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Article

Extracts from guava fruit protect renal tubular endothelial cells against acetaminophen‑induced cytotoxicity

  • Authors:
    • Tsai‑Kun Wu
    • Hsiao‑Chun Liu
    • Shu‑Yu Lin
    • Yung‑Luen Yu
    • Chyou‑Wei Wei
  • View Affiliations / Copyright

    Affiliations: The Ph.D. Program for Cancer Biology and Drug Discovery, China Medical University and Academia Sinica, Taichung 404, Taiwan, R.O.C., Department of Nursing, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei 231, Taiwan, R.O.C., Department of Nutrition, Master Program of Biomedical Nutrition, Hungkuang University, Taichung 433, Taiwan, R.O.C.
  • Pages: 5544-5551
    |
    Published online on: January 31, 2018
       https://doi.org/10.3892/mmr.2018.8529
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Abstract

Acetaminophen (APAP) is an analgesic and antipyretic agent primarily used in the clinical setting. However, high doses of APAP can cause oxidative stress. Guavas have been reported to provide anti‑inflammatory, anti‑microbial, anti‑oxidative and anti‑diarrheal functions. In addition, guavas have been reported to prevent renal damage due to progression of diabetes mellitus. Therefore, the aim of the present study was to investigate whether guavas can reduce APAP‑induced renal cell damage. In the present study, extracts from guavas were obtained and added to APAP‑treated renal tubular endothelial cells. The present results demonstrated that APAP induces cytotoxicity in renal tubular endothelial cells, while guava extracts inhibited this cytotoxicity. In addition, the study demonstrated that the protective effects of guava extracts against APAP‑induced cytotoxicity may be associated with inhibition of oxidative stress and caspase‑3 activation.
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Copy and paste a formatted citation
Spandidos Publications style
Wu TK, Liu HC, Lin SY, Yu YL and Wei CW: Extracts from guava fruit protect renal tubular endothelial cells against acetaminophen‑induced cytotoxicity. Mol Med Rep 17: 5544-5551, 2018.
APA
Wu, T., Liu, H., Lin, S., Yu, Y., & Wei, C. (2018). Extracts from guava fruit protect renal tubular endothelial cells against acetaminophen‑induced cytotoxicity. Molecular Medicine Reports, 17, 5544-5551. https://doi.org/10.3892/mmr.2018.8529
MLA
Wu, T., Liu, H., Lin, S., Yu, Y., Wei, C."Extracts from guava fruit protect renal tubular endothelial cells against acetaminophen‑induced cytotoxicity". Molecular Medicine Reports 17.4 (2018): 5544-5551.
Chicago
Wu, T., Liu, H., Lin, S., Yu, Y., Wei, C."Extracts from guava fruit protect renal tubular endothelial cells against acetaminophen‑induced cytotoxicity". Molecular Medicine Reports 17, no. 4 (2018): 5544-5551. https://doi.org/10.3892/mmr.2018.8529
Copy and paste a formatted citation
x
Spandidos Publications style
Wu TK, Liu HC, Lin SY, Yu YL and Wei CW: Extracts from guava fruit protect renal tubular endothelial cells against acetaminophen‑induced cytotoxicity. Mol Med Rep 17: 5544-5551, 2018.
APA
Wu, T., Liu, H., Lin, S., Yu, Y., & Wei, C. (2018). Extracts from guava fruit protect renal tubular endothelial cells against acetaminophen‑induced cytotoxicity. Molecular Medicine Reports, 17, 5544-5551. https://doi.org/10.3892/mmr.2018.8529
MLA
Wu, T., Liu, H., Lin, S., Yu, Y., Wei, C."Extracts from guava fruit protect renal tubular endothelial cells against acetaminophen‑induced cytotoxicity". Molecular Medicine Reports 17.4 (2018): 5544-5551.
Chicago
Wu, T., Liu, H., Lin, S., Yu, Y., Wei, C."Extracts from guava fruit protect renal tubular endothelial cells against acetaminophen‑induced cytotoxicity". Molecular Medicine Reports 17, no. 4 (2018): 5544-5551. https://doi.org/10.3892/mmr.2018.8529
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