|
1
|
Kumar A, Sinha C, Kumar A and Kumari P:
The effect of intravenous dexmedetomidine compared to propofol on
patients hemodynamics as a sedative in brachial plexus block: A
comparative study. Anesth Essays Res. 11:201–205. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
2
|
Zhang X, Wang J, Qian W, Zhao J, Sun L,
Qian Y and Xiao H: Dexmedetomidine inhibits tumor necrosis
factor-alpha and interleukin 6 in lipopolysaccharide-stimulated
astrocytes by suppression of c-Jun N-terminal kinases.
Inflammation. 37:942–949. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
3
|
Liu Z, Wang Y, Wang Y, Ning Q, Zhang Y,
Gong C, Zhao W, Jing G and Wang Q: Dexmedetomidine attenuates
inflammatory reaction in the lung tissues of septic mice by
activating cholinergic anti-inflammatory pathway. Int
Immunopharmacol. 35:210–216. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
4
|
Chen Z, Qiu PY and Ma CG: Dexmedetomidine
preconditioning protects against retinal ischemia/reperfusion
injury and inhibits inflammation response via toll-like receptor 4
(TLR4) pathway. Biomed Pharmacother. 93:1018–1024. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
5
|
Choi IY, Hwang L, Jin JJ, Ko IG, Kim SE,
Shin MS, Shin KM, Kim CJ, Park SW, Han JH and Yi JW:
Dexmedetomidine alleviates cerebral ischemia-induced short-term
memory impairment by inhibiting the expression of apoptosis-related
molecules in the hippocampus of gerbils. Exp Ther Med. 13:107–116.
2017. View Article : Google Scholar : PubMed/NCBI
|
|
6
|
Fu C, Dai X, Yang Y, Lin M, Cai Y and Cai
S: Dexmedetomidine attenuates lipopolysaccharide-induced acute lung
injury by inhibiting oxidative stress, mitochondrial dysfunction
and apoptosis in rats. Mol Med Rep. 15:131–138. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
7
|
Yan X, Cheng X, Zhou L, He X, Zheng W and
Chen H: Dexmedetomidine alleviates lipopolysaccharide-induced lung
injury in Wistar rats. Oncotarget. 8:44410–44417. 2017.PubMed/NCBI
|
|
8
|
Wang Y, Wu S, Yu X, Zhou S, Ge M, Chi X
and Cai J: Dexmedetomidine protects rat liver against
ischemia-reperfusion injury partly by the α2A-adrenoceptor subtype
and the mechanism is associated with the TLR4/NF-κB pathway. Int J
Mol Sci. 17(pii): E9952016. View Article : Google Scholar : PubMed/NCBI
|
|
9
|
Mottino AD and Catania VA: Hepatic drug
transporters and nuclear receptors: Regulation by therapeutic
agents. World J Gastroenterol. 14:7068–7074. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
10
|
Konig J, Muller F and Fromm MF:
Transporters and drug-drug interactions: Important determinants of
drug disposition and effects. Pharmacol Rev. 65:944–966. 2013.
View Article : Google Scholar : PubMed/NCBI
|
|
11
|
Chen Z, Shi T, Zhang L, Zhu P, Deng M,
Huang C, Hu T, Jiang L and Li J: Mammalian drug efflux transporters
of the ATP binding cassette (ABC) family in multidrug resistance: A
review of the past decade. Cancer Lett. 370:153–164. 2016.
View Article : Google Scholar : PubMed/NCBI
|
|
12
|
Nakanishi T and Tamai I: Interaction of
drug or food with drug transporters in intestine and liver. Curr
Drug Metab. 16:753–764. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
13
|
Wen J, Luo J, Huang W, Tang J, Zhou H and
Zhang W: The pharmacological and physiological role of
multidrug-resistant protein 4. J Pharmacol Exp Ther. 354:358–375.
2015. View Article : Google Scholar : PubMed/NCBI
|
|
14
|
Keppler D: Multidrug resistance proteins
(MRPs, ABCCs): Importance for pathophysiology and drug therapy.
Handb Exp Pharmacol. 2011:299–323. 2011. View Article : Google Scholar
|
|
15
|
Xia M, Ji NN, Duan ML, Tong JH, Xu JG,
Zhang YM and Wang SH: Dexmedetomidine regulate the malignancy of
breast cancer cells by activating α2-adrenoceptor/ERK signaling
pathway. Eur Rev Med Pharmacol Sci. 20:3500–3506. 2016.PubMed/NCBI
|
|
16
|
Wang Y, Wu C, Han B, Xu F, Mao M, Guo X
and Wang J: Dexmedetomidine attenuates repeated propofol
exposure-induced hippocampal apoptosis, PI3K/Akt/Gsk-3β signaling
disruption, and juvenile cognitive deficits in neonatal rats. Mol
Med Rep. 14:769–775. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
17
|
Sun Y, Jiang C, Jiang J and Qiu L:
Dexmedetomidine protects mice against myocardium
ischaemic/reperfusion injury by activating an AMPK/PI3K/Akt/eNOS
pathway. Clin Exp Pharmacol Physiol. 44:946–953. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
18
|
Mayati A, Moreau A, Le Vée M, Stieger B,
Denizot C, Parmentier Y and Fardel O: Protein kinases C-mediated
regulations of drug transporter activity, localization and
expression. Int J Mol Sci. 18(pii): E7642017. View Article : Google Scholar : PubMed/NCBI
|
|
19
|
Shan E, Zhu Z, He S, Chu D, Ge D, Zhan Y,
Liu W, Yang J and Xiong J: Involvement of pregnane X receptor in
the suppression of carboxylesterases by metformin in vivo and in
vitro, mediated by the activation of AMPK and JNK signaling
pathway. Eur J Pharm Sci. 102:14–23. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
20
|
Yan JK, Gong ZZ, Zhang T and Cai W: Sodium
butyrate attenuates soybean oil-based lipid emulsion-induced
increase in intestinal permeability of lipopolysaccharide by
modulation of P-glycoprotein in Caco-2 cells. Biochem Biophys Res
Commun. 482:791–795. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
21
|
Yan J, Jin G, Du L and Yang Q: Modulation
of intestinal folate absorption by erythropoietin in vitro. Mol
Pharm. 11:358–366. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
22
|
Wang Z, Zhang L, Ni Z, Sun J, Gao H, Cheng
Z, Xu J and Yin P: Resveratrol induces AMPK-dependent MDR1
inhibition in colorectal cancer HCT116/L-OHP cells by preventing
activation of NF-κB signaling and suppressing cAMP-responsive
element transcriptional activity. Tumour Biol. 36:9499–9510. 2015.
