubois E, Parrinello H, Skrzypczak M, et al: The histone deacetylases sir2 and rpd3 act on ribosomal DNA to control the replication program in budding yeast. Mol Cell. 54:691–697. 2014. View Article : Google Scholar : PubMed/NCBI

22 

Zill OA, Scannell D, Teytelman L and Rine J: Co-evolution of transcriptional silencing proteins and the DNA elements specifying their assembly. PLoS Biol. 8:e10005502010. View Article : Google Scholar : PubMed/NCBI

23 

Gallagher JE, Babiarz JE, Teytelman L, Wolfe KH and Rine J: Elaboration, diversification and regulation of the Sir1 family of silencing proteins in Saccharomyces. Genetics. 181:1477–1491. 2009. View Article : Google Scholar : PubMed/NCBI

24 

Hou Z, Bernstein DA, Fox CA and Keck JL: Structural basis of the Sir1-origin recognition complex interaction in transcriptional silencing. Proc Natl Acad Sci USA. 102:pp. 8489–8494. 2005; View Article : Google Scholar : PubMed/NCBI

25 

Donauer J, Schreck I, Liebel U and Weiss C: Role and interaction of p53, BAX and the stress-activated protein kinases p38 and JNK in benzo(a)pyrene-diolepoxide induced apoptosis in human colon carcinoma cells. Arch Toxicol. 86:329–337. 2012. View Article : Google Scholar : PubMed/NCBI

26 

Dziegielewska B, Brautigan DL, Larner JM and Dziegielewski J: T-type Ca2+ channel inhibition induces p53-dependent cell growth arrest and apoptosis through activation of p38-MAPK in colon cancer cells. Mol Cancer Res. 12:348–358. 2014. View Article : Google Scholar : PubMed/NCBI

27 

Hishida T, Nozaki Y, Nakachi Y, Mizuno Y, Iseki H, Katano M, Kamon M, Hirasaki M, Nishimoto M, Okazaki Y and Okuda A: Sirt1, p53, and p38(MAPK) are crucial regulators of detrimental phenotypes of embryonic stem cells with Max expression ablation. Stem Cells. 30:1634–1644. 2012. View Article : Google Scholar : PubMed/NCBI

28 

Wu XP, Xiong M, Xu CS, Duan LN, Dong YQ, Luo Y, Niu TH and Lu CR: Resveratrol induces apoptosis of human chronic myelogenous leukemia cells in vitro through p38 and JNK-regulated H2AX phosphorylation. Acta Pharmacol Sin. 36:353–361. 2015. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Gu X, Cai Z, Cai M, Liu K, Liu D, Zhang Q, Tan J and Ma Q: AMPK/SIRT1/p38 MAPK signaling pathway regulates alcohol‑induced neurodegeneration by resveratrol. Mol Med Rep 17: 5402-5408, 2018.
APA
Gu, X., Cai, Z., Cai, M., Liu, K., Liu, D., Zhang, Q. ... Ma, Q. (2018). AMPK/SIRT1/p38 MAPK signaling pathway regulates alcohol‑induced neurodegeneration by resveratrol. Molecular Medicine Reports, 17, 5402-5408. https://doi.org/10.3892/mmr.2018.8482
MLA
Gu, X., Cai, Z., Cai, M., Liu, K., Liu, D., Zhang, Q., Tan, J., Ma, Q."AMPK/SIRT1/p38 MAPK signaling pathway regulates alcohol‑induced neurodegeneration by resveratrol". Molecular Medicine Reports 17.4 (2018): 5402-5408.
Chicago
Gu, X., Cai, Z., Cai, M., Liu, K., Liu, D., Zhang, Q., Tan, J., Ma, Q."AMPK/SIRT1/p38 MAPK signaling pathway regulates alcohol‑induced neurodegeneration by resveratrol". Molecular Medicine Reports 17, no. 4 (2018): 5402-5408. https://doi.org/10.3892/mmr.2018.8482
Copy and paste a formatted citation
x
Spandidos Publications style
Gu X, Cai Z, Cai M, Liu K, Liu D, Zhang Q, Tan J and Ma Q: AMPK/SIRT1/p38 MAPK signaling pathway regulates alcohol‑induced neurodegeneration by resveratrol. Mol Med Rep 17: 5402-5408, 2018.
APA
Gu, X., Cai, Z., Cai, M., Liu, K., Liu, D., Zhang, Q. ... Ma, Q. (2018). AMPK/SIRT1/p38 MAPK signaling pathway regulates alcohol‑induced neurodegeneration by resveratrol. Molecular Medicine Reports, 17, 5402-5408. https://doi.org/10.3892/mmr.2018.8482
MLA
Gu, X., Cai, Z., Cai, M., Liu, K., Liu, D., Zhang, Q., Tan, J., Ma, Q."AMPK/SIRT1/p38 MAPK signaling pathway regulates alcohol‑induced neurodegeneration by resveratrol". Molecular Medicine Reports 17.4 (2018): 5402-5408.
Chicago
Gu, X., Cai, Z., Cai, M., Liu, K., Liu, D., Zhang, Q., Tan, J., Ma, Q."AMPK/SIRT1/p38 MAPK signaling pathway regulates alcohol‑induced neurodegeneration by resveratrol". Molecular Medicine Reports 17, no. 4 (2018): 5402-5408. https://doi.org/10.3892/mmr.2018.8482
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team