View Article : Google Scholar : PubMed/NCBI
|
|
23
|
Kim HG, Hien TT, Han EH, Hwang YP, Choi
JH, Kang KW, Kwon KI, Kim BH, Kim SK, Song GY, et al: Metformin
inhibits P-glycoprotein expression via the NF-kappaB pathway and
CRE transcriptional activity through AMPK activation. Br J
Pharmacol. 162:1096–1108. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
24
|
Kharasch ED, Hill HF and Eddy AC:
Influence of dexmedetomidine and clonidine on human liver
microsomal alfentanil metabolism. Anesthesiology. 75:520–524. 1991.
View Article : Google Scholar : PubMed/NCBI
|
|
25
|
Nakazato K, Yoshida Y, Takemori K,
Kobayashi K and Sakamoto A: Expressions of genes encoding
drug-metabolizing enzymes are altered after sevoflurane,
isoflurane, propofol or dexmedetomidine anesthesia. Biomed Res.
30:17–24. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
26
|
Lu Y, Shen T, Yang H and Gu W: Ruthenium
complexes induce HepG2 human hepatocellular carcinoma cell
apoptosis and inhibit cell migration and invasion through
regulation of the Nrf2 pathway. Int J Mol Sci. 17(pii): E7752016.
View Article : Google Scholar : PubMed/NCBI
|
|
27
|
Xiong J, Wang K, He J, Zhang G, Zhang D
and Chen F: TFE3 alleviates hepatic steatosis through
autophagy-induced lipophagy and PGC1α-mediated fatty acid
β-Oxidation. Int J Mol Sci. 17:3872016. View Article : Google Scholar : PubMed/NCBI
|
|
28
|
Zhao B, Xie GJ, Li RF, Chen Q and Zhang
XQ: Dexamethasone protects normal human liver cells from apoptosis
induced by tumor necrosis factor-related apoptosis-inducing ligand
by upregulating the expression of P-glycoproteins. Mol Med Rep.
12:8093–8100. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
29
|
Liu S, Cheng Y, Rao M, Tang M and Dong Z:
Muscone induces CYP1A2 and CYP3A4 enzyme expression in L02 human
liver cells and CYP1A2 and CYP3A11 enzyme expression in kunming
mice. Pharmacology. 99:205–215. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
30
|
Liao Z, Cao D, Han X, Liu C, Peng J, Zuo
Z, Wang F and Li Y: Both JNK and P38 MAPK pathways participate in
the protection by dexmedetomidine against isoflurane-induced
neuroapoptosis in the hippocampus of neonatal rats. Brain Res Bull.
107:69–78. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
31
|
Wang H, Jia XH, Chen JR, Yi YJ, Wang JY,
Li YJ and Xie SY: HOXB4 knockdown reverses multidrug resistance of
human myelogenous leukemia K562/ADM cells by downregulating P-gp,
MRP1 and BCRP expression via PI3K/Akt signaling pathway. Int J
Oncol. 49:2529–2537. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
32
|
Yan JK, Zhu J, Gu BL, Yan WH, Xiao YT,
Zhou KJ, Wen J, Wang Y and Cai W: Soybean oil-based lipid emulsion
increases intestinal permeability of lipopolysaccharide in Caco-2
cells by downregulation of P-Glycoprotein via ERK-FOXO 3a pathway.
Cell Physiol Biochem. 39:1581–1594. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
33
|
Chi X, Wei X, Gao W, Guan J, Yu X, Wang Y,
Li X and Cai J: Dexmedetomidine ameliorates acute lung injury
following orthotopic autologous liver transplantation in rats
probably by inhibiting Toll-like receptor 4-nuclear factor kappa B
signaling. J Transl Med. 13:1902015. View Article : Google Scholar : PubMed/NCBI
|
|
34
|
Requenez-Contreras JL, López-Castillejos
ES, Hernández-Flores R, Moreno-Eutimio MA, Granados-Riveron JT,
Martinez-Ruiz GU and Aquino-Jarquin G: MiR-138 indirectly regulates
the MDR1 promoter by NF-κB/p65 silencing. Biochem Biophys Res
Commun. 484:648–655. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
35
|
Chen Q, Bian Y and Zeng S: Involvement of
AP-1 and NF-κB in the up-regulation of P-gp in vinblastine
resistant Caco-2 cells. Drug Metab Pharmacokinet. 29:223–226. 2014.
View Article : Google Scholar : PubMed/NCBI
|
